The Pineal Gland, via Melatonin, Protects DNA, Coordinates the
... 70-80% of degraded melatonin (124). Minor quantities of melatonin (10-20%) are conjugated to glucuronic acid [Fig. 1]. The hydroxylation that occurs in the liver is inducible by phenobarbital and polyaromatic hydrocarbons (124). This secretion is consistent regardless of species and diurnal or noctu ...
... 70-80% of degraded melatonin (124). Minor quantities of melatonin (10-20%) are conjugated to glucuronic acid [Fig. 1]. The hydroxylation that occurs in the liver is inducible by phenobarbital and polyaromatic hydrocarbons (124). This secretion is consistent regardless of species and diurnal or noctu ...
LEPTIN AND OTHER ENDOCRINE SYSTEMS
... A 10% reduction in body weight through dieting results in decreased T3, T4 and leptin. Administration of recombinant leptin to achieve serum levels comparable to that prior to weight loss restored T3 and T4 to baseline levels^^. There were no changes in TSH with weight reduction or leptin administra ...
... A 10% reduction in body weight through dieting results in decreased T3, T4 and leptin. Administration of recombinant leptin to achieve serum levels comparable to that prior to weight loss restored T3 and T4 to baseline levels^^. There were no changes in TSH with weight reduction or leptin administra ...
PHYSIOLOGY OF THE HYPOTHALAMIC-PITUITARY
... Effects of thyroid hormone on TSH synthesis and release. In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA,(47,48) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradox ...
... Effects of thyroid hormone on TSH synthesis and release. In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA,(47,48) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradox ...
chapter 4 - Thyroid Disease Manager
... Effects of thyroid hormone on TSH synthesis and release. In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA,(47,48) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradox ...
... Effects of thyroid hormone on TSH synthesis and release. In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA,(47,48) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradox ...
Effect of ghrelin on regulation of growth hormone release: A review
... glucogenic actions.(4) It is suggested that the main physiological function of ghrelin is to stimulate growth hormone release from the pituitary and increase food intake.(5) Active ghrelin acts as an amplifier of GHRH, the primary agonist of GH secretion. Ghrelin is also acutely influenced by diet co ...
... glucogenic actions.(4) It is suggested that the main physiological function of ghrelin is to stimulate growth hormone release from the pituitary and increase food intake.(5) Active ghrelin acts as an amplifier of GHRH, the primary agonist of GH secretion. Ghrelin is also acutely influenced by diet co ...
Physiology of the Hypothalamic-Pituitary Thyroidal System The
... On the basis of crystallographic studies on hCG and other glycoprotein hormones, an homology model of the tridimensional structure of TSH has been proposed. (15) This model (Fig. 4-2) predicts for both α and β subunits the presence of two β-hairpin loops (L1 and L3) on one side of a central “cystine ...
... On the basis of crystallographic studies on hCG and other glycoprotein hormones, an homology model of the tridimensional structure of TSH has been proposed. (15) This model (Fig. 4-2) predicts for both α and β subunits the presence of two β-hairpin loops (L1 and L3) on one side of a central “cystine ...
physiology-of-the-hy.. - Thyroid Disease Manager
... Effects of thyroid hormone on TSH synthesis and release In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA, (38) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradoxica ...
... Effects of thyroid hormone on TSH synthesis and release In animal models, thyroid hormone administration is followed by a marked decrease of both α and TSH β subunit mRNA, (38) but TSH β is suppressed more rapidly and more completely than α subunit. In humans with primary hypothyroidism a paradoxica ...
Morphological Study of Sella Turcica in Gujarat State
... sella is occupied by the pituitary gland. Any abnormality or pathology in the gland could manifest from an altered size, shape and functions of the sella turcica. Around 13% of brain tumour are found in the sella turcica. Precise knowledge of dimensions of sella turcica is required for effective and ...
... sella is occupied by the pituitary gland. Any abnormality or pathology in the gland could manifest from an altered size, shape and functions of the sella turcica. Around 13% of brain tumour are found in the sella turcica. Precise knowledge of dimensions of sella turcica is required for effective and ...
A brief review of rat thyroid-stimulating hormone (TSH) and
... originated in the hypothalamus, directly stimulates TSH secretion. TRH, at a concentration of 10pg/ml, increased TSH release from rat anterior pituitary in vitro. An intravenous injection of 0.1-1ng of TRH caused an elevation of blood TSH in mice within 2 minutes. The cold exposure stress and thyroi ...
... originated in the hypothalamus, directly stimulates TSH secretion. TRH, at a concentration of 10pg/ml, increased TSH release from rat anterior pituitary in vitro. An intravenous injection of 0.1-1ng of TRH caused an elevation of blood TSH in mice within 2 minutes. The cold exposure stress and thyroi ...
In late 2001, I came across Nicholas Regush`s website
... therapy, including Lupron, is achieving results. • There is inadequate long-term care and what happens to the patients later is unclear. "The typical ObGyn gives the drug because it's the easiest thing to do and there is often just not enough time to do much else after diagnosis," Redwine said. Endo ...
