DNA asymmetry in stem cells – immortal or mortal?
... stem cells and differentiated cells (Rossi et al., 2007). Moreover, retaining older template strands would not prevent mutations caused by other naturally occurring DNA-damaging events (environmental factors and cellular stresses). Although this hypothesis has been intensively studied, the interpret ...
... stem cells and differentiated cells (Rossi et al., 2007). Moreover, retaining older template strands would not prevent mutations caused by other naturally occurring DNA-damaging events (environmental factors and cellular stresses). Although this hypothesis has been intensively studied, the interpret ...
Stable benefit of embryonic stem cell therapy in - AJP
... Pucéat, and Andre Terzic. Stable benefit of embryonic stem cell therapy in myocardial infarction. Am J Physiol Heart Circ Physiol 287: H471–H479, 2004; 10.1152/ajpheart.01247.2003.—Conventional therapies for myocardial infarction attenuate disease progression without contributing significantly to r ...
... Pucéat, and Andre Terzic. Stable benefit of embryonic stem cell therapy in myocardial infarction. Am J Physiol Heart Circ Physiol 287: H471–H479, 2004; 10.1152/ajpheart.01247.2003.—Conventional therapies for myocardial infarction attenuate disease progression without contributing significantly to r ...
Oligosaccharide signalling for defense responses in plant
... defence responses in plant cells and their involvement in the detection of ( potential) pathogens in plant has been discussed [5, 24, 34]. Oligosaccharides derived from fungal and plant cell wall polysaccharides are one class of well characterized elicitors that, in some cases, can induce defence re ...
... defence responses in plant cells and their involvement in the detection of ( potential) pathogens in plant has been discussed [5, 24, 34]. Oligosaccharides derived from fungal and plant cell wall polysaccharides are one class of well characterized elicitors that, in some cases, can induce defence re ...
making endothelial cells move – a study of angiomotin and
... reproduction. Further, the vascular system did not exhibit any changes in perfusion or vascular density. However, the growth of Lewis Lung Carcinoma tumor xenograft was significantly impaired in amot deficient mice as compared to sibling wt mice. Analysis of the tumor vasculature revealed a marked c ...
... reproduction. Further, the vascular system did not exhibit any changes in perfusion or vascular density. However, the growth of Lewis Lung Carcinoma tumor xenograft was significantly impaired in amot deficient mice as compared to sibling wt mice. Analysis of the tumor vasculature revealed a marked c ...
Downloaded - The Journal of Cell Biology
... the large granules is a major event in the maturation process of the neutrophil, and occurs at the myelocyte stage (3). In comparison with the azurophils and specifics, the large granules contain no serine or metalloproteases, acid hydrolases, or peroxidase (10). In contrast, they contain a set of s ...
... the large granules is a major event in the maturation process of the neutrophil, and occurs at the myelocyte stage (3). In comparison with the azurophils and specifics, the large granules contain no serine or metalloproteases, acid hydrolases, or peroxidase (10). In contrast, they contain a set of s ...
Gumbo JR and Cloete TE
... spherical inclusions of varying diameters located in the centre of the cell (Jensen, 1968). In our study numerous B. mycoides B16 numbers formed a ‘cover or shade’ over the Microcystis cells creating conditions of low light irradiance. It was hypothesized that the cyanobacteria then resorted to the ...
... spherical inclusions of varying diameters located in the centre of the cell (Jensen, 1968). In our study numerous B. mycoides B16 numbers formed a ‘cover or shade’ over the Microcystis cells creating conditions of low light irradiance. It was hypothesized that the cyanobacteria then resorted to the ...
Zasp is required for the assembly of functional integrin adhesion sites
... staining typical of integrin adhesion sites, with bright foci along the cell edge and streaks in areas of potentially increased local forces (Fig. 1 A). In contrast, S2 cells spread on concanavalin A do not exhibit these integrin adhesion sites (Fig. 1 B). Instead of distinct foci and streaks, βPS i ...
... staining typical of integrin adhesion sites, with bright foci along the cell edge and streaks in areas of potentially increased local forces (Fig. 1 A). In contrast, S2 cells spread on concanavalin A do not exhibit these integrin adhesion sites (Fig. 1 B). Instead of distinct foci and streaks, βPS i ...
Mechanism of Inhibition of Cell Proliferation by
... 2To whom requests for reprints should be addressed. ...
... 2To whom requests for reprints should be addressed. ...
TRANSPORT OF SODIUM, POTASSIUM, AND CALCIUM ACROSS
... level of cell-associated 45Ca. In the presence of .01 mM extracellular calcium, however, a transient decrease in the steady-state level of cell-associated 45Ca was induced by FMLP. The curves relating the concentration of FMLP to its effects on cation fluxes are very similar to those found for its e ...
