SCLEROTIUM ROLFSII AND ANTIFUNGAL ACTIVITY Research Article
... Antifungal activity and post antifungal effects The antifungal activity was based on minimal concentration of the drug (MIC) required to completely inhibit Candida spp. over a fixed period of time by standard broth dilution assays. Both C. albicans and C. glabrata isolates ...
... Antifungal activity and post antifungal effects The antifungal activity was based on minimal concentration of the drug (MIC) required to completely inhibit Candida spp. over a fixed period of time by standard broth dilution assays. Both C. albicans and C. glabrata isolates ...
A Warning on Gemcitabine Generics Used For
... except for oral drugs [3] concerning these drugs. In fact, ...
... except for oral drugs [3] concerning these drugs. In fact, ...
7 Antifungal therapy c h a P t e r
... speed with which the search for effective and safe antifungal agents was progressing.12,13 The introduction of oral griseofulvin and topical chlormidazole in 1958 and the subsequent introduction of IV AmB in 1960 heralded the beginning of the modern era of antifungal therapy.4 Unfortunately, after t ...
... speed with which the search for effective and safe antifungal agents was progressing.12,13 The introduction of oral griseofulvin and topical chlormidazole in 1958 and the subsequent introduction of IV AmB in 1960 heralded the beginning of the modern era of antifungal therapy.4 Unfortunately, after t ...
Selective Inhibitors of Picornavirus Replication
... Numerous studies have been performed in the past decades on a series of compounds developed by Sterling-Winthrop, commonly known as ‘‘WIN compounds.’’ Following lead optimization of an accidentally discovered compound, a drug was developed that would meet most of the criteria of a successful anti-pi ...
... Numerous studies have been performed in the past decades on a series of compounds developed by Sterling-Winthrop, commonly known as ‘‘WIN compounds.’’ Following lead optimization of an accidentally discovered compound, a drug was developed that would meet most of the criteria of a successful anti-pi ...
Doctoral Thesis
... extensively drug-resistant forms, their epidemiology and therapy. The development of new drugs against multidrug-resistant tuberculosis is largely discussed, including requirements for them, recent advances and present status of some perspective molecules in clinical and preclinical stages of the in ...
... extensively drug-resistant forms, their epidemiology and therapy. The development of new drugs against multidrug-resistant tuberculosis is largely discussed, including requirements for them, recent advances and present status of some perspective molecules in clinical and preclinical stages of the in ...
Modifying effects of boswellia carteri on clarithromycine action: In
... diseases such as Crohn’s disease and ulcerative colitis ...
... diseases such as Crohn’s disease and ulcerative colitis ...
EVALUATION OF ANTHELMINTIC ACTIVITY OF CAESALPINIA PULCHERRIMA (L). BARK Research Article
... inhibition of spontaneous motility (Paralysis) of earthworms. Albendazole(10mg/ml) is used as standard drug. Both the extracts were found to be more potent than albendazole. As compared to aqueous extract, hydroalcoholic extract took less time to cause paralysis & death of the earthworm. Thus the pr ...
... inhibition of spontaneous motility (Paralysis) of earthworms. Albendazole(10mg/ml) is used as standard drug. Both the extracts were found to be more potent than albendazole. As compared to aqueous extract, hydroalcoholic extract took less time to cause paralysis & death of the earthworm. Thus the pr ...
Inhibition of Purified Factor Xa Amidolytic Activity May Not Be
... anticoagulation therapy because it is at the intersection of the intrinsic and extrinsic coagulation pathways, and its selective inhibition is presumed to have a major anticoagulatory effect. The prothrombinase complex, of which fXa is the enzymatic component, is assembled on the surface of activate ...
... anticoagulation therapy because it is at the intersection of the intrinsic and extrinsic coagulation pathways, and its selective inhibition is presumed to have a major anticoagulatory effect. The prothrombinase complex, of which fXa is the enzymatic component, is assembled on the surface of activate ...
