MITOSIS & CYTOKINESIS
... Don & Ada Olins and Christopher Woodcock discovered that DNA was coiled around histone proteins. Nucleosomes: Bead-like structures of DNA and histones These are tightly compacted so they can separate in mitosis. ...
... Don & Ada Olins and Christopher Woodcock discovered that DNA was coiled around histone proteins. Nucleosomes: Bead-like structures of DNA and histones These are tightly compacted so they can separate in mitosis. ...
Overview of Vinca Alkaloids
... Microtubules are composed of 13 protofilaments aligned side-by-side around a hollow core with α- and β-tubulin subunits alternating with each other ...
... Microtubules are composed of 13 protofilaments aligned side-by-side around a hollow core with α- and β-tubulin subunits alternating with each other ...
1. The mitotic phase alternates with interphase in the cell cycle
... spindle fibers from each centrosome push off each other. • Two nuclei begin for form, surrounded by the fragments of the parent’s nuclear envelope. • Chromatin becomes less tightly coiled. • Cytokinesis, division of the cytoplasm, begins. ...
... spindle fibers from each centrosome push off each other. • Two nuclei begin for form, surrounded by the fragments of the parent’s nuclear envelope. • Chromatin becomes less tightly coiled. • Cytokinesis, division of the cytoplasm, begins. ...
Lecture Resource ()
... to a specific cellular binding site called a receptor Excess histamine in the body causes the symptoms associated with the common cold and allergic responses ...
... to a specific cellular binding site called a receptor Excess histamine in the body causes the symptoms associated with the common cold and allergic responses ...
Leukemias and Lymphomas
... Early stages – high growth fraction, short doubling times Late stages – low growth fraction, long doubling times Chemotherapy – most effective when growth fraction is high. ...
... Early stages – high growth fraction, short doubling times Late stages – low growth fraction, long doubling times Chemotherapy – most effective when growth fraction is high. ...
Paclitaxel
... Contraindicated in patients with history of severe hypersensitivity reaction to paclitaxel or to other drugs formulated in Cremophor EL, including cyclosporine, etoposide, or teniposide. Use with caution in patients with abnormal liver function. Dose reduction is required in this setting. Patients w ...
... Contraindicated in patients with history of severe hypersensitivity reaction to paclitaxel or to other drugs formulated in Cremophor EL, including cyclosporine, etoposide, or teniposide. Use with caution in patients with abnormal liver function. Dose reduction is required in this setting. Patients w ...
Alternative medicine - HEDC
... family are the combrestatins4. Combretastatin A4 (COA-4), an anti-vascular compound that acts as a tubulin binding protein, is the most active of these compounds. It inhibits tubulin polymerisation and thus prevents cells from producing microtubules5. Microtubules are essential to cytoskeleton produ ...
... family are the combrestatins4. Combretastatin A4 (COA-4), an anti-vascular compound that acts as a tubulin binding protein, is the most active of these compounds. It inhibits tubulin polymerisation and thus prevents cells from producing microtubules5. Microtubules are essential to cytoskeleton produ ...
What is (and is not) mitosis? Mitosis is nuclear division plus
... Mitosis is nuclear division plus cytokinesis, and produces two identical daughter cells during prophase, prometaphase, metaphase, anaphase, and telophase. Interphase is often included in discussions of mitosis, but interphase is technically not part of mitosis, but rather encompasses stages G1, S, a ...
... Mitosis is nuclear division plus cytokinesis, and produces two identical daughter cells during prophase, prometaphase, metaphase, anaphase, and telophase. Interphase is often included in discussions of mitosis, but interphase is technically not part of mitosis, but rather encompasses stages G1, S, a ...
Microtubule-active drugs: mechanism of action and resistance
... canonical drugs include colchicine, paclitaxel (and related taxanes) and vinblastine (or other vinca alkaloids), but several hundred of other similarly acting substances have been discovered,20 such as cryptophycins, dolastatins, epithilones, discodermolides, halichondrin and many more. The list is ...
... canonical drugs include colchicine, paclitaxel (and related taxanes) and vinblastine (or other vinca alkaloids), but several hundred of other similarly acting substances have been discovered,20 such as cryptophycins, dolastatins, epithilones, discodermolides, halichondrin and many more. The list is ...
Cancer Chemotherapy-2
... Vinca alkaloids (Vinblastine, vincristine) These drugs block the formation of mitotic spindle by preventing the assembly of tubulin dimers into microtubules They act primarily on the M phase of cancer cell cycle Resistance is due to d efflux of drugs from tumor cells ...
