Pediatric Endocrinology - The American Board of Pediatrics
... diabetes mellitus 15. Know what conditions require temporary adjustments in basal and bolus insulin doses 16. Understand the effects of puberty on blood glucose concentrations and insulin requirements in patients who have type 1 diabetes 17. Understand the effects of the insulin counter-regulatory h ...
... diabetes mellitus 15. Know what conditions require temporary adjustments in basal and bolus insulin doses 16. Understand the effects of puberty on blood glucose concentrations and insulin requirements in patients who have type 1 diabetes 17. Understand the effects of the insulin counter-regulatory h ...
Perchlorate Incidence in Oregon and
... perchlorate may be hypochlorite products (bleach) (MassDep, 2005). Sodium hypochlrorite is somewhat unstable and will decompose to chlorate. Chlorate can self-oxidize to perchlorate. These processes are accelerated with increasing temperature. ...
... perchlorate may be hypochlorite products (bleach) (MassDep, 2005). Sodium hypochlrorite is somewhat unstable and will decompose to chlorate. Chlorate can self-oxidize to perchlorate. These processes are accelerated with increasing temperature. ...
The roles of deiodinases in thyronamine biology
... competition assays, the newly identified TAM substrates inhibited an established iodothyronine deiodination reaction. By contrast, TAMs which had been excluded as Dio substrates in LCMS/MS experiments, failed to show any effect in the competition assays, thus verifying the former results. In summary ...
... competition assays, the newly identified TAM substrates inhibited an established iodothyronine deiodination reaction. By contrast, TAMs which had been excluded as Dio substrates in LCMS/MS experiments, failed to show any effect in the competition assays, thus verifying the former results. In summary ...
draft assessment report application a493 iodine as a processing aid
... Ioteq Limited (formerly Iodine Technologies Australia Pty Ltd) to approve the use of iodine as a processing aid under Standard 1.3.3 Processing Aids of the Australia New Zealand Food Standards Code (the Code). Iodine has a long history of use as a water disinfectant, and is also used as a sanitising ...
... Ioteq Limited (formerly Iodine Technologies Australia Pty Ltd) to approve the use of iodine as a processing aid under Standard 1.3.3 Processing Aids of the Australia New Zealand Food Standards Code (the Code). Iodine has a long history of use as a water disinfectant, and is also used as a sanitising ...
Thyroid hormone binding proteins as novel targets for hydroxylated
... 1982). The compounds acting through this Ah-receptor mediated pathway are the planar laterally substituted 2,3,7,8-PCDDs and PCDFs, with 2,3,7,8-TCDD as the most potent congener, and related coplanar and mono-ortho substituted PCB isomers. The Ahreceptor (AhR) is present in cytosol as a complex with ...
... 1982). The compounds acting through this Ah-receptor mediated pathway are the planar laterally substituted 2,3,7,8-PCDDs and PCDFs, with 2,3,7,8-TCDD as the most potent congener, and related coplanar and mono-ortho substituted PCB isomers. The Ahreceptor (AhR) is present in cytosol as a complex with ...
3-Iodothyronamine: A High Potency Metabolic Hormone and its
... was proposed to be a potential activator of thyramine receptor, TAAR1. This hypothesis was correct and T1AM was shown to be a more potent activator of TAAR1 compared to other thyronamines [1]. TAARs represent a family of 15 different subtypes that are G protein-coupled receptors (GCPRs) [18]. Whethe ...
... was proposed to be a potential activator of thyramine receptor, TAAR1. This hypothesis was correct and T1AM was shown to be a more potent activator of TAAR1 compared to other thyronamines [1]. TAARs represent a family of 15 different subtypes that are G protein-coupled receptors (GCPRs) [18]. Whethe ...
