Valpromide Inhibits Lytic Cycle Reactivation of Epstein
... ABSTRACT Reactivation of Epstein-Barr virus (EBV) from latency into the lytic phase of its life cycle allows the virus to spread among cells and between hosts. Valproic acid (VPA) inhibits initiation of the lytic cycle in EBV-infected B lymphoma cells. While VPA blocks viral lytic gene expression, i ...
... ABSTRACT Reactivation of Epstein-Barr virus (EBV) from latency into the lytic phase of its life cycle allows the virus to spread among cells and between hosts. Valproic acid (VPA) inhibits initiation of the lytic cycle in EBV-infected B lymphoma cells. While VPA blocks viral lytic gene expression, i ...
PDF manual - QIAGEN Bioinformatics
... This manual describes legacy RNA-Seq analysis functionality that was part of the CLC Genomics Workbench up until version 7.0 where it was replaced by a new RNA-Seq tool based on tracks. One of the differences between the new and the old version is the algorithm used to map the reads. The old algorit ...
... This manual describes legacy RNA-Seq analysis functionality that was part of the CLC Genomics Workbench up until version 7.0 where it was replaced by a new RNA-Seq tool based on tracks. One of the differences between the new and the old version is the algorithm used to map the reads. The old algorit ...
Gene Section EVI1 (ecotropic viral integration site 1 (EVI1) and
... Exon 3 of the human EVI1 gene contains two closely spaced ATG codons, either of which may serve as the translation initiation site. Depending on which ATG is used, proteins of 1051 or 1041 amino acids will be formed. EVI1 contains two domains of seven and three zinc finger motifs, respectively, a re ...
... Exon 3 of the human EVI1 gene contains two closely spaced ATG codons, either of which may serve as the translation initiation site. Depending on which ATG is used, proteins of 1051 or 1041 amino acids will be formed. EVI1 contains two domains of seven and three zinc finger motifs, respectively, a re ...
PDF
... halflives of mRNAs or proteins do not slow down the period sufficiently along the PSM and cannot accommodate the formation of two expression stripes. Jointly decreasing gradients of degradation rates of the two Her genes or of all three oscillating genes did not change the outcome. These modificatio ...
... halflives of mRNAs or proteins do not slow down the period sufficiently along the PSM and cannot accommodate the formation of two expression stripes. Jointly decreasing gradients of degradation rates of the two Her genes or of all three oscillating genes did not change the outcome. These modificatio ...
The Role of Six1 in the Genesis of Muscle Cell and Skeletal Muscle
... mice by replacing the conserved functional domains (HD and SD) regions of the Six1 gene using a homologous recombination approach. These Six1-/- transgenic mice die at birth due to extensive muscle hypoplasia and severe rib malformations [3]. Moreover, Six4 was also shown to play an important role i ...
... mice by replacing the conserved functional domains (HD and SD) regions of the Six1 gene using a homologous recombination approach. These Six1-/- transgenic mice die at birth due to extensive muscle hypoplasia and severe rib malformations [3]. Moreover, Six4 was also shown to play an important role i ...
CHAPTER 7 TUNING THE DRAGON PROMOTER FINDER SYSTEM FOR HUMAN PROMOTER RECOGNITION
... signal thresholds are also used. These parameters have to be adjusted so that the tuned system achieves the desired performance. The tuning process is conducted 10 times for each selected level of sensitivity, and different models are produced in the process. Then, from all of the models, the select ...
... signal thresholds are also used. These parameters have to be adjusted so that the tuned system achieves the desired performance. The tuning process is conducted 10 times for each selected level of sensitivity, and different models are produced in the process. Then, from all of the models, the select ...
Identification of the mRNA targets of tRNA
... site of the lattice, move along it translating the codons into amino acids, and hop off the lattice at the last site. Particles are considered to have a footprint of 9 codons to represent the actual ribosome width (44). Moreover, they cannot overtake each other, and a particle cannot initiate transl ...
... site of the lattice, move along it translating the codons into amino acids, and hop off the lattice at the last site. Particles are considered to have a footprint of 9 codons to represent the actual ribosome width (44). Moreover, they cannot overtake each other, and a particle cannot initiate transl ...
ACTIN-RELATED PROTEIN6 Regulates Female Meiosis By
... events in megasporogenesis using a pSPL:GUS line (harboring the SPOROCYTELESS promoter fused to the b-glucuronidase reporter gene; Ito et al., 2004) as a marker for differentiation of the archesporial cell to a megasporocyte (Yang et al., 1999) at the distal end of each ovule primordium (Schneitz et ...
