Nucleotide Bias Causes a Genomewide Bias in the Amino Acid
... Finally, we were concerned that our results might be skewed by the fact that not all genomes contain the same set of genes. For instance, some genomes might have a higher proportion of membrane-spanning proteins, and this could result in differences in amino acid composition that are functionally ba ...
... Finally, we were concerned that our results might be skewed by the fact that not all genomes contain the same set of genes. For instance, some genomes might have a higher proportion of membrane-spanning proteins, and this could result in differences in amino acid composition that are functionally ba ...
A global view of pleiotropy and phenotypically
... transport. One large class involved functions related to transcription by RNA Pol II, with several clusters enriched for transcriptional categories exclusively (Figure 2B and Supplementary Figure 4). Other functional categories included sporulation, ergosterol biosynthesis, phosphate metabolism, and ...
... transport. One large class involved functions related to transcription by RNA Pol II, with several clusters enriched for transcriptional categories exclusively (Figure 2B and Supplementary Figure 4). Other functional categories included sporulation, ergosterol biosynthesis, phosphate metabolism, and ...
The scs Boundary Element: Characterization of Boundary Element
... been shown to occur only in conjunction with the clustered binding sites from near the 59 long terminal repeat of the gypsy retrotransposon and thus may be a special situation. Also, evidence argues against mediation of scs or scs9 boundary activity by clustered binding sites for a single protein. I ...
... been shown to occur only in conjunction with the clustered binding sites from near the 59 long terminal repeat of the gypsy retrotransposon and thus may be a special situation. Also, evidence argues against mediation of scs or scs9 boundary activity by clustered binding sites for a single protein. I ...
Janelle Nunan and David H. Small - Proteolytic processing of the
... (long A) are major products of -secretase activity. The location of the -secretase cleavage site is unusual as it resides within the transmembrane region. Several transmembrane proteins are known to be cleaved within or close to their membrane-spanning domain. This phenomenon, known as regulated ...
... (long A) are major products of -secretase activity. The location of the -secretase cleavage site is unusual as it resides within the transmembrane region. Several transmembrane proteins are known to be cleaved within or close to their membrane-spanning domain. This phenomenon, known as regulated ...
Epsilon Toxin Characterization
... Introduction: Epsilon toxin is one of the most potent clostridial toxins known. It is a USDA and HHS select agent toxin and is included on the NIAID list of Category B Priority Pathogens. Not all C. perfringens strains contain the epsilon gene or express the protein, thus it is critical to know the ...
... Introduction: Epsilon toxin is one of the most potent clostridial toxins known. It is a USDA and HHS select agent toxin and is included on the NIAID list of Category B Priority Pathogens. Not all C. perfringens strains contain the epsilon gene or express the protein, thus it is critical to know the ...
A global view of pleiotropy and phenotypically derived gene function
... transport. One large class involved functions related to transcription by RNA Pol II, with several clusters enriched for transcriptional categories exclusively (Figure 2B and Supplementary Figure 4). Other functional categories included sporulation, ergosterol biosynthesis, phosphate metabolism, and ...
... transport. One large class involved functions related to transcription by RNA Pol II, with several clusters enriched for transcriptional categories exclusively (Figure 2B and Supplementary Figure 4). Other functional categories included sporulation, ergosterol biosynthesis, phosphate metabolism, and ...
General background text Pharmacogenetics - CYP3A4
... in question and the combination with environmental factors such as co-medication, diet and disease conditions. Variations can exist in a population for the DNA that encodes for a protein. Variations can result in alleles that encode for proteins with no or reduced activity. The simplest form of vari ...
... in question and the combination with environmental factors such as co-medication, diet and disease conditions. Variations can exist in a population for the DNA that encodes for a protein. Variations can result in alleles that encode for proteins with no or reduced activity. The simplest form of vari ...
emerson - ShopRite
... Bring in your little chefs for a cooking class! This month’s theme is Sweet Science! Menu will include strawberry lemonade, easy naan pizzas and pineapple sundaes! Sign up at the Courtesy ...
... Bring in your little chefs for a cooking class! This month’s theme is Sweet Science! Menu will include strawberry lemonade, easy naan pizzas and pineapple sundaes! Sign up at the Courtesy ...
Genoplante 2007, ANR-07-GPLA-002
... al., 2009) and genetic programs of early oogenesis. Finally, aphid symbiosis was first proved to respond early and dynamically to leucine stress by a fast mobilization of its symbiotic bacterium Buchnera plasmid gene expression (Viñuelas et al., 2011). It is the first evidence of a strong and specif ...
