Effects of phosphatidylethanolamine glycation on lipid–protein
... glycation by forming adducts with PE. Moreover, these authors found these complexes in human red blood cells, suggesting that this compound may act as a lipid glycation inhibitor in vivo, and demonstrated that supplementation of the diet of diabetic rats with pyridoxal 5 -phosphate reduces the leve ...
... glycation by forming adducts with PE. Moreover, these authors found these complexes in human red blood cells, suggesting that this compound may act as a lipid glycation inhibitor in vivo, and demonstrated that supplementation of the diet of diabetic rats with pyridoxal 5 -phosphate reduces the leve ...
Autophagy regulation by nutrient signaling
... mTOR is a highly conserved serine/threonine kinase that is capable of integrating signals from many stimuli including amino acids, energy levels, oxygen, growth factors, and stress to coordinate cell growth and maintain metabolic homeostasis [59]. mTOR forms two functionally distinct complexes in ma ...
... mTOR is a highly conserved serine/threonine kinase that is capable of integrating signals from many stimuli including amino acids, energy levels, oxygen, growth factors, and stress to coordinate cell growth and maintain metabolic homeostasis [59]. mTOR forms two functionally distinct complexes in ma ...
Autophagy in the Eukaryotic Cell - CiteSeerX
... ubiquitin-like (UBL) systems that are essential for vesicle biogenesis (84). Ubiquitin is first activated by binding to a ubiquitin-activating enzyme (also called E1). Then it is transferred to a ubiquitin-conjugating enzyme (also called E2). Then a ubiquitin protein ligase enzyme (also called E3) c ...
... ubiquitin-like (UBL) systems that are essential for vesicle biogenesis (84). Ubiquitin is first activated by binding to a ubiquitin-activating enzyme (also called E1). Then it is transferred to a ubiquitin-conjugating enzyme (also called E2). Then a ubiquitin protein ligase enzyme (also called E3) c ...
y. Cell Set. Suppl. ¡1, 1-11 (1989) Printed in
... III). Lanes: 1, 20% of the ADH III precursor added to each import assay; 2 -5 , import of ADH III precursor by four identical samples of control mitochondria; 6-9, import of ADH III precursor by mitochondria that had been preincubated with 12S, 250, 375 and 500 ng, respectively, of chimeric precurso ...
... III). Lanes: 1, 20% of the ADH III precursor added to each import assay; 2 -5 , import of ADH III precursor by four identical samples of control mitochondria; 6-9, import of ADH III precursor by mitochondria that had been preincubated with 12S, 250, 375 and 500 ng, respectively, of chimeric precurso ...
Arginine-glycine-aspartic acid motif incorporated within turnip yellow
... Mentors: Dr. Theo Dreher and Josh Powell, MS ...
... Mentors: Dr. Theo Dreher and Josh Powell, MS ...
Proteomic studies of the abiotic stresses response in model moss
... mechanisms, including root system, vascular tissues, and stomata, cuticles and lignin that restrict evaporative loss of water. However, the less complex plants, including the model moss species – P. patens, lack these kinds of anatomical adaptation, which means their primary response to dehydration ...
... mechanisms, including root system, vascular tissues, and stomata, cuticles and lignin that restrict evaporative loss of water. However, the less complex plants, including the model moss species – P. patens, lack these kinds of anatomical adaptation, which means their primary response to dehydration ...
Sequence elements of the fusion peptide of human respiratory
... the activity of other viral glycoproteins, at least in viruses with F as the only surface glycoprotein or in transfected cells expressing only F. The HRSV F protein is a type I glycoprotein that is synthesized as an inactive precursor (F0) of 574 amino acids. This precursor is cleaved by furin-like ...
... the activity of other viral glycoproteins, at least in viruses with F as the only surface glycoprotein or in transfected cells expressing only F. The HRSV F protein is a type I glycoprotein that is synthesized as an inactive precursor (F0) of 574 amino acids. This precursor is cleaved by furin-like ...
Lipids as hormones and second messengers
... [2 oo] that have been activated by the relevant agonist. Nearly all of the possible products of these cleavage reactions (i.e. phospholipid headgroups, lysophospholipids, DAGs, PA and fatty acids) have been implicated in signal transduction. For example, release of lysophospholipids and fatty acids ...
... [2 oo] that have been activated by the relevant agonist. Nearly all of the possible products of these cleavage reactions (i.e. phospholipid headgroups, lysophospholipids, DAGs, PA and fatty acids) have been implicated in signal transduction. For example, release of lysophospholipids and fatty acids ...
