Doctoral thesis from the Department of Immunology, the Wenner-Gren
... between CD4+ T cells and B cells in the secondary lymphoid tissues [6]. T-B cell interaction results in B cell activation via ligation of co-stimulatory molecules expressed on surfaces of activated T cells, such as CD40L and cytokines produced by them [7, 8]. Subsequent to this interaction, naïve B ...
... between CD4+ T cells and B cells in the secondary lymphoid tissues [6]. T-B cell interaction results in B cell activation via ligation of co-stimulatory molecules expressed on surfaces of activated T cells, such as CD40L and cytokines produced by them [7, 8]. Subsequent to this interaction, naïve B ...
ma - FixHepC
... T-Cell Regulation via Multiple Costimulatory and Inhibitory Interactions Antigen-Presenting Cell ...
... T-Cell Regulation via Multiple Costimulatory and Inhibitory Interactions Antigen-Presenting Cell ...
Exercise and Psychosocial Factors Modulate Immunity to Influenza
... with age including diminished T-cell proliferation, reduced IL-2 production, and decreased antibody production (1–4). The age-associated decline of immune function may contribute to an increased susceptibility to infectious disease. For example, in 1997, pneumonia/influenza was the fifth leading cau ...
... with age including diminished T-cell proliferation, reduced IL-2 production, and decreased antibody production (1–4). The age-associated decline of immune function may contribute to an increased susceptibility to infectious disease. For example, in 1997, pneumonia/influenza was the fifth leading cau ...
Janeway Chapters 1-3 Single Jeopardy 2014-2015
... • Answer: This region of an antibody determines its functional properties. • Question: What is the constant region? ...
... • Answer: This region of an antibody determines its functional properties. • Question: What is the constant region? ...
Persistence T Cell Function during Viral + CD8 Memory Generation
... mmunological memory is one of the hallmarks of the adaptive immune system and it can be functionally defined as the stronger protective response of the host to secondary Ag challenge (1, 2). It, thus, allows the immune system to respond more vigorously to infectious pathogens that have been encounte ...
... mmunological memory is one of the hallmarks of the adaptive immune system and it can be functionally defined as the stronger protective response of the host to secondary Ag challenge (1, 2). It, thus, allows the immune system to respond more vigorously to infectious pathogens that have been encounte ...
In situ pneumococcal vaccine production and delivery through a
... tested in the context of S. pneumoniae colonization followed by the addition of an in vivo virulence trigger (that is, administration of IAV). 4 of 9 ...
... tested in the context of S. pneumoniae colonization followed by the addition of an in vivo virulence trigger (that is, administration of IAV). 4 of 9 ...
Molecular mechanisms of severe acute respiratory syndrome (SARS
... SARS-CoV genome may lead to new SARS outbreaks and several regions of the viral genomes open reading frames have been identified which may contribute to the severe virulence of the virus. With regard to the pathogenesis of SARS, several mechanisms involving both direct effects on target cells and in ...
... SARS-CoV genome may lead to new SARS outbreaks and several regions of the viral genomes open reading frames have been identified which may contribute to the severe virulence of the virus. With regard to the pathogenesis of SARS, several mechanisms involving both direct effects on target cells and in ...
HELLP syndrome: a complication or a new autoimmune
... lial growth factor (VEGF) gene, the coagulation factor V Leiden mutation, the glucocorticoid receptor gene, and the Toll-like receptor gene [5]. These variants contribute to altered immune regulation and apoptosis, defects in angiogenesis and vasculogenesis, uncontrolled inflammation, and thrombophi ...
... lial growth factor (VEGF) gene, the coagulation factor V Leiden mutation, the glucocorticoid receptor gene, and the Toll-like receptor gene [5]. These variants contribute to altered immune regulation and apoptosis, defects in angiogenesis and vasculogenesis, uncontrolled inflammation, and thrombophi ...
Endometrial Receptivity to Implantation in Humans
... tripeptide arginine-glycine-aspartic acid (RGD) sequence (45). The RGD sequences of these ligand proteins are recognized by one or several members of the family of structurally related receptors that are collectively called integrins (45). Integrins are a family of heterodimeric transmembrane glycop ...
... tripeptide arginine-glycine-aspartic acid (RGD) sequence (45). The RGD sequences of these ligand proteins are recognized by one or several members of the family of structurally related receptors that are collectively called integrins (45). Integrins are a family of heterodimeric transmembrane glycop ...
EmrE, THE SMALLEST ION-COUPLED TRANSPORTER
... toxicants: methyl viologen, ethidium and acriflavine. Thus, only a fraction of the protein activity in the strains expressing EmrE from multicopy plasmids suffices to confer the resistance phenotype. It is therefore impossible to reach quantitative conclusions on the effect of mutations or reagents ...
... toxicants: methyl viologen, ethidium and acriflavine. Thus, only a fraction of the protein activity in the strains expressing EmrE from multicopy plasmids suffices to confer the resistance phenotype. It is therefore impossible to reach quantitative conclusions on the effect of mutations or reagents ...