... al., 2009) and genetic programs of early oogenesis. Finally, aphid symbiosis was first proved to respond early and dynamically to leucine stress by a fast mobilization of its symbiotic bacterium Buchnera plasmid gene expression (Viñuelas et al., 2011). It is the first evidence of a strong and specif ...
1. Project summary
... Paraplegin resembled a family of mitochondrial metalloproteases well-characterised in yeast and was shown to localize in the mitochondrion. Mutations in paraplegin cause neurodegeneration in an autosomal recessive form of HSP, but the pathogenetic mechanism of this disorder, in particular the role o ...
... Paraplegin resembled a family of mitochondrial metalloproteases well-characterised in yeast and was shown to localize in the mitochondrion. Mutations in paraplegin cause neurodegeneration in an autosomal recessive form of HSP, but the pathogenetic mechanism of this disorder, in particular the role o ...
Translation of an integral membrane protein in distal dendrites of
... Maintenance of synaptic plasticity requires protein translation. Because changes in synaptic strength are regulated at the level of individual synapses, a mechanism is required for newly translated proteins to specifically and persistently modify only a subset of synapses. Evidence suggests this may ...
... Maintenance of synaptic plasticity requires protein translation. Because changes in synaptic strength are regulated at the level of individual synapses, a mechanism is required for newly translated proteins to specifically and persistently modify only a subset of synapses. Evidence suggests this may ...
Identification of a Second Collagen-Like
... desorption/ionization time-of-flight mass spectrometry (MS) and the carbohydrate components by gas chromatography-mass spectrometry and tandem mass spectrometry. Spore-specific sugars were also demonstrated to be components of BclB. as demonstrated by monoclonal antibody labeling. The peptide backbo ...
... desorption/ionization time-of-flight mass spectrometry (MS) and the carbohydrate components by gas chromatography-mass spectrometry and tandem mass spectrometry. Spore-specific sugars were also demonstrated to be components of BclB. as demonstrated by monoclonal antibody labeling. The peptide backbo ...
Involvement of a High-Mobility-Group Protein in the Transcriptional
... functionally redundant for Sp1 binding. The reduction of LAP2 activity in the CT deletion mutant in mammalian cells suggested that other factors in addition to Sp1 may be interacting with elements within LAP2. In this report, we identify four sequence elements in LAP2 that are protected from nucleas ...
... functionally redundant for Sp1 binding. The reduction of LAP2 activity in the CT deletion mutant in mammalian cells suggested that other factors in addition to Sp1 may be interacting with elements within LAP2. In this report, we identify four sequence elements in LAP2 that are protected from nucleas ...
Neutrophil-specific granule deficiency: homozygous recessive
... These cells display, by histochemical staining, normal peroxidase-positive products and no alkaline phosphatase activity, an absence of specific granules upon electron microscopy, impaired chemotaxis, defective bactericidal activity against S aureus and Escherichia coli, and markedly decreased lacto ...
... These cells display, by histochemical staining, normal peroxidase-positive products and no alkaline phosphatase activity, an absence of specific granules upon electron microscopy, impaired chemotaxis, defective bactericidal activity against S aureus and Escherichia coli, and markedly decreased lacto ...
The Polypeptide Composition of Moving and Stationary
... expression of these proteins declines when these cells exit the cell cycle and differentiate into neurons. In adults, nestin expression is confined to neuronal stem cells [Lendahl et al., 1990] and vimentin expression is retained in only a few unusual neurons [Drager, 1983; Schwob et al., 1986], thou ...
... expression of these proteins declines when these cells exit the cell cycle and differentiate into neurons. In adults, nestin expression is confined to neuronal stem cells [Lendahl et al., 1990] and vimentin expression is retained in only a few unusual neurons [Drager, 1983; Schwob et al., 1986], thou ...
Manuela Richter - Late-Onset Alzheimer's Disease: Plaques, Tangles, and Genomics
... “neutral” and most common APOE 3, and the harmful APOE 4. 13 In 1994, Corder et al. showed that across a population, those with the APOE 2 allele had the lowest prevalence of Alzheimer’s, and those that did, developed it later in life than those with other alleles.15 However, it is a relatively rare ...
... “neutral” and most common APOE 3, and the harmful APOE 4. 13 In 1994, Corder et al. showed that across a population, those with the APOE 2 allele had the lowest prevalence of Alzheimer’s, and those that did, developed it later in life than those with other alleles.15 However, it is a relatively rare ...
