Genetic Control of X Chromosome Inactivation in Mice: Definition of
... 1973; Russell and Cacheiro 1978; Rastan 1983) hypothesize that it serves as a binding site for trans-acting factors that in turn regulate the expression of other loci in the Xic, such as Xist or Tsix. The various Xce alleles are thus predicted to have differential binding affinities for this factor ...
... 1973; Russell and Cacheiro 1978; Rastan 1983) hypothesize that it serves as a binding site for trans-acting factors that in turn regulate the expression of other loci in the Xic, such as Xist or Tsix. The various Xce alleles are thus predicted to have differential binding affinities for this factor ...
SEARCH_16S: A new algorithm for identifying 16S
... Validation datasets To test the sensitivity of SEARCH_16S I used all finished prokaryotic genomes in Genbank and three large curated databases containing small subunit (SSU) ribosomal sequences: SILVA (Pruesse et al., 2007) v23, RDP (Maidak et al., 2001) downloaded 30th Sept. 2016 and Greengenes v13 ...
... Validation datasets To test the sensitivity of SEARCH_16S I used all finished prokaryotic genomes in Genbank and three large curated databases containing small subunit (SSU) ribosomal sequences: SILVA (Pruesse et al., 2007) v23, RDP (Maidak et al., 2001) downloaded 30th Sept. 2016 and Greengenes v13 ...
De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl
... Histone-modifying enzymes play key roles in transcriptional regulation and control major cellular processes such as the cell cycle,1,2 stem cell maintenance, and differentiation.3,4 These enzymes function within multisubunit protein complexes that target acetyltransferases and deacetylases to specif ...
... Histone-modifying enzymes play key roles in transcriptional regulation and control major cellular processes such as the cell cycle,1,2 stem cell maintenance, and differentiation.3,4 These enzymes function within multisubunit protein complexes that target acetyltransferases and deacetylases to specif ...
Regulation of Bacterial Conjugation in Microaerobiosis by
... et al. 1999; Camacho and Casadesus 2002) and becomes derepressed in the ileum of infected mice (GarciaQuintanilla et al. 2008). High osmolarity and microaerobiosis, two reductionist conditions for imitation of the intestinal environment, derepress pSLT transfer in the laboratory (Garcia-Quintanilla ...
... et al. 1999; Camacho and Casadesus 2002) and becomes derepressed in the ileum of infected mice (GarciaQuintanilla et al. 2008). High osmolarity and microaerobiosis, two reductionist conditions for imitation of the intestinal environment, derepress pSLT transfer in the laboratory (Garcia-Quintanilla ...
Integrated analysis of whole-exome sequencing and transcriptome
... Recent findings support a highly heterogeneous and complex genetic etiology including rare de novo and inherited mutations or chromosomal rearrangements as well as double or multiple hits. Methods: We performed whole-exome sequencing (WES) and blood cell transcriptome by RNAseq in a subset of male p ...
... Recent findings support a highly heterogeneous and complex genetic etiology including rare de novo and inherited mutations or chromosomal rearrangements as well as double or multiple hits. Methods: We performed whole-exome sequencing (WES) and blood cell transcriptome by RNAseq in a subset of male p ...
Inferring gene-to-phenotype and gene-to
... endogenous mouse genes overlapping the deletion region. Gene-to-phenotype and gene-to-disease annotations can then be derived for the genes in nearly all genotypes with a single associated genetic locus (see docking sites below for the exception). For genotypes including more than one locus, such as ...
... endogenous mouse genes overlapping the deletion region. Gene-to-phenotype and gene-to-disease annotations can then be derived for the genes in nearly all genotypes with a single associated genetic locus (see docking sites below for the exception). For genotypes including more than one locus, such as ...
Targeting gene expression to cones with human cone opsin
... since two canine achromatopsic lines exist with either a genomic deletion (that is, functional null) or missense mutation of the CNGB3 gene.4 The work presented herein with human cone opsin promoters provides the groundwork for future cone-directed gene therapy in canine models, and complements rece ...
