NIH Public Access
... at significantly high shear stress (i.e., in larger vessels with higher blood pressure). This ability likely evolved to allow neutrophil recruitment to occur in a broader range of tissue areas. Most leukocytes roll along postcapillary venules at shear stresses of 0–3 dyn/cm2, whereas neutrophils can ...
... at significantly high shear stress (i.e., in larger vessels with higher blood pressure). This ability likely evolved to allow neutrophil recruitment to occur in a broader range of tissue areas. Most leukocytes roll along postcapillary venules at shear stresses of 0–3 dyn/cm2, whereas neutrophils can ...
The Role of Antibodies in Mouse Models of Rheumatoid Arthritis
... (IFA), CFA or saline is used but is not strictly required. Disease primarily affects the front and rear paws, with occasional involvement of the spinal column, tail, and ear (Courtenay et al., 1980). Investigators generally examine the tarsal joints histologically, and we are not aware of a study do ...
... (IFA), CFA or saline is used but is not strictly required. Disease primarily affects the front and rear paws, with occasional involvement of the spinal column, tail, and ear (Courtenay et al., 1980). Investigators generally examine the tarsal joints histologically, and we are not aware of a study do ...
The Comprehensive Sourcebook of Bacterial
... Introduction: an overview of RTX proteins Repeat-in-ToXin (RTX) toxins are important virulence factors produced by a variety of Gram-negative bacteria, the prototype of which is the α-hemolysin, HlyA, produced by pathogenic Escherichia coli. These RTX toxins, like HlyA, are able to form pores in the ...
... Introduction: an overview of RTX proteins Repeat-in-ToXin (RTX) toxins are important virulence factors produced by a variety of Gram-negative bacteria, the prototype of which is the α-hemolysin, HlyA, produced by pathogenic Escherichia coli. These RTX toxins, like HlyA, are able to form pores in the ...
experimental oncology and molecular medicine department
... molecular biology, biochemistry, and pharmacology to gain new insights in the pathogenesis of lung cancer and to find novel ways to provide early diagnosis and new treatment options. The goal of translational studies is the implementation of highly sensitive molecular tests that can be included in s ...
... molecular biology, biochemistry, and pharmacology to gain new insights in the pathogenesis of lung cancer and to find novel ways to provide early diagnosis and new treatment options. The goal of translational studies is the implementation of highly sensitive molecular tests that can be included in s ...
The Immune-Pineal Axis: the Role of Pineal and Extra
... while the agonist for the MT3 receptor, MCA-NAT, inhibits leukocyte adhesion to endothelial cells. The adhesion of neutrophils to endothelial cells is mediated by the interaction of neutrophils with 2 integrins (CD18), with adhesion molecules of the immunoglobulin superfamily expressed in endotheli ...
... while the agonist for the MT3 receptor, MCA-NAT, inhibits leukocyte adhesion to endothelial cells. The adhesion of neutrophils to endothelial cells is mediated by the interaction of neutrophils with 2 integrins (CD18), with adhesion molecules of the immunoglobulin superfamily expressed in endotheli ...
Gene Therapy Using Adeno-Associated Virus Vectors
... pression, and virion production. The adenoviral genes that provide helper functions regarding AAV gene expression have been identified and include E1a, E1b, E2a, E4, and VA RNA. Herpesvirus aids in AAV gene expression by providing viral DNA polymerase and helicase as well as the early functions nece ...
... pression, and virion production. The adenoviral genes that provide helper functions regarding AAV gene expression have been identified and include E1a, E1b, E2a, E4, and VA RNA. Herpesvirus aids in AAV gene expression by providing viral DNA polymerase and helicase as well as the early functions nece ...
Immunology and Immunopathogenesis of Malaria
... Immunity to malaria develops slowly and protection against the parasite occurs later than protection against disease symptoms. Because of the different location of the parasite and the different antigens expressed at the liver and blood stages, the relevant immune responses and their specificity and ...
... Immunity to malaria develops slowly and protection against the parasite occurs later than protection against disease symptoms. Because of the different location of the parasite and the different antigens expressed at the liver and blood stages, the relevant immune responses and their specificity and ...
degradation: a process unique to prokaryotes
... an extension of this, it has been suggested that the reactions leading to ring cleavage may involve substrates with substituents in both positions 2 and 6 (44), rather than in position 2 only, as originally proposed. Corroborating evidence for or against this has been difficult to obtain because the ...
... an extension of this, it has been suggested that the reactions leading to ring cleavage may involve substrates with substituents in both positions 2 and 6 (44), rather than in position 2 only, as originally proposed. Corroborating evidence for or against this has been difficult to obtain because the ...
Engineering of Lactic Acid Bacteria strains modulating immune
... invasive LL, were able to trigger DNA expression by epithelial cells both in vitro and in vivo. However, important information about how LL can transfer DNA plasmids is still missing. Therefore, we decided to construct a new recombinant invasive LL strain expressing mutated Internalin A (mInlA) fr ...
