Studying the Interaction Profiles of Nonnatural Amino Acids –
... large assemblies such as virus particles or muscle fibers. They also provide specific binding sites, as found in enzymes or proteins that carry oxygen and they regulate the function of DNA. The omnipresence of peptides and proteins in biological systems includes a wide variety of processes responsib ...
... large assemblies such as virus particles or muscle fibers. They also provide specific binding sites, as found in enzymes or proteins that carry oxygen and they regulate the function of DNA. The omnipresence of peptides and proteins in biological systems includes a wide variety of processes responsib ...
FUNCTIONAL CONSEQUENCES OF THE DIRECT PHYSICAL CBP/p300
... chromosome 19 (5). This translocation results in expression of a chimeric protein called E2A-PBX1 and is found in approximately 30% of patients diagnosed with precursor Bcell ALL (pre-B ALL). This translocation was initially associated with a poorer prognosis. However, more intensive treatment regim ...
... chromosome 19 (5). This translocation results in expression of a chimeric protein called E2A-PBX1 and is found in approximately 30% of patients diagnosed with precursor Bcell ALL (pre-B ALL). This translocation was initially associated with a poorer prognosis. However, more intensive treatment regim ...
Schubert, C. M., R. Lin, C. J. de Vries, R. H. A.
... Database searches with the mex-5 sequence showed that the C. elegans genome contains a predicted gene sequence, AH6.5, that could encode a protein with very high similarity to MEX-5; we have named this protein MEX-6. MEX-6 is about 70% identical and 85% similar to MEX-5 in amino acid sequence (Figur ...
... Database searches with the mex-5 sequence showed that the C. elegans genome contains a predicted gene sequence, AH6.5, that could encode a protein with very high similarity to MEX-5; we have named this protein MEX-6. MEX-6 is about 70% identical and 85% similar to MEX-5 in amino acid sequence (Figur ...
Temperature-dependent effects of cadmium and purine nucleotides
... involvement of mitochondrial uncoupling proteins (UCPs) inactivation in oysters. Overall, the results of this study in antioxidant protection in oyster mitochondria using indicate that temperature stress exaggerates toxicity of Cd purine nucleotides (GDP, ATP and ADP) as specific leading to elevated ...
... involvement of mitochondrial uncoupling proteins (UCPs) inactivation in oysters. Overall, the results of this study in antioxidant protection in oyster mitochondria using indicate that temperature stress exaggerates toxicity of Cd purine nucleotides (GDP, ATP and ADP) as specific leading to elevated ...
View PDF - Genes | Genomes | Genetics
... tissue from the same animal since all tissues within an animal are, with a few exceptions, genetically identical and at the same age. In our experiments, SHH protein levels were compared between limb buds within the same embryo, thus eliminating potential issues regarding the age of the two samples ...
... tissue from the same animal since all tissues within an animal are, with a few exceptions, genetically identical and at the same age. In our experiments, SHH protein levels were compared between limb buds within the same embryo, thus eliminating potential issues regarding the age of the two samples ...
The Major Component of the Paraflagellar Rod of Trypanosoma
... similarity to the intermediate filament proteins (solubility properties, amino acid composition, and high degree of helicity), the PFR protein does not belong in this class of cytoskeletal proteins. The PFR protein is coded for by two tandemly linked genes of identical nucleotide sequence. Both gene ...
... similarity to the intermediate filament proteins (solubility properties, amino acid composition, and high degree of helicity), the PFR protein does not belong in this class of cytoskeletal proteins. The PFR protein is coded for by two tandemly linked genes of identical nucleotide sequence. Both gene ...
An alternative, arginase-independent pathway for arginine Kluyveromyces lactis involves metabolism in
... Phenotypes of the deletion strains and of the heterologously complemented S. cerevisiae strains were first analysed on spot plates containing arginine, ornithine, proline or ammonia as a sole nitrogen source (Fig. 2). Consistent with earlier studies (Brandriss and Magasanik, 1980; Brandriss and Falv ...
... Phenotypes of the deletion strains and of the heterologously complemented S. cerevisiae strains were first analysed on spot plates containing arginine, ornithine, proline or ammonia as a sole nitrogen source (Fig. 2). Consistent with earlier studies (Brandriss and Magasanik, 1980; Brandriss and Falv ...
