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DNA - Franklin County Public Schools
DNA - Franklin County Public Schools

... DNA Structure  DNA consists of two molecules that are arranged into a ladder-like structure called a Double Helix.  A molecule of DNA is made up of millions of ...
Name Period
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Gene families
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Chapter 12
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... To find what molecule caused transformations they treated the mixtures w/ enzymes that killed proteins, lipids, carbohydrates, RNA, and then DNA. -Occured in all except one w/ DNA killed Avery and his team discovered that DNA stores and transmits genetic info. from generation to generation ...
Lab 8H - Constructing A Model of DNA Replication PDF
Lab 8H - Constructing A Model of DNA Replication PDF

... 1. Construct a model of a DNA nucleotide. Push together a phosphate group, deoxyribose, and a Guanine. Then assemble the remaining seven nucleotide models in this manner (in the nucleotide sequence from step 2). 2. Attach the eight nucleotides together in the following sequence: G, A, A, T, C, G, G, ...
1928: Frederick Griffith
1928: Frederick Griffith

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Pivotal Experiments
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Meiosis - mvhs

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From DNA to proteins

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Study Guide Chap 6: DNA

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The Central Dogma

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DNA Study Guide - Liberty Union High School District
DNA Study Guide - Liberty Union High School District

... 28. How many different amino acids are there? ____________ 29. How can that many amino acids form 100,000’s of different proteins? 30. Is the DNA exactly the same in each cell in your body? Explain! 31. If cells do all have the same DNA why don’t they all express the same proteins? 32. What are thre ...
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DNA: The Genetic Material
DNA: The Genetic Material

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Microbial Genetics - University of Montana
Microbial Genetics - University of Montana

... – After lysis, phage particles inject this DNA into new host – Homologous recombination: donor DNA incorporated into recipient genome • DNA replacement ...
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Homologous recombination



Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA. It is most widely used by cells to accurately repair harmful breaks that occur on both strands of DNA, known as double-strand breaks. Homologous recombination also produces new combinations of DNA sequences during meiosis, the process by which eukaryotes make gamete cells, like sperm and egg cells in animals. These new combinations of DNA represent genetic variation in offspring, which in turn enables populations to adapt during the course of evolution. Homologous recombination is also used in horizontal gene transfer to exchange genetic material between different strains and species of bacteria and viruses.Although homologous recombination varies widely among different organisms and cell types, most forms involve the same basic steps. After a double-strand break occurs, sections of DNA around the 5' ends of the break are cut away in a process called resection. In the strand invasion step that follows, an overhanging 3' end of the broken DNA molecule then ""invades"" a similar or identical DNA molecule that is not broken. After strand invasion, the further sequence of events may follow either of two main pathways discussed below (see Models); the DSBR (double-strand break repair) pathway or the SDSA (synthesis-dependent strand annealing) pathway. Homologous recombination that occurs during DNA repair tends to result in non-crossover products, in effect restoring the damaged DNA molecule as it existed before the double-strand break.Homologous recombination is conserved across all three domains of life as well as viruses, suggesting that it is a nearly universal biological mechanism. The discovery of genes for homologous recombination in protists—a diverse group of eukaryotic microorganisms—has been interpreted as evidence that meiosis emerged early in the evolution of eukaryotes. Since their dysfunction has been strongly associated with increased susceptibility to several types of cancer, the proteins that facilitate homologous recombination are topics of active research. Homologous recombination is also used in gene targeting, a technique for introducing genetic changes into target organisms. For their development of this technique, Mario Capecchi, Martin Evans and Oliver Smithies were awarded the 2007 Nobel Prize for Physiology or Medicine.
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