Protein Arginine Methylation in Candida albicans: Role
... similar to that of a mammalian small-molecule methyltransferase that targets guanidinoacetate (29), more closely related genes are found in fungal and plant genomes but are absent in animals. S. cerevisiae shares different subsets of PRMT genes with other fungi, including Schizosaccharomyces pombe, ...
... similar to that of a mammalian small-molecule methyltransferase that targets guanidinoacetate (29), more closely related genes are found in fungal and plant genomes but are absent in animals. S. cerevisiae shares different subsets of PRMT genes with other fungi, including Schizosaccharomyces pombe, ...
Functional studies of the BTB domain in the Drosophila GAGA and
... GAGA factor to activate binding site-dependent transcription in transfected S2 cells. Site-directed mutagenesis was used to generate GAGA cDNAs with mutations corresponding to those in the BTB domain of mod(mdg4)351. A double mutant D35N+G93S was made, as well as the single mutant D35N. The mutant c ...
... GAGA factor to activate binding site-dependent transcription in transfected S2 cells. Site-directed mutagenesis was used to generate GAGA cDNAs with mutations corresponding to those in the BTB domain of mod(mdg4)351. A double mutant D35N+G93S was made, as well as the single mutant D35N. The mutant c ...
Nuclear accumulation of hepatitis B virus preS fragments
... infection process can be assumed to be largely restricted to the early steps of infection. There are many examples that viral structural proteins have been shown to be associated with various subcellular structures, including actin filaments or the Golgi complex and even the nucleus. Depending on th ...
... infection process can be assumed to be largely restricted to the early steps of infection. There are many examples that viral structural proteins have been shown to be associated with various subcellular structures, including actin filaments or the Golgi complex and even the nucleus. Depending on th ...
found that these mutants differed greatly
... found that these mutants differed greatly in the activity of the phenylalanine (and p-fluorophenylalanine) permwre. They ranged in activity from as low 01 20% to greater than 100% when compared to the control (ST74A). Crosses between these mutants hove indicated that there are at least 2 and possibl ...
... found that these mutants differed greatly in the activity of the phenylalanine (and p-fluorophenylalanine) permwre. They ranged in activity from as low 01 20% to greater than 100% when compared to the control (ST74A). Crosses between these mutants hove indicated that there are at least 2 and possibl ...
novel therapy of high-priority citrus diseases
... protease. Thus, different chimeras can be constructed within each category, thereby allowing us to choose the chimera with the highest anti-bacterial activity. Thionin1-D4E1 chimera was the first one that we started working on three years ago. At that time, the sequence of the citrus genome was not ...
... protease. Thus, different chimeras can be constructed within each category, thereby allowing us to choose the chimera with the highest anti-bacterial activity. Thionin1-D4E1 chimera was the first one that we started working on three years ago. At that time, the sequence of the citrus genome was not ...
Escherichia Coli Improvement in Recombinant Protein Production in ppGpp-Deficient
... amount of ppGpp in cultures of CF1648 and CF1693 would be during slow-growing conditions. Fed-batch fermentations provide a means to create an extended period of slow culture growth to compare the effect of ppGpp deficiency on the production of CAT during extended slow growth. Cultures of CF1648 and ...
... amount of ppGpp in cultures of CF1648 and CF1693 would be during slow-growing conditions. Fed-batch fermentations provide a means to create an extended period of slow culture growth to compare the effect of ppGpp deficiency on the production of CAT during extended slow growth. Cultures of CF1648 and ...
Determinants of Drosophila zw10 protein localization and function
... kinetochores in cells mitotically arrested by either colchicine or taxol treatment. Second, we demonstrate that PSCS in mitotically arrested zw10 mutant cells occurs in the absence of cyclin B degradation. This supports the recent finding by Holloway et al. (1993) that sister chromatid separation ca ...
... kinetochores in cells mitotically arrested by either colchicine or taxol treatment. Second, we demonstrate that PSCS in mitotically arrested zw10 mutant cells occurs in the absence of cyclin B degradation. This supports the recent finding by Holloway et al. (1993) that sister chromatid separation ca ...
Gene Section BTK (Bruton agammaglobulinemia tyrosine kinase) Atlas of Genetics and Cytogenetics
... patients compromise BTK function either through gross structural changes (such as deletions or altered protein folding) or through specific loss of functionally relevant residues. Strikingly, none of the found unique missense mutations found in XLA patients is located in the SH3 domain of BTK, which ...
... patients compromise BTK function either through gross structural changes (such as deletions or altered protein folding) or through specific loss of functionally relevant residues. Strikingly, none of the found unique missense mutations found in XLA patients is located in the SH3 domain of BTK, which ...
