Drugs to Treat Autoimmune Diseases
... • Genetic predisposition and environmental factors relevant • Immunoglobulins, T cell receptors, major histocompatibilty complex • T Cell Bypass- The requirement of T cells to activate B cells in order to produce large amounts of antibodies is bypassed • Molecular Mimicry- An exogenous antigen share ...
... • Genetic predisposition and environmental factors relevant • Immunoglobulins, T cell receptors, major histocompatibilty complex • T Cell Bypass- The requirement of T cells to activate B cells in order to produce large amounts of antibodies is bypassed • Molecular Mimicry- An exogenous antigen share ...
BLOCK F – Krizia,Kevin,Synnove – Production of Antibodies
... 5. Cytokines secreted by the Helper T cell help the B cell to multiply and mature into antibody producing plasma cells. 6. Antibodies then lock onto matching antigens. 7. Antibodies are made up of white blood cells, called B lymphocytes or B Cells. Each B Cell carries a different membrane-bound ant ...
... 5. Cytokines secreted by the Helper T cell help the B cell to multiply and mature into antibody producing plasma cells. 6. Antibodies then lock onto matching antigens. 7. Antibodies are made up of white blood cells, called B lymphocytes or B Cells. Each B Cell carries a different membrane-bound ant ...
Environmental factors in the pathogenesis of autoimmunity
... schift and can protect against Th1 mediated autoimmune diseases Some autoimmune mouse strains develop autoimmunity strictly in pathogen free conditions ...
... schift and can protect against Th1 mediated autoimmune diseases Some autoimmune mouse strains develop autoimmunity strictly in pathogen free conditions ...
molecular mimicry - Institute of Pathophysiology
... are very variable, depending where the circulating immune complexes get deposited, causing an inflammatory reaction. ...
... are very variable, depending where the circulating immune complexes get deposited, causing an inflammatory reaction. ...
Snímek 1
... Genes assiciated with antigen clearance (complement proteins) Genes associated with tolerance induction (CTLA-4, Fas-FasL) ...
... Genes assiciated with antigen clearance (complement proteins) Genes associated with tolerance induction (CTLA-4, Fas-FasL) ...
241.Autoimmunity
... anxious female with slight exophthalmos (protrusion of the eyeball) and hand resting tremor (involuntary shaking). The patient also mentioned that her mother also had similar symptoms many years ago and died because there was no treatment. Q: What immunologic processes might be involved in her ...
... anxious female with slight exophthalmos (protrusion of the eyeball) and hand resting tremor (involuntary shaking). The patient also mentioned that her mother also had similar symptoms many years ago and died because there was no treatment. Q: What immunologic processes might be involved in her ...
1. dia
... NO SIGNAL 1. for CD4+ Th activation Normal tissue cells do not express co-stimulatory molecules and do not produce T cell differentiating cytokines NO SIGNAL 2. for CD4+ Th activation Migration of naive T lymphocytes to normal tissues is limited Antigen presenting cells are not activated in normal t ...
... NO SIGNAL 1. for CD4+ Th activation Normal tissue cells do not express co-stimulatory molecules and do not produce T cell differentiating cytokines NO SIGNAL 2. for CD4+ Th activation Migration of naive T lymphocytes to normal tissues is limited Antigen presenting cells are not activated in normal t ...
6_Autoimmune_2013
... NO SIGNAL 1. for CD4+ Th activation Normal tissue cells do not express co-stimulatory molecules and do not produce T cell differentiating cytokines NO SIGNAL 2. for CD4+ Th activation Migration of naive T lymphocytes to normal tissues is limited Antigen presenting cells are not activated in normal t ...
... NO SIGNAL 1. for CD4+ Th activation Normal tissue cells do not express co-stimulatory molecules and do not produce T cell differentiating cytokines NO SIGNAL 2. for CD4+ Th activation Migration of naive T lymphocytes to normal tissues is limited Antigen presenting cells are not activated in normal t ...
1. dia
... • Variety of symptoms and of target tissues • Mechanisms of recognition and effector functions are the same as those acting against pathogens and environmental antigens • Both genetic and environmental factors are involved in the predisposition to autoimmune diseases – HLA class I and II and other g ...
... • Variety of symptoms and of target tissues • Mechanisms of recognition and effector functions are the same as those acting against pathogens and environmental antigens • Both genetic and environmental factors are involved in the predisposition to autoimmune diseases – HLA class I and II and other g ...
Autoimmunity 3rd yr
... expressed in the thymus. These are not seen by the developing immune system – will not induce selftolerance. Exposure of T cells to these normally sequestered/tissue-specific self-antigens in the periphery results in their activation ...
... expressed in the thymus. These are not seen by the developing immune system – will not induce selftolerance. Exposure of T cells to these normally sequestered/tissue-specific self-antigens in the periphery results in their activation ...
ANTIBODY PRODUCTION
... Antigens from the ruined pathogen are displayed on the surface of the phagocyte (or B-cell), bound to a membrane called MHC protein. This combination of antigen and MHC attracts the help of a mature, matching Helper T Cell. ...
... Antigens from the ruined pathogen are displayed on the surface of the phagocyte (or B-cell), bound to a membrane called MHC protein. This combination of antigen and MHC attracts the help of a mature, matching Helper T Cell. ...
Computational Immunology An Introduction
... Learn MHC Binding Patterns • Binding databases – over 10,000 synthetic and pathogen-derived peptides – ~400 MHC I and II alleles – some qualitative affinity data – some TAP binding and T cell epitopes ...
... Learn MHC Binding Patterns • Binding databases – over 10,000 synthetic and pathogen-derived peptides – ~400 MHC I and II alleles – some qualitative affinity data – some TAP binding and T cell epitopes ...
March 24 (PP)
... Hypersensitivity – immune responses that causes tissue damage Autoimmune disease – immune responses to self-antigens Immunodeficiency – insufficient immune response ...
... Hypersensitivity – immune responses that causes tissue damage Autoimmune disease – immune responses to self-antigens Immunodeficiency – insufficient immune response ...
Autoimmunity - the IID and GHTP
... • Atassi MZ and Casali P. (2008). Molecular mechanisms of autoimmunity. Autoimmunity, 41 (2), p.123-132. • Wiegers GJ, Kaufmann M, Tischner D and Villunger A. (2011). Shaping the T-cell repertoire: a matter of life and death. Immunology and Cell Biology, ...
... • Atassi MZ and Casali P. (2008). Molecular mechanisms of autoimmunity. Autoimmunity, 41 (2), p.123-132. • Wiegers GJ, Kaufmann M, Tischner D and Villunger A. (2011). Shaping the T-cell repertoire: a matter of life and death. Immunology and Cell Biology, ...
Immunological tolerance
... Unresponsiveness to a given antigen induced by the interaction of that antigen with the lymphocytes; Antigen specific!!! Unlike immunosuppresion. ...
... Unresponsiveness to a given antigen induced by the interaction of that antigen with the lymphocytes; Antigen specific!!! Unlike immunosuppresion. ...
THE IMMUNE SYSTEM
... Reaction of immune system = Response Self & Non-self Molecules which belong to the body = Self Antigens which are foreign = Non-self ...
... Reaction of immune system = Response Self & Non-self Molecules which belong to the body = Self Antigens which are foreign = Non-self ...
MCQs: What cell types can be made tolerant? T
... 2. The major step in inducing T-cell tolerance occurs in : (a) Thymus ...
... 2. The major step in inducing T-cell tolerance occurs in : (a) Thymus ...