... events in megasporogenesis using a pSPL:GUS line (harboring the SPOROCYTELESS promoter fused to the b-glucuronidase reporter gene; Ito et al., 2004) as a marker for differentiation of the archesporial cell to a megasporocyte (Yang et al., 1999) at the distal end of each ovule primordium (Schneitz et ...
Chromosomal translocations deregulated BCL6
... 1995). Its features and pattern of expression suggest that BCL6 may function as a DNA-binding transcription factor involved in the control of B cell differentiation and lymphoid organ development. Chromosomal translocations affecting band 3q27 represent reciprocal recombinations between this genomic ...
... 1995). Its features and pattern of expression suggest that BCL6 may function as a DNA-binding transcription factor involved in the control of B cell differentiation and lymphoid organ development. Chromosomal translocations affecting band 3q27 represent reciprocal recombinations between this genomic ...
Robust gene silencing mediated by antisense small RNAs in the
... (personal communication)]. Additionally, little is known about the mechanism(s) of how these sRNA approaches target the appropriate mRNA. In this study, we analyzed the function of the secondary sRNAs in E. histolytica. We show for the first time that AS sRNAs directly mediate gene silencing. Our dat ...
... (personal communication)]. Additionally, little is known about the mechanism(s) of how these sRNA approaches target the appropriate mRNA. In this study, we analyzed the function of the secondary sRNAs in E. histolytica. We show for the first time that AS sRNAs directly mediate gene silencing. Our dat ...
Fitness landscapes of gene regulation in variable - UvA-DARE
... ll living organisms are equipped with mechanisms that enable them to sense their environment and respond to it. In many cases the response consists of regulating gene expression. For bacteria the link between sensing and response is often formed by a small network of interacting proteins and regulat ...
... ll living organisms are equipped with mechanisms that enable them to sense their environment and respond to it. In many cases the response consists of regulating gene expression. For bacteria the link between sensing and response is often formed by a small network of interacting proteins and regulat ...
Genomic Analysis of Hox Clusters in the Sea Lamprey
... The entire homeobox was sequenced from each clone, which had a unique restriction map. Nucleotide sequences are available in GenBank, accession numbers AF410908–AF410925. The deduced amino acid sequences are shown aligned to mouse and amphioxus sequences in Figure 2. To assign genes to Hox cognate g ...
... The entire homeobox was sequenced from each clone, which had a unique restriction map. Nucleotide sequences are available in GenBank, accession numbers AF410908–AF410925. The deduced amino acid sequences are shown aligned to mouse and amphioxus sequences in Figure 2. To assign genes to Hox cognate g ...
Identification of Genetic and Epigenetic Risk Factors for Psoriasis
... of the European population. ~10–30% of patients develop psoriatic arthritis (PsA). Genetic variation in the major histocompatibility complex (MHC) increases risk of developing PS. However, only ~10% of individuals with this risk factor develop PS, indicating that other genetic effects and environmen ...
... of the European population. ~10–30% of patients develop psoriatic arthritis (PsA). Genetic variation in the major histocompatibility complex (MHC) increases risk of developing PS. However, only ~10% of individuals with this risk factor develop PS, indicating that other genetic effects and environmen ...
KAIE LOKK Comparative genome-wide DNA methylation
... methylation profile in NSCLC tissues were identified and correlated with transcription levels. A number of genes that exhibited a significant association between DNA methylation and survival rates were also identified. In the second study, tissue-specific differences in methylated regions in 17 huma ...
... methylation profile in NSCLC tissues were identified and correlated with transcription levels. A number of genes that exhibited a significant association between DNA methylation and survival rates were also identified. In the second study, tissue-specific differences in methylated regions in 17 huma ...
Chapter 44 Self Test (EOC)
... millions of years, typically, for many of the traits examined to evolve? Answer—Development is a highly conserved and constrained process; small perturbations can have drastic consequences, and most of these are negative. Given the thousands or hundreds of thousands of variables that can change in e ...
... millions of years, typically, for many of the traits examined to evolve? Answer—Development is a highly conserved and constrained process; small perturbations can have drastic consequences, and most of these are negative. Given the thousands or hundreds of thousands of variables that can change in e ...
Xenobiotic-metabolizing cytochrome P450 enzymes in human lung
... xenobiotics, including most of the therapeutic drugs and environmental pollutants (Nelson et al. 1996, Bertz & Granneman 1997). The first report on the existence of a CYP enzyme or a “microsomal carbon monoxide-binding pigment”, as it was called at that time, was published in 1958 by Klingenberg et ...
... xenobiotics, including most of the therapeutic drugs and environmental pollutants (Nelson et al. 1996, Bertz & Granneman 1997). The first report on the existence of a CYP enzyme or a “microsomal carbon monoxide-binding pigment”, as it was called at that time, was published in 1958 by Klingenberg et ...
