![A report on TAK-875 analysis using the Heptox Virtual Liver Platform](http://s1.studyres.com/store/data/016367992_1-df78b7ff2b83d127a5fd0620be126866-300x300.png)
A report on TAK-875 analysis using the Heptox Virtual Liver Platform
... With the available PK information simulations are performed at various exposure levels. Reported average plasma concentration of TAK-875 is ~10 M. Model simulation predicted exposure dependent depolarisation of mitochondrial membrane (Fig. 6). ...
... With the available PK information simulations are performed at various exposure levels. Reported average plasma concentration of TAK-875 is ~10 M. Model simulation predicted exposure dependent depolarisation of mitochondrial membrane (Fig. 6). ...
IV. Microbial polyhydroxyalkanoates (PHA)
... The EPS may remain associated with the cell as a capsule or slime or simply dissolved in the medium, depending on the chemical structure and how vigorously the culture is agitated. On solid media, large slimy colonies may be produced. ...
... The EPS may remain associated with the cell as a capsule or slime or simply dissolved in the medium, depending on the chemical structure and how vigorously the culture is agitated. On solid media, large slimy colonies may be produced. ...
Chapter 16 Citric Acid Cycle
... And 3 NADH, 1 FADH2 and 1 GTP generated and oxalacetate regenerated to begin cycle again Cycle is nice 1 oxaloacetate can oxidized infinite # of acetate 4, 5, & 6C intermediates serve both and sources for synthesis of other compounds, and a ways to bring in other compound for oxidation In eukaryote ...
... And 3 NADH, 1 FADH2 and 1 GTP generated and oxalacetate regenerated to begin cycle again Cycle is nice 1 oxaloacetate can oxidized infinite # of acetate 4, 5, & 6C intermediates serve both and sources for synthesis of other compounds, and a ways to bring in other compound for oxidation In eukaryote ...
Ch16-1 Fatty-acid-and-triacylglycerol
... Free fatty acids can be oxidized by many tissues— particularly liver and muscle—to provide energy. Fatty acids are also structural components of membrane lipids, such as phospholipids and glycolipids. Fatty acids are attached to certain intracellular proteins to enhance the ability of those pr ...
... Free fatty acids can be oxidized by many tissues— particularly liver and muscle—to provide energy. Fatty acids are also structural components of membrane lipids, such as phospholipids and glycolipids. Fatty acids are attached to certain intracellular proteins to enhance the ability of those pr ...
Carbohydrates - Ukiah Adult School
... Glucose availability B reaki ng down body prot ein to yield glucose i s expensi ve because onl y about half of ami no acids can actually be converted to gl ucose Y et it i s more ef fici ent compared to the small amount of glucose available from glycerol in stored tri glycerides (5% of the triglyc ...
... Glucose availability B reaki ng down body prot ein to yield glucose i s expensi ve because onl y about half of ami no acids can actually be converted to gl ucose Y et it i s more ef fici ent compared to the small amount of glucose available from glycerol in stored tri glycerides (5% of the triglyc ...
acyl-CoA
... Activation of fatty acids for -oxidation • Activation of fatty acid to acyl-CoA form by acyl-CoA synthetaserequires CoASH and ATP (converted to AMP + PPi ) in the cytosol. • Acyl-CoA is converted to acyl-carnitine by carnitine acyltransferase (carnitine palmitoyl transferase I) in the cytosol for ...
... Activation of fatty acids for -oxidation • Activation of fatty acid to acyl-CoA form by acyl-CoA synthetaserequires CoASH and ATP (converted to AMP + PPi ) in the cytosol. • Acyl-CoA is converted to acyl-carnitine by carnitine acyltransferase (carnitine palmitoyl transferase I) in the cytosol for ...
Glycolysis - Oregon State University
... path-a-ways When cellsper have lots ofisATP and NADH too Six ATPs glucose the needed energy* They strive to store this energy as sugar yes they do liver’s specialty Oh Gluconeogenesis gluconeogenesis aispathway to revere Inside of mitochondria they start with pyruvate That makes a ton of glucose whe ...
... path-a-ways When cellsper have lots ofisATP and NADH too Six ATPs glucose the needed energy* They strive to store this energy as sugar yes they do liver’s specialty Oh Gluconeogenesis gluconeogenesis aispathway to revere Inside of mitochondria they start with pyruvate That makes a ton of glucose whe ...
medbiochem exam, 1999
... 33. You are treating a patient who exhibits extreme sensitivity to UV light. You supect a form of xeroderma pigmentosa. You ask about any other incidences of light sensitivity in the family, and learn that this is the first incident observed. Which of the following statements is TRUE? A. The trait m ...
... 33. You are treating a patient who exhibits extreme sensitivity to UV light. You supect a form of xeroderma pigmentosa. You ask about any other incidences of light sensitivity in the family, and learn that this is the first incident observed. Which of the following statements is TRUE? A. The trait m ...
