Cardiac optogenetics - Biomedical Engineering
... (K⫹) channel conformations are possible with direct fluorescence labeling and total internal reflection fluorescence microscopy imaging to infer membrane voltage changes (87, 113, 116, 117). Certain applications of genetics for development of new imaging probes, i.e., genetically encoded calcium and ...
... (K⫹) channel conformations are possible with direct fluorescence labeling and total internal reflection fluorescence microscopy imaging to infer membrane voltage changes (87, 113, 116, 117). Certain applications of genetics for development of new imaging probes, i.e., genetically encoded calcium and ...
Cancer stem cells and addicted cancer cells
... process of clonal selection [1,8]. Passenger mutations have no effect on the formation and progression of a tumor. They are only identified in a context-dependent manner, which means that their phenotypic effects are only observed under specific circumstances. For example, the function of the gene c ...
... process of clonal selection [1,8]. Passenger mutations have no effect on the formation and progression of a tumor. They are only identified in a context-dependent manner, which means that their phenotypic effects are only observed under specific circumstances. For example, the function of the gene c ...
Linköping University Post Print Neutralizing activity and cellular immune
... HIV-1/MuLV pseudovirus, which was then used to infect Concanavalin A (ConA)/rIL-2 activated syngeneic murine spleen cells. The content of HIV-1 p24 antigen was analysed by lysis of 1x106 HIV-1/MuLV infected splenocytes [20] . A total dose equivalent of 1ng of p24 was given on each day of immunizatio ...
... HIV-1/MuLV pseudovirus, which was then used to infect Concanavalin A (ConA)/rIL-2 activated syngeneic murine spleen cells. The content of HIV-1 p24 antigen was analysed by lysis of 1x106 HIV-1/MuLV infected splenocytes [20] . A total dose equivalent of 1ng of p24 was given on each day of immunizatio ...
Get PDF file - Botanik in Bonn
... fully functional cytoskeleton comprised principally of microtubules and microfilaments. These two polymeric macromolecules, because of their location within the cell, confer structure upon, and convey information to, the peripheral regions of the cytoplasm where much of cellular growth is controlled ...
... fully functional cytoskeleton comprised principally of microtubules and microfilaments. These two polymeric macromolecules, because of their location within the cell, confer structure upon, and convey information to, the peripheral regions of the cytoplasm where much of cellular growth is controlled ...
- de Duve Institute
... The aim of our research is to understand the molecular mechanisms underlying a variety of disorders of the cardiovascular and skeletal systems, as well as certain cancers. We are especially interested in evaluating the contribution of genetic variation to human disease. The bases of many disorders r ...
... The aim of our research is to understand the molecular mechanisms underlying a variety of disorders of the cardiovascular and skeletal systems, as well as certain cancers. We are especially interested in evaluating the contribution of genetic variation to human disease. The bases of many disorders r ...
Cell Structures and Functions
... Fifth Grade: Science: Cells: Structures and Processes (page 127) (this unit does not cover all of the content listed in this section) a. All living things are made up of cells. b. Structure of cells (both plant and animal). i. Cell membrane: selectively allows substances in and out ii. Nucleus: surr ...
... Fifth Grade: Science: Cells: Structures and Processes (page 127) (this unit does not cover all of the content listed in this section) a. All living things are made up of cells. b. Structure of cells (both plant and animal). i. Cell membrane: selectively allows substances in and out ii. Nucleus: surr ...
Address for Correspondence : VASaks
... gastrocnemius and EDL. As it has been described before for different rat and pig muscle fibers (Veksler et al. 1995; Kuznetsov et al. 1996; Gueguen et al. 2004), the apparent Km for exogenous ADP is tissue specific. In spite of smaller diameters of heart and soleus muscle fibers as compared to the g ...
... gastrocnemius and EDL. As it has been described before for different rat and pig muscle fibers (Veksler et al. 1995; Kuznetsov et al. 1996; Gueguen et al. 2004), the apparent Km for exogenous ADP is tissue specific. In spite of smaller diameters of heart and soleus muscle fibers as compared to the g ...
Echinoderm enteric nervous system
... hyponeural divisions. Nothing is known about how these connections occur, although it is highly probable that the extension of the visceral plexus into the mesenteries plays an important functional role in the neuronal circuitry. Basiepithelial plexus The basiepithelial plexus is probably the best-d ...
... hyponeural divisions. Nothing is known about how these connections occur, although it is highly probable that the extension of the visceral plexus into the mesenteries plays an important functional role in the neuronal circuitry. Basiepithelial plexus The basiepithelial plexus is probably the best-d ...
Negative Pressure Wound Therapy
... tissue while aiding in wound contraction. –V.A.C.® GranuFoam™ Silver for infected wounds. Dressing provides a protective barrier to reduce aerobic, gram-negative and gram-positive bacteria, yeast and fungi and may help reduce infections in wounds. –The V.A.C.® GranuFoam® Silver™ Dressing must be rem ...
