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p53
... sequestering p53 when the latter was supposed to inhibit tumor progression - T antigen binds also to pRb, sequestering it from negatively regulating cell cycle progression ...
... sequestering p53 when the latter was supposed to inhibit tumor progression - T antigen binds also to pRb, sequestering it from negatively regulating cell cycle progression ...
Meiotic Induction of the Yeast HOP1 Gene Is
... 22, 35, 37). It is appealing to imagine that these genes are regulated in a coordinated fashion to ensure that they are expressed at the proper time and level during meiosis. The signals that control entry into meiosis by the yeast Saccharomyces cerevisiae have been well studied and include a specif ...
... 22, 35, 37). It is appealing to imagine that these genes are regulated in a coordinated fashion to ensure that they are expressed at the proper time and level during meiosis. The signals that control entry into meiosis by the yeast Saccharomyces cerevisiae have been well studied and include a specif ...
The human uncoupling protein-3 gene promoter muscle cells
... RARE identified here acts as a multihormonal cisacting element in the UCP-3 gene. The presence of deletion and point mutation constructs that are responsive to MyoD but unresponsive to RA indicated that the RARE in the UCP-3 gene promoter is distinct and physically separated in the DNA from the cis- ...
... RARE identified here acts as a multihormonal cisacting element in the UCP-3 gene. The presence of deletion and point mutation constructs that are responsive to MyoD but unresponsive to RA indicated that the RARE in the UCP-3 gene promoter is distinct and physically separated in the DNA from the cis- ...
Cell cycle progression in response to oxygen levels | SpringerLink
... but p53 independent. In addition, loss of HIF1α leads to progression of cells into S phase and a loss of the induction of p21 and p27 [65]. In this way, it is proposed that the expression of p27 is dependent on HIF1α. Conversely, additional studies have shown that p27 is regulated independent of HIF ...
... but p53 independent. In addition, loss of HIF1α leads to progression of cells into S phase and a loss of the induction of p21 and p27 [65]. In this way, it is proposed that the expression of p27 is dependent on HIF1α. Conversely, additional studies have shown that p27 is regulated independent of HIF ...
Transcription
... unwinding and rewinding of the two strands to create a moving bubble. Note that the non-template strand has the same sequence as the RNA transcript. Note too that the direction of transcription–left to right as shown–is determined by the strand that is being copied as dictated by the 5’ to 3’ rule a ...
... unwinding and rewinding of the two strands to create a moving bubble. Note that the non-template strand has the same sequence as the RNA transcript. Note too that the direction of transcription–left to right as shown–is determined by the strand that is being copied as dictated by the 5’ to 3’ rule a ...
figure 18.2
... FIGURE 18.1 A) Signal ON. Binding of the appropriate Wnt proteins to the Fzd family of receptors activates the cytoplasmic signaling protein Dvl, which in turn recruits the axin-GSK3 complex, leading to LRP5/6 phosphorylation. LRP5/6 phosphorylation prevents phosphorylation of β-catenin and thereby ...
... FIGURE 18.1 A) Signal ON. Binding of the appropriate Wnt proteins to the Fzd family of receptors activates the cytoplasmic signaling protein Dvl, which in turn recruits the axin-GSK3 complex, leading to LRP5/6 phosphorylation. LRP5/6 phosphorylation prevents phosphorylation of β-catenin and thereby ...
Monocyte-Derived Dendritic Cells CCL19 Gene Expression in
... DC traffic and impaired immune responses (5–7). Because DCs are also capable of producing both CCL19 and CCL20, it is evident that these chemokines have a unique role in DC biology. Transcription of cytokine and chemokine genes requires the controlled action of multiple transcription factors activat ...
... DC traffic and impaired immune responses (5–7). Because DCs are also capable of producing both CCL19 and CCL20, it is evident that these chemokines have a unique role in DC biology. Transcription of cytokine and chemokine genes requires the controlled action of multiple transcription factors activat ...
Domain organization of human cleavage factor Im 1 Distinct
... protein synthesis. Transcription is coupled spatially and temporally to capping of the premRNA at the 5’!end, splicing and 3’!end formation. The mature 3’!ends of most eukaryotic mRNAs are generated by endonucleolytic cleavage of the primary transcript followed by the addition of a poly(A) tail to t ...
... protein synthesis. Transcription is coupled spatially and temporally to capping of the premRNA at the 5’!end, splicing and 3’!end formation. The mature 3’!ends of most eukaryotic mRNAs are generated by endonucleolytic cleavage of the primary transcript followed by the addition of a poly(A) tail to t ...
FUNCTIONAL CONSEQUENCES OF THE DIRECT PHYSICAL CBP/p300
... Clues to the molecular mechanisms of leukemogenesis have been provided by the discovery of non-random chromosomal abnormalities in the leukemic cells. More than half of all leukemias have detectable chromosomal abnormalities by karyotypic analysis (2). Some of these abnormalities are consistently as ...
... Clues to the molecular mechanisms of leukemogenesis have been provided by the discovery of non-random chromosomal abnormalities in the leukemic cells. More than half of all leukemias have detectable chromosomal abnormalities by karyotypic analysis (2). Some of these abnormalities are consistently as ...