Chapter 8 Your Body`s Metabolism
... • Excess can be used for energy production, converted to glucose, or stored as fat • Used, in a limited extent, for energy in diets low in kilocalories and/or carbohydrate ...
... • Excess can be used for energy production, converted to glucose, or stored as fat • Used, in a limited extent, for energy in diets low in kilocalories and/or carbohydrate ...
Fermentation Fermentation is an ancient mode of metabolism, and it
... and acetyl phosphate. As a fermentation pathway, it is employed mainly by the heterolactic acid bacteria, which include some species of Lactobacillus and Leuconostoc. In this pathway, glucose-phosphate is oxidized to 6-phosphogluconic acid, which becomes oxidized and decarboxylated to form pentose p ...
... and acetyl phosphate. As a fermentation pathway, it is employed mainly by the heterolactic acid bacteria, which include some species of Lactobacillus and Leuconostoc. In this pathway, glucose-phosphate is oxidized to 6-phosphogluconic acid, which becomes oxidized and decarboxylated to form pentose p ...
Hepatic Steatosis - Arteriosclerosis, Thrombosis, and Vascular Biology
... A number of studies have addressed the relation between steatosis and basal VLDL TG production in mice and rats, and vice versa. Inhibition of microsomal TG transfer protein (MTP) impairs the assembly and probably the secretion of VLDL TG particles and results in intrahepatic accumulation of TG.25 A ...
... A number of studies have addressed the relation between steatosis and basal VLDL TG production in mice and rats, and vice versa. Inhibition of microsomal TG transfer protein (MTP) impairs the assembly and probably the secretion of VLDL TG particles and results in intrahepatic accumulation of TG.25 A ...
Gluconeogenesis
... for synthesis and storage of glucose When energy status is low, glucose should be rapidly degraded to provide energy The regulated steps of glycolysis are the very steps that are regulated in the reverse direction ...
... for synthesis and storage of glucose When energy status is low, glucose should be rapidly degraded to provide energy The regulated steps of glycolysis are the very steps that are regulated in the reverse direction ...
Engineering of Metabolic Pathways and Global Regulators of
... Strategies to Build an EPA Production Strain • Build an efficient EPA biosynthetic pathway - Use of different strong promototers - Codon-optimization of heterologous genes - Multiple copies of structural genes - Focus on limiting steps - Push and pull carbon flux ...
... Strategies to Build an EPA Production Strain • Build an efficient EPA biosynthetic pathway - Use of different strong promototers - Codon-optimization of heterologous genes - Multiple copies of structural genes - Focus on limiting steps - Push and pull carbon flux ...
200 µmol /L is far too low a concentration of ammonium to affect
... The effect of forming glutamate from ketoglutarate is to deplete the mitochondrial pool of ketoglutarate, which is a key intermediate in the citric acid cycle. As a result, the rate of citric acid cycle activity falls, so reducing very considerably the rate of formation of ATP. It is this lack of AT ...
... The effect of forming glutamate from ketoglutarate is to deplete the mitochondrial pool of ketoglutarate, which is a key intermediate in the citric acid cycle. As a result, the rate of citric acid cycle activity falls, so reducing very considerably the rate of formation of ATP. It is this lack of AT ...
Luiziana Ferreira da Silva Lab of Bioproducts Department of Microbiology
... B. derxii pure & associate cultures ...
... B. derxii pure & associate cultures ...
Biochemistry I, Spring Term 2000 - Third Exam
... A mutant lysozyme was made such that Asp53 was replaced with Asn. Would this enzyme still be active? Why? Do you expect the activity to be the same, decrease, or increase? Justify your answer. Asp53 stabilizes the carbocation. It is not essential for activity, but replacement of it with Asn would re ...
... A mutant lysozyme was made such that Asp53 was replaced with Asn. Would this enzyme still be active? Why? Do you expect the activity to be the same, decrease, or increase? Justify your answer. Asp53 stabilizes the carbocation. It is not essential for activity, but replacement of it with Asn would re ...
LIPID MOBILIZATION
... Fatty acids must be esterified to Coenzyme A before they can undergo oxidative degradation, be utilized for synthesis of complex lipids (e.g., triacylglycerols or membrane lipids), or be attached to proteins as lipid anchors. ...
... Fatty acids must be esterified to Coenzyme A before they can undergo oxidative degradation, be utilized for synthesis of complex lipids (e.g., triacylglycerols or membrane lipids), or be attached to proteins as lipid anchors. ...
Metabolism Stages Figure
... Overview of Glucose Metabolism Carbons One 6C glucose SPLITS TO FORM two 3C molecules OXIDIZED TO FORM two 3C pyruvates BREAKING INTO two 1C CO 2 and CO2 two 2C Acetyl CoA ...
... Overview of Glucose Metabolism Carbons One 6C glucose SPLITS TO FORM two 3C molecules OXIDIZED TO FORM two 3C pyruvates BREAKING INTO two 1C CO 2 and CO2 two 2C Acetyl CoA ...