Pierce Trypsin Protease, MS Grade
... Products are warranted to operate or perform substantially in conformance with published Product specifications in effect at the time of sale, as set forth in the Product documentation, specifications and/or accompanying package inserts (“Documentation”). No claim of suitability for use in applicati ...
... Products are warranted to operate or perform substantially in conformance with published Product specifications in effect at the time of sale, as set forth in the Product documentation, specifications and/or accompanying package inserts (“Documentation”). No claim of suitability for use in applicati ...
CHAPTER G5 PEPTIDES AND PROTEINS ANALYSIS BY MS
... The ions so produced are separated by their mass-to-charge (m/z) ratios. For peptides and proteins, the intact molecules become protonated with a number (n) of protons (H+). Thus, in place of the true molecular mass (M), molecular ions have a mass of [M+nH]. More importantly, the ion has n positive ...
... The ions so produced are separated by their mass-to-charge (m/z) ratios. For peptides and proteins, the intact molecules become protonated with a number (n) of protons (H+). Thus, in place of the true molecular mass (M), molecular ions have a mass of [M+nH]. More importantly, the ion has n positive ...
The Ovine Lens Cytoskeleton - Lincoln University Research Archive
... The process of epithelial cell differentiation occurs throughout life, with fibres being added the periphery of the lens fibre mass over the pre-existing fibre cells, resulting in the lens constantly increasing in size and early fibre cells progressively becoming internalised toward the lens nucleus ...
... The process of epithelial cell differentiation occurs throughout life, with fibres being added the periphery of the lens fibre mass over the pre-existing fibre cells, resulting in the lens constantly increasing in size and early fibre cells progressively becoming internalised toward the lens nucleus ...
Calcium, a signaling molecule in the endoplasmic reticulum?
... or calnexin, or both. Figure 3 shows how changes in the free [Ca21]ER in agonist-stimulated cells might regulate interactions between certain chaperones via Ca21 binding to calreticulin. In addition to these effects, it is likely that the function of other chaperones in the lumen of the ER is sensit ...
... or calnexin, or both. Figure 3 shows how changes in the free [Ca21]ER in agonist-stimulated cells might regulate interactions between certain chaperones via Ca21 binding to calreticulin. In addition to these effects, it is likely that the function of other chaperones in the lumen of the ER is sensit ...
Peptides and proteins Chapter 36:
... are incorporated into peptides and proteins via the genetic code. Individually, these amino acids in isolation have no specific intrinsic biological activity. Within cells, they exist in a pool from which they can be called upon to make peptides and proteins or, sometimes, biogenic amines, such as s ...
... are incorporated into peptides and proteins via the genetic code. Individually, these amino acids in isolation have no specific intrinsic biological activity. Within cells, they exist in a pool from which they can be called upon to make peptides and proteins or, sometimes, biogenic amines, such as s ...
The nucleotide sequence of Saccharomyces cerevisiae
... a feature which does not necessarily mean that they are membranebound. All ORFs have been submitted to PSORT analysis8 to predict their subcellular localization. If we consider a high certainty score to be at least 0.8 for a given localization, and a low one to be less than 0.5 for all other possibl ...
... a feature which does not necessarily mean that they are membranebound. All ORFs have been submitted to PSORT analysis8 to predict their subcellular localization. If we consider a high certainty score to be at least 0.8 for a given localization, and a low one to be less than 0.5 for all other possibl ...
The most abundant protein in bovine herpes 1 virions is
... monoclonal antibodies and polyclonal serum directed against VP8. T h e primary structure of VP8 showed considerable homology with the product o f the U L 4 7 reading frame o f herpes simplex virus type 1. ...
... monoclonal antibodies and polyclonal serum directed against VP8. T h e primary structure of VP8 showed considerable homology with the product o f the U L 4 7 reading frame o f herpes simplex virus type 1. ...
Phosphorylation of apoproteins in VLDL, and LDL by protein
... for apo BlOO phosphorylated by CAMP-PKcompared with AMPPK (Figure lb). This indicates that these two kinases phosphorylate different sites. This has also been suggested by reversed phase HPLC separation of tryptic peptides from apo BlOO phosphorylated by either kinase and will be confmed when these ...
... for apo BlOO phosphorylated by CAMP-PKcompared with AMPPK (Figure lb). This indicates that these two kinases phosphorylate different sites. This has also been suggested by reversed phase HPLC separation of tryptic peptides from apo BlOO phosphorylated by either kinase and will be confmed when these ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.