... Vinca alkaloids (Vinblastine, vincristine) These drugs block the formation of mitotic spindle by preventing the assembly of tubulin dimers into microtubules They act primarily on the M phase of cancer cell cycle Resistance is due to d efflux of drugs from tumor cells ...
Targeting Microtubules by Natural Agents for Cancer Therapy
... inhibitory effects on cell proliferation primarily by blocking mitosis, which requires an intense control of microtubule dynamics. Therefore, their actions on microtubule stability and dynamic parameters differ from each other. At relatively high concentrations, MTAs either inhibit microtubule polym ...
... inhibitory effects on cell proliferation primarily by blocking mitosis, which requires an intense control of microtubule dynamics. Therefore, their actions on microtubule stability and dynamic parameters differ from each other. At relatively high concentrations, MTAs either inhibit microtubule polym ...
Diapositive 1
... Paclitaxel and docetaxel • Paclitaxel is currently regarded as one of the best new anticancer agents (1-5). The drug was approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced ovarian cancer in 1992 and breast cancer in 1994. Since the isolation of p ...
... Paclitaxel and docetaxel • Paclitaxel is currently regarded as one of the best new anticancer agents (1-5). The drug was approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced ovarian cancer in 1992 and breast cancer in 1994. Since the isolation of p ...
Albumin-Bound Paclitaxel
... albumin receptors present on tumor cells versus normal cells. Active moiety is paclitaxel, which is isolated from the bark of the Pacific yew tree, Taxus brevifolia . Cell cycle–specific, active in the mitosis (M) phase of the cell cycle. High-affinity binding to microtubules enhances tubulin polyme ...
... albumin receptors present on tumor cells versus normal cells. Active moiety is paclitaxel, which is isolated from the bark of the Pacific yew tree, Taxus brevifolia . Cell cycle–specific, active in the mitosis (M) phase of the cell cycle. High-affinity binding to microtubules enhances tubulin polyme ...
Now - Diazon Pharmaceuticals
... that exhibits potent anti-tumor activity in models of multiple cancer types. It is an anti-mitotic drug that has high safety margin and lacks neurotoxicity in rats at effective plasma levels. DZ-2384 binds the vinca domain of tubulin in a distinct way, imparting structurally and functionally differe ...
... that exhibits potent anti-tumor activity in models of multiple cancer types. It is an anti-mitotic drug that has high safety margin and lacks neurotoxicity in rats at effective plasma levels. DZ-2384 binds the vinca domain of tubulin in a distinct way, imparting structurally and functionally differe ...
D - Rci.rutgers.edu
... B) DNA synthesis begins immediately in the original G1 nucleus C) The two Nuclei Fuse and Further Division is Arrested D) The Chromosomes of the Original G1 Nucleus condense in preparation for mitosis E) The original G1 cell will divide immediately ...
... B) DNA synthesis begins immediately in the original G1 nucleus C) The two Nuclei Fuse and Further Division is Arrested D) The Chromosomes of the Original G1 Nucleus condense in preparation for mitosis E) The original G1 cell will divide immediately ...
Structure activity relationship (SAR) investigation on the binding
... of ligands to colchicine site of tubulin performed with leadIT software (version 2.1.0 BioSolveIT, GmbH, Germany) and the interaction energy of different compounds was obtained. Results: 60 compounds from 1600 similar structures to combretastatin had highest absolute interaction energies compared to ...
... of ligands to colchicine site of tubulin performed with leadIT software (version 2.1.0 BioSolveIT, GmbH, Germany) and the interaction energy of different compounds was obtained. Results: 60 compounds from 1600 similar structures to combretastatin had highest absolute interaction energies compared to ...
Interesting Facts 1. Cytoskeleton is involved in cell division cycle of
... 1. Cytoskeleton is involved in cell division cycle of mitosis and meiosis which can be visualized by confocal fluorescence micrograph. 2. Cytoskeleton in orientation of cell division in contact guided cells like Single human skin fibroblasts and the skin keratinocyte. 3. Microtubule dynamics can als ...
... 1. Cytoskeleton is involved in cell division cycle of mitosis and meiosis which can be visualized by confocal fluorescence micrograph. 2. Cytoskeleton in orientation of cell division in contact guided cells like Single human skin fibroblasts and the skin keratinocyte. 3. Microtubule dynamics can als ...