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Differential Regulation of NF-κB Signaling during Human
Differential Regulation of NF-κB Signaling during Human

Tips to Remember: What is an allergic reaction
Tips to Remember: What is an allergic reaction

... vasoactive amine) causes several allergic symptoms. 1) It contributes to an inflammatory response. 2) It causes constriction of smooth muscle. Histamine can cause inflammation directly as well as indirectly. Upon release of histamine by an antigen activated mast cell, permeability of vessels near th ...
Suppression of adaptive immunity to heterologous antigens during
Suppression of adaptive immunity to heterologous antigens during

... to 2.7 million deaths each year [1]. In addition to infectioninduced mortality, malaria is also associated with publichealth problems resulting from impairment of immune responses. Although this immunosuppression may have evolved as a mechanism by which the parasite can prevent immune-mediated clear ...
this PDF file - Cell and Biopharmaceutical Institute
this PDF file - Cell and Biopharmaceutical Institute

Once the proerythroblast has been formed, it divides several more
Once the proerythroblast has been formed, it divides several more

basic immunology
basic immunology

... relaxing blood vessels (vasodilation) hence increasing the permeability of the local capillary bed. Not only does this allow fluid to accumulate, but neutrophils then also move out of the blood vessel and towards the wound site. This movement is not random, however, because the neutrophils have rece ...
IDENTIFICATION OF  THE SEROTYPE-SPECIFIC AND  GROUP-SPECIFIC
IDENTIFICATION OF THE SEROTYPE-SPECIFIC AND GROUP-SPECIFIC

... disease virus (EHDV) were precipitated with homologous GP antiserum and antiserum from a heterologous EHDV strain (Alberta). Immune precipitates are shown in Fig. 2. ...
Effects of temperature on fish immune defences
Effects of temperature on fish immune defences

Deep Insight Section The Fas - Fas Ligand apoptotic pathway
Deep Insight Section The Fas - Fas Ligand apoptotic pathway

... (Itoh et al., 1991) and has a major role in the immune system. The Fas protein is a type 1 transmembrane glycoprotein with three extra-cellular cysteine-rich domains (CRD). Fas is ubiquitously expressed on a variety of normal cells, including lymphocytes and hepatocytes. It expression can be increas ...
Immunological and fibrotic mechanisms in Cardiac Allograft
Immunological and fibrotic mechanisms in Cardiac Allograft

... CAV only affects donor arteries and not recipient arteries. New evidence to support this approach is generated by a retrospective study by Guihaire et al. They show that patients who receive a heartlung transplantation (HLTx) develop significantly less severe CAV compared to HTx patients. The sugges ...
IRRIIS Integrated Risk Reduction of Information
IRRIIS Integrated Risk Reduction of Information

... characteristics of the living organism. Charles Darwin introduced the theory of natural selection, which is one of the main mechanisms controlling the evolutionary process. Natural selection ensures that in each generation only the fittest organisms survive, i.e. those who have the characteristics, ...
CD8 T cell activation predominate early immune
CD8 T cell activation predominate early immune

... atherosclerotic plaques are specific for antigens formed in oxidized LDL [18]. T cells specific for oxidized LDL are also present in the circulation [19] and transfer of CD4+ T cells isolated from mice immunized with aldehyde-modified LDL results in a more aggressive development of atherosclerosis [ ...
NIH Public Access
NIH Public Access

Poster
Poster

... Hemolytic disease of the newborn (HDN) occurs during pregnancy when the red blood cells of an RhD positive (RhD+) baby comes in contact with the immune system of an RhD negative (RhD-) mother. The mother’s immune system identifies the RhD protein on the baby’s erythrocytes as foreign, and produces a ...
Cell-Mediated Immunity to Bordetella pertussis: Role of Thl
Cell-Mediated Immunity to Bordetella pertussis: Role of Thl

... cells have been demonstrated in humans rendered immune after immunization or infection (15, 39, 40). Furthermore, a number of cases of pertussis have been documented in patients with AIDS, a disease characterized by a depletion of CD4+ T cells (1, 8). B. pertussis organisms were found inside pulmona ...
Antiviral applications of Toll-like receptor agonists
Antiviral applications of Toll-like receptor agonists

... further 13 week animal toxicity study. Analysis of this study indicated that daily dosing of the compound was unlikely to support an adequate therapeutic index. Interestingly, Anadys rationalized their prodrug approach primarily on the basis of avoiding exposure of gut immune tissue to a TLR7 agonis ...
No Slide Title
No Slide Title

... Human populations possess many variants of each type of MHC molecule Variant MHC may not protect every individual from every pathogen. However, the existence of a large number of variants means that the population is prevented from extinction ...
The Role of Natural Killer Cells in Murine Early Embryo Loss.
The Role of Natural Killer Cells in Murine Early Embryo Loss.

... Trophoblast cells also express Fas ligand that is thought to confer on the uterus immune privilege-like properties (Hammer et al., 1999). Fas is usually expressed on activated T cells and when bound to its naturalligand, Fas ligand (FasL), will transmit a signal to the T cell to induce apoptosis (Su ...
Full Reviews Immunity in arterial hypertension
Full Reviews Immunity in arterial hypertension

... Evidence on a causal link between immunity and hypertension in humans is limited. As a future research line, clinical trials testing immunosuppressant drugs should be evaluated on their effect on BP, like it has been done in patients with psoriasis [19]. Vice versa, antihypertensive drugs and BP con ...
IMMUNE EVASION BY STAPHYLOCOCCI
IMMUNE EVASION BY STAPHYLOCOCCI

The Adaptive Immune System
The Adaptive Immune System

... molecules, and phagocytic cells that ingest and destroy invading microorganisms (microbes) and larger parasites (such as worms). Vertebrates, too, depend on such innate immune responses as a first line of defense (discussed in Chapter 24), but they can also mount much more sophisticated defenses, ca ...
T Cell Memory in the Context of Persistent Herpes Viral Infections
T Cell Memory in the Context of Persistent Herpes Viral Infections

... to process and present those antigens whose processing is independent of the immunoproteasome. A series of recent findings and observations are supporting the hypothesis that non-immune cells are indeed the key antigen-presenting cells during CMV latency. Firstly, contrary to priming of the MCMV-spe ...
Modulation of cellular innate immune responses by lactobacilli
Modulation of cellular innate immune responses by lactobacilli

Review The pathogenesis of liver disease in the setting of HIV
Review The pathogenesis of liver disease in the setting of HIV

Assessment Report - Nexus Research Group
Assessment Report - Nexus Research Group

< 1 ... 65 66 67 68 69 70 71 72 73 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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