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Studies on the Mechanisms of Autophagy
Studies on the Mechanisms of Autophagy

... The above results were further substantiated using monoclonal antibodies specific for two different lysosome integral membrane proteins, LIMP I (35-50 kD) and LIMP V (93 kD) (3, 36, 37). These proteins were localized to lysosomes including AVds and to a significant number of autophagic vacuoles limi ...
PLoS One
PLoS One

... Vibrio owensii DY05 is a serious pathogen causing epizootics in the larviculture of ornate spiny lobster Panulirus ornatus. In the present study a multi-tiered probiotic screening strategy was used to identify a probiotic combination capable of protecting P. ornatus larvae (phyllosomas) from experim ...
Pollen-Induced Oxidative Stress Influences Both Innate and
Pollen-Induced Oxidative Stress Influences Both Innate and

... Atopic allergy is considered as a Th2 cell-mediated inflammatory disease, because Th2-derived cytokines could promote mast cell development, Ig isotype switch to IgE, and activation of eosinophils (2). Although many details of the mechanism by which inhaled allergens induce the development of clinic ...
SERIES "INFECTION: FRIEND OR FOE TO THE DEVELOPMENT OF ASTHMA?"
SERIES "INFECTION: FRIEND OR FOE TO THE DEVELOPMENT OF ASTHMA?"

... in a primary C. pneumoniae infection, elicit a Th1-type response in reinfection, shown by markedly increased IFN-c production [43]. Only modest amounts of chlamydial antigen appear to be needed to confer immunopathological tissue destruction [45]. A single chlamydial antigen, a 57–60-kDa protein, ha ...
Thesis - doktori
Thesis - doktori

Blaustein et al. 2012 ecophysiology
Blaustein et al. 2012 ecophysiology

... directly limit pathogen burden, include immunity and other processes whereby the host actively ‘fights’ infection. Tolerance strategies limit the damage caused by infectious disease. Tolerance mechanisms include processes for tissue repair [38], but in general are less well-understood than those rel ...
Pharmaceutical Microbiology
Pharmaceutical Microbiology

... The entire course-content presented in ‘Pharmaceutical Microbiology’ has been meticulously and painstakingly developed and expanded as per the AICTE-Approved Syllabus–2000. Each chapter has been duly expatiated in a simple, lucid, and crisp language easily comprehensible by its august readers. A uni ...
Deep Insight Section
Deep Insight Section

... inflammatory tumour-infiltrating cells were observed in malignant melanoma lesions in comparison to begnin ones (Ibrahim el et al., 2004) and (iv) up-regulation of HLA-G in melanocytes is a better predictor of malignancy than classical HLA class I antigens defects, (Ibrahim el et al., 2004) which ar ...
Neuropilin 1 is expressed on thymus-derived natural
Neuropilin 1 is expressed on thymus-derived natural

... by qPCR (Fig. 1 g). Of the latter genes, we focused more on Dapl1 (death-associated protein-like 1) as its mRNA expression correlates well with the iT reg origin of Foxp3+ cells under a variety of conditions, as shown below. Thus, there is good agreement in the gene expression between splenic bona f ...
Development of acquired immunity to Salmonella
Development of acquired immunity to Salmonella

Monotreme Lactation Protein Is Highly Expressed
Monotreme Lactation Protein Is Highly Expressed

... are laid (Morrow et al. 2009). The short-beaked echidna incubates its egg in a functional incubatorium pouch on the abdomen (Griffiths et al. 1969), whereas those of the platypus are probably held between the curled tail and the abdomen of the female in the nesting burrow (Burrell 1927; Griffiths 19 ...
Document
Document

... outcome following microbial infection in an organism. Invasion of a host by pathogenic infectious agents initiates a sequence of immune responses through interactions between a diverse array of pathogen-borne virulence factors and the immune surveillance mechanisms of the host. In ...
dendritic cell-specific ICAM- grabbing non-integrin
dendritic cell-specific ICAM- grabbing non-integrin

... biological functions, many of which are related to immunity. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C-type lectin expressed by dendritic cells. Dendritic cells are potent antigen-presenting ...
Generation of Monoclonal Antibodies to Cryptic Collagen Sites by
Generation of Monoclonal Antibodies to Cryptic Collagen Sites by

Maggini S et al. Selected vitamins and trace elements support
Maggini S et al. Selected vitamins and trace elements support

5,7-DIAMINO-3,5,7,9-TETRADEOXYNON-2
5,7-DIAMINO-3,5,7,9-TETRADEOXYNON-2

... L. pneumophila serogroup 144 (Fig. 5). The monomethyl derivative 19 occurs as two stereoisomers, E and Z, whereas only one isomer was observed for the dimethyl derivative 20. Molecular modeling data suggested that this is the sterically less-hindered E isomer.44 The N-methylated derivatives are pres ...
STREPTOCOCCI
STREPTOCOCCI

... some of which are susceptible and others of which are resistant. Principle: Bacitracin test is used to determine the effect of a small amount of bacitracin (0.04 U2) on an organism. Streptococcus pyogenes (GAS) is inhibited by the small amount of bacitracin in the disk (visible zone of inhibition of ...
Lymphatic Vessels, Inflammation, and Immunity
Lymphatic Vessels, Inflammation, and Immunity

... (21). B cells secrete (auto)antibodies that form immune complexes with complement proteins—these accumulate in skin and influence resident and recruited myeloid cells’ activation and function (20). Tumor-infi ltrating leukocytes play an important role in regulating angiogenic responses, which, in turn ...
Autoimmunity to glomerular antigens in
Autoimmunity to glomerular antigens in

Molecular basis of the CRAC channel - Cahalan Lab-Home
Molecular basis of the CRAC channel - Cahalan Lab-Home

Serum Dioxin and Immunologic Response in Veterans of Operation
Serum Dioxin and Immunologic Response in Veterans of Operation

T cells - University of East Anglia
T cells - University of East Anglia

... features between small and large intestinal epithelial cells (EC) that have evolved out of the need to perform different digestive processes. Small intestine EC play a critical role in nutrient absorption that is reflected in their unique structure. In addition to the small intestinal epithelium bei ...
5. Thrombocytopenia
5. Thrombocytopenia



... the neutrophils [15]. Furthermore, recently it has been observed that basophilic granular cells (acidophilic/eosinophilic granule cells or mast cells) of fish belonging to the Perciformes order, the largest and most evolutionarily advanced order of teleosts, are endowed with histamine, which is biol ...


... Moreover, both cell wall components and mediators may increase the permeability of adjacent capillaries leading to raised fluid accumulation. In addition, bacterial cell wall-derived fragments may also induce expression of tissue factor on both endothelial cells [36] and mesothelial cells [30] that ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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