A different ontogenesis for chronic lymphocytic leukemia cases
... a true innate immune system and the conventional adaptive B-cell immune system, functionally similar to what has been suggested previously for mouse B1 cells. Leukemia (2010) 24, 125–132; doi:10.1038/leu.2009.186; published online 17 September 2009 Keywords: CLL; B-cell receptor; stereotypy; pattern ...
... a true innate immune system and the conventional adaptive B-cell immune system, functionally similar to what has been suggested previously for mouse B1 cells. Leukemia (2010) 24, 125–132; doi:10.1038/leu.2009.186; published online 17 September 2009 Keywords: CLL; B-cell receptor; stereotypy; pattern ...
Complement in skin diseases
... biologically important. The most important are cleavage products of C5, C5b, and C5a. C5b is the basis for the formation of membrane-bound lytic complex and C5a is the most powerful chemo-attractant for neutrophils and macrophages. In addition, in some conditions C5a can activate mast cells and star ...
... biologically important. The most important are cleavage products of C5, C5b, and C5a. C5b is the basis for the formation of membrane-bound lytic complex and C5a is the most powerful chemo-attractant for neutrophils and macrophages. In addition, in some conditions C5a can activate mast cells and star ...
The heparin-binding domain confers diverse functions of VEGF
... 55 residues, with clearly defined N-terminal and C-terminal subdomains (residues 1–29 and 29–55 respectively), each containing a two-stranded, antiparallel, β-sheet and two disulfide bonds which dominate the fold. In addition, a single α-helix is located in the C-terminal subdomain, where it is pack ...
... 55 residues, with clearly defined N-terminal and C-terminal subdomains (residues 1–29 and 29–55 respectively), each containing a two-stranded, antiparallel, β-sheet and two disulfide bonds which dominate the fold. In addition, a single α-helix is located in the C-terminal subdomain, where it is pack ...
Subpopulations of bovine WC1 than CD4 CD25 Foxp3
... Abstract – Regulatory T cells (Treg) are regarded essential components for maintenance of immune homeostasis. Especially CD4+ CD25high T cells are considered to be important regulators of immune reactivity. In humans and rodents these natural Treg are characterized by their anergic nature, defined a ...
... Abstract – Regulatory T cells (Treg) are regarded essential components for maintenance of immune homeostasis. Especially CD4+ CD25high T cells are considered to be important regulators of immune reactivity. In humans and rodents these natural Treg are characterized by their anergic nature, defined a ...
Mesenchymal stem cell-based therapy in kidney transplantation
... highest potential and lowest immunogenicity [31, 32]. Human umbilical cord MSCs are mainly isolated from Wharton’s jelly in the umbilical cord, which can be easily, noninvasively and painlessly obtained without causing adverse effects on the fetus and mother, can be utilized without ethical restrict ...
... highest potential and lowest immunogenicity [31, 32]. Human umbilical cord MSCs are mainly isolated from Wharton’s jelly in the umbilical cord, which can be easily, noninvasively and painlessly obtained without causing adverse effects on the fetus and mother, can be utilized without ethical restrict ...
Basic Microbiology and Immunology (MICRO 402)
... infusions and then sealed the openings of his vessels in a flame, none of them revealed spoilage. However, others claimed that the absence of decomposition in these sealed vessels was due to the limited supply of air rather than to the exclusion of air-borne contaminants. The answer to this objectio ...
... infusions and then sealed the openings of his vessels in a flame, none of them revealed spoilage. However, others claimed that the absence of decomposition in these sealed vessels was due to the limited supply of air rather than to the exclusion of air-borne contaminants. The answer to this objectio ...
Epithelial microRNAs regulate gut mucosal immunity via epithelium
... (TH2) responses. Abolishing the induction of microRNA by gut-specific deletion of Dicer1 (Dicer1Dgut), which encodes an enzyme involved in microRNA biogenesis, deprived goblet cells of RELMb, a key TH2 antiparasitic cytokine; this predisposed the host to parasite infection. Infection of Dicer1Dgut m ...
... (TH2) responses. Abolishing the induction of microRNA by gut-specific deletion of Dicer1 (Dicer1Dgut), which encodes an enzyme involved in microRNA biogenesis, deprived goblet cells of RELMb, a key TH2 antiparasitic cytokine; this predisposed the host to parasite infection. Infection of Dicer1Dgut m ...
