Pediatric Endocrinology - The American Board of Pediatrics
... 13. Know the signs and symptoms of celiac disease in a child with type 1 diabetes 14. Know the tests that may be useful for diagnosis of celiac disease 15. Understand the treatment of celiac disease and when treatment should be recommended 16. Know the effects of blood pressure on later development ...
... 13. Know the signs and symptoms of celiac disease in a child with type 1 diabetes 14. Know the tests that may be useful for diagnosis of celiac disease 15. Understand the treatment of celiac disease and when treatment should be recommended 16. Know the effects of blood pressure on later development ...
PDF hosted at the Radboud Repository of the Radboud University
... The thyroid gland, composed of thyroid follicles, is the single site of biosynthesis of thyroid hormones in vertebrates. The synthesis of thyroid hormones involves the coupling of iodide to the phenolic ring of tyrosine residues in thyroglobulin. This organification of iodide in thyroglobulin is loc ...
... The thyroid gland, composed of thyroid follicles, is the single site of biosynthesis of thyroid hormones in vertebrates. The synthesis of thyroid hormones involves the coupling of iodide to the phenolic ring of tyrosine residues in thyroglobulin. This organification of iodide in thyroglobulin is loc ...
Thyroid hormones and their effects: a new
... Another prejudice stems from my early physiological training. It is that the scientific use of the word ‘ regulation ’ involves homeostasis and therefore requires negative feedback to be involved somewhere. This meaning of ‘ regulation ’ is also applicable to biochemistry, with respect to the contro ...
... Another prejudice stems from my early physiological training. It is that the scientific use of the word ‘ regulation ’ involves homeostasis and therefore requires negative feedback to be involved somewhere. This meaning of ‘ regulation ’ is also applicable to biochemistry, with respect to the contro ...
- Repository of the Academy`s Library
... experimental variables that demand consideration when thyroid studies are being designed. The conclusions of the task force are presented in this document as ‘‘American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models.’’ The 70 recommendations a ...
... experimental variables that demand consideration when thyroid studies are being designed. The conclusions of the task force are presented in this document as ‘‘American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models.’’ The 70 recommendations a ...
The Pineal Gland, via Melatonin, Protects DNA, Coordinates the
... pineal gland, but also in the retina and GI tract. Two other consistencies in human melatonin production are the calcification of the pineal gland with age and the steady decline of melatonin production with age after reproductive viability has expired. The calcification of the pineal gland is not r ...
... pineal gland, but also in the retina and GI tract. Two other consistencies in human melatonin production are the calcification of the pineal gland with age and the steady decline of melatonin production with age after reproductive viability has expired. The calcification of the pineal gland is not r ...
Ascorbic Acid Increases the Thyrotropin
... chemical amidation, and pyro-glutamyl formationwas converted into material possessing TRH immunoactivity and bioactivity. However, studies demonstrating the incorporation of radioactivity into TRH by cultured cells have been few, and the convincing demonstration of the formation of authentic TRH fro ...
... chemical amidation, and pyro-glutamyl formationwas converted into material possessing TRH immunoactivity and bioactivity. However, studies demonstrating the incorporation of radioactivity into TRH by cultured cells have been few, and the convincing demonstration of the formation of authentic TRH fro ...
Neuroendocrine regulation of GnRH release and expression of
... GnRH mRNA level in the entire hypothalamus of anestrous ewes was significantly lower than in the follicular and/or luteal phase animals (fig. 2). The low GnRH gene expression in the hypothalamus of anestrous ewes may be responsible for the decrease in GnRH biosynthesis and release as well as the non ...
... GnRH mRNA level in the entire hypothalamus of anestrous ewes was significantly lower than in the follicular and/or luteal phase animals (fig. 2). The low GnRH gene expression in the hypothalamus of anestrous ewes may be responsible for the decrease in GnRH biosynthesis and release as well as the non ...
nr. 502 - 2016 Semi-Mechanistic Pharmacokinetic and
... With an interest in applied mathematics, in particular modelling within human physiology, pharmacokinetic (PK) and pharmacodynamic (PD) modelling in drug development was the ideal topic for my PhD work. The project was an industrial PhD as a collaboration between the department of Science, Systems, ...
... With an interest in applied mathematics, in particular modelling within human physiology, pharmacokinetic (PK) and pharmacodynamic (PD) modelling in drug development was the ideal topic for my PhD work. The project was an industrial PhD as a collaboration between the department of Science, Systems, ...
LEPTIN AND OTHER ENDOCRINE SYSTEMS
... prolactin secretion at much higher concentrations (10"^-10'^M). Low concentrations of leptin stimulate GH release from human fetal pituitary cell cultures but not ACTH, prolactin or gonadotropin secretion^^. The ability of leptin to stimulate GH release decreased as gestational age at which the pitu ...