... invasive LL, were able to trigger DNA expression by epithelial cells both in vitro and in vivo. However, important information about how LL can transfer DNA plasmids is still missing. Therefore, we decided to construct a new recombinant invasive LL strain expressing mutated Internalin A (mInlA) fr ...
from um.ac.ir
... mouse ES cells [9–11]. These cells have been shown to expand in vitro and to engraft longterm. The caveat is that it has so far not been possible to show multi-lineage commitment and functional studies of ES cell derivatives. So far, few studies have been reported on the function of iPS cell derivat ...
... mouse ES cells [9–11]. These cells have been shown to expand in vitro and to engraft longterm. The caveat is that it has so far not been possible to show multi-lineage commitment and functional studies of ES cell derivatives. So far, few studies have been reported on the function of iPS cell derivat ...
Quorum sensing in fungi – a review Review Article
... Saccharomyces cerevisiae without compromising cell viability. The inhibition was linked to G1 cell cycle arrest and a significant decrease in the intracellular diacylglycerol (DAG) levels. The reduced levels of DAG lead to inactivation of the protein kinase C (PKC) signaling pathway that regulates c ...
... Saccharomyces cerevisiae without compromising cell viability. The inhibition was linked to G1 cell cycle arrest and a significant decrease in the intracellular diacylglycerol (DAG) levels. The reduced levels of DAG lead to inactivation of the protein kinase C (PKC) signaling pathway that regulates c ...
Definition of the disease
... expressions. The acute forms commonly range from a self-limiting flu-like syndrome to pneumonia or granulomatous hepatitis that may require hospitalisation. The main clinical manifestations of chronic Q fever are endocarditis, valvular, vascular or aneurismal infections, hepatitis, pneumonia or chr ...
... expressions. The acute forms commonly range from a self-limiting flu-like syndrome to pneumonia or granulomatous hepatitis that may require hospitalisation. The main clinical manifestations of chronic Q fever are endocarditis, valvular, vascular or aneurismal infections, hepatitis, pneumonia or chr ...
CXCL10 Inhibits Viral Replication Through Recruitment of Natural
... response in combating viral myocarditis has been demonstrated by recent studies using a series of knockout (KO) mice. Conversely, others have argued that the robust protective response can also be deleterious to host tissue to some extent. For instance, mice lacking T cells or T cell subsets develop ...
... response in combating viral myocarditis has been demonstrated by recent studies using a series of knockout (KO) mice. Conversely, others have argued that the robust protective response can also be deleterious to host tissue to some extent. For instance, mice lacking T cells or T cell subsets develop ...
CHAPTER ONE
... usually effective, severe fluid losses requires additional pharmacological treatment to mitigate the on-going fluid loss. For this, drugs with antispasmodic, antimotility, antioxidative, anti-secretory/pro-absorptive and/or antiinflammatory properties (depending on the causative agents) may be used ...
... usually effective, severe fluid losses requires additional pharmacological treatment to mitigate the on-going fluid loss. For this, drugs with antispasmodic, antimotility, antioxidative, anti-secretory/pro-absorptive and/or antiinflammatory properties (depending on the causative agents) may be used ...
RAD18independent ubiquitination of
... protein in rad18 DT40 (Fig 4). Expression of human RAD18 fully restored ultraviolet light sensitivity and SCE to wild-type levels. However, expression of human RAD18 (C28F), which lacks ubiquitin-ligase activity (Kannouche et al, 2004), did not restore the wild-type phenotype. Significantly, it also ...
... protein in rad18 DT40 (Fig 4). Expression of human RAD18 fully restored ultraviolet light sensitivity and SCE to wild-type levels. However, expression of human RAD18 (C28F), which lacks ubiquitin-ligase activity (Kannouche et al, 2004), did not restore the wild-type phenotype. Significantly, it also ...
Phagocytosis: a repertoire of receptors and Ca as a key second
... It is becoming apparent that a growing number of cell-surface receptors can mediate phagocytic uptake of particles. These include non-complement-receptor integrins, such as α5β1 and αvβ3, which mediate uptake of particles coated with fibronectin [43], lectins, such as the mannose receptor [44], the ...
... It is becoming apparent that a growing number of cell-surface receptors can mediate phagocytic uptake of particles. These include non-complement-receptor integrins, such as α5β1 and αvβ3, which mediate uptake of particles coated with fibronectin [43], lectins, such as the mannose receptor [44], the ...
1-C
... a-self regeneration b- regeneration in the presence of two parents c- regeneration in the presence of one parent d- All of them 6- the first scientist described the relationship between Microorganisms & diseases was a- Antony von Leeuwenhoek ...
... a-self regeneration b- regeneration in the presence of two parents c- regeneration in the presence of one parent d- All of them 6- the first scientist described the relationship between Microorganisms & diseases was a- Antony von Leeuwenhoek ...