Food allergy: separating the science from the mythology
... potential threats under the pressure of a dirty environment. In this evolutionary process the mucosal immune system has generated two anti-inflammatory strategies (Figure 2): immune exclusion—performed by SIgA to control the epithelial colonization of microorganisms and inhibit the penetration of po ...
... potential threats under the pressure of a dirty environment. In this evolutionary process the mucosal immune system has generated two anti-inflammatory strategies (Figure 2): immune exclusion—performed by SIgA to control the epithelial colonization of microorganisms and inhibit the penetration of po ...
The nature of adhesion factors which lie on the surfaces of
... Lactobacillus adheres to intestinal epithelial cells and yeast fungus cells with the aid of adhesion factors expressed on its cell surface. To identify adhesion factors nature on the surface of Lactobacillus, an adhesion experiment was carried out by pre-treating the Lactobacillus supernatant with d ...
... Lactobacillus adheres to intestinal epithelial cells and yeast fungus cells with the aid of adhesion factors expressed on its cell surface. To identify adhesion factors nature on the surface of Lactobacillus, an adhesion experiment was carried out by pre-treating the Lactobacillus supernatant with d ...
Express Inducible NKG2D Ligands That Mouse NK Cell Activity
... and channels them, in a receptor-mediated manner, into the MHC class I presentation pathway of professional APCs, which then prime peptide-specific CTL (12). Therefore, HSP70 derived from tumors can be used as tumor-specific vaccines (13). HSP70 also elicits the release of proinflammatory cytokines ...
... and channels them, in a receptor-mediated manner, into the MHC class I presentation pathway of professional APCs, which then prime peptide-specific CTL (12). Therefore, HSP70 derived from tumors can be used as tumor-specific vaccines (13). HSP70 also elicits the release of proinflammatory cytokines ...
Understanding MGUS and Smoldering Multiple Myeloma
... see the IMF publication Understanding Freelite® and Hevylite® Tests or call the IMF InfoLine. Researchers have developed some understanding of the biologic events that take place when MGUS develops into myeloma, but they do not yet know what triggers the progression in certain patients and not in ot ...
... see the IMF publication Understanding Freelite® and Hevylite® Tests or call the IMF InfoLine. Researchers have developed some understanding of the biologic events that take place when MGUS develops into myeloma, but they do not yet know what triggers the progression in certain patients and not in ot ...
Metabolic syndrome: the danger signal in atherosclerosis
... infectious threat. For years it was taught that the immune system functions as sensor that allows recognition of ‘self’ from ‘non-self’, and to mount a specific response against ‘non-self ’ by the use of adaptive immune responses. However, this immunological paradigm has been challenged in the 1990s ...
... infectious threat. For years it was taught that the immune system functions as sensor that allows recognition of ‘self’ from ‘non-self’, and to mount a specific response against ‘non-self ’ by the use of adaptive immune responses. However, this immunological paradigm has been challenged in the 1990s ...
How Mycobacterium tuberculosis Manipulates Innate and Adaptive Immunity: New Views of
... receptors on the host cell surface, including the mannose receptor and the complement receptor (Le Cabec, Carreno et al. 2002; Kang, Azad et al. 2005) and during prolonged infection of cell cultures, the glycolipid is trafficked throughout the membrane compartments of the host cell (Xu, Cooper et al ...
... receptors on the host cell surface, including the mannose receptor and the complement receptor (Le Cabec, Carreno et al. 2002; Kang, Azad et al. 2005) and during prolonged infection of cell cultures, the glycolipid is trafficked throughout the membrane compartments of the host cell (Xu, Cooper et al ...
Current Progress in Non-Invasive Imaging of Beta Cell Mass of the
... rubella develop T1DM at very high rates, which are usually preceded by islet cell autoantibodies [10]. Coxsackie B4 virus has been studied extensively: a landmark study in 1979 demonstrated that a virus isolated from the pancreas of a child who died at presentation was able to cause diabetic activit ...
... rubella develop T1DM at very high rates, which are usually preceded by islet cell autoantibodies [10]. Coxsackie B4 virus has been studied extensively: a landmark study in 1979 demonstrated that a virus isolated from the pancreas of a child who died at presentation was able to cause diabetic activit ...