... therapy, including Lupron, is achieving results. • There is inadequate long-term care and what happens to the patients later is unclear. "The typical ObGyn gives the drug because it's the easiest thing to do and there is often just not enough time to do much else after diagnosis," Redwine said. Endo ...
Serum Concentrations of Luteinizing Hormone, Growth Hormone
... the follicular-phase and the ovariectomized gilts. Serum concentrations of estradiol were 5.38 ± 2.33 pg/ mL for follicular-phase gilts and were undetectable for luteal-phase and ovariectomized gilts. There was an effect ( P < .03) of treatment × period × reproductive status on mean LH concentration ...
... the follicular-phase and the ovariectomized gilts. Serum concentrations of estradiol were 5.38 ± 2.33 pg/ mL for follicular-phase gilts and were undetectable for luteal-phase and ovariectomized gilts. There was an effect ( P < .03) of treatment × period × reproductive status on mean LH concentration ...
Morphometry of Sella Turcica in An Indian Population Using
... and Cushing’s syndrome due to disturbances in the levels of GH, prolactin, TSH and ACTH respectively [2-3]. The increase in size of sella turcica on lateral cephalometric radiographs in patients leading to an incidental diagnosis of pituitary adenoma has been reported in previous studies ...
... and Cushing’s syndrome due to disturbances in the levels of GH, prolactin, TSH and ACTH respectively [2-3]. The increase in size of sella turcica on lateral cephalometric radiographs in patients leading to an incidental diagnosis of pituitary adenoma has been reported in previous studies ...
28 Endocrinology of Complex Life Cycles: Amphibians
... threshold of minimum body size that must be reached before metamorphosis is possible and that larval growth rates determine the timing of metamorphosis after this minimum size has been attained. Werner (1986) added mortality risk in the larval and adult habitats to the list of factors that ultimatel ...
... threshold of minimum body size that must be reached before metamorphosis is possible and that larval growth rates determine the timing of metamorphosis after this minimum size has been attained. Werner (1986) added mortality risk in the larval and adult habitats to the list of factors that ultimatel ...
Peak cortisol response to corticotropin
... hypopituitarism are at increased risk for adrenocorticotropic hormone (ACTH) deficiency, or central adrenal insufficiency [1, 4]. Despite considerable clinical experience, the diagnosis of ACTH deficiency remains complex [5], and the “optimal― method to reliably diagnose ACTH deficiency remains ...
... hypopituitarism are at increased risk for adrenocorticotropic hormone (ACTH) deficiency, or central adrenal insufficiency [1, 4]. Despite considerable clinical experience, the diagnosis of ACTH deficiency remains complex [5], and the “optimal― method to reliably diagnose ACTH deficiency remains ...
The Straight Facts About Human Growth Hormone (hGH)
... useful amounts of hGH; they claim that these products are actually taken up by the body through topical, oral, sublingual or nasal administration. One should be skeptical of such claims, as none of the published benefits of injected hGH have been objectively measured with oral tablets, capsules, or ...
... useful amounts of hGH; they claim that these products are actually taken up by the body through topical, oral, sublingual or nasal administration. One should be skeptical of such claims, as none of the published benefits of injected hGH have been objectively measured with oral tablets, capsules, or ...
Growth-Hormone-Releasing Hormone
... in GH-deficient patients alike. Thus, although most normal subjects have an increase in serum GH of>10 pg/L after an intravenous GHRH dose of 1 pg/kg, a less dramatic increase may not be abnormal (28,30). Acromegaly, a disease of excess GH secretion, is most commonly caused by a pituitary adenoma. R ...
... in GH-deficient patients alike. Thus, although most normal subjects have an increase in serum GH of>10 pg/L after an intravenous GHRH dose of 1 pg/kg, a less dramatic increase may not be abnormal (28,30). Acromegaly, a disease of excess GH secretion, is most commonly caused by a pituitary adenoma. R ...
Reproductive Biology of Salmoniform and Pleuronectiform Fishes with Special Reference to
... in the sea; they spawn in autumn and then die. The masu salmon used in this experiment also smoltified at 1.5 years old and matured at 3 years old in fresh water, although the growth rate was not very rapid. There is a landlocked form of masu salmon called “yamame.” This variety for the most part do ...
... in the sea; they spawn in autumn and then die. The masu salmon used in this experiment also smoltified at 1.5 years old and matured at 3 years old in fresh water, although the growth rate was not very rapid. There is a landlocked form of masu salmon called “yamame.” This variety for the most part do ...
Phylogenetic Distribution and Function of the Hypophysiotropic
... role for TRH in tadpole metamorphosis as postulated by Etkin (1963). He suggested that development of the tadpole hypothalamus is under positive feedback control by thyroid hormone and that a gradually rising level of circulating thyroid hormone during prometamorphosis induces maturation of the hypo ...
... role for TRH in tadpole metamorphosis as postulated by Etkin (1963). He suggested that development of the tadpole hypothalamus is under positive feedback control by thyroid hormone and that a gradually rising level of circulating thyroid hormone during prometamorphosis induces maturation of the hypo ...
