- 1 - Human chorionic gonadotropin (hCG) isoforms and their
... is 92 amino acids (aa) in length and common to all four human GPHs. Consequently measurement of the α-subunit is not specific for hCG or any other GPH. The βsubunits of GPHs confer receptor- as well as immunological specificity with the exception of hCGβ and hLHβ that share to a high degree genetic, ...
... is 92 amino acids (aa) in length and common to all four human GPHs. Consequently measurement of the α-subunit is not specific for hCG or any other GPH. The βsubunits of GPHs confer receptor- as well as immunological specificity with the exception of hCGβ and hLHβ that share to a high degree genetic, ...
Iodine Deficiency
... paid to iodine deficiency in public health programs in most countries— goiter was considered a lump in the neck primarily of cosmetic concern. This changed during the period of 1970 –1990. Controlled studies in iodine-deficient regions showed that iodine supplementation not only eliminated new cases ...
... paid to iodine deficiency in public health programs in most countries— goiter was considered a lump in the neck primarily of cosmetic concern. This changed during the period of 1970 –1990. Controlled studies in iodine-deficient regions showed that iodine supplementation not only eliminated new cases ...
Reaccumulation of Thyroglobulin and Colloid in Rat and Mouse
... TSH injection and therefore the pinocytotic response to TSH decreased rapidly within 1 d after the onset of TSH treatment and even more so after 4 d. If a single dose of 50 mg NaC104 was injected together with the last TSH dose, droplet formation was immediately restored (Fig. 3D). In Table II the n ...
... TSH injection and therefore the pinocytotic response to TSH decreased rapidly within 1 d after the onset of TSH treatment and even more so after 4 d. If a single dose of 50 mg NaC104 was injected together with the last TSH dose, droplet formation was immediately restored (Fig. 3D). In Table II the n ...
Ghrelin: Structure and Function
... stimulate the release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G proteincoupled receptor whose ligand has only been discovered recently. Using a reverse pharmacology paradigm with a stable cell line expressing GHS-R, we purified an endogenous ligand for GHS-R from rat ...
... stimulate the release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G proteincoupled receptor whose ligand has only been discovered recently. Using a reverse pharmacology paradigm with a stable cell line expressing GHS-R, we purified an endogenous ligand for GHS-R from rat ...
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... stimulate the release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G proteincoupled receptor whose ligand has only been discovered recently. Using a reverse pharmacology paradigm with a stable cell line expressing GHS-R, we purified an endogenous ligand for GHS-R from rat ...
... stimulate the release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G proteincoupled receptor whose ligand has only been discovered recently. Using a reverse pharmacology paradigm with a stable cell line expressing GHS-R, we purified an endogenous ligand for GHS-R from rat ...
Ghrelin: Structure and Function - Physiological Reviews
... stimulate the release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G proteincoupled receptor whose ligand has only been discovered recently. Using a reverse pharmacology paradigm with a stable cell line expressing GHS-R, we purified an endogenous ligand for GHS-R from rat ...
... stimulate the release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G proteincoupled receptor whose ligand has only been discovered recently. Using a reverse pharmacology paradigm with a stable cell line expressing GHS-R, we purified an endogenous ligand for GHS-R from rat ...
Oral Octreotide Absorption in Human Subjects: Comparable
... PK and pharmacodynamic (PD) data were collected to evaluate the oral octreotide formulation in healthy adult volunteers in four separate studies (Fig. 1). In study 1, octreotide PK measurements were performed in 12 males (mean age, 23 yr) using a partly randomized, dose-escalation two-way crossover ...
... PK and pharmacodynamic (PD) data were collected to evaluate the oral octreotide formulation in healthy adult volunteers in four separate studies (Fig. 1). In study 1, octreotide PK measurements were performed in 12 males (mean age, 23 yr) using a partly randomized, dose-escalation two-way crossover ...
The Pineal Gland, via Melatonin, Protects DNA, Coordinates the
... rhythms, tachykinin concentrations in the pineal gland do not Tachykinin, NKA., concentrations in the hypothalamus (39) and anterior pituitary (22) increase when exposed to testosterone and decrease with the loss of testosterone. This is the opposite effect seen in the pineal gland. The tachykinins ...
... rhythms, tachykinin concentrations in the pineal gland do not Tachykinin, NKA., concentrations in the hypothalamus (39) and anterior pituitary (22) increase when exposed to testosterone and decrease with the loss of testosterone. This is the opposite effect seen in the pineal gland. The tachykinins ...
Determination of iodine content in different brands table salt of
... 1993. Since then, more than 90 million newborns are protected each year from learning disabilities caused by IDD (WHO). More than 90 percent of the populations of 21 developing countries use iodized salt. In 1998, nearly 60% of world's edible salt was iodized and there was a significant decrease in ...
