Y chromosome polymorphisms in medicine
... analysis, can in theory cause spermatogenic failure. Among these, partial gene copy deletions of multicopy genes or rearrangements/inversions occurring in non-coding sequences but with possible functional effects on gene expression, are the most obvious candidates. These types of alterations may seg ...
... analysis, can in theory cause spermatogenic failure. Among these, partial gene copy deletions of multicopy genes or rearrangements/inversions occurring in non-coding sequences but with possible functional effects on gene expression, are the most obvious candidates. These types of alterations may seg ...
CTLA-4 gene expression is influenced by promoter and
... operative in various T-cell subpopulations. Indeed, two recent studies have demonstrated the existence, in mice, of a subset of regulatory T cells whose immune-suppressive effects are dependent upon signaling via constitutively expressed CTLA-4.24,25 Genotype-conditioned regulation of CTLA-4 cellsur ...
... operative in various T-cell subpopulations. Indeed, two recent studies have demonstrated the existence, in mice, of a subset of regulatory T cells whose immune-suppressive effects are dependent upon signaling via constitutively expressed CTLA-4.24,25 Genotype-conditioned regulation of CTLA-4 cellsur ...
Homeotic genes regulate the spatial expression
... interactions have been observed among the homeotic genes; thus the first target genes to have been identified are homeotic genes (Hafen et al. 1984; Struhl and White, 1985; Carroll et al. 1986; Casanova and White, 1989). In addition some of the homeotic genes have been found to autoregulate, includi ...
... interactions have been observed among the homeotic genes; thus the first target genes to have been identified are homeotic genes (Hafen et al. 1984; Struhl and White, 1985; Carroll et al. 1986; Casanova and White, 1989). In addition some of the homeotic genes have been found to autoregulate, includi ...
mMESSAGE mMACHINE® Kit User Guide
... amounts of capped RNA. Capped RNA mimics most eukaryotic mRNAs found in vivo, because it has a 7-methyl guanosine cap structure at the 5' end. mMESSAGE mMACHINE® Kit reactions include cap analog [m7G(5')ppp(5')G] in an ultra highyield transcription reaction. The cap analog is incorporated only as th ...
... amounts of capped RNA. Capped RNA mimics most eukaryotic mRNAs found in vivo, because it has a 7-methyl guanosine cap structure at the 5' end. mMESSAGE mMACHINE® Kit reactions include cap analog [m7G(5')ppp(5')G] in an ultra highyield transcription reaction. The cap analog is incorporated only as th ...
Quantitative expression of cholera toxin mRNA in Vibrio cholerae
... showed that the level of CT in the classical strain was higher than that in the El Tor strain because of the influence of toxR on CT production in the classical strain. Both classical and El Tor strains have been shown to express equivalent levels of ToxR. In contrast, the classical strain expresses ...
... showed that the level of CT in the classical strain was higher than that in the El Tor strain because of the influence of toxR on CT production in the classical strain. Both classical and El Tor strains have been shown to express equivalent levels of ToxR. In contrast, the classical strain expresses ...
Patterns of Segmental Duplication in the Human Genome
... duplication than others, we examined these regions for possible causes of duplication. Specifically, we divided each chromosome into nonoverlapping regions of 500 kb, except for pericentromeric and subtelomeric regions (see the definition used in Bailey et al. [2001]). For each region, we calculated ...
... duplication than others, we examined these regions for possible causes of duplication. Specifically, we divided each chromosome into nonoverlapping regions of 500 kb, except for pericentromeric and subtelomeric regions (see the definition used in Bailey et al. [2001]). For each region, we calculated ...
Pax6 lights-up the way for eye development Ruth Ashery
... OV invaginates to form the optic cup (Figure 4c). This step is completely dependent on the development of a lens placode as demonstrated by analysis of the Le-mutant embryos where the loss of Pax6 activity in the SE resulted in genetic ablation of the lens placode (Figure 4c,d). In Le-mutants the op ...