Primary Structure of a Novel Gonadotropin
... (tGnRH-I and tGnRH-II) were characterized from protochordate nervous tissue (18). In all bony fish species examined to date, it is well documented that at least two GnRH variants coexist in the brain of a single species. cGnRH-II is universally distributed in bony fish (1). In addition to cGnRH-II, ...
... (tGnRH-I and tGnRH-II) were characterized from protochordate nervous tissue (18). In all bony fish species examined to date, it is well documented that at least two GnRH variants coexist in the brain of a single species. cGnRH-II is universally distributed in bony fish (1). In addition to cGnRH-II, ...
Curriculum Vitae Joel Tabak-Sznajder
... neurons of the arcuate nucleus. Poster presentation at Annual meeting, Society for Neuroscience, New Orleans, LA. (International) Tabak, J., Gonzelez-Iglesias, A. E., Cristancho-Gordo, R., & Bertram, R. (presented 2012). Multiple actions of hypothalamic oxytocin on pituitary cells. Poster presentati ...
... neurons of the arcuate nucleus. Poster presentation at Annual meeting, Society for Neuroscience, New Orleans, LA. (International) Tabak, J., Gonzelez-Iglesias, A. E., Cristancho-Gordo, R., & Bertram, R. (presented 2012). Multiple actions of hypothalamic oxytocin on pituitary cells. Poster presentati ...
Thyroid-Stimulating Hormone
... TSH P-subunits, of which one does not recombine with a-subunits and thus represents a nonfunctional form of TSH-P. Whether such structural and hence functional microheterogeneity is artifactual, occurring during the preparation and purification of the subunits, or biologically relevant remains to be ...
... TSH P-subunits, of which one does not recombine with a-subunits and thus represents a nonfunctional form of TSH-P. Whether such structural and hence functional microheterogeneity is artifactual, occurring during the preparation and purification of the subunits, or biologically relevant remains to be ...
effect of leptin on thyroid-stimulating hormone secretion and nitric
... female rats. However, Ortiga-Carvalho et al. (16) showed that leptin presents a stimulating effect on the secretion of TSH in vivo, but decreases it in vitro in male Wistar rats. The obtained results indicated that thyroid-stimulating hormone secretion from pituitary cells isolated from ewe lambs is ...
... female rats. However, Ortiga-Carvalho et al. (16) showed that leptin presents a stimulating effect on the secretion of TSH in vivo, but decreases it in vitro in male Wistar rats. The obtained results indicated that thyroid-stimulating hormone secretion from pituitary cells isolated from ewe lambs is ...
Neuroendocrinology of Amphibian Metamorphosis
... proteins can serve as a reservoir for hormone in the blood; TTR could therefore help to sustain increasing plasma TH concentrations prior to the acceleration of thyroid gland activity induced by rising plasma thyroid-stimulating hormone (TSH) titers. The TTR concentration in the blood declines at me ...
... proteins can serve as a reservoir for hormone in the blood; TTR could therefore help to sustain increasing plasma TH concentrations prior to the acceleration of thyroid gland activity induced by rising plasma thyroid-stimulating hormone (TSH) titers. The TTR concentration in the blood declines at me ...
name and intended use
... Normal Serum TSH levels of plasma TSH are generally reported as under 6 uIU per milliliter, with most assays being unable to detect levels less thatn 1 uIU per milliliter. Primary hypothyroidism in thyroprivic and goitrous varieties: An elevated TSH level is the most sensitive screen test for detect ...
... Normal Serum TSH levels of plasma TSH are generally reported as under 6 uIU per milliliter, with most assays being unable to detect levels less thatn 1 uIU per milliliter. Primary hypothyroidism in thyroprivic and goitrous varieties: An elevated TSH level is the most sensitive screen test for detect ...
The Selective Loss of the Type 2 Iodothyronine Deiodinase in
... increased 1.5- to 1.8-fold, but serum T4 and T3 were not different from the controls in adult mice. In hypothyroid adult mice, suppression of TSH by T4, but not T3, was impaired. Despite mild basal TSH elevation, the TSH increase in response to hypothyroidism was 4-fold reduced in the Cga-cre D2KO c ...
... increased 1.5- to 1.8-fold, but serum T4 and T3 were not different from the controls in adult mice. In hypothyroid adult mice, suppression of TSH by T4, but not T3, was impaired. Despite mild basal TSH elevation, the TSH increase in response to hypothyroidism was 4-fold reduced in the Cga-cre D2KO c ...
Pituitary apoplexy
Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the pituitary gland at the base of the brain. This usually occurs in the presence of a tumor of the pituitary, although in 80% of cases this has not been diagnosed previously. The most common initial symptom is a sudden headache, often associated with a rapidly worsening visual field defect or double vision caused by compression of nerves surrounding the gland. This is followed in many cases by acute symptoms caused by lack of secretion of essential hormones, predominantly adrenal insufficiency.The diagnosis is achieved with magnetic resonance imaging and blood tests. Treatment is by the timely correction of hormone deficiencies, and in many cases surgical decompression is required. Many people who have had a pituitary apoplexy develop pituitary hormone deficiencies and require long-term hormone supplementation. The first case of the disease was recorded in 1898.