Prevention from Iodine Deficiency Disorders and Iodine Analysis
... enlargement of the thyroid, hypothyroidism and to mental retardation in infants and children whose mothers were iodine deficient during pregnancy [1, 2]. Iodine deficiency is the most common preventable cause of mental retardation and approximately 800 million people are at risk of iodine deficiency ...
... enlargement of the thyroid, hypothyroidism and to mental retardation in infants and children whose mothers were iodine deficient during pregnancy [1, 2]. Iodine deficiency is the most common preventable cause of mental retardation and approximately 800 million people are at risk of iodine deficiency ...
PARATHYROID HORMONE
... Anatomy of Parathyroid Glands Histological appearance of the gland changes with age: The predominant cells (chief cells) Are present throughout life Source of PTH They have abundant glycogen, Golgi apparatus and few clusters of secretory granules ...
... Anatomy of Parathyroid Glands Histological appearance of the gland changes with age: The predominant cells (chief cells) Are present throughout life Source of PTH They have abundant glycogen, Golgi apparatus and few clusters of secretory granules ...
- Repository of the Academy`s Library
... central regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Hypophysiotropic TRH neurons involved in this neuroendocrine process are located in the hypothalamic paraventricular nucleus and secrete TRH into the pericapillary space of the external zone of the median eminence for conveyance to ...
... central regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Hypophysiotropic TRH neurons involved in this neuroendocrine process are located in the hypothalamic paraventricular nucleus and secrete TRH into the pericapillary space of the external zone of the median eminence for conveyance to ...
1 Iodine accumulation in sea urchin larvae is dependent on
... J Exp Biol Advance Online Articles. First posted online on 15 November 2012 as doi:10.1242/jeb.077958 Access the most recent version at http://jeb.biologists.org/lookup/doi/10.1242/jeb.077958 ...
... J Exp Biol Advance Online Articles. First posted online on 15 November 2012 as doi:10.1242/jeb.077958 Access the most recent version at http://jeb.biologists.org/lookup/doi/10.1242/jeb.077958 ...
doc PHGY311
... Hormones released into the circulation can circulate either freely or bound to carrier proteins, also known as binding proteins. The binding proteins serve as a reservoir for the hormone and prolong the hormone's half-life, the time during which the concentration of a hormone decreases to 50% of its ...
... Hormones released into the circulation can circulate either freely or bound to carrier proteins, also known as binding proteins. The binding proteins serve as a reservoir for the hormone and prolong the hormone's half-life, the time during which the concentration of a hormone decreases to 50% of its ...
ESPE Classification of Paediatric Endocrine Diagnoses
... individual patients in their files and registries. This can then improve patient care, because it makes information about the natural history and treatment responses available of patients that had been seen in the past. It can also be helpful for scientific research, for example in collecting data on ...
... individual patients in their files and registries. This can then improve patient care, because it makes information about the natural history and treatment responses available of patients that had been seen in the past. It can also be helpful for scientific research, for example in collecting data on ...
Thyroid hormones and breast cancer-prospective
... women with 146 incident breast cancer cases. The association of free T3 and free thyroxin (T4) levels in relation to breast cancer risk was studied in 676 breastcancer cases and 680 controls. It was found that: Total T3 levels in postmenopausal women are positively associated with the risk of develo ...
... women with 146 incident breast cancer cases. The association of free T3 and free thyroxin (T4) levels in relation to breast cancer risk was studied in 676 breastcancer cases and 680 controls. It was found that: Total T3 levels in postmenopausal women are positively associated with the risk of develo ...
THE EFFECTS OF POSTNATAL HYPERTHYROIDISM ON
... After the physiologic growth for all cranial sutures is completed closure occurs. At age 6, the time for high peak of brain growth, development and maturity of brain is completed. We would observe various clinical consequences if suture fusion happens pathologically before the brain develop to the ...
... After the physiologic growth for all cranial sutures is completed closure occurs. At age 6, the time for high peak of brain growth, development and maturity of brain is completed. We would observe various clinical consequences if suture fusion happens pathologically before the brain develop to the ...
