View Full Article - PDF - International Research Journals
... the oral absorption of vancomycin and teicoplanin is very low so they must be administered intravenously to control systemic infections, which is not the preferred route of administration for many patients (Andre et al., 2010). Oxazolidinones are a novel class of synthetic antimicrobials with potent ...
... the oral absorption of vancomycin and teicoplanin is very low so they must be administered intravenously to control systemic infections, which is not the preferred route of administration for many patients (Andre et al., 2010). Oxazolidinones are a novel class of synthetic antimicrobials with potent ...
PDF Full-text
... observed after two days of incubation. The MIC (minimum inhibitory concentration) was expressed as the lowest concentration of the drug that inhibited Mtb-growth or prevented change in color of the resazurin from blue to pink based on a REMA. 2.6. Evaluation of Drug Susceptibility of M. tuberculosis ...
... observed after two days of incubation. The MIC (minimum inhibitory concentration) was expressed as the lowest concentration of the drug that inhibited Mtb-growth or prevented change in color of the resazurin from blue to pink based on a REMA. 2.6. Evaluation of Drug Susceptibility of M. tuberculosis ...
Amphotericin B as a mycolic acid specific targeting agent in tuberculosis
... The serious threat of tuberculosis, especially XDR-TB, is a reality in Southern Africa particularly in individuals with HIV/AIDS. Therefore the importance of development of new or improved anti-TB treatment must now be emphasized more than ever. In this study, a model was created to target isoniazid ...
... The serious threat of tuberculosis, especially XDR-TB, is a reality in Southern Africa particularly in individuals with HIV/AIDS. Therefore the importance of development of new or improved anti-TB treatment must now be emphasized more than ever. In this study, a model was created to target isoniazid ...
A review on pharmacological property of Mimusops elengi Linn.
... made from the dried flowers induces nasal discharge and relieves headache [6]. Fruits are used as astringent, coolant and anthelmintic. The tender stems are used as tooth brushes, and in cystorrhea, diarrhea and dysentery [5]. Flowers are brain tonic and are useful as snuff to relieve cephalalgia [7 ...
... made from the dried flowers induces nasal discharge and relieves headache [6]. Fruits are used as astringent, coolant and anthelmintic. The tender stems are used as tooth brushes, and in cystorrhea, diarrhea and dysentery [5]. Flowers are brain tonic and are useful as snuff to relieve cephalalgia [7 ...
International Journal of Ayurveda and Pharma Research
... human skin fibroblasts to evaluate in vitro anti-aging activity. The cold water extract of T. chebula gall indicated the highest stimulation index (SI) on normal human fibroblast proliferation. The extract also demonstrated MMP-2 inhibition on fibroblasts 1.37 times more potent than ascorbic acid. T ...
... human skin fibroblasts to evaluate in vitro anti-aging activity. The cold water extract of T. chebula gall indicated the highest stimulation index (SI) on normal human fibroblast proliferation. The extract also demonstrated MMP-2 inhibition on fibroblasts 1.37 times more potent than ascorbic acid. T ...
BIOLOGICAL EVALUATION OF OPIOIDS, STIMULANTS, AND
... is that both the N-methyl and N-cyclopropylmethyl analogs are mu agonists, whereas N-cyclopropylmethyl substitution generally leads to mu antagonists. Thus, both the N-methyl NIH 11149 and its Ncyclopropylmethyl analog, NIH 11150, were active as antinociceptive agents, albeit with the Ncyclopropylme ...
... is that both the N-methyl and N-cyclopropylmethyl analogs are mu agonists, whereas N-cyclopropylmethyl substitution generally leads to mu antagonists. Thus, both the N-methyl NIH 11149 and its Ncyclopropylmethyl analog, NIH 11150, were active as antinociceptive agents, albeit with the Ncyclopropylme ...
Evaluation of different mycobacterial species for drug discovery and
... The main objectives of this study were to identify an appropriate in vitro model that could be used for anti-Tb drug high-throughput screening (HTS), and to use this model to identify a novel candidate anti-tubercular drug and its cognate cellular target. A sensitive growth inhibition assay was set ...
... The main objectives of this study were to identify an appropriate in vitro model that could be used for anti-Tb drug high-throughput screening (HTS), and to use this model to identify a novel candidate anti-tubercular drug and its cognate cellular target. A sensitive growth inhibition assay was set ...