... tissue while aiding in wound contraction. –V.A.C.® GranuFoam™ Silver for infected wounds. Dressing provides a protective barrier to reduce aerobic, gram-negative and gram-positive bacteria, yeast and fungi and may help reduce infections in wounds. –The V.A.C.® GranuFoam® Silver™ Dressing must be rem ...
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... extensive underground network of roots necessary for water and mineral uptake. The shoot apical meristem consists of a small mound of densely cytoplasmic, undifferentiated, dividing cells. Based on several criteria, the cells in the meristem can be classified as stem cells (Potten and Loeffler, 1990 ...
... extensive underground network of roots necessary for water and mineral uptake. The shoot apical meristem consists of a small mound of densely cytoplasmic, undifferentiated, dividing cells. Based on several criteria, the cells in the meristem can be classified as stem cells (Potten and Loeffler, 1990 ...
In Vivo Analysis of Riboswitch Activity Using Luciferase Assays
... conformation change of the RNA structure and leads to gene repression or activation (Atkins et al., 2001). Riboswitches are found in the 5’ untranslated regions of mRNA in bacteria and in 5’ and 3’ untranslateed regions and introns of pre-mRNA’s of plants and fungi (Villa, 2009). Riboswitches genera ...
... conformation change of the RNA structure and leads to gene repression or activation (Atkins et al., 2001). Riboswitches are found in the 5’ untranslated regions of mRNA in bacteria and in 5’ and 3’ untranslateed regions and introns of pre-mRNA’s of plants and fungi (Villa, 2009). Riboswitches genera ...
Clear Cell Tumors of the Head and Neck: An
... behavior, clear cell salivary gland tumors are considered low grade malignancies because in spite of their benign appearance they are capable of local infiltrative growth and destruction as well as metastasis with poor prognosis.23 Clear Cell Metastatic Tumors Metastatic tumors in the oral cavity ar ...
... behavior, clear cell salivary gland tumors are considered low grade malignancies because in spite of their benign appearance they are capable of local infiltrative growth and destruction as well as metastasis with poor prognosis.23 Clear Cell Metastatic Tumors Metastatic tumors in the oral cavity ar ...
Pulmonary 4 Transport of
... During heavy exercise, the muscle cells use oxygen at a rapid rate, which, in extreme cases, can cause the muscle interstitial fluid Po2 to fall from the normal 40 mm Hg to as low as 15 mm Hg. At this low pressure, only 4.4 milliliters of oxygen remain bound with the hemoglobin in each 100 millilite ...
... During heavy exercise, the muscle cells use oxygen at a rapid rate, which, in extreme cases, can cause the muscle interstitial fluid Po2 to fall from the normal 40 mm Hg to as low as 15 mm Hg. At this low pressure, only 4.4 milliliters of oxygen remain bound with the hemoglobin in each 100 millilite ...
Whole-cell biocatalysts by design - Microbial Cell Factories
... (GAD; EC 4.1.1.15). GADs from different species were expressed and screened, and the enzyme from Lactococcus lactis was chosen. The gene gadAB was subsequently deleted from the genome of the E. coli host to prevent the degradation of GABA. As a result, 614.15 g/L GABA was produced with a high molar ...
... (GAD; EC 4.1.1.15). GADs from different species were expressed and screened, and the enzyme from Lactococcus lactis was chosen. The gene gadAB was subsequently deleted from the genome of the E. coli host to prevent the degradation of GABA. As a result, 614.15 g/L GABA was produced with a high molar ...
Neuromas
... twist if a schwann cells are damaged at this site Nerve may also be transposed into other tissues: 1. Implantation into same nerve (neurocampsis) a. The nerve stump is coapted into the same nerve more proximally through an opening in the epineurium. b. may get neuroma in continuity at this site 2. I ...
... twist if a schwann cells are damaged at this site Nerve may also be transposed into other tissues: 1. Implantation into same nerve (neurocampsis) a. The nerve stump is coapted into the same nerve more proximally through an opening in the epineurium. b. may get neuroma in continuity at this site 2. I ...
Two distinct classes of prestalk
... very low level of expression detectable in overexposed autoradiograms in the absence of DIF. After prolonged incubation without DIF, a low level of expression becomes apparent (Fig. 1). The pDd63 gene might be expected to be responsive to a very low level of DIF, as it is highly induced within 1 h o ...
... very low level of expression detectable in overexposed autoradiograms in the absence of DIF. After prolonged incubation without DIF, a low level of expression becomes apparent (Fig. 1). The pDd63 gene might be expected to be responsive to a very low level of DIF, as it is highly induced within 1 h o ...
regulator of cell-plate formation in plant cytokinesis The NPK1
... MAPKKK family, and the kinase domain of NPK1 can replace the functions of several yeast MAPKKKs (Banno et al. 1993; Nishihama and Machida 2000). NPK1 and its Arabidopsis orthologous genes, ANP1/2/3, are transcribed in proliferating and division-competent cells or in organs rich in these cells, an ob ...
