Comparative Analysis of Structural Diversity and
... cleavage sites. Results of the targeting prediction programs are shown in supplementary table S2, Supplementary Material online. We considered a sequence to be mitochondrially targeted if two or more of the prediction programs predicted mitochondrial targeting. In addition to mitochondrial targeting ...
... cleavage sites. Results of the targeting prediction programs are shown in supplementary table S2, Supplementary Material online. We considered a sequence to be mitochondrially targeted if two or more of the prediction programs predicted mitochondrial targeting. In addition to mitochondrial targeting ...
Price, DK, Zhang, F, Ashley, CT and Warren, ST: The chicken FMR1 gene is highly conserved containing a CTT 5\' untranslated repeat and encodes an RNA-binding protein. Genomics 31:3-12 (1996).
... this type of mutation, fragile X syndrome, is the most frequent inherited form of mental retardation. Fragile X syndrome segregates as an X-linked dominant disorder with reduced penetrance and has been mapped to the fragile X mental retardation (FMR1) gene located at human Xq27.3 (Warren and Ashley, ...
... this type of mutation, fragile X syndrome, is the most frequent inherited form of mental retardation. Fragile X syndrome segregates as an X-linked dominant disorder with reduced penetrance and has been mapped to the fragile X mental retardation (FMR1) gene located at human Xq27.3 (Warren and Ashley, ...
Linköping University Post Print Segment-specific Neuronal Sub-type Specification by the Integration of
... visualization of the NB 5–6 lineage throughout the developing Drosophila CNS. (A) Expression of lbe(K)-lacZ at embryonic stage 11 in the NB 5–6 lineage in brain (B1–B3), subesophageal (S1–S3), thoracic (T1–T3), and abdominal segments (A1–A9). (B) At stage 14, the difference in size between NB 5-6A a ...
... visualization of the NB 5–6 lineage throughout the developing Drosophila CNS. (A) Expression of lbe(K)-lacZ at embryonic stage 11 in the NB 5–6 lineage in brain (B1–B3), subesophageal (S1–S3), thoracic (T1–T3), and abdominal segments (A1–A9). (B) At stage 14, the difference in size between NB 5-6A a ...
Functional Genomics
... from what biologists have been doing for many years, or is it just the scale on which experiments can be done that is different? One could argue, for example, that geneticists who have been conducting screens to identify all genes in a pathway for 80 years are conducting a 'whole-genome' experiment. ...
... from what biologists have been doing for many years, or is it just the scale on which experiments can be done that is different? One could argue, for example, that geneticists who have been conducting screens to identify all genes in a pathway for 80 years are conducting a 'whole-genome' experiment. ...
Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice
... response to GCs. It has been observed that both overexpression of GR and expression of antisense GR mRNA in transgenic mice alters thymocyte survival in vitro and in vivo (9 –11). Furthermore, the relative ratio of GR to other transcription factors within a given cell type determines whether the pre ...
... response to GCs. It has been observed that both overexpression of GR and expression of antisense GR mRNA in transgenic mice alters thymocyte survival in vitro and in vivo (9 –11). Furthermore, the relative ratio of GR to other transcription factors within a given cell type determines whether the pre ...
A Genetic Linkage Map of Mouse Chromosome 10
... to the human exon 1 probe was cloned and mapped in the IB, as well. Again, the mouse genomic probe exhibited no crossovers with the first two probes. Since the exon 1 probes detect single copy sequences and do not cross-hybridize with the BCR-related loci in humans, we concludethat we have mapped th ...
... to the human exon 1 probe was cloned and mapped in the IB, as well. Again, the mouse genomic probe exhibited no crossovers with the first two probes. Since the exon 1 probes detect single copy sequences and do not cross-hybridize with the BCR-related loci in humans, we concludethat we have mapped th ...
Non-Cell-Autonomous Regulation of Root Hair
... the wrky75 mutant root hair phenotype, indicating that the promoter sequences are sufficient for rescue and that the YFP-WRKY75 fusion protein is functional (Supplemental Table S3). The WRKY75 transcript levels of plants carrying this construct in the wrky75-25 background are lower than in Col-0 (Sup ...
... the wrky75 mutant root hair phenotype, indicating that the promoter sequences are sufficient for rescue and that the YFP-WRKY75 fusion protein is functional (Supplemental Table S3). The WRKY75 transcript levels of plants carrying this construct in the wrky75-25 background are lower than in Col-0 (Sup ...
SPATULA, a bHLH carpel development gene
... cDNA 3.5 corresponds to predicted gene 44 in the AP2 contig of Terryn et al. (1999) (also called AT4g36930 by the Martinsried Institute for Protein Sequences, see http://www.mips.biochem.mpg.de/proj/thal/). Comparison of cDNA 3.5 and the predicted ORF suggested that it is not full length. Two longer ...
... cDNA 3.5 corresponds to predicted gene 44 in the AP2 contig of Terryn et al. (1999) (also called AT4g36930 by the Martinsried Institute for Protein Sequences, see http://www.mips.biochem.mpg.de/proj/thal/). Comparison of cDNA 3.5 and the predicted ORF suggested that it is not full length. Two longer ...
Biomarker for Spinal Muscular Atrophy: Expression
... causing weakness and atrophy of proximal muscles (for review see [2]). All SMA patients have at least one copy of SMN2, an inverted gene duplication of SMN1 that is exclusively present in humans ([3]). However, SMN2 has a transcriptionally silent C to T mutation in exon 7. This mutation drastically ...
... causing weakness and atrophy of proximal muscles (for review see [2]). All SMA patients have at least one copy of SMN2, an inverted gene duplication of SMN1 that is exclusively present in humans ([3]). However, SMN2 has a transcriptionally silent C to T mutation in exon 7. This mutation drastically ...