Pyruvate Dehydrogenase Phosphatase Deficiency
... reverity of the acidosis was diminished by intravenous administration of glucose in large doses and by bicarbonate. On two occasions, when the acidosis was particularly se\ere. peritoneal dialvsis using an acetate buffer was required. Restriction of the dietar! intake of saturated fatty acids or tre ...
... reverity of the acidosis was diminished by intravenous administration of glucose in large doses and by bicarbonate. On two occasions, when the acidosis was particularly se\ere. peritoneal dialvsis using an acetate buffer was required. Restriction of the dietar! intake of saturated fatty acids or tre ...
pharmaceutical biochemistry
... compounds (lactate, glucoplastic amino acids, glycerol and propionic acid). Gluconeogenesis and glycolysis are not identical pathways running in opposite directions, although they do share reversible steps. However, three reactions of glycolysis are irreversible and cannot be used in gluconeogenesis ...
... compounds (lactate, glucoplastic amino acids, glycerol and propionic acid). Gluconeogenesis and glycolysis are not identical pathways running in opposite directions, although they do share reversible steps. However, three reactions of glycolysis are irreversible and cannot be used in gluconeogenesis ...
L10v02a_-_glycolysis.stamped_doc
... [00:03:46.71] And then finally pyruvate is the molecule that will be shuttled into the mitochondria for the citric acid cycle. [00:03:53.52] I'd like to look at a detail of step three in glycolysis. As you know, we invested two molecules of ATP. The first ones produces fructose 6-phosphate. At this ...
... [00:03:46.71] And then finally pyruvate is the molecule that will be shuttled into the mitochondria for the citric acid cycle. [00:03:53.52] I'd like to look at a detail of step three in glycolysis. As you know, we invested two molecules of ATP. The first ones produces fructose 6-phosphate. At this ...
Glucose (C6H12O6), also known as D
... addition of water by fructose-1,6-bisphosphatase. Phosphoglucose Isomerase transforms fructose-6-phosphate into glucose-6-phosphate and then it finally becomes glucose with the addition of water from Glucose-6-phosphatase. This pathway is spontaneous, but overall, it consumes six phosphate bonds of ...
... addition of water by fructose-1,6-bisphosphatase. Phosphoglucose Isomerase transforms fructose-6-phosphate into glucose-6-phosphate and then it finally becomes glucose with the addition of water from Glucose-6-phosphatase. This pathway is spontaneous, but overall, it consumes six phosphate bonds of ...
Biochemistry review
... 24. A high omega-6:omega 1 fatty acid ratio in the diet favors the synthesis of which eicosanoid via the Δ5-desaturase enzyme a. 1-series prostaglandins b. 2-series prostaglandins c. 3-series prostaglandins d. 5-series leukotrienes ...
... 24. A high omega-6:omega 1 fatty acid ratio in the diet favors the synthesis of which eicosanoid via the Δ5-desaturase enzyme a. 1-series prostaglandins b. 2-series prostaglandins c. 3-series prostaglandins d. 5-series leukotrienes ...
doc BIOC 311 Final Study Guide
... 4. Fructose-1-6-bisphosphate → Dihydroxyacetone phosphate (DHAP) + glyceraldehyde-3-phosphate (GAP) (via aldolase – class I). a. [DHAP] >> [GAP], but GAP is the only metabolite that can continue. b. For this reason, triose phosphate isomerase converts DHAP to GAP, splitting the glycolytic pathway in ...
... 4. Fructose-1-6-bisphosphate → Dihydroxyacetone phosphate (DHAP) + glyceraldehyde-3-phosphate (GAP) (via aldolase – class I). a. [DHAP] >> [GAP], but GAP is the only metabolite that can continue. b. For this reason, triose phosphate isomerase converts DHAP to GAP, splitting the glycolytic pathway in ...
Glyceroneogenesis
![](https://commons.wikimedia.org/wiki/Special:FilePath/Glycerol-3-phosphate.png?width=300)
Glyceroneogenesis is a metabolic pathway which synthesizes glycerol 3-phosphate or triglyceride from precursors other than glucose. Usually glycerol 3-phosphate is generated from glucose by glycolysis, but when glucose concentration drops in the cytosol, it is generated by another pathway called glyceroneogenesis. Glyceroneogenesis uses pyruvate, alanine, glutamine or any substances from the TCA cycle as precursors for glycerol 3-phophate. Phosphoenolpyruvate carboxykinase (PEPC-K), which is an enzyme that catalyses the decarboxylation of oxaloacetate to phosphoenolpyruvate is the main regulator for this pathway. Glyceroneogenesis can be observed in adipose tissue and also liver. It is a significant biochemical pathway which regulates cytosolic lipid levels. Intense suppression of glyceroneogenesis may lead to metabolic disorder such as type 2 diabetes.