Utilization and Transport of Mannitol in Olea
... charges into the cells, the effect of the dissipation of transmembrane electric potential on mannitol transport was studied. Fig. 4B shows the effect of the lipophilic cation tetraphenylphosphonium (TPPþ) on the initial uptake rates of 0.2–2 mM D-[14C]mannitol. TPPþ inhibited mannitol uptake, indica ...
... charges into the cells, the effect of the dissipation of transmembrane electric potential on mannitol transport was studied. Fig. 4B shows the effect of the lipophilic cation tetraphenylphosphonium (TPPþ) on the initial uptake rates of 0.2–2 mM D-[14C]mannitol. TPPþ inhibited mannitol uptake, indica ...
The Vitamin K-dependent Carboxylase*
... earlier protection data, Dowd and co-workers postulated the presence of two catalytic cysteines on carboxylase (40) (Fig. 5). One cysteine, in the form of a thiolate, acts as a weak base to catalyze deprotonation of KH2; oxygen adduction to the KH– anion is predicted to drive the formation of the Vi ...
... earlier protection data, Dowd and co-workers postulated the presence of two catalytic cysteines on carboxylase (40) (Fig. 5). One cysteine, in the form of a thiolate, acts as a weak base to catalyze deprotonation of KH2; oxygen adduction to the KH– anion is predicted to drive the formation of the Vi ...
Microbiology
... Bacteriophages WeiAU and WeiDWF are lytic to the catfish pathogen Edwardsiella (Edw.) ictaluri. The Edw. ictaluri host factors that modulate phage–host interactions have not been described previously. This study identified eleven unique Edw. ictaluri host factors essential for phage infection by scr ...
... Bacteriophages WeiAU and WeiDWF are lytic to the catfish pathogen Edwardsiella (Edw.) ictaluri. The Edw. ictaluri host factors that modulate phage–host interactions have not been described previously. This study identified eleven unique Edw. ictaluri host factors essential for phage infection by scr ...
Nitrate regulation of metabolism and growth Mark Stitt
... It has been known for a long time that root growth and architecture is modified by nitrogen fertilisation. High nitrate preferentially inhibits root growth, leading to a decrease of the root:shoot ratio [1,41] and decreasing the frequency of lateral roots [1,42]. Local application of nitrate to root ...
... It has been known for a long time that root growth and architecture is modified by nitrogen fertilisation. High nitrate preferentially inhibits root growth, leading to a decrease of the root:shoot ratio [1,41] and decreasing the frequency of lateral roots [1,42]. Local application of nitrate to root ...
Identification of a C-terminal Poly(A)-binding Protein (PABP)
... sufficient to confer viability to cells depleted of the normal PABP gene (11). In Xenopus oocytes, RRMs can stimulate translation when tethered to reporter mRNA (18). As to the C terminus, although it does not bind RNA, it enables PABP to multimerize on poly(A) (12). Recently it was shown to include ...
... sufficient to confer viability to cells depleted of the normal PABP gene (11). In Xenopus oocytes, RRMs can stimulate translation when tethered to reporter mRNA (18). As to the C terminus, although it does not bind RNA, it enables PABP to multimerize on poly(A) (12). Recently it was shown to include ...
Coordination of microtubule and microfilament dynamics by
... crosslinking by SpireC in the presence of SpireD (data not shown). These new bundling and crosslinking activities raise the possibility that Capu and Spire regulate the onset of ooplasmic streaming by directly mediating coordination of actin assembly and microtubule architecture. Moreover, our find ...
... crosslinking by SpireC in the presence of SpireD (data not shown). These new bundling and crosslinking activities raise the possibility that Capu and Spire regulate the onset of ooplasmic streaming by directly mediating coordination of actin assembly and microtubule architecture. Moreover, our find ...
the thyroid and thyroid hormones
... 5' proximal (closer) to the side chain-bearing ring. Because the activity of compounds such as 3',5-dimethyl-3,5-diiodothyronine had demonstrated that alkyl groups could replace the 3'- and 5'-iodine substituents, model compounds bearing alkyl groups in the 3'-position and alkyl or iodine substituen ...
... 5' proximal (closer) to the side chain-bearing ring. Because the activity of compounds such as 3',5-dimethyl-3,5-diiodothyronine had demonstrated that alkyl groups could replace the 3'- and 5'-iodine substituents, model compounds bearing alkyl groups in the 3'-position and alkyl or iodine substituen ...
Amino acid homeostasis and signalling in mammalian cells and
... The study of amino acid transporters in mammalian cells was pioneered by Halvor Christensen [50], who recognised that certain groups of amino acids compete with each other for uptake into cells. More detailed studies revealed many transport activities, which were subsequently confirmed by molecular c ...
