Length of the Circulating T Cell Pool Cytomegalovirus Infection
... DNA polymerase, telomeres shorten after each cell division. Therefore, decreasing telomere length can be regarded as a biological clock: when a critical length is reached, telomeres cannot function anymore, and cells will either become senescent or apoptotic (1). Although telomeres steadily decrease ...
... DNA polymerase, telomeres shorten after each cell division. Therefore, decreasing telomere length can be regarded as a biological clock: when a critical length is reached, telomeres cannot function anymore, and cells will either become senescent or apoptotic (1). Although telomeres steadily decrease ...
Architecture for an Artificial Immune System
... Lymphocytes are called negative detectors because they are trained to bind to nonself; i.e. when a lymphocyte is activated, the IS responds as if nonself were detected. This simple form of learning is known as tolerization, because the lymphocytes are trained to be tolerant of self. Lymphocytes are ...
... Lymphocytes are called negative detectors because they are trained to bind to nonself; i.e. when a lymphocyte is activated, the IS responds as if nonself were detected. This simple form of learning is known as tolerization, because the lymphocytes are trained to be tolerant of self. Lymphocytes are ...
Exosomes: From biogenesis and secretion to biological function
... 1.1.3. Sorting into the MVB and exosomes Only very little is know about the sorting signals which are responsible for the sorting of proteins into vesicles within MVBs, which can be subsequently released as exosomes. As mentioned earlier, binding of a ligand to cell surface receptors results in rece ...
... 1.1.3. Sorting into the MVB and exosomes Only very little is know about the sorting signals which are responsible for the sorting of proteins into vesicles within MVBs, which can be subsequently released as exosomes. As mentioned earlier, binding of a ligand to cell surface receptors results in rece ...
Regression of Nevi After Candida Injection for the Treatment of
... imiquimod and contact sensitizers such as diphencyprone and squaric acid dibutyl ester. There are accounts of Candida immunotherapy inducing vitiligo (2). The induction of vitiligo may occur secondary to immune modulators that may induce cytotoxic effects on melanocytes or by revealing occult diseas ...
... imiquimod and contact sensitizers such as diphencyprone and squaric acid dibutyl ester. There are accounts of Candida immunotherapy inducing vitiligo (2). The induction of vitiligo may occur secondary to immune modulators that may induce cytotoxic effects on melanocytes or by revealing occult diseas ...
Allo-HLA reactivity of virus-specific memory T cells is common
... specificity of the expanded lines and clones was confirmed by tetramer staining, cytotoxicity, and cytokine production assays. Polyclonality or monoclonality of the T-cell lines and clones was analyzed by TCR V analysis using the TCR V kit (Beckman Coulter). Allo-HLA reactivity of the virus-specif ...
... specificity of the expanded lines and clones was confirmed by tetramer staining, cytotoxicity, and cytokine production assays. Polyclonality or monoclonality of the T-cell lines and clones was analyzed by TCR V analysis using the TCR V kit (Beckman Coulter). Allo-HLA reactivity of the virus-specif ...
daniela tesi on line 3 - Padis
... from an RNA template. AMPs are usually synthesized as inactive, larger, precursor molecules, which are then processed by specific proteases to release the mature, active peptide. Most of the precursors consist of a signal sequence, for targeting to the endoplasmic reticulum, and an anionic pro-regio ...
... from an RNA template. AMPs are usually synthesized as inactive, larger, precursor molecules, which are then processed by specific proteases to release the mature, active peptide. Most of the precursors consist of a signal sequence, for targeting to the endoplasmic reticulum, and an anionic pro-regio ...
Fatty acids and lymphocyte functions
... These are a class of lymphocyte which do not express surface markers identifying them as either T- or B-lymphocytes. They are capable of lysing tumour or virus-infected cells and have a role in graft rejection. NK cells are activated by IL-2, IL-12, IFN-g and tumour necrosis factor (TNF)-a. Lymphocy ...
... These are a class of lymphocyte which do not express surface markers identifying them as either T- or B-lymphocytes. They are capable of lysing tumour or virus-infected cells and have a role in graft rejection. NK cells are activated by IL-2, IL-12, IFN-g and tumour necrosis factor (TNF)-a. Lymphocy ...
Anti-inflammatory properties of peptides derived Ornithodoros savignyi
... Innate immunity is known to be triggered by conserved bacterial components that interact with receptors on the host cells, activating a pro-inflammatory cascade (Bowdish and Hancock, 2005). Sepsis is a life-threatening condition that occurs when oxidative stress and inflammatory responses associated ...
... Innate immunity is known to be triggered by conserved bacterial components that interact with receptors on the host cells, activating a pro-inflammatory cascade (Bowdish and Hancock, 2005). Sepsis is a life-threatening condition that occurs when oxidative stress and inflammatory responses associated ...