Pituitary gland information
... Empty Sella Syndrome (ESS) is a disorder that involves the ‘sella turcica’ – a bony structure at the base of the brain that surrounds and protects the pituitary gland. ESS would show up on an MRI scan revealing a sella turcica that appears to be empty. There are two types of ESS: primary and seconda ...
... Empty Sella Syndrome (ESS) is a disorder that involves the ‘sella turcica’ – a bony structure at the base of the brain that surrounds and protects the pituitary gland. ESS would show up on an MRI scan revealing a sella turcica that appears to be empty. There are two types of ESS: primary and seconda ...
the effect of human growth hormone in hypopituitary dwarfism
... injections a week are given, we have used a schedule that this test is a valuable aid in the diagnosis of of two injections a week, keeping the total dosage growth hormone deficiency. Since growth is based near 2 mg. M..2, day. Though a definite conclusion on N retention the test should enable one t ...
... injections a week are given, we have used a schedule that this test is a valuable aid in the diagnosis of of two injections a week, keeping the total dosage growth hormone deficiency. Since growth is based near 2 mg. M..2, day. Though a definite conclusion on N retention the test should enable one t ...
the effect of human growth hormone in hypopituitary dwarfism
... injections a week are given, we have used a schedule that this test is a valuable aid in the diagnosis of of two injections a week, keeping the total dosage growth hormone deficiency. Since growth is based near 2 mg. M..2, day. Though a definite conclusion on N retention the test should enable one t ...
... injections a week are given, we have used a schedule that this test is a valuable aid in the diagnosis of of two injections a week, keeping the total dosage growth hormone deficiency. Since growth is based near 2 mg. M..2, day. Though a definite conclusion on N retention the test should enable one t ...
abnormal-thyroid-hor.. - Thyroid Disease Manager
... Complete Deficiency of TBG (TBG-CD) TBG-CD is defined as undetectable TBG in serum of affected hemizygous subjects or a value lesser than 0.03% the normal mean; the current limits of detection using the most sensitive radioimmunoassay (RIA) being 5ng/dl (24). The prevalence is approximately 1:15,00 ...
... Complete Deficiency of TBG (TBG-CD) TBG-CD is defined as undetectable TBG in serum of affected hemizygous subjects or a value lesser than 0.03% the normal mean; the current limits of detection using the most sensitive radioimmunoassay (RIA) being 5ng/dl (24). The prevalence is approximately 1:15,00 ...
defects of thyroid hormone transport in serum
... Complete Deficiency of TBG (TBG-CD) TBG-CD is defined as undetectable TBG in serum of affected hemizygous subjects or a value lesser than 0.03% the normal mean; the current limits of detection using the most sensitive radioimmunoassay (RIA) being 5ng/dl (24). The prevalence is approximately 1:15,00 ...
... Complete Deficiency of TBG (TBG-CD) TBG-CD is defined as undetectable TBG in serum of affected hemizygous subjects or a value lesser than 0.03% the normal mean; the current limits of detection using the most sensitive radioimmunoassay (RIA) being 5ng/dl (24). The prevalence is approximately 1:15,00 ...
abstracts - American Association of Clinical Endocrinologists
... heparin induced thrombocytopenia was also negative. No patients was on medications commonly implicated in thromobocytopenia. Bone marrow biopsy in one patient showed inappropriately normal megakaryocyte numbers. Two patients underwent bilateral adrenalectomy including one with a concomitant splenect ...
... heparin induced thrombocytopenia was also negative. No patients was on medications commonly implicated in thromobocytopenia. Bone marrow biopsy in one patient showed inappropriately normal megakaryocyte numbers. Two patients underwent bilateral adrenalectomy including one with a concomitant splenect ...
