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Genetics Rules Rule #1? Rule #2: Incomplete dominancesome alleles aren’t completely dominant so they BLEND Rule #3: Codominancesome alleles dominate together so BOTH ARE SEEN Rule #4: sex-linked genesALL alleles on a male’s X chromosome (X-linked) are expressed. Complete Dominance Rule #1—some alleles completely dominate over others: B=brown eyes b=blue eyes Bb= brown eyes, so B is completely dominant. Incomplete Dominance Rule #2—some alleles DON’T COMPLETELY DOMINATE, so they blend: RR= red flowers rr = white flowers Rr = pink flowers PINK FLOWERS!!! BLENDING!!! Codominance Rule #3—some alleles dominate TOGETHER so they BOTH are shown H = brown hair on horses H’ = white hair on horses HH’ = both brown and white hairs, so the horse is roan color. Blood types are like this, too. Roan Horse Blood Types Antigens-markers on cells Blood type determined by your carbohydrate markers on your red blood cells 4 blood group phenotypes: Type A has A antigens Type B has B antigens Type AB has A and B antigens Type O has no antigens Multiple Alleles Multiple alleles- 3 different forms of the gene code for blood types IA, IB, and i A Allele I makes an “A” antigen B I makes a “B” antigen i makes none 6 blood group genotypes Complete dominance- IA and IB dominate over i Codominance- IAIB genotype shows BOTH A and B carbs Blood Types Reactivity to blood transfusions and organs: Antibodies-proteins produced by your immune system to fight off things that look “foreign.” Type A (makes anti-B antibodies) Type B (makes anti-A antibodies) Type AB (makes NO antibodies—universal receiver) Type O (makes anti-A and anti-B antibodies— universal donor) Free Write Journal Entry Why? Take time to absorb the material and think about and process the information. What should you do? Take a couple of minutes to write down any thoughts, questions, or ideas at the bottom of your notes. There are no right or wrong entries, as long as you try. Sex-Linked Genes Rule #4: sex-linked genesALL alleles on a male’s X chromosome (X-linked) are expressed. Male sex chromosomes?_________ Female sex chromosomes?_________ We also call sex-linked genes by another name, X-linked, because the X chromosome has the majority of the genes. Sex-Linked Genes In males, EVERY gene on their X chromosome is expressed. The Y doesn’t have the same genes. In females this is not the case because they have another copy on their other X chromosome to overcome it. Sex-Linked Genes Examples of sex-linked disorders: Colorblindness Hemophilia Fragile X Syndrome Duchene Muscular Dystrophy Cleft Palate Vitamin D Resistant Ricketts 3 types of deafness Male Pattern Baldness Sex-Linked Genes The genes that occur on the sex chromosomes must be written with X’s and Y’s to show this special situation. For example: red-green colorblindness is a recessive trait. It is found on the X chromosome, not the Y. We write the alleles (forms of the gene) this way: XC = colorblindness XC = normal Sex-Linked Genes Try to complete this table: Phenotypes Normal Male Colorblind Male Normal Female Normal “carrier” Female Colorblind female Genotypes