Thrombocytopenia: How Best to Determine the Cause
... However, platelet destruction that is immune-mediated also occurs independently of infection. Immune-mediated thrombocytopenia is common. One of the most frequently seen types is idiopathic thrombocytopenic purpura (ITP) (see Case 1 on page 114). In addition, antibodies to platelet surface antigens ...
... However, platelet destruction that is immune-mediated also occurs independently of infection. Immune-mediated thrombocytopenia is common. One of the most frequently seen types is idiopathic thrombocytopenic purpura (ITP) (see Case 1 on page 114). In addition, antibodies to platelet surface antigens ...
Angioimmunoblastic T-cell lymphoma
... and (4) the presence of large B-cell blasts often infected by the Epstein-Barr virus (EBV) which may morphologically mimic ReedSternberg cells. The neoplastic cells are mature CD4+αβ T-cells with a frequent aberrant loss of one or several T-cell markers, most commonly CD7, and a frequent coexpressio ...
... and (4) the presence of large B-cell blasts often infected by the Epstein-Barr virus (EBV) which may morphologically mimic ReedSternberg cells. The neoplastic cells are mature CD4+αβ T-cells with a frequent aberrant loss of one or several T-cell markers, most commonly CD7, and a frequent coexpressio ...
Non‐invasive imaging of allogeneic transplanted skin graft by 131I
... essential for clinicians to identify and monitor tolerance accurately. CD4+CD25+Foxp3+Treg is the first choice which associates with allograft tolerance induction. Although it has been suggested by a number of studies reporting an increased circulating proportion of Treg in operationally tolerant tr ...
... essential for clinicians to identify and monitor tolerance accurately. CD4+CD25+Foxp3+Treg is the first choice which associates with allograft tolerance induction. Although it has been suggested by a number of studies reporting an increased circulating proportion of Treg in operationally tolerant tr ...
(Poly(I:C)) Induces Stable Maturation of Polyriboinosinic
... of supernatants of activated monocytes (monocyte-conditioned medium (MCM)). MCM contains an undefined mixture of cytokines and is difficult to standardize. Here we report that stable maturation of DC can be simply induced by the addition of polyriboinosinic polyribocytidylic acid (poly(I:C)), a synt ...
... of supernatants of activated monocytes (monocyte-conditioned medium (MCM)). MCM contains an undefined mixture of cytokines and is difficult to standardize. Here we report that stable maturation of DC can be simply induced by the addition of polyriboinosinic polyribocytidylic acid (poly(I:C)), a synt ...
Genetic and phenotypic variation of the equine infectious anemia
... propagation of the genome by the cell. In addition, RNA viruses, such as lentiviruses, typically maintain chronic, low levels of virus replication. On the other hand, DNA viruses more effectively establish latency because the host cell performs processes that help maintain the genome in a quiescent ...
... propagation of the genome by the cell. In addition, RNA viruses, such as lentiviruses, typically maintain chronic, low levels of virus replication. On the other hand, DNA viruses more effectively establish latency because the host cell performs processes that help maintain the genome in a quiescent ...
Structural and functional aspects of factor viii in the initiation of the
... numerous people. First of all, I am thankful to Dr. Isabelle CREMER for kindly accepting the invitation to be the president of the jury. I wish to convey my sincere gratitude to Dr. Peter LENTING and Dr. Bernard MAILLERE for agreeing to be rapporteurs. I am grateful to Dr. Veronique OLLIVIER and Dr. ...
... numerous people. First of all, I am thankful to Dr. Isabelle CREMER for kindly accepting the invitation to be the president of the jury. I wish to convey my sincere gratitude to Dr. Peter LENTING and Dr. Bernard MAILLERE for agreeing to be rapporteurs. I am grateful to Dr. Veronique OLLIVIER and Dr. ...
Identification of Gelsolin, a Ca`-dependent Regulatory Protein of
... strongly with the immune serum, suggesting that they were very rich in gelsolin content . Since these tissues may contain a heterogeneous population of cells, it is not possible with this technique to determine whether gelsolin is associated with one or more types of cells in the tissue . However, a ...
... strongly with the immune serum, suggesting that they were very rich in gelsolin content . Since these tissues may contain a heterogeneous population of cells, it is not possible with this technique to determine whether gelsolin is associated with one or more types of cells in the tissue . However, a ...
Delayed acquisition of Plasmodium falciparum antigen
... prevents severe and life threatening illness [1, 2]. Evidence from mouse models and experimental human infections suggests that both CD4+ and CD8+ T cells play an important role in protective immunity to P. falciparum malaria [3–6]. T cells directly control the development of pre-erythrocytic Plasmo ...
... prevents severe and life threatening illness [1, 2]. Evidence from mouse models and experimental human infections suggests that both CD4+ and CD8+ T cells play an important role in protective immunity to P. falciparum malaria [3–6]. T cells directly control the development of pre-erythrocytic Plasmo ...