Thyroid hormones are direct modulators of human hair follicle
... morphogenic properties even in the adult organism (Paus and Cotsarelis 1999, Schneider et al. 2009). The DP is located in the proximal part of the HF and changes its shape and location dependent on the state of hair follicle cycling (see below) (Handjiski et al. 1994). By the number and profound sec ...
... morphogenic properties even in the adult organism (Paus and Cotsarelis 1999, Schneider et al. 2009). The DP is located in the proximal part of the HF and changes its shape and location dependent on the state of hair follicle cycling (see below) (Handjiski et al. 1994). By the number and profound sec ...
Response of the Pituitary and Thyroid to Tropic Hormones in
... thyrotropin-releasing hormone (TRH) from the median eminence of the hypothalamus stimulates thyroid-stimulating hormone (TSH) secretion from the anterior pituitary thyrotrophs. TSH stimulates the synthesis and secretion of triiodothyronine ...
... thyrotropin-releasing hormone (TRH) from the median eminence of the hypothalamus stimulates thyroid-stimulating hormone (TSH) secretion from the anterior pituitary thyrotrophs. TSH stimulates the synthesis and secretion of triiodothyronine ...
Clinical and Investigative Endocrinology and Diabetes
... after chemotherapy revealed negative for metastases. Discussion: There are only 18 cases of ectopic ACTHsecreting olfactory neuroblastoma in the international registry. The youngest of which presented in a 3 year-old male and the oldest case was that of a 70 year old male. Olfactory neuroblastoma is ...
... after chemotherapy revealed negative for metastases. Discussion: There are only 18 cases of ectopic ACTHsecreting olfactory neuroblastoma in the international registry. The youngest of which presented in a 3 year-old male and the oldest case was that of a 70 year old male. Olfactory neuroblastoma is ...
Graves' disease
Graves' disease, also known as toxic diffuse goiter and Flajani-Basedow-Graves disease, is an autoimmune disease that affects the thyroid. It frequently results in hyperthyroidism and an enlarged thyroid. Signs and symptoms of hyperthyroidism may include irritability, muscle weakness, sleeping problems, a fast heartbeat, poor tolerance of heat, diarrhea, and weight loss. Other symptoms may include thickening of the skin on the shins, known as pretibial myxedema, and eye problems such as bulging, a condition known as Graves' ophthalmopathy. About 25% to 80% of people develop eye problems.The exact cause is unclear; however, it is believed to involve a combination of genetic and environmental factors. A person is more likely to be affected if they have a family member with the disease. If one twin is affected there is a 30% chance the other twin will also have the disease. The onset of disease may be triggered by stress, infection, or giving birth. Those with other autoimmune diseases such as type 1 diabetes and rheumatoid arthritis are more likely to be affected. Smoking increases the risk of disease and may make the eye problems worse. The disorder results from an antibody, called thyroid stimulating immunoglobulin (TSI), that has a similar effect to thyroid stimulating hormone (TSH). These antibodies cause the thyroid gland to produce excess thyroid hormone. The diagnosis may be suspected based on symptoms with blood tests and radioiodine uptake used to confirm the disease. Typically blood tests show a raised T3 and T4, low TSH, increased radioiodine uptake in all areas of the thyroid, and TSI antibodies.There are three treatment options: radioiodine therapy, medications, and thyroid surgery. Radioiodine therapy involves taking iodine-131 by mouth which is then concentrated in and destroys the thyroid over weeks to months. The resulting hypothyroidism is treated with synthetic thyroid hormone. Medications such as beta blockers may control the symptoms and anti-thyroid medications such as methimazole may temporarily help people while other treatments are having effect. Surgery to remove the thyroid is another option. Eye problems may require additional treatments.Graves' disease occurs in about 0.5% of people. It occurs about 7.5 times more often in women than men. Often it starts between the ages of forty and sixty. It is the most common cause of hyperthyroidism in the United States (about 50% to 80% of cases). The condition is named after Robert Graves who described it in 1835. A number of prior descriptions also exist.