PDF - Pharmacological Reviews
... A. An approach of merging the mass-action law with mathematical induction and deduction . . 1. The power of mathematical induction and deduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Nature’s law . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
... A. An approach of merging the mass-action law with mathematical induction and deduction . . 1. The power of mathematical induction and deduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Nature’s law . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
IDENTIFICATION OF NATURAL PRODUCTS AS ANTIDIABETIC AGENTS Laura Guasch Pàmies
... infections have also been linked to the risk of developing T1DM. Several risk factors have been associated with T2DM, including obesity, changes in diet and physical activity, age, insulin resistance, a family history of diabetes and ethnicity [9,10]. Changes in diet and physical activity related to ...
... infections have also been linked to the risk of developing T1DM. Several risk factors have been associated with T2DM, including obesity, changes in diet and physical activity, age, insulin resistance, a family history of diabetes and ethnicity [9,10]. Changes in diet and physical activity related to ...
P-Glycoprotein functional activity in peripheral blood lymphocytes. Role of immunosuppressants,
... perform many and different functions [6]. Of particular interest, family members that mediate drug transport, since these proteins can have a major impact on drug disposition and drug resistance to chemotherapy, as ...
... perform many and different functions [6]. Of particular interest, family members that mediate drug transport, since these proteins can have a major impact on drug disposition and drug resistance to chemotherapy, as ...
Pharmacologically Active Drug Metabolites: Impact on Drug
... Address correspondence to: Dr. R. Scott Obach, Pfizer Inc., Eastern Point Rd., Groton, CT 06340. E-mail: [email protected] dx.doi.org/10.1124/pr.111.005439. ...
... Address correspondence to: Dr. R. Scott Obach, Pfizer Inc., Eastern Point Rd., Groton, CT 06340. E-mail: [email protected] dx.doi.org/10.1124/pr.111.005439. ...
polyalthia longifolia and its pharmacological activities : review
... Polyalthia longifolia var. angustifolia is a member of the Annonaceae family and is a small medium-sized tree distributed in many tropical countries around the world, commonly used as ornamental street tree due to its effectiveness in combating noise pollution. In traditional and indigenous systems ...
... Polyalthia longifolia var. angustifolia is a member of the Annonaceae family and is a small medium-sized tree distributed in many tropical countries around the world, commonly used as ornamental street tree due to its effectiveness in combating noise pollution. In traditional and indigenous systems ...
as a PDF
... 2002; Liu et al., 2006; Lee et al., 2012). These specific reactions can be useful tools to determine CYP2J2 activity and its roles in drug metabolism. Moreover, the specific tool inhibitor preferably should not be the substrate of CYP2J2, because it would otherwise add unnecessary complexity in both ...
... 2002; Liu et al., 2006; Lee et al., 2012). These specific reactions can be useful tools to determine CYP2J2 activity and its roles in drug metabolism. Moreover, the specific tool inhibitor preferably should not be the substrate of CYP2J2, because it would otherwise add unnecessary complexity in both ...
week5
... • As a result, these mutations have not been considered in addressing the selectivity problem. Instead people have been looking for analogs with non-natural AA and adducts. Over 400 analogs of ShK were developed at the Norton Lab (Melbourne) but only a few had some Kv1.3/Kv1.1 selectivity. ...
... • As a result, these mutations have not been considered in addressing the selectivity problem. Instead people have been looking for analogs with non-natural AA and adducts. Over 400 analogs of ShK were developed at the Norton Lab (Melbourne) but only a few had some Kv1.3/Kv1.1 selectivity. ...
Full-Text PDF
... Poor solubility is one of the main problems faced by researchers during drug development. Commonly, even with the use of current computational “filters” to minimize this problem, compounds that are active in vitro may lack adequate pharmacokinetic properties and/or may be difficult to formulate [1]. ...
... Poor solubility is one of the main problems faced by researchers during drug development. Commonly, even with the use of current computational “filters” to minimize this problem, compounds that are active in vitro may lack adequate pharmacokinetic properties and/or may be difficult to formulate [1]. ...
Review On The Medicinial Plant - Aerva Lanata
... Diuretic and anti-inflammatory activities of Aerva lanata in Rats: Male Albino rats were used for studying the diuretic activity of Aerva lanata, while the alcoholic extract of Aerva lanata increased the urine volume of rats moderately; this was equivalent to that of acetzolamide. The Na+ and K+ rat ...
... Diuretic and anti-inflammatory activities of Aerva lanata in Rats: Male Albino rats were used for studying the diuretic activity of Aerva lanata, while the alcoholic extract of Aerva lanata increased the urine volume of rats moderately; this was equivalent to that of acetzolamide. The Na+ and K+ rat ...
BoNT_A Presentation UMass Dartmouth 081029
... Greater than 100K compounds with greater than 200 druglike chemotypes ...
... Greater than 100K compounds with greater than 200 druglike chemotypes ...