Antisense-mediated FLC transcriptional repression requires the P
... much total antisense transcripts as wild-type plants (Fig. S6B), likely to result from Pol II firing from the efficient rbcs3B terminator (40). The FLC-TEX line was crossed to a cdkc;2 mutation (using the Col cdkc;2–2 allele to avoid mixing genetic backgrounds, selecting for fri individuals, but mai ...
... much total antisense transcripts as wild-type plants (Fig. S6B), likely to result from Pol II firing from the efficient rbcs3B terminator (40). The FLC-TEX line was crossed to a cdkc;2 mutation (using the Col cdkc;2–2 allele to avoid mixing genetic backgrounds, selecting for fri individuals, but mai ...
hos1 - Oxford Academic - Oxford University Press
... consider that these signalling pathways do not work in isolation but are tightly connected. Therefore, future research on HOS1 and other nuclear pore proteins would benefit from considering whether the phenotype being studied is a direct consequence of the mutation or an indirect effect acting throu ...
... consider that these signalling pathways do not work in isolation but are tightly connected. Therefore, future research on HOS1 and other nuclear pore proteins would benefit from considering whether the phenotype being studied is a direct consequence of the mutation or an indirect effect acting throu ...
Activation of Heat-Shock Factor by Stretch-Activated
... levels have been suggested as potential mediators for induction of cardiac hypertrophy and IE gene expression.26,27 Since Vandenburgh and Kaufman28 reported that mechanical stretch without confounding factors caused increased protein synthesis in cultured skeletal muscle cells, however, many studies ...
... levels have been suggested as potential mediators for induction of cardiac hypertrophy and IE gene expression.26,27 Since Vandenburgh and Kaufman28 reported that mechanical stretch without confounding factors caused increased protein synthesis in cultured skeletal muscle cells, however, many studies ...
Lecture 24
... The DNA template is thawed and then placed on ice during the preparatory process. For in vitro protein synthesis to take place, the DNA template must contain the gene coding for the protein of interest. In addition to this, there must be a promoter sequence, which can initiate the transcription proc ...
... The DNA template is thawed and then placed on ice during the preparatory process. For in vitro protein synthesis to take place, the DNA template must contain the gene coding for the protein of interest. In addition to this, there must be a promoter sequence, which can initiate the transcription proc ...
during Drosophila melanogaster Embryogenesis
... results). Our results have revealed that chromosomes are not synapsed during the mitotic portion of the early embryonic nuclear cycles. However, they leave open the possibility that homolog pairing is dynamic, occuring only during interphase and breaking down for mitosis, or that synapsis begins at ...
... results). Our results have revealed that chromosomes are not synapsed during the mitotic portion of the early embryonic nuclear cycles. However, they leave open the possibility that homolog pairing is dynamic, occuring only during interphase and breaking down for mitosis, or that synapsis begins at ...
Chimeric phosphorylation indicator
... dephosphorylated by a speci?c phosphatase. Thus, the phos phorylatable domain can be a synthetic peptide, a peptide portion of a naturally-occurring kinase or phosphatase sub strate, a peptidomimetic, a polynucleotide, or the like. By Way of example, a PKC phosphorylatable domain may include an amin ...
... dephosphorylated by a speci?c phosphatase. Thus, the phos phorylatable domain can be a synthetic peptide, a peptide portion of a naturally-occurring kinase or phosphatase sub strate, a peptidomimetic, a polynucleotide, or the like. By Way of example, a PKC phosphorylatable domain may include an amin ...
Regulation of Heat Shock Response in Yeast and - E
... machinery, which, in addition to RNAPII complex, consists of a series of additional factors called general transcription factors. They recognize specific promoter sequences and perform the steps required for transcription initiation. The general transcription machinery binds to a specific region ups ...
... machinery, which, in addition to RNAPII complex, consists of a series of additional factors called general transcription factors. They recognize specific promoter sequences and perform the steps required for transcription initiation. The general transcription machinery binds to a specific region ups ...
42(5): 551-557. 2010 Insecticidal activities of essential oils from
... The Pho regulon is controlled by the histidine kinase-response regulator pair SphS-SphR in many cyanobacteria and up-regulation of the Pho regulon can be monitored by measuring alkaline phosphatase activity. However, the mechanism regulating signal transduction between SphS and SphR has not been des ...
... The Pho regulon is controlled by the histidine kinase-response regulator pair SphS-SphR in many cyanobacteria and up-regulation of the Pho regulon can be monitored by measuring alkaline phosphatase activity. However, the mechanism regulating signal transduction between SphS and SphR has not been des ...
Evaluation of existing motif detection tools on their
... • Chromatin > complex of DNA and proteins (Histones) Chromatin function: – Storage of long DNA molecules into nucleus Nucleus ...
... • Chromatin > complex of DNA and proteins (Histones) Chromatin function: – Storage of long DNA molecules into nucleus Nucleus ...
