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Midbrain Dopamine Neurons Encode a Quantitative Reward
Midbrain Dopamine Neurons Encode a Quantitative Reward

Branching out: mechanisms of dendritic arborization
Branching out: mechanisms of dendritic arborization

... that it ensures the simple morphology of class I dendritic arborization neurons28,29. Future identification of genes that are downstream of Abrupt will help elucidate the mechanism underlying dendrite confinement. Moreover, larval class I dendritic arborization neurons extend secondary dendrites mos ...
Mechanisms Underlying the Cardioinhibitory and Pressor
Mechanisms Underlying the Cardioinhibitory and Pressor

... A stimulation of the gigantocellular tegmental field (FTG) in the medulla oblongata often increases systemic arterial blood pressure (SAP) and decreases heart rate (HR). We investigated if the cardioinhibitory/depressor areas, including the nucleus ambiguus (NA), the dorsal motor nucleus of vagus (D ...
Resonance properties of different neuronal populations in the
Resonance properties of different neuronal populations in the

... oscillations have been suggested to indicate a wakeful period during sleep. Alpha waves are associated with relaxed wakefulness and are enhanced in the visual cortex when the eyes are closed (Buzsaki, 2006). Moreover, these waves have also been observed over the motor cortex (central scalp), which a ...
Voluntary Movement: The Primary Motor Cortex
Voluntary Movement: The Primary Motor Cortex

Cell-intrinsic drivers of dendrite morphogenesis
Cell-intrinsic drivers of dendrite morphogenesis

... cell downstream or independently of cell surface receptors and other neurons, and their role in dendrite morphogenesis in both invertebrates and mammals. In doing so, we provide a comprehensive review of dendrite biology, offering insights into potential areas of future investigation and conveying b ...
(2010) Surround suppression sharpens the priority map in the lateral
(2010) Surround suppression sharpens the priority map in the lateral

... flashed spot that elicited the maximum activity. We then ran a nosaccade control, where the monkeys fixated a central red fixation spot for 2050 ms. One thousand milliseconds after the monkey achieved fixation, a brief white spot flashed for ⬍50 ms (2–3 video frames in 90% of trials; 1 video frame o ...
Intrinsic and synaptic plasticity in the vestibular system
Intrinsic and synaptic plasticity in the vestibular system

... calcium influx that occurs with each action potential: decreases in CaMKII activity oppose excitability by reducing BK currents. This unusual form of plasticity might be common to spontaneously active neurons throughout the brain, and would not have been observed in typical plasticity studies that c ...
Cystatin C prevents degeneration of rat nigral dopaminergic neurons
Cystatin C prevents degeneration of rat nigral dopaminergic neurons

... Destruction of nigrostriatal dopaminergic (DA) pathway triggers various persistent responses, such as inflammation and increased synthesis of neural growth factors, both in striatum and in substantia nigra. The pathological processes involved in such responses are poorly characterized and could cont ...
The Role of Kisspeptin Signaling in Reproduction
The Role of Kisspeptin Signaling in Reproduction

... transcriptional start site function together to facilitate transcriptional activation by estrogen (63). In mice, an analogous region also containing a TATA box is located just upstream of the noncoding exon but this has not been assessed for promoter activity. Several alternatively spliced Kiss1 tra ...
Principles of Neural Science - Weizmann Institute of Science
Principles of Neural Science - Weizmann Institute of Science

... Psychophysical studies typically involve a subject performing a specific task (pushing a button, pointing, or reaching for an object) on signal. Light or sound cues may be used to instruct the subjects to delay a response or to vary it. The physiological circuits mediating behavior can be understood ...
Full Article
Full Article

... and they were manifested by well-defined varicosities apparently lying directly on the apposed neuron. To be considered apposed by an axon, a neuron needed to exhibit only one, well-characterized, axonal varicosity on its soma or one of its dendrites. We inferred the existence of synapses by close a ...
$doc.title

... strategy  approach  to  maximize  reward  and  minimize  costs;  otherwise,  competitive   opponents  can  exploit  predictable  choice  patterns.  This  thesis  tested  the  hypothesis   that  the  frontal  eye  field  (FEF)  are  involved   ...
Dendritic Spine Density Varies Between Unisensory
Dendritic Spine Density Varies Between Unisensory

... density in temporal and frontal cortical regions, respectively (Garey et al 1998). Another study (Glantz et al 2000) showed a 21% decrease in spine density in schizophrenic patients compared with age-matched controls. It is well known that the cognitive functions are impaired during normal aging. So ...
Fig. 1
Fig. 1

... when medium was changed to neuronal medium from plating medium (0 h) or 3, 6 or 24 h later (Fig. 2A,B). Neurons were then kept till 3 DIV and stained with axonal (tau-1) and somatodendritic (MAP2) markers. First, we quantified the number of tau-1 positive axons per neuron (Fig. 2D). As expected, most ...
Dopamine Receptor–Mediated Mechanisms Involved in the
Dopamine Receptor–Mediated Mechanisms Involved in the

