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Cellular Respiration
Cellular Respiration

... The cyanide ion (CN-) binds irreversibly to the enzyme that catalyses the oxidation of cytochrome a (cytochrome oxidase) As a result, cyanide stops the flow of electrons essential to oxidative phosphorylation. This prevents the re-oxidation of NADH and FADH and thus the production of the majority of ...
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... 12-The H atoms removed in the successive dehydrogenations are accepted by corresponding coenzymes. Reduced coenzymes transfer the reducing equivalents to electron-transport system, where oxidative phosphorylation product ATP molecules. ...
Learning Objectives
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... 9. Explain why ATP is required for the preparatory steps of glycolysis. 10. Identify where substrate-level phosphorylation and the reduction of NAD+ occur in glycolysis. 11. Describe where pyruvate is oxidized to acetyl CoA, what molecules are produced, and how this process links glycolysis to the c ...
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Chapter 15 Review Worksheet and Key

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... regenerated for glycolysis to continue. How is cytosolic NADH reoxidized under aerobic conditions? NADH cannot simply pass into mitochondria for oxidation by the respiratory chain, because the inner mitochondrial membrane is impermeable to NADH and NAD+. The solution is that electrons from NADH, rat ...
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... and 2500 lux. At different times, samples were withdrawn from the suspension and analyzed for NI-~ and uri~acid. Because of the lack of a carbon source, the A6~0 of the cell suspension did not increase significancy during 3 days. The ratio between the NI~ libe~ted and the uric acid degraded ranged f ...
The electron transport chain is a part of cellular respiration. The
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WEEK 8 - WordPress.com
WEEK 8 - WordPress.com

... Electrons are removed from PYRUVATE by NAD+ = Pyruvate is OXIDIZED One prep reaction per pyruvate = 2 acetyl-CoA ...
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Nicotinamide adenine dinucleotide



Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. The compound is a dinucleotide, because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms, an oxidized and reduced form abbreviated as NAD+ and NADH respectively.In metabolism, nicotinamide adenine dinucleotide is involved in redox reactions, carrying electrons from one reaction to another. The coenzyme is, therefore, found in two forms in cells: NAD+ is an oxidizing agent – it accepts electrons from other molecules and becomes reduced. This reaction forms NADH, which can then be used as a reducing agent to donate electrons. These electron transfer reactions are the main function of NAD. However, it is also used in other cellular processes, the most notable one being a substrate of enzymes that add or remove chemical groups from proteins, in posttranslational modifications. Because of the importance of these functions, the enzymes involved in NAD metabolism are targets for drug discovery.In organisms, NAD can be synthesized from simple building-blocks (de novo) from the amino acids tryptophan or aspartic acid. In an alternative fashion, more complex components of the coenzymes are taken up from food as the vitamin called niacin. Similar compounds are released by reactions that break down the structure of NAD. These preformed components then pass through a salvage pathway that recycles them back into the active form. Some NAD is also converted into nicotinamide adenine dinucleotide phosphate (NADP); the chemistry of this related coenzyme is similar to that of NAD, but it has different roles in metabolism.Although NAD+ is written with a superscript plus sign because of the formal charge on a particular nitrogen atom, at physiological pH for the most part it is actually a singly charged anion (charge of minus 1), while NADH is a doubly charged anion.
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