... OV invaginates to form the optic cup (Figure 4c). This step is completely dependent on the development of a lens placode as demonstrated by analysis of the Le-mutant embryos where the loss of Pax6 activity in the SE resulted in genetic ablation of the lens placode (Figure 4c,d). In Le-mutants the op ...
PDF
... where TP, TN, FP and FN denote number of true positives, true negatives, false positives and false negatives, respecexons with 17% false positives. tively. We find that the accuracy of FirstEF is significantly higher for CpG-related than non-CpG-related genes. To study the performance of FirstEF on ...
... where TP, TN, FP and FN denote number of true positives, true negatives, false positives and false negatives, respecexons with 17% false positives. tively. We find that the accuracy of FirstEF is significantly higher for CpG-related than non-CpG-related genes. To study the performance of FirstEF on ...
The ara Operon - University of Pennsylvania
... araI, transcription of araB, A and D ensues. CAP stands for catabolite activator protein which is also involved in arabinose regulation, the same way it did in the lac operon. This model actually proposes two operators, O1 and O2 that are also the binding sites of AraC. When AraC binds to any of the ...
... araI, transcription of araB, A and D ensues. CAP stands for catabolite activator protein which is also involved in arabinose regulation, the same way it did in the lac operon. This model actually proposes two operators, O1 and O2 that are also the binding sites of AraC. When AraC binds to any of the ...
In Silico method for identification of MHC class I
... This method performs best with well assembled genomes like the human or mouse genome. The more incomplete the assembly of the genome is, the more difficult it is to find all homologs. In incompletely assembled genomes the following problems can arise: genes can be misse ...
... This method performs best with well assembled genomes like the human or mouse genome. The more incomplete the assembly of the genome is, the more difficult it is to find all homologs. In incompletely assembled genomes the following problems can arise: genes can be misse ...
Linear Dominance Relationship among Four Class
... phenotype, usually a mutant phenotype. By using recent molecular techniques, two of Mendel’s genes have been identified (Bhattacharyya et al. 1990, Lester et al. 1997). In the case of the recessive allele on the R (rugosus) locus, there was a transposon-like insertion in a gene encoding a starch-bra ...
... phenotype, usually a mutant phenotype. By using recent molecular techniques, two of Mendel’s genes have been identified (Bhattacharyya et al. 1990, Lester et al. 1997). In the case of the recessive allele on the R (rugosus) locus, there was a transposon-like insertion in a gene encoding a starch-bra ...
Development 130, 3567-3578. - Howard Hughes Medical Institute
... the SfiI site was replaced by an EcoRV site (Fig. 1G). The presence of the IRES-lacZ and neor cassettes introduces a frameshift immediately after CR1. The construct with the mutant allele was electroporated into R1 embryonic stem (ES) cells (Nagy et al., 1993), and homologous recombination in the Ch ...
... the SfiI site was replaced by an EcoRV site (Fig. 1G). The presence of the IRES-lacZ and neor cassettes introduces a frameshift immediately after CR1. The construct with the mutant allele was electroporated into R1 embryonic stem (ES) cells (Nagy et al., 1993), and homologous recombination in the Ch ...
Gene Section CPM (carboxypeptidase M) Atlas of Genetics and Cytogenetics
... factor binding sites were identified in the 5' region flanking the proximal initiation sites, including a vitamin D3 responsive element and Sp1. The distal promoter (~ 30 kb upstream of the coding region) differs from the proximal promoter in that it mainly consists of repetitive elements and lacks ...
... factor binding sites were identified in the 5' region flanking the proximal initiation sites, including a vitamin D3 responsive element and Sp1. The distal promoter (~ 30 kb upstream of the coding region) differs from the proximal promoter in that it mainly consists of repetitive elements and lacks ...
Specification of floral organs in Arabidopsis
... (the uppermost) cell layer of the floral meristem (Bossinger and Smyth, 1996). Similar to the formation of other plant organs, the initiation and outgrowth of floral organ primordia depend on the activities of different phytohormones, and in particular, the formation of auxin concentration maxima in ...