- LSHTM Research Online
... strating frequent acquisition of genomic islands by horizontal transfer (8). The size and recombinogenic nature of the genome mean that our understanding of the survival and pathogenesis of this important bacterium at the genetic level is still rudimentary. The size and plasticity of the B. pseudom ...
... strating frequent acquisition of genomic islands by horizontal transfer (8). The size and recombinogenic nature of the genome mean that our understanding of the survival and pathogenesis of this important bacterium at the genetic level is still rudimentary. The size and plasticity of the B. pseudom ...
JunctionSeq Package User Manual
... Under the default parameterization, JunctionSeq also builds upon and expands the basic design put forth by DEXSeq, providing (among other things) the ability to test for both differential exon usage and differential splice junction usage. These two types of analyses are complementary: Exons represen ...
... Under the default parameterization, JunctionSeq also builds upon and expands the basic design put forth by DEXSeq, providing (among other things) the ability to test for both differential exon usage and differential splice junction usage. These two types of analyses are complementary: Exons represen ...
Comparative Analysis Using DNA Microarrays: Sensitivity
... sensitivity of gene arrays is not nearly so simple as specificity With same-vs.-same, we had a large set of equivalently expressed genes whose SLRTRUE was, by definition, equal to zero But what to do for differentially expressed genes? ...
... sensitivity of gene arrays is not nearly so simple as specificity With same-vs.-same, we had a large set of equivalently expressed genes whose SLRTRUE was, by definition, equal to zero But what to do for differentially expressed genes? ...
Imprinting in the endosperm: a possible role in preventing wide
... Phil. Trans. R. Soc. Lond. B (2003) 358, 1105–1111 ...
... Phil. Trans. R. Soc. Lond. B (2003) 358, 1105–1111 ...
Natural variation in nucleolar dominance reveals
... suecica. Instead, A. thaliana-derived NORs can be either silenced or active in different natural strains of A. suecica. This discovery of natural variation in nucleolar dominance presented a unique opportunity to study the same NORs in an active or silenced state, an opportunity we exploited to dedu ...
... suecica. Instead, A. thaliana-derived NORs can be either silenced or active in different natural strains of A. suecica. This discovery of natural variation in nucleolar dominance presented a unique opportunity to study the same NORs in an active or silenced state, an opportunity we exploited to dedu ...
Disclosure All authors have no competing financial relationships to
... TLR7 in PBMCs, resulting in a trend of decreased downstream production of type I IFNs; whereas inhibition of miR-3148 has an opposite effect. ...
... TLR7 in PBMCs, resulting in a trend of decreased downstream production of type I IFNs; whereas inhibition of miR-3148 has an opposite effect. ...
Engineered bacteriophage-defence systems in bioprocessing
... and genome encapsidation)24. Furthermore, functionally coupled genes are found arranged into conserved clusters within these modules, such that gene order was predicated by developmental order, or vice versa. In some cases, two or more alternative and likely interchangeable modules, which are compos ...
... and genome encapsidation)24. Furthermore, functionally coupled genes are found arranged into conserved clusters within these modules, such that gene order was predicated by developmental order, or vice versa. In some cases, two or more alternative and likely interchangeable modules, which are compos ...
Bcl-2–Modifying Factor Induces Renal Proximal Tubular
... The mechanisms underlying tubular atrophy are incompletely delineated. Studies have shown that high glucose (HG) concentrations are associated with increased reactive oxygen species (ROS) production, which inhibits proximal tubular function and induces apoptosis (8–10). Apoptosis has been detected i ...
... The mechanisms underlying tubular atrophy are incompletely delineated. Studies have shown that high glucose (HG) concentrations are associated with increased reactive oxygen species (ROS) production, which inhibits proximal tubular function and induces apoptosis (8–10). Apoptosis has been detected i ...
Gene Section KLK4 (kallikrein-related peptidase 4) Atlas of Genetics and Cytogenetics
... given its role in degrading extracellular matrix (ECM) proteins in teeth, and potentially increasing IGF levels by degrading IGFBP3, IGFBP4, IGFBP5, IGFBP6. KLK4 is also reported to activate pro- HGFA and thereby potentially leading to tumour progression through activation of the MET receptor. A sub ...
... given its role in degrading extracellular matrix (ECM) proteins in teeth, and potentially increasing IGF levels by degrading IGFBP3, IGFBP4, IGFBP5, IGFBP6. KLK4 is also reported to activate pro- HGFA and thereby potentially leading to tumour progression through activation of the MET receptor. A sub ...
Mutations at the Darkener of apricot Locus Modulate Transcript
... 1993; ZACHAR, CHoU and BINGHAM1987). In general, the products of second-site modifier loci play a role in the expression of the mutation-causing transposable element, and in modifying its activity, result in an alteration of the mutant phenotype. We are seeking to understand the functions these modi ...
... 1993; ZACHAR, CHoU and BINGHAM1987). In general, the products of second-site modifier loci play a role in the expression of the mutation-causing transposable element, and in modifying its activity, result in an alteration of the mutant phenotype. We are seeking to understand the functions these modi ...
Genome Biology - Department of Computer Science and
... Upon binding, TFs interact with RNA polymerase II to activate or repress transcription. TFs also recruit chromatin modification enzymes to induce chromatin structure changes, which in turn affect the accessibility of factors to genomic DNA regions [3, 4]. The target genes of a TF change according to ...
... Upon binding, TFs interact with RNA polymerase II to activate or repress transcription. TFs also recruit chromatin modification enzymes to induce chromatin structure changes, which in turn affect the accessibility of factors to genomic DNA regions [3, 4]. The target genes of a TF change according to ...