Glycogen Synthase Sensitivity to Insulin and Glucose-6
... important for regulation of glycogen synthase (4). At the NH2terminus, both Ser-7 (site 2) and Ser-10 (site 2a) influence glycogen synthase activity (5,6). Insulin administration causes dephosphorylation of glycogen synthase and, consequently, activation of the enzyme. In one study, insulin treatmen ...
... important for regulation of glycogen synthase (4). At the NH2terminus, both Ser-7 (site 2) and Ser-10 (site 2a) influence glycogen synthase activity (5,6). Insulin administration causes dephosphorylation of glycogen synthase and, consequently, activation of the enzyme. In one study, insulin treatmen ...
Lecture 8
... • ADF/Cofilin - found throughout tail – important for increasing actin filament turnover by 10-100 times compared with in vitro – Immunodepletion leads to formation of very long tails - actin turnover rate? – Addition of excess decreases tail length – actin turnover rate? ...
... • ADF/Cofilin - found throughout tail – important for increasing actin filament turnover by 10-100 times compared with in vitro – Immunodepletion leads to formation of very long tails - actin turnover rate? – Addition of excess decreases tail length – actin turnover rate? ...
Microtubule Associated Protein 1b (MAP1B) Is a Marker of the
... other mouse tissues has been detected [11]. MAP1B is involved in neuronal differentiation, particularly axon outgrowth and growth cone turning, neuronal migration, as well as axonal regeneration. It is regulated by phosphorylation and dephosphorylation through GSK3ß and PP2A, respectively [12–18]. H ...
... other mouse tissues has been detected [11]. MAP1B is involved in neuronal differentiation, particularly axon outgrowth and growth cone turning, neuronal migration, as well as axonal regeneration. It is regulated by phosphorylation and dephosphorylation through GSK3ß and PP2A, respectively [12–18]. H ...
Heterodimerization and Endocytosis of Arabidopsis
... In single transfections, BRI1-CFP and AtSERK3-CFP fusion proteins are localized to the plasma membrane as early as 3 h after transfection, and this pattern was unchanged up to 16 h (overnight) incubation of the protoplasts. In Figures 1A to 1D, representative images are shown after 8 h of incubation ...
... In single transfections, BRI1-CFP and AtSERK3-CFP fusion proteins are localized to the plasma membrane as early as 3 h after transfection, and this pattern was unchanged up to 16 h (overnight) incubation of the protoplasts. In Figures 1A to 1D, representative images are shown after 8 h of incubation ...
Molecular paleontology and complexity in the last eukaryotic
... triangles, respectively. The possibility that eukaryotes evolved before prokaryotes is not discussed. It is unknown if FECA (red arrow head) and the origin of the nucleus, acquisition of the mitochondrion or internal compartments (green, purple and yellow arrow heads) are coincident, or near coincid ...
... triangles, respectively. The possibility that eukaryotes evolved before prokaryotes is not discussed. It is unknown if FECA (red arrow head) and the origin of the nucleus, acquisition of the mitochondrion or internal compartments (green, purple and yellow arrow heads) are coincident, or near coincid ...
Motoneurons Derived from Induced Pluripotent Stem Cells Develop
... Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with ...
... Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with ...
Plant–pathogen interactions: what is proteomics telling us?
... main secretion system used by pathogenic bacteria during infection is the type III secretion system (TTSS), which is involved in some of the most devastating diseases in animals and plants (for a review, see [15]). This system enables bacteria to directly inject proteins, called effectors or virulen ...
... main secretion system used by pathogenic bacteria during infection is the type III secretion system (TTSS), which is involved in some of the most devastating diseases in animals and plants (for a review, see [15]). This system enables bacteria to directly inject proteins, called effectors or virulen ...
Pathology - specific Gene Discovery Program
... Example: Proteins A, B, and C Proteins A and B interact Protein A phosphorylates a residue on B ...
... Example: Proteins A, B, and C Proteins A and B interact Protein A phosphorylates a residue on B ...
Protein phosphorylation
Protein phosphorylation is a post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or modifying its function. The reverse reaction of phosphorylation is called dephosphorylation, and is catalyzed by protein phosphatases. Protein kinases and phosphatases work independently and in a balance to regulate the function of proteins. The amino acids most commonly phosphorylated are serine, threonine, and tyrosine in eukaryotes, and histidine in prokaryotes, which play important and well-characterized roles in signaling pathways and metabolism. However, many other amino acids can also be phosphorylated, including arginine, lysine, and cysteine. Protein phosphorylation was first reported in 1906 by Phoebus Levene at the Rockefeller Institute for Medical Research with the discovery of phosphorylated vitellin. However, it was nearly 50 years until the enzymatic phosphorylation of proteins by protein kinases was discovered.