... prolactin secretion at much higher concentrations (10"^-10'^M). Low concentrations of leptin stimulate GH release from human fetal pituitary cell cultures but not ACTH, prolactin or gonadotropin secretion^^. The ability of leptin to stimulate GH release decreased as gestational age at which the pitu ...
Endocrine Module (PYPP 5260), Thyroid Section, Spring 2002 Jack DeRuiter
... “True” hyperthyroidism (Table 2) is caused by production of elevated levels of TSH (tumors, pituitary resistance), production of thyroid stimulators other than TSH (antibodies as in Graves’ disease), or by thyroid autonomy (multinodular goiters). “True” hyperthyroidism is differentiated from other f ...
... “True” hyperthyroidism (Table 2) is caused by production of elevated levels of TSH (tumors, pituitary resistance), production of thyroid stimulators other than TSH (antibodies as in Graves’ disease), or by thyroid autonomy (multinodular goiters). “True” hyperthyroidism is differentiated from other f ...
evaluation-of-thyroi.. - Thyroid Disease Manager
... procedures provide a means to directly evaluate thyroid gland function. Formerly these tests were used in the diagnosis of hypothyroidism and thyrotoxicosis, but this application has been supplanted by measurement of serum TSH and thyroid hormone concentrations in blood. Also, alterations of thyroid ...
... procedures provide a means to directly evaluate thyroid gland function. Formerly these tests were used in the diagnosis of hypothyroidism and thyrotoxicosis, but this application has been supplanted by measurement of serum TSH and thyroid hormone concentrations in blood. Also, alterations of thyroid ...
Thyroid status in exercising horses and laminitic ponies
... The objective of these studies was to contribute to the understanding and assessment of thyroid function in horses. The first study evaluated methods of assessing thyroid function in horses, including validation of an enzyme immunoassay (EIA) for measuring equine thyroid hormones and development and ...
... The objective of these studies was to contribute to the understanding and assessment of thyroid function in horses. The first study evaluated methods of assessing thyroid function in horses, including validation of an enzyme immunoassay (EIA) for measuring equine thyroid hormones and development and ...
Controversies In The Diagnosis And Treatment Of Hypothyroidism
... Diagnosis of hypothyroidism: Why TSH testing may not be an accurate marker of tissue thyroid levels Hypothyroidism is a common disorder characterized by an inadequate cellular thyroid effect to meet the needs of the tissues. Typical symptoms of hypothyroidism include the following: fatigue, weight g ...
... Diagnosis of hypothyroidism: Why TSH testing may not be an accurate marker of tissue thyroid levels Hypothyroidism is a common disorder characterized by an inadequate cellular thyroid effect to meet the needs of the tissues. Typical symptoms of hypothyroidism include the following: fatigue, weight g ...
Effect of ghrelin on regulation of growth hormone release: A review
... ghrelin, obestatin and ghrelin-associated peptides originated from the ghrelin gene.(10) In the rat stomach, a second type of ghrelin peptide with a C8:0-modification has been identified as the desGln14-form of “ghrelin” (C8:0-des-Gln14-ghrelin), a 27-amino acid peptide hormone.(11) Another ligand, ...
... ghrelin, obestatin and ghrelin-associated peptides originated from the ghrelin gene.(10) In the rat stomach, a second type of ghrelin peptide with a C8:0-modification has been identified as the desGln14-form of “ghrelin” (C8:0-des-Gln14-ghrelin), a 27-amino acid peptide hormone.(11) Another ligand, ...
MODELING THE DYNAMICS OF THYROID HORMONES AND
... for scenario analysis to support medical education, training and research, without risking patients’ health. Initially, the model structure is tested by standard structure validity tests. After the validation part, four common thyroid disorders are simulated. Firstly, Graves’ disease, the most commo ...
... for scenario analysis to support medical education, training and research, without risking patients’ health. Initially, the model structure is tested by standard structure validity tests. After the validation part, four common thyroid disorders are simulated. Firstly, Graves’ disease, the most commo ...
Interpreting Thyroid Toxicity for Risk Assessment
... In principle, the adverse effects of toxicant-induced thyroid dysfunction would most effectively be reflected in the specific effects of low or high circulating concentrations of thyroid hormone. This could be envisioned as equivalent to the uterotrophic assay for estrogens (31), or the Hershberger ...
... In principle, the adverse effects of toxicant-induced thyroid dysfunction would most effectively be reflected in the specific effects of low or high circulating concentrations of thyroid hormone. This could be envisioned as equivalent to the uterotrophic assay for estrogens (31), or the Hershberger ...
this PDF file - Design for Scientific Renaissance
... between hypothyroidism and PCOS in comparison with the healthy control group. We found alterations in some serum hormones and serum lipid profiles indicating occurrence of similar metabolic disturbances between hypothyroidism and PCOS. TSH and FT4 levels are useful indicators for both subclinical an ...
