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General Endocrinology(AP 723) Faculty of Agriculture Department of Animal Production First Semester 2005/2006 Instructor: Dr. Mustafa Beni-Domi Phone:7201000 Ext. 22221 E-mail: [email protected] Office hours: (Sun, Mon, Tue & Wed 8:15-9:15) or by an appointment. Lecture hall: M2 006 or the Animal Physiology Lab Lecture time: 9:45 – 11:15 (Mon and Wed) Course objectives: 1) Develop student’s knowledge of hormonal actions and regulatory aspects of the endocrine system. 2) Relate basic information to applied/clinical endocrinology. 3) Expose students to current research findings and literature. What are expected to learn from this course: This course covers the endocrinology of animals, including man: physiology and anatomy of the endocrine glands and the biosynthesis and chemistry of hormones. Upon completion of the course, each student should be able to discuss the actions of all hypothalamic, pituitary, and reproductive hormones. Students should be able describe methodologies used in endocrinology and be able to apply those to various endocrine research approaches. Provide detail about the pituitary gland and the hormones associated with it. Describe the class, synthesis, secretion and modes of action of various hormones. Describe adrenal gland hormones and hormonal control of reproduction for males and females. Course Contents: Week 1-2 3 4 5-6 Subject Endocrine tissues, hormones and actions Endocrine hypothalamus Endocrine methodologies Pituitary hormones Reference 1 1 1 1 7 8 9 10 11 12 13 14 15 16 Neurohypophysial hormones Growth hormones Thyroid hormones Adrenal hormones - Glucocorticoids - Minralocoticoids - Catecholamines Pancreatic hormones Gastrointestinal hormones Calcium homeostasis Male reproductive endocrinology Female reproductive endocrinology Pineal gland 1 1 1 1 1 1 1 1 1 1 Lecture text: 1. Required text: Endocrinology, 5th Edition, Mac E Hadley, Prentice Hall, 2000. Grading: First exam Second exam Final exam Written Comprehensive Term paper 25% (Wed-November 9, 2005) 25% (Wed-December 7, 2005) 40% to be scheduled 10% (not later than May 9th, 2004) Notes: Attendance in class is required. Students are expected to attend class regularly. Participation in class discussions is strongly encouraged. No make-up exams unless absence was excused. The Term Paper In an effort to provide you the opportunity to learn unique writing and presentation skills, I have incorporated two different writing assignments in AP 723. The first writing exercise will be a critique of a journal article relevant and recent to endocrinology. In this assignment, you shall be given a choice of recent journal articles and shall select one to evaluate. The article must be approved by the instructor. The critique will examine both the science and the presentation of data used by the author(s). Contact me for further information about this assignment. The second writing exercise will be a case study or research report in Veterinary Endocrinology. Organization of your written report should conform to the following outlines: First page: Title of report, your name, course title and number, semester and year. List which species and endocrine topic (i.e., hypothalamus, pituitary, growth hormone, prolactin, insulin, ….etc)the report covers. Abstract: A concise summary (about half page). Introduction: Describe the situation in general terms. Provide background information needed to understand the study. What circumstances initiated the study (about half page)? Pages 2 to 5: Symptoms (1/4 to 1/2 page). Diagnosis. Describe any diagnostic tests that were performed; why were they performed; test results and their interpretation (1/2 to 1 page). Therapy: What was the nature of treatment and response (1/4 to 1/2 page). Endocrine aspects of the case. Describe underlying endocrine physiology (1-2 pages). Diagrams, illustrations, tables, graphs, pictures etc. Include legends. List source material (references) used for report as in the Journal of Journal of Clinical Endocrinology and Metabolism. Format of the paper: Double-spaced typed (12 pt font, Arial), 1-inch margins and numbered pages. Source of material for Vet cases may be found in Vet Medicine Journals, Journal of Clinical Endocrinology and Metabolism or any other related clinical reports. Oral presentations at the end of the semester will be limited to 15-20 minutes. General Endocrinology(AP 723) Faculty of Agriculture Department of Animal Production First Semester 2001/2002 Instructor: Dr. Mustafa Beni-Domi Phone:7095111 Ext. [email protected] 22221 E-mail: Office hours: (Mon & Wed 10:15-1:15). Lecture hall: G2 120 Lecture time: 11:15 – 12:15 (Sun, Tue & Thu) Course objectives: 1) Develop student’s knowledge of hormonal actions and regulatory aspects of the endocrine system. 