... MAPKKK family, and the kinase domain of NPK1 can replace the functions of several yeast MAPKKKs (Banno et al. 1993; Nishihama and Machida 2000). NPK1 and its Arabidopsis orthologous genes, ANP1/2/3, are transcribed in proliferating and division-competent cells or in organs rich in these cells, an ob ...
Cell Lineage and Fate Map of the Primary Somatoblast of the
... Synopsis Like most polychaete annelids, Capitella teleta (formerly Capitella sp. I) exhibits a highly stereotypic program of early development known as spiral cleavage. Animals with spiral cleavage have diverse body plans, and homologous embryonic cells can be readily identified among distantly rela ...
... Synopsis Like most polychaete annelids, Capitella teleta (formerly Capitella sp. I) exhibits a highly stereotypic program of early development known as spiral cleavage. Animals with spiral cleavage have diverse body plans, and homologous embryonic cells can be readily identified among distantly rela ...
Activation of Metallothionein Gene Expression
... cellular proliferation and apoptosis (6 –9), perhaps through an interaction of MT with nuclear factor-kB-DNA complexes (10). These properties of MTs reflect their potential importance for malignant progression; high expression of MTs correlates with poor prognosis and progressive disease in a number ...
... cellular proliferation and apoptosis (6 –9), perhaps through an interaction of MT with nuclear factor-kB-DNA complexes (10). These properties of MTs reflect their potential importance for malignant progression; high expression of MTs correlates with poor prognosis and progressive disease in a number ...
Mouse models of graft-versus-host disease: advances and limitations
... post-transplant disorder that results from immune-mediated attack of recipient tissue by donor T cells contained in the transplant. Mouse models of GvHD have provided important insights into the pathophysiology of this disease, which have helped to improve the success rate of HSCT in humans. The kin ...
... post-transplant disorder that results from immune-mediated attack of recipient tissue by donor T cells contained in the transplant. Mouse models of GvHD have provided important insights into the pathophysiology of this disease, which have helped to improve the success rate of HSCT in humans. The kin ...
Goblet Cells Contribute to Ocular Surface Immune Tolerance
... Th2 response to house dust mite (HDM) extract induced pulmonary inflammation was significantly attenuated in the Spdef − /− strain [9]. Goblet cell associated passages (GAPs) under cholinergic regulation have been described in the mouse small intestine [10,11]. These GAPs deliver luminal antigens to ...
... Th2 response to house dust mite (HDM) extract induced pulmonary inflammation was significantly attenuated in the Spdef − /− strain [9]. Goblet cell associated passages (GAPs) under cholinergic regulation have been described in the mouse small intestine [10,11]. These GAPs deliver luminal antigens to ...
Penium margaritaceum: A Unicellular Model Organism for
... and under various experimental treatments. Likewise, after a designated period of time, the labeled cells may be labeled with the same mAb followed by labeling with a different secondary antibody-fluorophore conjugate. Imaging of the two fluorescent signals with different channels and/or filter sets ...
... and under various experimental treatments. Likewise, after a designated period of time, the labeled cells may be labeled with the same mAb followed by labeling with a different secondary antibody-fluorophore conjugate. Imaging of the two fluorescent signals with different channels and/or filter sets ...
The Arabidopsis repressor of light signaling SPA1
... pRTL2/GUS-SPA1 (Hoecker et al., 1999). GUS-SPA1 was subsequently excised by partial SacI digestion and ligated into the SacI site of pGWB1 (Nakagawa et al., 2007). The 2260 bp SPA1 promoter, the 1537 bp CAB3 promoter and the 1208 bp CER6 promoter (upstream of the respective coding region) were PCR a ...
... pRTL2/GUS-SPA1 (Hoecker et al., 1999). GUS-SPA1 was subsequently excised by partial SacI digestion and ligated into the SacI site of pGWB1 (Nakagawa et al., 2007). The 2260 bp SPA1 promoter, the 1537 bp CAB3 promoter and the 1208 bp CER6 promoter (upstream of the respective coding region) were PCR a ...
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... and under various experimental treatments. Likewise, after a designated period of time, the labeled cells may be labeled with the same mAb followed by labeling with a different secondary antibody-fluorophore conjugate. Imaging of the two fluorescent signals with different channels and/or filter sets ...
... and under various experimental treatments. Likewise, after a designated period of time, the labeled cells may be labeled with the same mAb followed by labeling with a different secondary antibody-fluorophore conjugate. Imaging of the two fluorescent signals with different channels and/or filter sets ...
Dominant-lethal alpha-tubulin mutants defective in microtubule depolymerization in yeast.
... (Nogales et al., 1998a). The TUB1-828 phenotype is dominant-lethal, although the lethality can be suppressed by increased dosage of the wild-type allele (Richards et al., 2000). The dominance is particularly striking, considering that changing glutamate or aspartate to alanine is usually thought of ...
... (Nogales et al., 1998a). The TUB1-828 phenotype is dominant-lethal, although the lethality can be suppressed by increased dosage of the wild-type allele (Richards et al., 2000). The dominance is particularly striking, considering that changing glutamate or aspartate to alanine is usually thought of ...
Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.