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lecture1
lecture1

... Metabolic pathways can be linear, e.g. glycolysis or can be cyclic, e.g. TCA. In general, the rate of catabolism is controlled not by the conc. of nutrients available in the environment of the cell, but by the cell’s need for energy in the form of ATP. Similarly, the rate of biosynthesis of cell com ...
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... Aerobic – in the presence of oxygen Anaerobic – in the absence of oxygen ATP (Adenosine triphosphate) – a molecule that stores energy in the form of phosphate bonds. The conversion of ATP  ADP (Adenosine diphosphate) releases energy Fermentation – the chemical conversion of carbohydrates into alcoh ...
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Class22 2-9 Win17 Respiration Regulation and

... How does the ATP yield of fermentation compared to that of aerobic respiration? In what conditions would the evolution of enzymes and regulation to allow fermentation be advantageous? ...
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AP Biology Ch. 9 Cellular Respiration

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Nutrition and Metabolism (Chap 4)

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Must-Knows: Unit 4 (Cellular Respiration) Ms. Ottolini, AP Biology

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... combination of the reactions catalyzed by α-ketoglutarate dehydrogenase and succinyl-CoA synthetase). Initially, the energy released during the oxidation step is captured to form a thioester (covalently linked to glyceraldehyde-3-P dehydrogenase in glycolysis; succinyl-CoA in the TCA cycle). This th ...
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... pass from NADH/FADH2 to the final electron acceptor oxygen, which then combines with H+ and leaves as water. It also pumps H+ ions from the matrix to the intermembrane space. Chemiosmosis is the coupling of the electron transport chain and ATP synthase to move H+ ions from the matrix to the intermem ...
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Nicotinamide adenine dinucleotide



Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. The compound is a dinucleotide, because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms, an oxidized and reduced form abbreviated as NAD+ and NADH respectively.In metabolism, nicotinamide adenine dinucleotide is involved in redox reactions, carrying electrons from one reaction to another. The coenzyme is, therefore, found in two forms in cells: NAD+ is an oxidizing agent – it accepts electrons from other molecules and becomes reduced. This reaction forms NADH, which can then be used as a reducing agent to donate electrons. These electron transfer reactions are the main function of NAD. However, it is also used in other cellular processes, the most notable one being a substrate of enzymes that add or remove chemical groups from proteins, in posttranslational modifications. Because of the importance of these functions, the enzymes involved in NAD metabolism are targets for drug discovery.In organisms, NAD can be synthesized from simple building-blocks (de novo) from the amino acids tryptophan or aspartic acid. In an alternative fashion, more complex components of the coenzymes are taken up from food as the vitamin called niacin. Similar compounds are released by reactions that break down the structure of NAD. These preformed components then pass through a salvage pathway that recycles them back into the active form. Some NAD is also converted into nicotinamide adenine dinucleotide phosphate (NADP); the chemistry of this related coenzyme is similar to that of NAD, but it has different roles in metabolism.Although NAD+ is written with a superscript plus sign because of the formal charge on a particular nitrogen atom, at physiological pH for the most part it is actually a singly charged anion (charge of minus 1), while NADH is a doubly charged anion.
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