... The study of amino acid transporters in mammalian cells was pioneered by Halvor Christensen [50], who recognised that certain groups of amino acids compete with each other for uptake into cells. More detailed studies revealed many transport activities, which were subsequently confirmed by molecular c ...
Amino Acids in Animal Nutrition
... to produce the quantity of meat, milk, fish and eggs demanded by European consumers. The availability of amino acids has allowed feeds to be produced using smaller quantities of protein rich raw materials allowing these limited scarce resources to be used more sparingly. Starting in the 1950’s with ...
... to produce the quantity of meat, milk, fish and eggs demanded by European consumers. The availability of amino acids has allowed feeds to be produced using smaller quantities of protein rich raw materials allowing these limited scarce resources to be used more sparingly. Starting in the 1950’s with ...
Developement of strategies for the isotopic labeling of methyl
... Solution NMR spectroscopy has been limited to small biological objects for a long time. Nowadays, it is unequivocally recognized that the strategy of specific isotope labeling of methyl groups in a perdeuterated protein has significantly extended the frontier of this technique. Indeed, proteins as l ...
... Solution NMR spectroscopy has been limited to small biological objects for a long time. Nowadays, it is unequivocally recognized that the strategy of specific isotope labeling of methyl groups in a perdeuterated protein has significantly extended the frontier of this technique. Indeed, proteins as l ...
LCAT activation by apoA-I in HDL3 exposed to HOCl or MPO
... Cholesterol efflux capacity, HDL function, and atherosclereosis Khera et al. N Engl J Med. 2011;364:127. Macrophage Cholesterol Efflux to “Serum HDL” Associates with CAD status Independent of HDL-C Independent of ApoA-I Better predictor of CAD status than HDL-C or apoA-I ...
... Cholesterol efflux capacity, HDL function, and atherosclereosis Khera et al. N Engl J Med. 2011;364:127. Macrophage Cholesterol Efflux to “Serum HDL” Associates with CAD status Independent of HDL-C Independent of ApoA-I Better predictor of CAD status than HDL-C or apoA-I ...
Balancing between respiration and fermentation - UvA-DARE
... pyruvate,, oxaloacetate) involved in assimilatory processes within the mitochondria remains a necessity,, raising a problem of energizing these transport processes in the absence of electron transferr through the respiratory chain. In S. cerevisiae, this problem is overcome by the entry of cytoplasm ...
... pyruvate,, oxaloacetate) involved in assimilatory processes within the mitochondria remains a necessity,, raising a problem of energizing these transport processes in the absence of electron transferr through the respiratory chain. In S. cerevisiae, this problem is overcome by the entry of cytoplasm ...
Functional characterization of the Mycobacterium
... Eukaryotic-like Ser/Thr protein kinases (STPKs) are present in many bacterial species, where they control various physiological and virulence processes by enabling microbial adaptation to specific environmental signals. PknJ is the only member of the 11 STPKs identified in Mycobacterium tuberculosis ...
... Eukaryotic-like Ser/Thr protein kinases (STPKs) are present in many bacterial species, where they control various physiological and virulence processes by enabling microbial adaptation to specific environmental signals. PknJ is the only member of the 11 STPKs identified in Mycobacterium tuberculosis ...
Spotlight on the microbes that produce heat shock protein 90
... Since these discoveries of Hsp90 as the target of the benzoquinone ansamycins and RAD, several other natural compounds—including a number derived from medicinal plants—have been found to bind, and inhibit, this chaperone (table 1). Each of these is now providing a lead for further drug development [ ...
... Since these discoveries of Hsp90 as the target of the benzoquinone ansamycins and RAD, several other natural compounds—including a number derived from medicinal plants—have been found to bind, and inhibit, this chaperone (table 1). Each of these is now providing a lead for further drug development [ ...
A storage form of ribosomes in mouse oocytes
... intact whole oocytes which were then used for making whole mount preparations or for of the beads averaged 212 A while the con embedding and sectioning. DNase had no nections between beads were approx. 1 25 A effect on the lattices, but they were readily in diameter. destroyed by either trypsin or ...
... intact whole oocytes which were then used for making whole mount preparations or for of the beads averaged 212 A while the con embedding and sectioning. DNase had no nections between beads were approx. 1 25 A effect on the lattices, but they were readily in diameter. destroyed by either trypsin or ...