... between hypothyroidism and PCOS in comparison with the healthy control group. We found alterations in some serum hormones and serum lipid profiles indicating occurrence of similar metabolic disturbances between hypothyroidism and PCOS. TSH and FT4 levels are useful indicators for both subclinical an ...
A brief review of rat thyroid-stimulating hormone (TSH) and
... seen immediately after the start of lighting, while peaks of T4 and T3 appeared 3-4 hours later, and corticosterone and prolactin increased soon after the light off. If the light and dark periods are reversed, i.e. light off: 7:30 and light on: 19:30, for 3 weeks, all the hormone peaks shifted 12 h ...
... seen immediately after the start of lighting, while peaks of T4 and T3 appeared 3-4 hours later, and corticosterone and prolactin increased soon after the light off. If the light and dark periods are reversed, i.e. light off: 7:30 and light on: 19:30, for 3 weeks, all the hormone peaks shifted 12 h ...
Neuroendocrine Tumors: A Comprehensive Guide to Diagnosis and
... Compounds® handbook presents comprehensive information for many rare procedures and tests that have been requested in the course of the past twenty-eight years. The handbook reflects the tremendous advances that have been made since 1977. The number of tests offered has increased six-fold in additio ...
... Compounds® handbook presents comprehensive information for many rare procedures and tests that have been requested in the course of the past twenty-eight years. The handbook reflects the tremendous advances that have been made since 1977. The number of tests offered has increased six-fold in additio ...
PHYSIOLOGY OF THE HYPOTHALAMIC-PITUITARY
... In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA,(47,48) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradoxical increase of serum TSH concentration has been observe ...
... In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA,(47,48) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradoxical increase of serum TSH concentration has been observe ...
chapter 4 - Thyroid Disease Manager
... In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA,(47,48) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradoxical increase of serum TSH concentration has been observe ...
... In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA,(47,48) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradoxical increase of serum TSH concentration has been observe ...
crustacean hyperglycemic hormone: structural variants
... etc.) has been demonstrated [6, 15, 23, 47, 55, 72, 80]. It has been recognized that CHH is a pleiotropic hormone. It was noted that CHH, in addition to MIH, also suppresses ecdysteroidogenesis by the Y-organs though at a higher dose than MIH [7, 14, 73, 78]. The physiological significance of the CH ...
... etc.) has been demonstrated [6, 15, 23, 47, 55, 72, 80]. It has been recognized that CHH is a pleiotropic hormone. It was noted that CHH, in addition to MIH, also suppresses ecdysteroidogenesis by the Y-organs though at a higher dose than MIH [7, 14, 73, 78]. The physiological significance of the CH ...
320 Disorders of the Thyroid Gland
... synthesis and secretion. Thyroid hormones feed back negatively to inhibit TRH and TSH production (Fig. 320-2). The “set-point” in this axis is established by TSH. TRH is the major positive regulator of TSH synthesis and secretion. Peak TSH secretion occurs ~15 min after administration of exogenous T ...
... synthesis and secretion. Thyroid hormones feed back negatively to inhibit TRH and TSH production (Fig. 320-2). The “set-point” in this axis is established by TSH. TRH is the major positive regulator of TSH synthesis and secretion. Peak TSH secretion occurs ~15 min after administration of exogenous T ...
Physiology of the Hypothalamic-Pituitary Thyroidal System The
... in primary hypothyroidism and/or in post-menopausal women and decreases (about to one half) in hyperthyroidism. (4) The PR of free TSH β subunit is too low to be calculated in all hyperthyroid and in most euthyroid subjects, while is 25-30 μg/day in primary hypothyroidism. (4) The MCR of free subuni ...
... in primary hypothyroidism and/or in post-menopausal women and decreases (about to one half) in hyperthyroidism. (4) The PR of free TSH β subunit is too low to be calculated in all hyperthyroid and in most euthyroid subjects, while is 25-30 μg/day in primary hypothyroidism. (4) The MCR of free subuni ...
physiology-of-the-hy.. - Thyroid Disease Manager
... In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA, (38) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradoxical increase of serum TSH concentration has been observed ...
... In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA, (38) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradoxical increase of serum TSH concentration has been observed ...
Hypopituitarism
Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain. If there is decreased secretion of most pituitary hormones, the term panhypopituitarism (pan meaning ""all"") is used.The signs and symptoms of hypopituitarism vary, depending on which hormones are undersecreted and on the underlying cause of the abnormality. The diagnosis of hypopituitarism is made by blood tests, but often specific scans and other investigations are needed to find the underlying cause, such as tumors of the pituitary, and the ideal treatment. Most hormones controlled by the secretions of the pituitary can be replaced by tablets or injections. Hypopituitarism is a rare disease, but may be significantly underdiagnosed in people with previous traumatic brain injury. The first description of the condition was made in 1914 by the German physician Dr Morris Simmonds.