1 Review for Current Topics in Microbiology and Immunology
... The first moonlighting bacterial protein described was the glycolytic enzyme, glyceraldehyde-3phosphate dehydrogenase (GAPD), which was found on the cell surface of group A streptococci (Streptococcus pyogenes) in studies that were conducted before the moonlighting concept was introduced (Pancholi a ...
... The first moonlighting bacterial protein described was the glycolytic enzyme, glyceraldehyde-3phosphate dehydrogenase (GAPD), which was found on the cell surface of group A streptococci (Streptococcus pyogenes) in studies that were conducted before the moonlighting concept was introduced (Pancholi a ...
The Role of Mechanistic Target of Rapamycin (mTOR) Complexes
... in protein synthesis [2], lipid biosynthesis [15], and inhibition of triacylglycerol lipolysis [20,21]. Thus it may have a significant impact on maintaining metabolic homeostasis in the whole body [3]. 2.1. Upstream of mTOR mTOR Multiple Signaling Components mTOR governs and integrates signals from ...
... in protein synthesis [2], lipid biosynthesis [15], and inhibition of triacylglycerol lipolysis [20,21]. Thus it may have a significant impact on maintaining metabolic homeostasis in the whole body [3]. 2.1. Upstream of mTOR mTOR Multiple Signaling Components mTOR governs and integrates signals from ...
Annual Report 2011 - Davos - Swiss Institute of Allergy and Asthma
... 1922 Swiss Research Institute for High Altitude Climate and Tuberculosis 1922-1933 A. Loewy, High Altitude Physiology 1934-1937 F. Roulet, Chemistry of Mycobacterium Tuberculosis 1938-1954 W. Berblinger, Pathology of Tuberculosis 1954-1960 W. A. Vischer, Resistance to Mycobacterium Tuberculosis ...
... 1922 Swiss Research Institute for High Altitude Climate and Tuberculosis 1922-1933 A. Loewy, High Altitude Physiology 1934-1937 F. Roulet, Chemistry of Mycobacterium Tuberculosis 1938-1954 W. Berblinger, Pathology of Tuberculosis 1954-1960 W. A. Vischer, Resistance to Mycobacterium Tuberculosis ...
Role of the PD‐1 Pathway in the Immune Response
... Recently described roles for PD-1 expression on DCs and monocytes highlight the possibility that PD-1 signaling may also occur independently of T cell or B cell antigen receptor signaling, possibly by impinging on other receptor signaling pathways (45,46). For example, PD-1 ligation in monocytes has ...
... Recently described roles for PD-1 expression on DCs and monocytes highlight the possibility that PD-1 signaling may also occur independently of T cell or B cell antigen receptor signaling, possibly by impinging on other receptor signaling pathways (45,46). For example, PD-1 ligation in monocytes has ...
Candida Infections: An Update on Host Immune Defenses and Anti
... played by Als proteins in host–fungus interactions. Als3 is a major component of the hyphal cell wall, but not for the yeast phase[22]. Deletion of C. albicans ALS3 results in striking adhesion and biofilm formation defects. ALS3 is also required for C. albicans cell binding to E-cadherin on epithel ...
... played by Als proteins in host–fungus interactions. Als3 is a major component of the hyphal cell wall, but not for the yeast phase[22]. Deletion of C. albicans ALS3 results in striking adhesion and biofilm formation defects. ALS3 is also required for C. albicans cell binding to E-cadherin on epithel ...
Immunoprecipitation of Triton X-100-solubilized
... The major antigenic component of M. mycoides subsp. mycoides is a galactan (Buttery, 1970) and that of M. mycoides subsp. capri is a glucan (Jones et al., 1965). It is well-established that strains of subsp. mycoides that may be quite distinct in many respects, such as growth rate and colony size on ...
... The major antigenic component of M. mycoides subsp. mycoides is a galactan (Buttery, 1970) and that of M. mycoides subsp. capri is a glucan (Jones et al., 1965). It is well-established that strains of subsp. mycoides that may be quite distinct in many respects, such as growth rate and colony size on ...
Novel drug therapies in myeloid leukemia
... IgG2 and IgG4 type antibodies are unable to activate either ADCC or CDC and work only by modulating signaling pathways, resulting in fewer immune related adverse events (irAE) [43,44] . Perhaps the most important factor associated with antibody-mediated therapy success is the induction of adaptive i ...
... IgG2 and IgG4 type antibodies are unable to activate either ADCC or CDC and work only by modulating signaling pathways, resulting in fewer immune related adverse events (irAE) [43,44] . Perhaps the most important factor associated with antibody-mediated therapy success is the induction of adaptive i ...