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Research Report 2012 | 2013
Research Report 2012 | 2013

... Hospital. These include the working group “Infections in haematology / oncology” managed by Prof. Marie von Lilienfeld-Toal that studies infectious diseases on patients suffering from malign neoplasia. The working group “Network modelling”, headed by Prof. Rainer König, investigates different clinic ...
Psoriasis - New England Journal of Medicine
Psoriasis - New England Journal of Medicine

... donors45 or may develop for the first time after bone marrow transplantation from a donor with psoriasis.46 The aforementioned association of psoriasis with certain MHC alleles — such as HLA-B13, HLA-B17, HLA-Bw57, and HLA-Cw6 — also suggests a pathogenic role of T cells.4 Indeed, some investigators ...
Human norovirus transmission and evolution in a
Human norovirus transmission and evolution in a

... VP2. The capsid attaches to the cell surface through interactions between VP1 and host histo-blood group antigens (HBGAs) (step 1), and is subsequently internalized, uncoated and disassembled (steps 2,3). The (+)RNA is then transcribed and translated in the cytoplasm of the host cell. Translation is ...
Viral antibodies in normal tears.
Viral antibodies in normal tears.

STP-A11, an oncoprotein of Herpesvirus saimiri augments
STP-A11, an oncoprotein of Herpesvirus saimiri augments

... al., 2000), studies on Herpesvirus saimiri (HVS), a member of -herpesvirus family have been extensively performed as an alternative animal model for studies on Epstein Barr Virus- or Kaposi’s sarcomaassociated herpesvirus-mediated pathogenic disease of human (Jung and Desrosiers, 1991; 1995; Jung et ...
ACUTE ANTERIOR UVEITIS AND HLA-B27: INFECTIOUS BACKGROUND, SYSTEMIC INFLAMMATION,
ACUTE ANTERIOR UVEITIS AND HLA-B27: INFECTIOUS BACKGROUND, SYSTEMIC INFLAMMATION,

... significantly higher in the patient group than in the control group in the presence of LPS 10 ng/mL and LPS 1000 ng/mL. The basal TNF-α release into culture media was low in both groups. The CD14 expression of CD14brightCD16- monocytes, defined as antibody binding capacity (ABC), was similar in the ...
Licentiate thesis from the Department of Immunology,
Licentiate thesis from the Department of Immunology,

... example Th1 type or Th2 type. Th1 cells secreting interleukin-2 (IL-2) and interferon-γ (IFN-γ) are associated with cell-mediated immunity, whereas Th2 cells that produce typically IL-4, IL-5, IL-10 and IL-13, are responsible for humoral immunity. After phagocytosis of mycobacteria, antigens are pro ...
COLOSTRUM THE WHITE GOLD DISCOVERY
COLOSTRUM THE WHITE GOLD DISCOVERY

... These ingredients, in and of them, would make bovine colostrum a healthy dietary supplement. But what really makes colostrum amazing, and of such benefit to us are the immune and growth factors. The individual factors that fall under these two categories work both independently, and synergistically, ...
Endogenous MMTV Proviruses Induce Susceptibility to Both Viral
Endogenous MMTV Proviruses Induce Susceptibility to Both Viral

Pseudomonas syringae type III effector repertoires: last words in
Pseudomonas syringae type III effector repertoires: last words in

... suggest that several have been acquired, lost and reacquired repeatedly and in diverse pathovars [8]. ETI surveillance of these effectors may be widespread in plants, as indicated by the many plant accessions that respond with cell death to Agrobacterium-mediated transgenic expression of them (Figur ...
Recent developments in basophil research
Recent developments in basophil research

... [46]. These findings along with the notion that basophils produce IL-9 [35] suggest a role for basophils ...
department of biochemistry - University Of Nigeria Nsukka
department of biochemistry - University Of Nigeria Nsukka

... randomly assigned to eight treatment groups of five rats each. The animals were served with single oral daily doses of 5 ml/kg body weight normal saline, 5, 10, 15 and 20 mg/kg body weight of the extract to the control (Group A) and test groups (Groups B, C, D and E) respectively for 14 days. The bl ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... Saveetha Dental College ...
PhD thesis MAP Kinase 4 substrates and plant innate immunity
PhD thesis MAP Kinase 4 substrates and plant innate immunity

... ideas. Lastly, thank you Tine for bear with me the numerous times when I’ve told you that that I’m almost on my way home and end up staying two hours extra in the lab. ...
Early cytokine release in response to live largely complement independent
Early cytokine release in response to live largely complement independent

... is part of innate immunity and consists of a complex network of plasma and membrane-associated proteins that are activated in a cascade-like manner. It can be activated through three different pathways: the classical, lectin, and alternative, all of which ...
NF- B signaling pathways in mammalian and insect innate immunity
NF- B signaling pathways in mammalian and insect innate immunity

... Innate immunity is the first line of defense against infectious microorganisms. The innate immune system relies on germ line-encoded pattern recognition receptors (PRRs) to recognize pathogen-derived substances (Janeway 1989). Activation of the innate immune system through these receptors leads to t ...
An Introduction to Lipid Rafts
An Introduction to Lipid Rafts



... Of the PRRs, Toll-like receptors (TLRs) are the most studied. TLRs are evolutionary conserved proteins that have a highly conserved intracellular Toll/IL-1R domain involved in protein-protein interactions and signalling activation [10]. In humans, 11 TLRs have been identified and based on their cell ...
FONGAnti-inflammatoryRole2010
FONGAnti-inflammatoryRole2010

... production, suggesting negative cross talk between NF-B and STAT1 signalling pathways. ...
View/Open - UTMB Health SHARED Home
View/Open - UTMB Health SHARED Home

... effects on CD4+ T cells including induction of chemotaxis, Interleukin-2 receptor and HLA-DR expression, suppression HIV replication and subsequent CD4+ T cell activation by antigens. Because of its function, IL-16 was originally described as lymphocytes chemoattractant factor. However, IL-16 requir ...
Differential switching to IgG and IgA healthy controls
Differential switching to IgG and IgA healthy controls

... (B-cell-activating factor of the tumour necrosis factor family) in these follicles, which is a marker of B-cell survival and activation, and has been associated with autoimmune diseases [11, 12]. In addition to B-cells, the presence of oligoclonal CD4-positive T-cells has been demonstrated in the lu ...
VitaminDWiki
VitaminDWiki

... ac0vi0es as the “ba`le” against the invader is won.  •  In chronic disease states, both Th1 and Th2 may be over‐ac0ve  Vitamin D and Infec0ous Diseases ‐ LDA  2010 ‐ Shippen   ...
Verotoxin -producing Escherichia coli Old Bug New Infections
Verotoxin -producing Escherichia coli Old Bug New Infections

... pathotypes that can cause specific type of illness in both in normal hosts and those with compromised nonspecific defense mechanisms .E.coli exhibits tremendous versatility in its ability to cause disease and the mechanisms by which it does so. Pathogenic strains differ from commensal organisms in t ...
Molecular Dissection of Psoriasis: Integrating Genetics and Biology
Molecular Dissection of Psoriasis: Integrating Genetics and Biology

Bacterial lipopolysaccharide stimulates bovine neutrophil production
Bacterial lipopolysaccharide stimulates bovine neutrophil production

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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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