... since two canine achromatopsic lines exist with either a genomic deletion (that is, functional null) or missense mutation of the CNGB3 gene.4 The work presented herein with human cone opsin promoters provides the groundwork for future cone-directed gene therapy in canine models, and complements rece ...
trans - bioRxiv
... bioRxiv preprint first posted online Jul. 15, 2014; doi: http://dx.doi.org/10.1101/007153. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. ...
... bioRxiv preprint first posted online Jul. 15, 2014; doi: http://dx.doi.org/10.1101/007153. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. ...
Hypoxia-inducible factor 1 is a new target of microphthalmia
... positive control and again the effect of Co2 and cAMP appeared additive (Fig. 1 D). Among the multiple HIF1 target genes containing an HRE core sequence in their promoter region, Vegf has been largely studied because it is required for tumor angiogenesis. We therefore analyzed the effects of cAMP i ...
... positive control and again the effect of Co2 and cAMP appeared additive (Fig. 1 D). Among the multiple HIF1 target genes containing an HRE core sequence in their promoter region, Vegf has been largely studied because it is required for tumor angiogenesis. We therefore analyzed the effects of cAMP i ...
Finding biologically relevant information using ADIOS
... The Project • Use ADIOS to create grammar rules from biomedical sentences • Look for gene-gene associations • Look for gene-disease associations • Infer information about a pair of genes in an unseen sentence based on its sentence structure (pattern) ...
... The Project • Use ADIOS to create grammar rules from biomedical sentences • Look for gene-gene associations • Look for gene-disease associations • Infer information about a pair of genes in an unseen sentence based on its sentence structure (pattern) ...
Dorsoventral Patterning in Hemichordates
... expressed in the three germ layers of hemichordate embryos in distinct dorsoventral domains, such as pox neuro, pituitary homeobox, distalless, and tbx2/3 on the Bmp side and netrin, mnx, mox, and single-minded on the ChordinAdmp side. When we expose the embryo to excess Bmp protein, or when we depl ...
... expressed in the three germ layers of hemichordate embryos in distinct dorsoventral domains, such as pox neuro, pituitary homeobox, distalless, and tbx2/3 on the Bmp side and netrin, mnx, mox, and single-minded on the ChordinAdmp side. When we expose the embryo to excess Bmp protein, or when we depl ...
Accepted Version - CSIRO Research Publications Repository
... cycle regulator Swm1/Apc13. In wild type, the BNS gene is normally expressed and not methylated (Figure 1). However, in a self-pollinated ddm1 mutant, the BNS gene is methylated and stochastically silenced (Figure 1), indicating that bns is a loss of function epigenetic mutant. The BNS gene is flank ...
... cycle regulator Swm1/Apc13. In wild type, the BNS gene is normally expressed and not methylated (Figure 1). However, in a self-pollinated ddm1 mutant, the BNS gene is methylated and stochastically silenced (Figure 1), indicating that bns is a loss of function epigenetic mutant. The BNS gene is flank ...
New methods for tightly regulated gene expression and
... is shown in Figure 1. In this system, non-replicating plasmids carrying either the attB or attP recombination sites are used to transform strains carrying the complementary recombination site and a constitutively expressed φC31 integrase (int) gene. Site-specific recombination between the attB and a ...
... is shown in Figure 1. In this system, non-replicating plasmids carrying either the attB or attP recombination sites are used to transform strains carrying the complementary recombination site and a constitutively expressed φC31 integrase (int) gene. Site-specific recombination between the attB and a ...
Network properties of human disease genes with pleiotropic effects
... whereas those of pleiotropic genes with effects on divergent phenotypes and genes associated with specific diseases have not been examined. We hypothesized that the network properties of a gene in molecular interaction network and its tissue co-expression with its interactors determines the number o ...
... whereas those of pleiotropic genes with effects on divergent phenotypes and genes associated with specific diseases have not been examined. We hypothesized that the network properties of a gene in molecular interaction network and its tissue co-expression with its interactors determines the number o ...