... level of cell-associated 45Ca. In the presence of .01 mM extracellular calcium, however, a transient decrease in the steady-state level of cell-associated 45Ca was induced by FMLP. The curves relating the concentration of FMLP to its effects on cation fluxes are very similar to those found for its e ...
Jamming prokaryotic cell-to-cell communications in a model biofilm†
... Quorum-sensing has been implicated in the regulation of processes such as bioluminescence, swarming, swimming, and virulence.1–5 But despite its appeal, the QS hypothesis may not be an accurate description of all these phenomena.6–8 To elucidate how cell-to-cell signaling works in bacteria, it is vi ...
... Quorum-sensing has been implicated in the regulation of processes such as bioluminescence, swarming, swimming, and virulence.1–5 But despite its appeal, the QS hypothesis may not be an accurate description of all these phenomena.6–8 To elucidate how cell-to-cell signaling works in bacteria, it is vi ...
Integrin modulation of signaling to transcription factors
... Tournier et al., 1997). A variety of activators of MKK4 and MKK7 have been described, including MAP/ERK kinase kinases (MEKKs) 1-4, members of the mixed-lineage kinase family and the apoptosis-stimulated kinases (reviewed by Davis, 2000; Garrington and Johnson, 1999). Activated JNK translocates to t ...
... Tournier et al., 1997). A variety of activators of MKK4 and MKK7 have been described, including MAP/ERK kinase kinases (MEKKs) 1-4, members of the mixed-lineage kinase family and the apoptosis-stimulated kinases (reviewed by Davis, 2000; Garrington and Johnson, 1999). Activated JNK translocates to t ...
Dictyostelium cytokinesis: from molecules to mechanics
... the amount predicted at each stage through cytokinesis (Figure 3). In terms of concentration, wild type myosinII increases by roughly twofold by the end of cytokinesis. The difference in the trends of absolute amounts and concentrations is due to the fact that the cleavagefurrow cortex volume decreas ...
... the amount predicted at each stage through cytokinesis (Figure 3). In terms of concentration, wild type myosinII increases by roughly twofold by the end of cytokinesis. The difference in the trends of absolute amounts and concentrations is due to the fact that the cleavagefurrow cortex volume decreas ...
CHRISTIAN_PECULIAR_1
... myosin filament is thicker, lending a darker appearance to the alternating A bands as observed with electron microscopy. However, in contrast to skeletal muscle, cardiac muscle cells are typically branch-like instead of linear. Another histological difference between cardiac muscle and skeletal musc ...
... myosin filament is thicker, lending a darker appearance to the alternating A bands as observed with electron microscopy. However, in contrast to skeletal muscle, cardiac muscle cells are typically branch-like instead of linear. Another histological difference between cardiac muscle and skeletal musc ...
A Role for Eosinophils in Adaptive Humoral Immunity
... permeability, presumably by forming ion channels [42] and/or by membrane depolarization. RNase-3 also acts to inhibit further growth of cells without being catalytic. RNase-2 is composed of fewer arginine molecules and is associated with higher RNAse activity but less cell toxicity. Some arginine-ri ...
... permeability, presumably by forming ion channels [42] and/or by membrane depolarization. RNase-3 also acts to inhibit further growth of cells without being catalytic. RNase-2 is composed of fewer arginine molecules and is associated with higher RNAse activity but less cell toxicity. Some arginine-ri ...
06_Lecture_Presentation
... (EMs) are used to study subcellular structures • Scanning electron microscopes (SEMs) focus a beam of electrons onto the surface of a specimen, providing images that look 3-D • Transmission electron microscopes (TEMs) focus a beam of electrons through a specimen • TEMs are used mainly to study the i ...
... (EMs) are used to study subcellular structures • Scanning electron microscopes (SEMs) focus a beam of electrons onto the surface of a specimen, providing images that look 3-D • Transmission electron microscopes (TEMs) focus a beam of electrons through a specimen • TEMs are used mainly to study the i ...
Protein sensing in living cells by molecular rotor
... off/on cycles would present a more desirable feature that can be applied to detect the protein expression level and activity, and also subsequent analysis of protein degradation, translocation and inhibitor screening in cells.8,9 There are many obstacles that need to be addressed in order to construc ...
... off/on cycles would present a more desirable feature that can be applied to detect the protein expression level and activity, and also subsequent analysis of protein degradation, translocation and inhibitor screening in cells.8,9 There are many obstacles that need to be addressed in order to construc ...
