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Exhibition of Undergraduate Research and Creative
Exhibition of Undergraduate Research and Creative

... Apoptotic cell death is crucial for the normal development of animals. Apoptosis is a form of programmed cell death in which cell death is precisely regulated by a genetic program. Drosophila melanogaster has been extensively used as a model system to study the molecular bases of apoptosis. Reaper ( ...
The Major Transitions in Evolution
The Major Transitions in Evolution

... prolonging vegetative development. b, Exposure to a long period of cold (that is, vernalization) results in the expression of VIN3 (red), which initiates repression of FLC transcription, and the binding of the PcG protein VRN2, as well as VRN1 and LHP1 (blue). In this process, chromatin at FLC is ep ...
The Major Transitions in Evolution
The Major Transitions in Evolution

... prolonging vegetative development. b, Exposure to a long period of cold (that is, vernalization) results in the expression of VIN3 (red), which initiates repression of FLC transcription, and the binding of the PcG protein VRN2, as well as VRN1 and LHP1 (blue). In this process, chromatin at FLC is ep ...
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2b Unit 5 Cell cycle notes

... o DNA is ____________________________ before division to insure that each daughter cell gets one complete set of genetic information o Problem of DNA overload and nutrient/waste exchange is solved. ...
Epigenetic regulation of gene transcription. Publications
Epigenetic regulation of gene transcription. Publications

... The fundamental subunit of chromatin is the nucleosome, which consists of DNA wrapped around an octamer of four core histone proteins (H2A, H2B, H3 and H4). Chromatin packages DNA within the cell and is repressive to any process which requires access to the DNA including DNA repair, replication, rec ...
Leukaemia Section t(8;12)(q24;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(8;12)(q24;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... Iwai K, Hirata K, Ishida T, Takeuchi S, Hirase T, Rikitake Y, Kojima Y, Inoue N, Kawashima S, Yokoyama M. An antiproliferative gene BTG1 regulates angiogenesis in vitro. Biochem Biophys Res Commun 2004 Apr 9;316(3):628-35. ...
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Making Transgenic Plants and Animals

... progeny will be brown (which is dominant), indicating fertilization with a germ-line cell (gamete) that ultimately came from a KO-ES cell. Only about 50% of the brown progeny mice, however, will have the KO allele, because the transgenic ES cell that underwent meiosis to produce the germ-line cell w ...
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Sunlight Water Entropy

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Laboratory of Insect Genetics and Biosciences (IGB) Dept. Biology

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AMWA Plenary Session report

... Functionally, there are several types of stem cells with different capacities that give rise to differentiated cell types. The rule of thumb is that the more different cell types that a stem cell can give rise to, the earlier it comes in the lineage process—thus, totipotent stem cells can give rise ...
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File - Enders Science Page

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Epigenetics in stem-cell differentiation

Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on its position within the body. Stem cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has been used to refer to changes in gene expression, which are heritable through modifications not affecting the DNA sequence.The mammalian epigenome undergoes global remodeling during early stem cell development that requires commitment of cells to be restricted to the desired lineage. There has been multiple evidence suggesting that the maintenance of the lineage commitment of stem cells are controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of chromatin structure. Based on the histone code hypothesis, distinct covalent histone modifications can lead to functionally distinct chromatin structures that influence the fate of the cell.This regulation of chromatin through epigenetic modifications is a molecular mechanism that will determine whether the cell will continue to differentiate into the desired fate. A research study performed by Lee et al. examined the effects of epigenetic modifications on the chromatin structure and the modulation of these epigenetic markers during stem cell differentiation through in vitro differentiation of murine embryonic stem (ES) cells.
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