Serum albumin, the most abundant protein in the
... Serum albumin, the most abundant protein in the circulatory system, has been one of the most extensively studied of all proteins 1. Serum albumins are prone to bind effectively many small organic molecules. Bovine serum albumin (BSA), a large globular protein (65,000 Daltons), consists of a single c ...
... Serum albumin, the most abundant protein in the circulatory system, has been one of the most extensively studied of all proteins 1. Serum albumins are prone to bind effectively many small organic molecules. Bovine serum albumin (BSA), a large globular protein (65,000 Daltons), consists of a single c ...
Novel Approaches to the Treatment of Systemic Anthrax
... Figure 1. Schematic representation of events in the pathogenesis of anthrax and the potential therapeutic opportunities (identified as numbers) that relate to each event. Entities within parentheses represent examples of agents that may inhibit or block a particular pathogenic event (see text): (1) ...
... Figure 1. Schematic representation of events in the pathogenesis of anthrax and the potential therapeutic opportunities (identified as numbers) that relate to each event. Entities within parentheses represent examples of agents that may inhibit or block a particular pathogenic event (see text): (1) ...
Inhibitory Effects of Fruit Juices on Cytochrome P450
... activities observed with 0.25 ml (0.05% v/v) of pineapple juice at preincubation periods of 0, 5, 15, and 30 min were 79.4%, 72.4%, 64.9%, and 55.1% respectively. These data suggest that pineapple juice causes irreversible inhibition of human CYP2C9 activity. Thus, we discovered that pineapple juice ...
... activities observed with 0.25 ml (0.05% v/v) of pineapple juice at preincubation periods of 0, 5, 15, and 30 min were 79.4%, 72.4%, 64.9%, and 55.1% respectively. These data suggest that pineapple juice causes irreversible inhibition of human CYP2C9 activity. Thus, we discovered that pineapple juice ...
Review Advances in nucleoside monophosphate prodrugs as anti
... On the basis of anti-HCV data obtained in cell culture for the ProTides of 2′-C-methylcytidine, additional studies were performed with 1 in human hepatocytes [37]. High intracellular concentrations of the 2′-C-methylcytidine-TP were obtained after incubation at 10 µM for 4 h. When expressed as the ...
... On the basis of anti-HCV data obtained in cell culture for the ProTides of 2′-C-methylcytidine, additional studies were performed with 1 in human hepatocytes [37]. High intracellular concentrations of the 2′-C-methylcytidine-TP were obtained after incubation at 10 µM for 4 h. When expressed as the ...
TECTONA GRANDIS Research Article NEHA KHERA
... significant activity against cancerous tumors in rats[37].Its antitumor property alone and in combination with radiation was evaluated in female Swiss albino mice, 6-8 weeks old, bearing sarcoma-180 (S-180) ascetic tumor cells. In female mice 2x105, S180 viable ascetic cells were injected intraperit ...
... significant activity against cancerous tumors in rats[37].Its antitumor property alone and in combination with radiation was evaluated in female Swiss albino mice, 6-8 weeks old, bearing sarcoma-180 (S-180) ascetic tumor cells. In female mice 2x105, S180 viable ascetic cells were injected intraperit ...
Full-Text PDF
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
assessment of the opiate properties of two constituents of a toxic
... The tail flick results (Fig. 2) confirmed the analgesic activity of MPPP, while revealing that MPTP has no analgesic effect and, in fact, causes a sensitization of the tail flick response. Higher doses of MPTP than that shown in Fig. 2 (40 PM/kg) did not lower the tail flick latency further and lowe ...
... The tail flick results (Fig. 2) confirmed the analgesic activity of MPPP, while revealing that MPTP has no analgesic effect and, in fact, causes a sensitization of the tail flick response. Higher doses of MPTP than that shown in Fig. 2 (40 PM/kg) did not lower the tail flick latency further and lowe ...
PHYTOCHEMICAL, BIOLOGICAL AND TOXICOLOGICAL STUDIES
... Yan and Mr. Liu Zheng Simon. I also want to acknowledge the support and contribution of Madame Fu Shu-Qin, the Director, TWAS Regional Office, Beijing. My thanks go to the immediate past Dean, College of Science and Technology, Covenant University, Prof. J. Katende and the present Dean, Prof. F.K. H ...
... Yan and Mr. Liu Zheng Simon. I also want to acknowledge the support and contribution of Madame Fu Shu-Qin, the Director, TWAS Regional Office, Beijing. My thanks go to the immediate past Dean, College of Science and Technology, Covenant University, Prof. J. Katende and the present Dean, Prof. F.K. H ...