Chapter 13 - Fission Yeast TOR and Rapamycin
... studies of the two yeasts have taught us that cellular processes that at first sight appeared substantially different, later proved to share common and conserved molecular mechanisms. For example, the regulation of the cell cycle first appeared fundamentally dissimilar in the two yeasts, partly owin ...
... studies of the two yeasts have taught us that cellular processes that at first sight appeared substantially different, later proved to share common and conserved molecular mechanisms. For example, the regulation of the cell cycle first appeared fundamentally dissimilar in the two yeasts, partly owin ...
Syndecan-1 regulates αvß5 integrin activity in B82L fibroblasts
... (Sdc1), proteoglycan-deficient Raji cells gain the ability to bind to Sdc1 antibody and spread on Sdc1 antibody-coated surfaces in two phases that depend on the syndecan transmembrane and ectodomains, respectively (Lebakken et al., 2000; Lebakken and Rapraeger, 1996; McQuade and Rapraeger, 2003). Co ...
... (Sdc1), proteoglycan-deficient Raji cells gain the ability to bind to Sdc1 antibody and spread on Sdc1 antibody-coated surfaces in two phases that depend on the syndecan transmembrane and ectodomains, respectively (Lebakken et al., 2000; Lebakken and Rapraeger, 1996; McQuade and Rapraeger, 2003). Co ...
Science Summer Project - Rising 7th Grade
... Summer Assignment Focus: Recap of Cells Your Task: Draw and label a diagram of two cells: one plant and one animal. Understand and include a brief description of the function of each organelle that you label. Your Diagrams: ● You must draw each diagram yourself ● One labelled diagram of a plant ...
... Summer Assignment Focus: Recap of Cells Your Task: Draw and label a diagram of two cells: one plant and one animal. Understand and include a brief description of the function of each organelle that you label. Your Diagrams: ● You must draw each diagram yourself ● One labelled diagram of a plant ...
70 Histopathology The mouse liver is made up of a large number of
... and hyalinisation of hepatocytes are prominent. Dilated spaces of sinusoids are distinct. Day 4 of infection (Fig. 3-C2): On histological examination of liver, the pathological symptoms include the appearance of hepatocytes undergoing necrosis. Pycnotic nuclei in some hepatocytes (at certain places) ...
... and hyalinisation of hepatocytes are prominent. Dilated spaces of sinusoids are distinct. Day 4 of infection (Fig. 3-C2): On histological examination of liver, the pathological symptoms include the appearance of hepatocytes undergoing necrosis. Pycnotic nuclei in some hepatocytes (at certain places) ...
Plant Cell Growth and Elongation
... complex networks of intracellular and extracellular signals to start growth, expand, and then to stop growth in a coordinated fashion. Plant cell growth is a cellular process that integrates the ‘loosening’ of the cell wall, the outward push of the protoplast driven by osmotic forces, and the deposi ...
... complex networks of intracellular and extracellular signals to start growth, expand, and then to stop growth in a coordinated fashion. Plant cell growth is a cellular process that integrates the ‘loosening’ of the cell wall, the outward push of the protoplast driven by osmotic forces, and the deposi ...
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... Biological tubes composed of polarized epithelial cells perform many functions in multicellular organisms. The establishment and maintenance of epithelial polarity depend on polarized trafficking of membrane components to the apical or basolateral domains of epithelial cells, but exactly how traffic ...
... Biological tubes composed of polarized epithelial cells perform many functions in multicellular organisms. The establishment and maintenance of epithelial polarity depend on polarized trafficking of membrane components to the apical or basolateral domains of epithelial cells, but exactly how traffic ...
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... Biological tubes composed of polarized epithelial cells perform many functions in multicellular organisms. The establishment and maintenance of epithelial polarity depend on polarized trafficking of membrane components to the apical or basolateral domains of epithelial cells, but exactly how traffic ...
... Biological tubes composed of polarized epithelial cells perform many functions in multicellular organisms. The establishment and maintenance of epithelial polarity depend on polarized trafficking of membrane components to the apical or basolateral domains of epithelial cells, but exactly how traffic ...
Hematopoietic cells expressing the peripheral cannabinoid receptor
... Two distinct cannabinoid receptors have previously been identified: the central1 (Cb1) and the peripheral (Cb2) cannabinoid receptor.2 In retrovirally induced murine leukemia, proviral insertions frequently occur in the gene encoding Cb2, suggesting that the peripheral cannabinoid receptor is an onc ...
... Two distinct cannabinoid receptors have previously been identified: the central1 (Cb1) and the peripheral (Cb2) cannabinoid receptor.2 In retrovirally induced murine leukemia, proviral insertions frequently occur in the gene encoding Cb2, suggesting that the peripheral cannabinoid receptor is an onc ...
Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.