... increase of regional blood flow in the putamen and globus pallidus in the process of learning sequential finger movements. Matsumoto et al. (1994) showed that there is a selective impairment of learning arm movement sequences after destruction of the nigrostriatal DA system by local infusion of dopa ...
View/Open - DukeSpace
View/Open - DukeSpace

... The paradox of the SEF – that it seems so saccade related but is so blatantly unnecessary for generating saccades – and the early findings on multiple coordinate systems in the SEF inspired a new generation of experiments that have been very informative. This nascent research posits a higher level f ...
Antinociceptive Action of Nitrous Oxide Is Mediated
Antinociceptive Action of Nitrous Oxide Is Mediated

... muscle relaxation. We have investigated the mechanisms for N2O analgesic effect (it is more accurate to refer to its antinociceptive effect when studies are performed in animals who are unable to communicate the emotive experience of pain) and demonstrated that intrathecally, but not supraspinally, ...
Hybrid Scheme for Modeling Local Field Potentials from Point
Hybrid Scheme for Modeling Local Field Potentials from Point

... rates, synaptic currents and membrane potentials) has nevertheless been used as a proxy for the LFP when comparing with experiments. In a recent study comparing different candidate proxies, it was found that a suitably chosen sum of synaptic currents could provide a good LFP proxy, but only for the ...
the resonate-and-fire neuron: time dependent and frequency
the resonate-and-fire neuron: time dependent and frequency

Pansynaptic Enlargement at Adult Cortical
Pansynaptic Enlargement at Adult Cortical

... dyes with similar absorption and emission peaks to the AF488 and AF568 used to fill neurons (Supplementary Fig. S3A,B). The size of the PSF is usually measured by the full-width half-maximum (FWHM) and increases with imaging wavelength. Therefore, the signal from the AF568 dye limits the resolution a ...
Characterization of peripheral osmoreceptors - diss.fu
Characterization of peripheral osmoreceptors - diss.fu

... glucose and many others. The osmolality of the ECF is a measure of the concentration of each of these substances and is defined as the number of moles of the chemical compounds in solution per kilogram of solvent. Loss or gain of systemic water or electrolytes results in changes in ECF osmolality wh ...
Neural Control of the Pancreas
Neural Control of the Pancreas

... exerts a tonic inhibition of the endocrine pancreas. Taken together, these findings indicate that the overall effect of sympathetic nervous system stimulation is to maintain glycemic levels ...
THESIS D - Krishikosh
THESIS D - Krishikosh

... and well wishes, I want to preserve a special love for my relatives and well wishers, which enable me to complete the entire research program successfully. I would always remember the invaluable help, active cooperation and constant inspiration of my wife Dr. Sanjivani and my lovely son Arjun who ma ...
Neuron
Neuron

... was even better in subsequent trials: 97.3% and 82.0% in the second trial and 97.9% and 87.1% in the third trial after the inevitable-error trial for monkeys W and G, respectively. The switch cost (performance decline in the shift trials; see Experimental Procedures) reflected in the error rate was ...
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Mirror neuron

A mirror neuron is a neuron that fires both when an animal acts and when the animal observes the same action performed by another. Thus, the neuron ""mirrors"" the behavior of the other, as though the observer were itself acting. Such neurons have been directly observed in primate species. Birds have been shown to have imitative resonance behaviors and neurological evidence suggests the presence of some form of mirroring system. In humans, brain activity consistent with that of mirror neurons has been found in the premotor cortex, the supplementary motor area, the primary somatosensory cortex and the inferior parietal cortex.The function of the mirror system is a subject of much speculation. Many researchers in cognitive neuroscience and cognitive psychology consider that this system provides the physiological mechanism for the perception/action coupling (see the common coding theory). They argue that mirror neurons may be important for understanding the actions of other people, and for learning new skills by imitation. Some researchers also speculate that mirror systems may simulate observed actions, and thus contribute to theory of mind skills, while others relate mirror neurons to language abilities. Neuroscientists such as Marco Iacoboni (UCLA) have argued that mirror neuron systems in the human brain help us understand the actions and intentions of other people. In a study published in March 2005 Iacoboni and his colleagues reported that mirror neurons could discern if another person who was picking up a cup of tea planned to drink from it or clear it from the table. In addition, Iacoboni has argued that mirror neurons are the neural basis of the human capacity for emotions such as empathy.It has also been proposed that problems with the mirror neuron system may underlie cognitive disorders, particularly autism. However the connection between mirror neuron dysfunction and autism is tentative and it remains to be seen how mirror neurons may be related to many of the important characteristics of autism.Despite the excitement generated by these findings, to date, no widely accepted neural or computational models have been put forward to describe how mirror neuron activity supports cognitive functions such as imitation. There are neuroscientists who caution that the claims being made for the role of mirror neurons are not supported by adequate research.
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