... 1993. Since then, more than 90 million newborns are protected each year from learning disabilities caused by IDD (WHO). More than 90 percent of the populations of 21 developing countries use iodized salt. In 1998, nearly 60% of world's edible salt was iodized and there was a significant decrease in ...
kaunas university of medicine
... Lithuanian National survey data presented in 1995, revealed 62% of population with UI less than 100 μg/L (42, 48). In addition, there is growing evidence that iodine deficiency has reappeared in some European countries where it was thought to have been eliminated (31). Salt iodization remains the re ...
... Lithuanian National survey data presented in 1995, revealed 62% of population with UI less than 100 μg/L (42, 48). In addition, there is growing evidence that iodine deficiency has reappeared in some European countries where it was thought to have been eliminated (31). Salt iodization remains the re ...
Thyroid hormone binding proteins as novel targets for hydroxylated
... metabolite. In addition a concommitant shift (NIH-shift) is possible of chlorine substituents from the site of hydroxylation to the next neighbour carbon atom in the aromatic ring. The presence of 2 vicinal unsubstituted carbon atoms greatly facilitates metabolic hydroxylation (Safe, 1989). The hydr ...
... metabolite. In addition a concommitant shift (NIH-shift) is possible of chlorine substituents from the site of hydroxylation to the next neighbour carbon atom in the aromatic ring. The presence of 2 vicinal unsubstituted carbon atoms greatly facilitates metabolic hydroxylation (Safe, 1989). The hydr ...
History of the Fluoride/Iodine Antagonism
... for fluoride to cause thyroid changes. (This in accord with May (1950), who found that although it might take months - “sometimes even a year” - even low fluoride amounts would always be successful in lowering iodine levels...May urged the practioner to be patient...) 1955 - Korrodi, Wegmann, Galett ...
... for fluoride to cause thyroid changes. (This in accord with May (1950), who found that although it might take months - “sometimes even a year” - even low fluoride amounts would always be successful in lowering iodine levels...May urged the practioner to be patient...) 1955 - Korrodi, Wegmann, Galett ...
Melatonin treatment of aging women: doses, side effects, how to manage them
... Melatonin therapy may reduce or stop benzodiazenine theray prescribe in case of sleep disorders n = 22 ...
... Melatonin therapy may reduce or stop benzodiazenine theray prescribe in case of sleep disorders n = 22 ...
PDF hosted at the Radboud Repository of the Radboud University
... biosynthesis depends on iodine availability; in fact, thyroid hormones are one of the few biological compounds in which iodine is incorporated. For thyroid hormone biosynthesis to rely on a trace element at first seems strange, not in the least when we consider the many fundamental processes under c ...
... biosynthesis depends on iodine availability; in fact, thyroid hormones are one of the few biological compounds in which iodine is incorporated. For thyroid hormone biosynthesis to rely on a trace element at first seems strange, not in the least when we consider the many fundamental processes under c ...
Plasma Thyrotropin-Releasing Hormone Concentrations in the Rat
... TRH by bioassay in some inistainces (2, 3), is relati-ely easy. Detection of TRH in plasma has proveen more (lifficult, due in part to insufficient assay sensitivity anid also to the presence in plasma of an enzymile(s) wN-lichl very rapidly destroys TRH (4, 5). The significance of TRH in peripheral ...
... TRH by bioassay in some inistainces (2, 3), is relati-ely easy. Detection of TRH in plasma has proveen more (lifficult, due in part to insufficient assay sensitivity anid also to the presence in plasma of an enzymile(s) wN-lichl very rapidly destroys TRH (4, 5). The significance of TRH in peripheral ...
laboratory support for the diagnosis of thyroid disease
... Ewen Downie Metabolic Unit, Alfred Hospital, Melbourne, Victoria, Australia Section 1. Foreword and Introduction Physicians need quality laboratory testing support for the accurate diagnosis and cost-effective management of thyroid disorders. On occasion, when the clinical suspicion is strong, as in ...
... Ewen Downie Metabolic Unit, Alfred Hospital, Melbourne, Victoria, Australia Section 1. Foreword and Introduction Physicians need quality laboratory testing support for the accurate diagnosis and cost-effective management of thyroid disorders. On occasion, when the clinical suspicion is strong, as in ...
NACB: Laboratory Support for the Diagnosis and Monitoring of Thyroid... Laurence M. Demers, Ph.D., F.A.C.B.and Carole A. Spencer Ph.D., F.A.C.B.
... Ewen Downie Metabolic Unit, Alfred Hospital, Melbourne, Victoria, Australia Section 1. Foreword and Introduction Physicians need quality laboratory testing support for the accurate diagnosis and cost-effective management of thyroid disorders. On occasion, when the clinical suspicion is strong, as in ...
... Ewen Downie Metabolic Unit, Alfred Hospital, Melbourne, Victoria, Australia Section 1. Foreword and Introduction Physicians need quality laboratory testing support for the accurate diagnosis and cost-effective management of thyroid disorders. On occasion, when the clinical suspicion is strong, as in ...