... (the uppermost) cell layer of the floral meristem (Bossinger and Smyth, 1996). Similar to the formation of other plant organs, the initiation and outgrowth of floral organ primordia depend on the activities of different phytohormones, and in particular, the formation of auxin concentration maxima in ...
BROWSING GENES AND GENOMES WITH ENSEMBL
... 8 Go to the Ensembl homepage (http://www.ensembl.org/). 8 Click on the ‘BioMart’ link on the toolbar. ... or if you are already in BioMart: 8 Click the [New] button on the toolbar. 8 Choose the ‘Ensembl Genes 69’ database. 8 Choose the ‘Homo sapiens genes (GRCh37.p8)’ dataset. 8 Click on ‘Filt ...
... 8 Go to the Ensembl homepage (http://www.ensembl.org/). 8 Click on the ‘BioMart’ link on the toolbar. ... or if you are already in BioMart: 8 Click the [New] button on the toolbar. 8 Choose the ‘Ensembl Genes 69’ database. 8 Choose the ‘Homo sapiens genes (GRCh37.p8)’ dataset. 8 Click on ‘Filt ...
Genes - Gerstein Lab Publications
... Intronic pseudogenes are pseudogenes that are contained completely within a single intron. A substantial fraction of G is estimated to be intronic (39%) (Table 1). Interestingly, there is no preference for sense or antisense alignment for an intronic pseudogene relative to the exons of the surround ...
... Intronic pseudogenes are pseudogenes that are contained completely within a single intron. A substantial fraction of G is estimated to be intronic (39%) (Table 1). Interestingly, there is no preference for sense or antisense alignment for an intronic pseudogene relative to the exons of the surround ...
The Origin and Development of Neural Crest
... promoter (53,54). Together, these studies indicate that Wnt/E-catenin signaling may promote both melanoblast induction and melanoblast differentiation. Somewhat paradoxically, however, E-catenin is also sufficient for formation of other neural crest derivatives, such as sensory neurons, that are ind ...
... promoter (53,54). Together, these studies indicate that Wnt/E-catenin signaling may promote both melanoblast induction and melanoblast differentiation. Somewhat paradoxically, however, E-catenin is also sufficient for formation of other neural crest derivatives, such as sensory neurons, that are ind ...
Chromosomal Microarray Analysis
... Chromosomal Microarray Analysis revealed an approximately 28.2 Mb LOSS in copy number in the distal and subtelomeric regions of the long arm of chromosome 18 suggestive of mosaicism. This deletion includes the critical region of chromosome 18q deletion syndrome (OMIM 601808). FISH analysis and parti ...
... Chromosomal Microarray Analysis revealed an approximately 28.2 Mb LOSS in copy number in the distal and subtelomeric regions of the long arm of chromosome 18 suggestive of mosaicism. This deletion includes the critical region of chromosome 18q deletion syndrome (OMIM 601808). FISH analysis and parti ...
RT2 Profiler PCR Arrays: Pathway-focused gene
... process also streamlines the preparation stages of the experiment because the relevant genes are already grouped into one ready-to-use assay. ...
... process also streamlines the preparation stages of the experiment because the relevant genes are already grouped into one ready-to-use assay. ...
Imprinting and Seed Development
... nutrients from the maternal parent to the endosperm and thus are likely to be a site of parental conflict and subject to parentof-origin effects. This phenotype, however, contradicts the hypothesis that paternal genomic excess will be associated with an increased transfer of nutrients from mother to ...
... nutrients from the maternal parent to the endosperm and thus are likely to be a site of parental conflict and subject to parentof-origin effects. This phenotype, however, contradicts the hypothesis that paternal genomic excess will be associated with an increased transfer of nutrients from mother to ...
here
... Prevent their associated proteins from being produced • histone acetylation • methylation • small RNA interference Sexual reproduction has been suggested to play a role in reducing the number of deleterious transposable elements ...
... Prevent their associated proteins from being produced • histone acetylation • methylation • small RNA interference Sexual reproduction has been suggested to play a role in reducing the number of deleterious transposable elements ...