Download Chemistry 400 A

Chem 400A Spring 09 Term Examination 2
March 12, 2009
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Chemistry 400 A - Spring 2009 - Term Examination 2
Dr. David J. Berg
Name: ______KEY______________
This examination is multiple choice. For each subsection, write the best choice
from the selection provided in the space immediately after the question. I need to
be able to read it, so please write the letters legibly – if it is ambiguous, it is wrong!
For a given subsection, a choice MAY be the answer to more than one question.
There are 70 questions and 70 minutes so ration your time appropriately.
Of the choices:
a) lysergic acid
f) hashish
1.
2.
3.
4.
5.
b) PCP
c) Li2CO3 d) Prozac
g) mescaline
h) Rauwolfia
e) chlorpromazine
i) anandamide
Which is a serotonin mimic?
Which comes from a fungus on rye?
Which antidepressant blocks serotonin re-uptake (is an SSRI)?
Which can cause extremely high blood pressure and convulsions?
Which binds the cannabinoid receptors and causes short
term memory loss?
6. Which neurotransmitter is displaced by marijuana?
7. Which is a dopamine mimic?
8. Which anti-psychotic causes serotonin and catecholamine
depletion as well as nightmares?
9. Which drug is commonly used to treat manic depression?
10. Which failed tricyclic antihistamine proved active as an
anti-depressant?
a or h
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Chem 400A Spring 09 Term Examination 2
Of the choices:
a) estrogen
e) amine
i) fluticasone
m) cortisone
b) RU-486
f) aromatic ring
j) gossypol
n) cyclopropane
March 12, 2009
c) alkyne
g) acetate
k) diosgenin
o) digitalis
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d) aldehyde
h) diethylstilbestrol
L) androstenedione
p) progesterone
11. Which plant-derived steroid has long been used to treat
heart patients?
12. Which female hormone is present early in the menstrual cycle?
13. Which female hormone is present after day 14 of the
menstrual cycle?
14. Which compound found in Mexican yams lead to the cheap
synthesis of progesterone?
15. Which functional group was critical in making a birth
control pill that could be taken orally?
16. What structural feature distinguishes estrogen from both
progesterone and testosterone?
17. Depo-provera is a long lasting progesterone mimic. What
functional group is present to achieve this effect?
18. What ‘morning after’ pill was commonly prescribed until
the 1980’s but was originally used to prevent miscarriages?
19. Which drug acts as a progesterone antagonist and can be used
to terminate pregnancies?
20. What plant-derived male contraceptive can cause permanent
sterility if used long term?
21. Which synthetic steroid reduces inflammation in the lungs
of asthmatics?
22. Which anabolic steroid has been used by many high profile
athletes?
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__L_
Chem 400A Spring 09 Term Examination 2
Of the choices:
a) anabolic steroid
d) sex hormone
March 12, 2009
b) corticosteroid
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c) not a steroid
23. Which type of steroid is prednisone?
24. Which type of steroid is THG?
25. Which type of steroid is ethisterone?
__b__
__a__
__d__
Match the drug with its class or mode of action in cancer therapy:
a) DNA strand cross-linker
b) anti-hormone
c) antibiotic
d) anti-metabolite
e) ene-diyne antibiotic
f) interferes with folic acid metabolism
g) tubulin assembly promoter
h) singlet oxygen generator
i) or emitter causing DNA damage by ionization
26. Iobenguane
27. Flutamide
28. Tamoxifen
29. cis-Platin
30. N-mustards (eg. Cytoxan)
31. Actinomycin
32. Paclitaxel (Taxol)
33. Photofrin
34. Dynemycin (or Dynemicin A)
35. Andrucil
36. Methotrexate
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__b__
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Chem 400A Spring 09 Term Examination 2
Of the choices:
a) Ciprofloxacin
b) Iodine
d) Erythromycin
e) Phenol
g) Cetyl pyridinium bromide
i) Iclaprim
j) Clotrimazole
March 12, 2009
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c) Sulphanilimide
f) Cephalosporin
h) Doxycycline
k) p-Aminobenzoic acid
37. Which oxidizes bacterial cells?
38. Which destroys bacterial walls as a surfactant?
39. Which do bacteria use to make folic acid in nature?
40. Which was first found in sewage?
41. Which has the side effect of causing diarrhea?
42. Which is an efflux pump blocker used on resistant bacteria?
b or e
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43. Which contains a -lactam ring?
44. Which contains amino sugar residues?
45. Which has a cyclopropane unit and is effective against Anthrax?
46. Which has a 5-membered N-containing ring as a key feature?
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__d__
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Of the choices:
a) Benadryl
d) Claritin (loratidine)
b) Dramamine
e) Zyvoxam
c) Allegra (fexofenadine)
47. Which is a salt of an antihistamine and a stimulant?
48. Which causes serious drowsiness in most people?
49. Which is a non-sedating antihistamine that does not cross
the blood-brain barrier?
50. Which contains a fused 6-7-6 three ring structure that does not
closely resemble histamine?
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c or d
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Chem 400A Spring 09 Term Examination 2
March 12, 2009
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Match the structural choices on this page and the top of the next page with the
appropriate name, feature or function given in the section that follows:
A
HO
B
NMe2
C
OH
OH
N
H
O
C5H11
O
D
E
H19C9
O
F
H
N
O
O nH
O
F3C
HO
O
N
OH HN
N
O
N
N
H2
Cl-
+
H
G
O S
N
O
I
S
F
S
O
NH2
N
O
O
HO
H
N
O
HO
O
O
N
O
N
F
J
H
O
K
L
HO
F
OH
O
Na
N
SO2 N
OH
Cl
N
M
O
O
HO
O
H
N
O
H
N
S
HN
NH2
O
S
N
P
NH2
Cl
CO2H
S
N
N
Cl
Q
N
O
O
R
CO2H
Chem 400A Spring 09 Term Examination 2
March 12, 2009
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O
Cl
N
Cl
N
OH
OH
O
O
OH
HO
O
HO
HO
O
Cl
NH2
NMe2
O
O
S
O
Cl
T
O
OH
OH
OMe
O
OH
NMe2
U
51. DDC, a synthetic anti-metabolite used in HIV therapy
52. The active ingredient in Lysol disinfectant
53. Erythromycin
54. The anti-fungal Monistat (miconazole)
55. The SSRI Prozac (fluoxetine)
56. The active compound in marijuana
57. The anti-hormone Raloxifene used in breast cancer therapy
58. Cefachlor
59. Cloxacillin
60. The inhaled corticosteroid found in Advair
61. Viagra (sildenafil)
62. The natural compound released from mast cells that causes
an allergic reaction
63. A hallucinogen that mimics serotonin
64. A stimulant used to treat ADHD
65. A spermicide also found in some shampoos
66. The parent member of a new class of non-steroidal,
performance enhancing drugs now being used by some athletes
67. A natural anabolic steroid and sex hormone
68. The disinfectant Choramine-T
69. Cholesterol
70. Doxycycline (vibramycin), an anti-biotic related to tetracycline
END
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