Natural variation in monoterpene synthesis in kiwifruit
... signaling (Kou et al., 2012). Studies in banana have shown that expression levels of several ...
... signaling (Kou et al., 2012). Studies in banana have shown that expression levels of several ...
Sequence comparison of aflR from different Aspergillus species
... Cys6 Zn2 DNA-binding domain and C-terminal transcription activation domain typical of GAL4-type fungal and yeast transcription factors. AflR binds to the partially palindromic consensus sequence 50 -TCGN5 CGR-30 found in promoters of most of the aflatoxin biosynthesis genes (Chang et al., 1995; Ehrlic ...
... Cys6 Zn2 DNA-binding domain and C-terminal transcription activation domain typical of GAL4-type fungal and yeast transcription factors. AflR binds to the partially palindromic consensus sequence 50 -TCGN5 CGR-30 found in promoters of most of the aflatoxin biosynthesis genes (Chang et al., 1995; Ehrlic ...
Sex-specific Trans-regulatory Variation on the Drosophila melanogaster X Chromosome
... Genome-wide standing genetic variation has been most extensively studied empirically in Drosophila melanogaster. Evidence from this species points to reduced sequence (e.g. [2,30,31]) and transcriptional variation [32] on the X chromosome. In contrast to this, the X chromosome shows no reduction in ...
... Genome-wide standing genetic variation has been most extensively studied empirically in Drosophila melanogaster. Evidence from this species points to reduced sequence (e.g. [2,30,31]) and transcriptional variation [32] on the X chromosome. In contrast to this, the X chromosome shows no reduction in ...
Anterior-posterior patterning within the
... expressed relative to the ges-1 ATG codon. The ges-1∆B::GFP/lacZ transgene was constructed by inserting the 3.3 kb ges-1∆B upstream region (−3317 to −3) into the multiple cloning site (HindIII-SalI) of the vector pPD96.04 (kindly provided by A. Fire, Carnegie Institute of Washington). Transformation ...
... expressed relative to the ges-1 ATG codon. The ges-1∆B::GFP/lacZ transgene was constructed by inserting the 3.3 kb ges-1∆B upstream region (−3317 to −3) into the multiple cloning site (HindIII-SalI) of the vector pPD96.04 (kindly provided by A. Fire, Carnegie Institute of Washington). Transformation ...
Y chromosome azoospermia factor region microdeletions and
... demonstrated to be is testis-specific, so it is reasonable to hypothesize that RPS4Y2 may potentially play a role in posttranscriptional regulation of the spermatogenic program [33]. The CYORF15A and CYORF15B sequences belong to the taxilin family and are involved in transcriptional regulation in os ...
... demonstrated to be is testis-specific, so it is reasonable to hypothesize that RPS4Y2 may potentially play a role in posttranscriptional regulation of the spermatogenic program [33]. The CYORF15A and CYORF15B sequences belong to the taxilin family and are involved in transcriptional regulation in os ...
The development of apical embryonic pattern in Arabidopsis
... regions of the presumptive SAM express detectable levels of STM not migrate, the cells in the valleys where the cotyledons meet mRNA, but the central region does not. By the early heart stage must derive from the EPR. In agreement with this, the bases of of embryogenesis, expression has spread and i ...
... regions of the presumptive SAM express detectable levels of STM not migrate, the cells in the valleys where the cotyledons meet mRNA, but the central region does not. By the early heart stage must derive from the EPR. In agreement with this, the bases of of embryogenesis, expression has spread and i ...
The photosynthetic apparatus of Prochlorococcus
... It is appealing to suppose that the presence of phycoerythrin as an additional light-harvesting system in the high B/A ecotypes may support photosynthesis in these genotypes under very low irradiances, i.e. those receiving only about 0.21 % surface PAR (Johnson et al., 1999). The presence of phycour ...
... It is appealing to suppose that the presence of phycoerythrin as an additional light-harvesting system in the high B/A ecotypes may support photosynthesis in these genotypes under very low irradiances, i.e. those receiving only about 0.21 % surface PAR (Johnson et al., 1999). The presence of phycour ...
Report Number of Nuclear Divisions in the Drosophila Blastoderm
... expression of CyclinB. Although the altered levels of RNA polymerase II in X161 mutants probably affect expression of many genes during oogenesis, these changes seem not to matter in functional terms, given the overall normal morphology and specific mutant phenotype. It is conceivable that transcrip ...
... expression of CyclinB. Although the altered levels of RNA polymerase II in X161 mutants probably affect expression of many genes during oogenesis, these changes seem not to matter in functional terms, given the overall normal morphology and specific mutant phenotype. It is conceivable that transcrip ...