Biological interpretation of genome-wide association studies using
... he causal variants, genes and pathways in many genomewide association studies (GWAS) loci often remain elusive, due to linkage disequilibrium (LD) between associated variants, long-range regulation and incomplete biological knowledge of gene function. To translate genetic associations into biologica ...
... he causal variants, genes and pathways in many genomewide association studies (GWAS) loci often remain elusive, due to linkage disequilibrium (LD) between associated variants, long-range regulation and incomplete biological knowledge of gene function. To translate genetic associations into biologica ...
SpliceCenter_DataBuild
... of NCBI websites. Subsequently, Dr. Liu and Zeeberg constructed a unique transcript database for AffyProbeMiner[4]. The techniques for obtaining and aligning transcripts developed for the AffyProbeMiner build and its methods of assuring transcript quality have been incorporated into the current Spli ...
... of NCBI websites. Subsequently, Dr. Liu and Zeeberg constructed a unique transcript database for AffyProbeMiner[4]. The techniques for obtaining and aligning transcripts developed for the AffyProbeMiner build and its methods of assuring transcript quality have been incorporated into the current Spli ...
Volume 16 - Number 1 January 2012 Atlas of Genetics and Cytogenetics
... androgen-independent. ADAM10 have been found to be expressed in all prostate tumor samples (Karan et al., 2003). Interestingly, McCulloch et al. have observed that ADAM10 expression was up-regulated by androgen stimulation. Those observations were confirmed in a study published by Arima et al. Howev ...
... androgen-independent. ADAM10 have been found to be expressed in all prostate tumor samples (Karan et al., 2003). Interestingly, McCulloch et al. have observed that ADAM10 expression was up-regulated by androgen stimulation. Those observations were confirmed in a study published by Arima et al. Howev ...
Genome-Wide Identification of Allelic Expression in Hypertensive Rats
... by polymorphism in the gene that we detected. Resequencing Sod1 in the 2 rat strains across the RGU34A hybridization probes revealed an insertion-deletion polymorphism in the transcribed sequence from which differential array hybridization signals arose. We screened all genes in Table 2 by dHPLC for ...
... by polymorphism in the gene that we detected. Resequencing Sod1 in the 2 rat strains across the RGU34A hybridization probes revealed an insertion-deletion polymorphism in the transcribed sequence from which differential array hybridization signals arose. We screened all genes in Table 2 by dHPLC for ...
The Mycobacterium tuberculosis katG promoter region contains a
... is in the correct orientation to promote expression of the luciferase gene. The 262 bp HindIII–SphI fragment of pK20 containing the katG upstream activator region (UAR) was cloned upstream of the PAN promoter in pLPan to form pLPuar. The structures of all the above constructs were confirmed by DNA s ...
... is in the correct orientation to promote expression of the luciferase gene. The 262 bp HindIII–SphI fragment of pK20 containing the katG upstream activator region (UAR) was cloned upstream of the PAN promoter in pLPan to form pLPuar. The structures of all the above constructs were confirmed by DNA s ...
Global Transcriptional Profiling Reveals Distinct Functions of Thymic
... we identified Aire-regulated genes by analyzing published expression data from Aire-deficient versus wild-type mTEChi cells (Derbinski et al., 2005). After excluding genes not shared between microarray platforms, we compared the list of Aireregulated genes to mTEChi-upregulated DEGs. Of the 560 mTEC ...
... we identified Aire-regulated genes by analyzing published expression data from Aire-deficient versus wild-type mTEChi cells (Derbinski et al., 2005). After excluding genes not shared between microarray platforms, we compared the list of Aireregulated genes to mTEChi-upregulated DEGs. Of the 560 mTEC ...
Alternative Splicing in Higher Plants
... – Humans have > 7million ESTs currently and mouse has >4 million ESTs – As EST numbers increase, alternative splicing rates in a genome are also found to increase. ...
... – Humans have > 7million ESTs currently and mouse has >4 million ESTs – As EST numbers increase, alternative splicing rates in a genome are also found to increase. ...