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1 - Wk 1-2
1 - Wk 1-2

... in the citric acid cycle (TCA cycle). However, if the amounts of acetyl-CoA generated in fatty-acid β-oxidation challenge the processing capacity of the TCA cycle (as will result from an over supply of FA from excessive lipolysis) or if activity in the TCA cycle is low due to low amounts of intermed ...
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... 3. The refed state begins with the ingestion of a meal. Fatty acids are processed normally. However, the liver does not initially absorb glucose, leaving this fuel in the blood for use by other tissues. The liver remains in the gluconeogenic mode in order to replenish its own glycogen store. As glu ...
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... • Some of the acetyl-CoA produced by fatty acid oxidation in liver mitochondria is converted to acetone, acetoacetate and b-hydroxybutyrate • These are called "ketone bodies" • Source of fuel for brain, heart and muscle • Major energy source for brain during starvation • They are transportable forms ...
Biochemistry Objectives 43
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PowerPoint 演示文稿

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... Liver cells have a responsibility to support blood glucose levels by first releasing glucose from their internal glycogen stores, and if necessary synthesizing glucose from amino acids. They will shut down glycolysis and rely on other energy sources for their own needs under these conditions. Liver ...
Chapter-4 part-2 Energy Metabolism
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... 1. Describe the activation and translocation of free fatty acids into skeletal muscle that is required prior to metabolism as fuel. (do not include the regulation of translocation in your answer). 2. Describe the mobilization, circulation and uptake of free fatty acids during exercise. Why do resear ...
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... effect of maternal diabetes and intrauterine growth retardation. Pediatr Res 1975;31:52–8. Sokoloff L. Metabolism of ketone bodies by the brain. Ann Rev Med 1973;24:271–80. Sunehag AL, Haymond MW, Schanler RJ, Reeds PJ, Bier DM. Gluconeogenesis in very low birth weight ...
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Bio302 Biochemistry II

... markedly in their activities: an inactive protomer to an active filamentous polymer. Citrate and isocitrate bind to the filamentous form, and palmitoyl-CoA binds preferentially to the protomer. Explain how this property is consistent with the regulatory role of acetyl-coA carboxylase in the biosynth ...
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Ketosis



Ketosis /kɨˈtoʊsɨs/ is a metabolic state where most of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis where blood glucose provides most of the energy. It is characterised by serum concentrations of ketone bodies over 0.5 millimolar, with low and stable levels of insulin and blood glucose. It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder.Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet, and deliberately induced ketosis serves as a medical intervention for intractable epilepsy. In glycolysis, higher levels of insulin promote storage of body fat and block release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed. For this reason, ketosis is sometimes referred to as the body's ""fat burning"" mode.
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