Binding of Imipramine to Phospholipid Bilayers Using
... The tendency to refer to the result of drug-lipid bilayer interaction as “binding” has been subject to discussion because of the general meaning of this term in the classic enzyme-substrate or ligand-receptor interaction studies (Heirwegh et al. 1992). Binding into a bilayer is considered a restrict ...
... The tendency to refer to the result of drug-lipid bilayer interaction as “binding” has been subject to discussion because of the general meaning of this term in the classic enzyme-substrate or ligand-receptor interaction studies (Heirwegh et al. 1992). Binding into a bilayer is considered a restrict ...
Impact of nanoparticle albumin-bound paclitaxel on microscopic
... by which it is possible to infuse higher doses of the drug than the standard dose used in the slandered paclitaxel therapy.10 Clinical studies have shown that nab-paclitaxel is significantly more effective than the standard solvent containing paclitaxel with almost double the response rate and incre ...
... by which it is possible to infuse higher doses of the drug than the standard dose used in the slandered paclitaxel therapy.10 Clinical studies have shown that nab-paclitaxel is significantly more effective than the standard solvent containing paclitaxel with almost double the response rate and incre ...
Role of Pharmacokinetics and Metabolism in Drug Discovery and
... pulmonary tuberculosis that had failed to show improvement after any therapy. Furthermore, both indomethacin and ibuprofen compounds were developed as antirheumatic agents even without any knowledge of their mode of action (Shen, 1972; Adams et al., 1969, 1970). The mode of action was established se ...
... pulmonary tuberculosis that had failed to show improvement after any therapy. Furthermore, both indomethacin and ibuprofen compounds were developed as antirheumatic agents even without any knowledge of their mode of action (Shen, 1972; Adams et al., 1969, 1970). The mode of action was established se ...
okf"kZd izfrosnu@Annual Report 2014-15
... the country's expectations and aspirations have continued. We are also making a conscious attempt to identify and overcome our weaknesses. The achievements of our faculty members and students, at national as well as international stages, provide us with impetus to continue with our work despite vari ...
... the country's expectations and aspirations have continued. We are also making a conscious attempt to identify and overcome our weaknesses. The achievements of our faculty members and students, at national as well as international stages, provide us with impetus to continue with our work despite vari ...
Ahead of print online version Moxidectin causes adult worm
... Forrester et al. 2002). Some reports also demonstrate the efficacy of MOX against those nematodes that did not respond to IVM (Craig et al. 1992, Coles et al. 1994), suggesting some differences in the mode of action of these two compounds. The proposed study has been planned to evaluate the in vitro ...
... Forrester et al. 2002). Some reports also demonstrate the efficacy of MOX against those nematodes that did not respond to IVM (Craig et al. 1992, Coles et al. 1994), suggesting some differences in the mode of action of these two compounds. The proposed study has been planned to evaluate the in vitro ...
Allosteric Binding Sites on Muscarinic Acetylcholine Receptors
... of this modulation differs among the individual receptor subtypes and depends on the choice of orthosteric and allosteric ligands and their concentrations (Ellis, 1997; Christopoulos, 2002; Mohr et al., 2003; Birdsall and Lazareno, 2005). The amino acids forming the binding site for orthosteric musc ...
... of this modulation differs among the individual receptor subtypes and depends on the choice of orthosteric and allosteric ligands and their concentrations (Ellis, 1997; Christopoulos, 2002; Mohr et al., 2003; Birdsall and Lazareno, 2005). The amino acids forming the binding site for orthosteric musc ...
Review. Current advances on ABC drug transporters in fish
... transporters controlling the transition of compounds across internal and external interfaces of ...
... transporters controlling the transition of compounds across internal and external interfaces of ...
Case Report - Thalidomide and hyperkalemia
... proliferation In some tumor types, such as RCC and certain lymphomas, mTOR as key role in tumor cell proliferation and angiogenesis Temsirolimus and everolimus are approved as monotherapy in advanced RCC ...
... proliferation In some tumor types, such as RCC and certain lymphomas, mTOR as key role in tumor cell proliferation and angiogenesis Temsirolimus and everolimus are approved as monotherapy in advanced RCC ...