2011: master class reptilian thyroid anatomy, physiology and disease
... by T3, free T3 (fT3), and free T4 (fT4). In Testudo spp. fT4 is often below the limits of detection (< 0.45 pmol/L) of mammalian thyroid assays (Buhler, 2006). It is believed T4 plays a more central role in thyroid metabolism as Kohel et al, 2001, were unable to measure any T3 over a two-year period ...
... by T3, free T3 (fT3), and free T4 (fT4). In Testudo spp. fT4 is often below the limits of detection (< 0.45 pmol/L) of mammalian thyroid assays (Buhler, 2006). It is believed T4 plays a more central role in thyroid metabolism as Kohel et al, 2001, were unable to measure any T3 over a two-year period ...
HardasNails-Marianco
... are measured at 1-hour intervals for the next 3 hours. If the glucose levels do not fall appropriately, then a person has insulin resistance. If the insulin levels are much higher than usual, then the person has insulin resistance. The person taking the test usually feels sick after ingesting 75 gra ...
... are measured at 1-hour intervals for the next 3 hours. If the glucose levels do not fall appropriately, then a person has insulin resistance. If the insulin levels are much higher than usual, then the person has insulin resistance. The person taking the test usually feels sick after ingesting 75 gra ...
Sleep Disorders Editorial
... about its generally minor side effects, as would be obligatory for hypnotic drugs or for other hormones, such estrogens or thyroxine. This is because, from a regulatory standpoint, orally-administered melatonin is classified not as a drug or hormone but as a ‘dietary supplement’—even though no food ...
... about its generally minor side effects, as would be obligatory for hypnotic drugs or for other hormones, such estrogens or thyroxine. This is because, from a regulatory standpoint, orally-administered melatonin is classified not as a drug or hormone but as a ‘dietary supplement’—even though no food ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... methods employing specific antibody reagents directed at these ligands (6,20). However, sensitivity, specificity andstandardization issues still result in substantial between-method variability for many of these tests (21-23). To address this issue, new performance standards are being established by ...
... methods employing specific antibody reagents directed at these ligands (6,20). However, sensitivity, specificity andstandardization issues still result in substantial between-method variability for many of these tests (21-23). To address this issue, new performance standards are being established by ...
Author Stephen LaFranchi, MD Section Editor Mitchell Geffner, MD
... Congenital central hypothyroidism also can be caused by insufficient treatment of maternal hyperthyroidism during pregnancy [42,43]. Congenital central hypothyroidism may persist beyond 6 months of age especially when maternal thyrotoxicosis occurred before 32 weeks gestation [43]. One study suggest ...
... Congenital central hypothyroidism also can be caused by insufficient treatment of maternal hyperthyroidism during pregnancy [42,43]. Congenital central hypothyroidism may persist beyond 6 months of age especially when maternal thyrotoxicosis occurred before 32 weeks gestation [43]. One study suggest ...
disorders of the thyroid gland in infancy, childhood and adolescence
... in thyroid gland development or inborn errors of thyroid hormonogenesis present in infancy whereas babies with less severe defects or acquired abnormalities, particularly autoimmune thyroid disease, present later in childhood and adolescence. In the newborn infant, thyroid function is influenced no ...
... in thyroid gland development or inborn errors of thyroid hormonogenesis present in infancy whereas babies with less severe defects or acquired abnormalities, particularly autoimmune thyroid disease, present later in childhood and adolescence. In the newborn infant, thyroid function is influenced no ...
Serum human chorionic gonadotropin concentrations greater than
... hCG methods have been extensively characterized previously; both assays recognize hyperglycosylated hCG, hCGb, and nicked hCG (16). The dynamic range of each assay was as follows: Siemens Centaur TSH ¼ 0.02–150 mIU=mL, FT4 ¼ 0.1– 12 ng=dL; Ortho Vitros ECi TSH ¼ 0.01–100 mIU=mL, FT4 ¼ ...
... hCG methods have been extensively characterized previously; both assays recognize hyperglycosylated hCG, hCGb, and nicked hCG (16). The dynamic range of each assay was as follows: Siemens Centaur TSH ¼ 0.02–150 mIU=mL, FT4 ¼ 0.1– 12 ng=dL; Ortho Vitros ECi TSH ¼ 0.01–100 mIU=mL, FT4 ¼ ...
Adrenal failure
... • In primary adrenal insufficiency, all the above mentioned causes result in gradual destruction of the adrenal cortex. However, the clinical manifestations of the condition appear when the loss of the adrenocortical tissue of both glands is higher than 90% . In the initial phase of chronic gradual ...
... • In primary adrenal insufficiency, all the above mentioned causes result in gradual destruction of the adrenal cortex. However, the clinical manifestations of the condition appear when the loss of the adrenocortical tissue of both glands is higher than 90% . In the initial phase of chronic gradual ...