Neutrophil-specific granule deficiency: homozygous recessive
... with the vector-specific primer 32N (5⬘-tcgccggaattcatgtcccacgggacctactacgagtgtgagccccgg-3⬘) and the gene-specific primer SGDMUT-AS 5⬘-ggcctttgagaacgcgcagaggctggccgg-3⬘). In the second reaction, the vectorspecific primer NdelC 5⬘-agcctggtcgacgtgcccacaatccaccagcca-3⬘) was mixed with the gene-specific ...
... with the vector-specific primer 32N (5⬘-tcgccggaattcatgtcccacgggacctactacgagtgtgagccccgg-3⬘) and the gene-specific primer SGDMUT-AS 5⬘-ggcctttgagaacgcgcagaggctggccgg-3⬘). In the second reaction, the vectorspecific primer NdelC 5⬘-agcctggtcgacgtgcccacaatccaccagcca-3⬘) was mixed with the gene-specific ...
Serine/threonine/tyrosine phosphorylation regulates
... TCSs are signal transduction devices that were initially discovered in bacteria (Ninfa & Magasani, 1986; Nixon et al., 1986). They play an important role in signal sensing and response to various stimuli, enabling the organisms to adapt to environmental changes. A typical TCS consists of a histidine ...
... TCSs are signal transduction devices that were initially discovered in bacteria (Ninfa & Magasani, 1986; Nixon et al., 1986). They play an important role in signal sensing and response to various stimuli, enabling the organisms to adapt to environmental changes. A typical TCS consists of a histidine ...
Full-Text PDF
... PIG-L domain (Pfam [2] PF02585; Table 1). The PIG-L domain name itself comes from the enzyme N-acetyl-D-glucosaminylphosphatidylinositol deacetylase (PIG-L), one of the initial members of this family to be identified [3]. Although the structure of PIG-L has not been reported, the structures of five ...
... PIG-L domain (Pfam [2] PF02585; Table 1). The PIG-L domain name itself comes from the enzyme N-acetyl-D-glucosaminylphosphatidylinositol deacetylase (PIG-L), one of the initial members of this family to be identified [3]. Although the structure of PIG-L has not been reported, the structures of five ...
Systematic Analysis of Arabidopsis Organelles
... et al., 2004). These attributes of structured annotations allow quantitative comparison of protein characteristics. We asked two related questions utilizing GO annotations and the computational tool GeneMerge (version 1.2; Castillo-Davis and Hartl, 2003; as described in ‘‘Materials and Methods’’): ( ...
... et al., 2004). These attributes of structured annotations allow quantitative comparison of protein characteristics. We asked two related questions utilizing GO annotations and the computational tool GeneMerge (version 1.2; Castillo-Davis and Hartl, 2003; as described in ‘‘Materials and Methods’’): ( ...
Core promoter
... CpG islands = clusters of expected frequency of CpGs Length = 200 bp to several kb. CpGs within CpG islands are normally unmethylated while most CpGs outside CpG islands are methylated. An estimated 29 000 CpG islands in the genome (1-2% of genome) CpG islands nearly always encompass promoters and/o ...
... CpG islands = clusters of expected frequency of CpGs Length = 200 bp to several kb. CpGs within CpG islands are normally unmethylated while most CpGs outside CpG islands are methylated. An estimated 29 000 CpG islands in the genome (1-2% of genome) CpG islands nearly always encompass promoters and/o ...
PowerPoint 簡報
... The transition from closed to open complex involves structural changes in the enzyme and the opening of the DNA double helix to reveal the template and nontemplate strands. In bacterial enzyme with σ70, this transition called isomerization, does not require energy from ATP hydrolysis. The active si ...
... The transition from closed to open complex involves structural changes in the enzyme and the opening of the DNA double helix to reveal the template and nontemplate strands. In bacterial enzyme with σ70, this transition called isomerization, does not require energy from ATP hydrolysis. The active si ...
Histone acetylation and deacetylation
![](https://commons.wikimedia.org/wiki/Special:FilePath/Nucleosome_1KX5_colour_coded.png?width=300)
Histone acetylation and deacetylation are the processes by which the lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation. Histone acetylation and deacetylation are essential parts of gene regulation. These reactions are typically catalysed by enzymes with ""histone acetyltransferase"" (HAT) or ""histone deacetylase"" (HDAC) activity. Acetylation is the process where an acetyl functional group is transferred from one molecule (in this case, Acetyl-Coenzyme A) to another. Deacetylation is simply the reverse reaction where an acetyl group is removed from a molecule.Acetylated histones, octameric proteins that organize chromatin into nucleosomes and ultimately higher order structures, represent a type of epigenetic marker within chromatin. Acetylation removes the positive charge on the histones, thereby decreasing the interaction of the N termini of histones with the negatively charged phosphate groups of DNA. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. This relaxation can be reversed by HDAC activity. Relaxed, transcriptionally active DNA is referred to as euchromatin. More condensed (tightly packed) DNA is referred to as heterochromatin. Condensation can be brought about by processes including deacetylation and methylation; the action of methylation is indirect and has no effect upon charge.