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Immune function across generations: integrating mechanism and
Immune function across generations: integrating mechanism and

The impact of Toll-like receptor activation on - diss.fu
The impact of Toll-like receptor activation on - diss.fu

... Disputation am 18.11.2014 ...
Cytoplasmic pH Measurement and Homeostasis in Bacteria
Cytoplasmic pH Measurement and Homeostasis in Bacteria

... products containing inhibitory acids, such as dairy products and vinegar (Buckenhüskes, 2001; Johnson and Steele, 2001) or foods containing alkali, such as natto from soybeans and dadawa from locust beans (Wang and Fung, 1996). Acidophiles have been exploited for thousands of years for the recovery ...
A Scientists Are Amazed at Progress of Alopecia Areata Treatment
A Scientists Are Amazed at Progress of Alopecia Areata Treatment

... of Directors but have no medical or scientific background. I was a lay attendee at the meeting, so much that was said was way over my head! But here are a few of the many highlights I picked up at the meeting: ...
Current Topics in Microbiology and Immunology
Current Topics in Microbiology and Immunology

... myeloid leukemia (AML). This disease is characterized by accumulation of immature malignant cells that show constitutive release of several chemokines that may contribute to leukemia-associated angiogenesis, chemosensitivity, and regulation of antileukemic immune reactivity. The biological backgroun ...
The Role of Donor‐Specific HLA Alloantibodies in Liver
The Role of Donor‐Specific HLA Alloantibodies in Liver

... cells and liver sinusoidal endothelial cells need exploration. In fact, one focus of future research should be to understand how the effects of DSA vary depending on cofactors, some of which may promote immunostimulatory/profibrogenic effects while others could promote toleragenic effects. The contr ...
The Innate and Adaptive Immune Response to
The Innate and Adaptive Immune Response to

... response to measles virus has not been characterized. Th17 cell differentiation was inhibited early after measles virus infection in vitro. There was a significant decrease in IL-23A transcript ts and a significant increase in IL-27 transcripts, both of which affect Th17 cell differentiation negativ ...
Additional evidence of the facultative intracellular nature of the fish
Additional evidence of the facultative intracellular nature of the fish

... obligate intracellular nature condition of the pathogen still remain without answer. In this study, we address these remaining questions which over a decade have held back the research into the biology of the agent, in order to promote the design of strategies for its control. The prototype strain L ...
Accept your fate? Defence strategies of yeast and filamentous fungi
Accept your fate? Defence strategies of yeast and filamentous fungi

... young scientists, either giving presentations or displaying posters. Offering this forum to them is an important aspect, one that supports scientific development and the integration into the VAAM scientific community. The attractiveness of our Annual Conference is reflected in the high number of par ...
NIH Public Access: Skin microbiota: a source of disease or defence?
NIH Public Access: Skin microbiota: a source of disease or defence?

Slide 1
Slide 1

... May present as abdominal mass. Most rapidly growing human tumor. Typical chromosome abnormality: c-myc oncogene linked to one of the immunoglobulin genes. ...
Thrombocytopenia in neonates
Thrombocytopenia in neonates

... Infection: bacterial, viral, and fungal organisms. – Bacterial mechanisms for thrombocytopenia include DIC, endothelial damage, antibody-mediated, and platelet aggregation caused by adherence of bacterial products to platelet membranes. • Decreased plt production due to injury to megakaryocytes in B ...
Department of Cellular Biology, Physiology and Immunology Faculty of Medicine
Department of Cellular Biology, Physiology and Immunology Faculty of Medicine

... INTRODUCTION I: DENDRITIC CELLS AND TRANSPLANTATION Solid-organ transplantation is often the most effective therapy for end-stage organ failure. However, the disparity of major histocompatibility antigens between donor and recipient promotes the activation of the immune system in the host which resu ...
Cells Intestinal Lamina Propria as Regulatory T Cells in Human
Cells Intestinal Lamina Propria as Regulatory T Cells in Human

... cells, indicate an increased state of activation of the T cell system in IBD (28). Although intestinal lamina propria (LP) T cells are already preactivated, the activation is further increased in both the circulation and mucosa from IBD patients as determined by several activation markers as compare ...
Clever tricks EBV employed to modulate innate immunity during
Clever tricks EBV employed to modulate innate immunity during

Evolution and manipulation of vector host choice
Evolution and manipulation of vector host choice

... vector behavior, but also on pathogen manipulation of this behavior. This model identifies multiple  evolutionary  conflicts  over  the  control  of  this  behavior  and  generates  testable  predictions  under  different  scenarios.  In  general,  the  vector  should  evolve  the  ability  to  avoi ...
Antibodies to Chlamydia trachomatis heat shock proteins in women
Antibodies to Chlamydia trachomatis heat shock proteins in women

The Discovery and Application of Bacteriophage Receptor Binding
The Discovery and Application of Bacteriophage Receptor Binding

xia immune activation 1
xia immune activation 1

... and NKT cells, are also activated in other inflamed organs, such as the liver, to contribute indirectly to the atherosclerosis by increasing systemic inflammation and metabolic dysfunction. However, molecular events that link activation of different immune cells and abnormal metabolic conditions in ...
Innate cellular responses to rotavirus infection
Innate cellular responses to rotavirus infection

The Equine Endometrial Cup Reaction
The Equine Endometrial Cup Reaction

Crosstalk between cancer and immune cells: role of
Crosstalk between cancer and immune cells: role of

... role of DCs in inducing anti-tumour immunity is well documented, DCs in the tumour microenvironment are usually immature, being characterized by an insufficient level of expression of MHC class II complexes, co-stimulatory signals such as CD80 and CD86, and IL-12 (REFS 7,8,52). Not only are these DC ...
neuropeptides activate t cells
neuropeptides activate t cells

Imd Signaling Pathway Drosophila The
Imd Signaling Pathway Drosophila The

... and the adaptor protein Imd, thus likely interrupting signal transduction at the receptor complex (91, 93, 94). 20-Hydroxyecdysterone (ecdysone) is a steroid hormone known to coordinate tissue remodeling in flies undergoing metamorphosis, including the phagocytosis of dead cells. In addition, it is ...
TUMOR NECROSIS FACTOR ALPHA (TNF-a)
TUMOR NECROSIS FACTOR ALPHA (TNF-a)

... signaling, which undergo embryonic lethality as a consequence of TNF-mediated liver cell apoptosis. The biologic role of TNF-mediated apoptosis, however, requires further clarification. Insights into the biological function of TNF have also come from studies utilizing transgenic models. TNF knockout ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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