Download Interesting Facts 1. Cytoskeleton is involved in cell division cycle of

NPTEL – Biotechnology – Cell Biology
Interesting Facts
1. Cytoskeleton is involved in cell division cycle of mitosis and meiosis which can be
visualized by confocal fluorescence micrograph.
2. Cytoskeleton in orientation of cell division in contact guided cells like Single human
skin fibroblasts and the skin keratinocyte.
3. Microtubule dynamics can also be altered by drugs. For example, the taxane drug used
in the treatment of cancer, blocks dynamic instability by stabilizing GDP-bound tubulin
in the microtubule. Nocodazole and Colchicine have the opposite effect, blocking the
polymerization of tubulin into microtubules.
4. Neurodegenerative diseases like Alzheimer's disease, are associated with dysfunction
of cytoskeletal components that influence vesicular biogenesis, vesicle/organelle
trafficking and synaptic signaling.
Questions:
Q1. Do all cells possess cytoskeleton?
Q2. Where are microfilaments, microtubules and intermediate filaments located in a cell?
Q3. Differentiate among the structure and functions of microfilaments, microtubules and
intermediate filaments.
Q4. What are cytoplasmic microtrabecular system?
Q5. Write about the different types of microtubules.
Q6. Describe the prokaryotic cytoskeletal system.
Q7. Name the different proteins that make up intermediate filaments.
Joint initiative of IITs and IISc – Funded by MHRD
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