2) Relate basic endocrinology. information 3) Expose students literature. to current to applied/clinical research findings What are expected to learn from this course: This course covers the endocrinology of animals, including man: physiology and anatomy of the endocrine glands and the biosynthesis and chemistry of hormones. Students should be able describe methodologies used in endocrinology and be able to apply those to various endocrine research approaches. Provide detail about the pituitary gland and the hormones associated with it. Describe the class, synthesis, secretion and modes of action of various hormones. Describe adrenal gland hormones and hormonal control of reproduction for males and females. Course Contents: Week Subject Reference and 1-2 Endocrine tissues, hormones and actions 1 3 Endocrine hypothalamus 1 4 Endocrine methodologies 1 5-6 Pituitary hormones 1 7 Neurohypophysial hormones 1 8 Growth hormones 1 9 10 Thyroid hormones Adrenal hormones - Glucocorticoids - Minralocoticoids - Catecholamines 1 1 11 Pancreatic hormones 1 12 Gastrointestinal hormones 1 13 Calcium homeostasis 1 14 Male reproductive endocrinology 1 15 Female reproductive endocrinology 1 16 Pineal gland 1 Lecture text: 1. Required text: Endocrinology, Hadley, Prentice Hall, 2000 Grading: First exam Second exam Term paper Final exam 20% 20% 10% 50% 5th Edition, Mac E (Thursday-November 15th, 2001) (Thursday-December 20th, 2001) (Due January 14th, 2001) (to be scheduled) Notes: Attendance in class is required. Students are expected to attend class regularly. Participation in class discussions is strongly encouraged. No make-up exams unless absence was excused. General Endocrinology (AP 723) A case study or research report in Vet endocrinology Organization of your following outlines: written report should name, course title First page: Title of report, your semester and year. conform and to number, List which species and endocrine topic (i.e., hypothalamus, pituitary, growth hormone, prolactin, insulin, ….etc)the report covers. Abstract: A concise summary (about half page). Introduction: Describe the situation in general terms. Provide background information needed to understand the study. What circumstances initiated the study (about half page)? Pages 2 to 5: Symptoms (1/4 to 1/2 page). Diagnosis. Describe any diagnostic performed; why were they performed; their interpretation (1/2 to 1 page). tests that were test results and Therapy: What was the nature of treatment and response (1/4 to 1/2 page). Endocrine aspects of the case. endocrine physiology (1-2 pages). Diagrams, illustrations, Include legends. tables, Describe graphs, List source material used for report. Format of the paper: underlying pictures etc. the Typed (12 pt font) 1-inch margins Double-spaced Numbered pages Source material for Vet cases may be found in Vet Medicine Journals or any other related clinical reports. LECTURE/DATE 1 Sept 2 3 4 5 6 7 8 9 Oct 2 Introduction - Endocrinology, Neuroendocrinology, and their Methods 1-3 6 NO CLASS LABOR DAY 9 Mechanism of Hormone Action Receptors, Steroids & Thyroid Hormones 1-4 13 Mechanism of Hormone Action Peptide, Protein and Neurohormones 1-4,21 16 Hypothalamus / Pituitary Hypophysiotropic Neurohormones 5-6,21 20 Hypothalamus /Anterior Pituitary - Pituitary Anatomy and Hierarchies 5-6,21 23 Hypothalamus /Posterior Pituitary - Vasopressin and Oxytocin 7 27 Intermediary Pituitary and Pineal - Melanotropins and Melatonin 8,20,21 30 REVIEW - Material from lecture #1 through lecture #7 1-8,20,21 4 EXAM #1 - 25% of final grade (lectures #1 through #7) 1-8,20,21 10 7 D 11 11 12 13 TOPIC & CHAPTER IN COURSE TEXTBOOK 14 18 Calcium Regulating Hormones - PTH, Calcitonin, Vit 9 Gastrointestinal Endocrine System Gastrointestinal Hormones 10 Pancreas - Insulin and Glucagon from the Pancreas 11 Growth - Growth Hormones and Growth Regulators (Growth Factors) 12 Thyroid - Thyroxine and Triiodotyronine from the Thyroid 13 25 Adrenal Gland - Catecholamines and Adrenal Medulla 14 28 Steroid Hormones - Adrenal, Ovarian, and Testicular Steroid Hormones 15 1 Adrenal Gland - Glucocorticoids and the Adrenal Cortex 15 4 Adrenal and Kidney - Aldosterone and the Renin-Angiotensin System 15 8 REVIEW - Material from lecture #10 through lecture #18 8-15,20 11 EXAM #2 - 25% of final grade (lectures #1 through #18) 1-15,20,21 14 15 16 17 Nov 18 19 20 21 21 22 23 24 25 26 Dec 15 Reproduction - Sexual Determination, Differentiation and Development 16 18 Reproduction - Endocrinology of Male and Female Reproduction 16,17,18 22 Reproduction - Neuroendocrine Control of Reproductive Cyclicity 18 29 Reproduction Overview - From Fertility to Menopause 16-19 2 Course Summary - Neural, Endocrine and Neuroendocrine Control 1-21 6 REVIEW - Material from lecture #21 through lecture #25