The effects of bleomycin, mitomycin C, and in vitro in vivo
... Her thesis is entitled The effects of bleomycin, mitomycin C, and cytoskeletaldisrupting drugs on angiogenesis in vitro and haemangioma development in vivo. Haemangiomas are tumours of the vasculature commonly encountered in pediatrics. The treatment of these tumours has over the years remained unsa ...
... Her thesis is entitled The effects of bleomycin, mitomycin C, and cytoskeletaldisrupting drugs on angiogenesis in vitro and haemangioma development in vivo. Haemangiomas are tumours of the vasculature commonly encountered in pediatrics. The treatment of these tumours has over the years remained unsa ...
week5
... a) Determine the key contact residues involved in the binding and compare with mutagenesis data to validate the complex model. b) Calculate the potential of mean force for the ligand, determine the binding constant and free energy, and compare with experiments. ...
... a) Determine the key contact residues involved in the binding and compare with mutagenesis data to validate the complex model. b) Calculate the potential of mean force for the ligand, determine the binding constant and free energy, and compare with experiments. ...
Fragment-Based Discovery of the Pyrazol-4
... A in order to identify fragments. The effect of small molecule Aurora kinase inhibitors on cells has been well described in the literature.24-28 Typically, dual Aurora A/Aurora B inhibitors result in cellular phenotypes predominantly related to Aurora B inhibition. This is characterized by rapid inh ...
... A in order to identify fragments. The effect of small molecule Aurora kinase inhibitors on cells has been well described in the literature.24-28 Typically, dual Aurora A/Aurora B inhibitors result in cellular phenotypes predominantly related to Aurora B inhibition. This is characterized by rapid inh ...
Chemotherapy Counteracts Metastatic Dissemination Induced by
... data on the effect of antiangiogenesis in general, or antiVEGF therapy, on malignant progression are lacking and widely debated. With certain tumors, such as glioblastoma, there was an increase in the volume of infiltrative tumor after bevacizumab, or a switch to more infiltrating growth after cedir ...
... data on the effect of antiangiogenesis in general, or antiVEGF therapy, on malignant progression are lacking and widely debated. With certain tumors, such as glioblastoma, there was an increase in the volume of infiltrative tumor after bevacizumab, or a switch to more infiltrating growth after cedir ...
Macrocycles in new drug discovery
... may be associated with the production of second ary metabolites based upon these scaffolds [1,11] . There are different classes that macrocycles could fall into, including peptidic and nonpeptidic nat ural products, non-natural (synthetic) peptides and non-natural (synthetic) macroc ycles. This r ...
... may be associated with the production of second ary metabolites based upon these scaffolds [1,11] . There are different classes that macrocycles could fall into, including peptidic and nonpeptidic nat ural products, non-natural (synthetic) peptides and non-natural (synthetic) macroc ycles. This r ...
Liposome- A Versatile Drug Delivery System
... biodistribution of drugs in such a way that a greater fraction of the dose reaches the target site. Liposomes are micro-particulate or colloidal carriers, usually 0.05-5.0 /~m in diameter which form spontaneously when certain lipids are hydrated in aqueous media Liposomes are composed of relatively ...
... biodistribution of drugs in such a way that a greater fraction of the dose reaches the target site. Liposomes are micro-particulate or colloidal carriers, usually 0.05-5.0 /~m in diameter which form spontaneously when certain lipids are hydrated in aqueous media Liposomes are composed of relatively ...
DESIGNING OF POTENTIAL NEW ESTROGEN ANTAGONISTS FOR TREATMENT OF
... called endometriosis implants. These implants are most commonly found on the ovaries, the fallopian tubes, outer surfaces of the uterus or intestines, and on the surface lining of the pelvic cavity. They can also be found in the vagina, cervix, and bladder, although less commonly than other location ...
... called endometriosis implants. These implants are most commonly found on the ovaries, the fallopian tubes, outer surfaces of the uterus or intestines, and on the surface lining of the pelvic cavity. They can also be found in the vagina, cervix, and bladder, although less commonly than other location ...
Thiazide and Thiazide
... •is a thiazide like drug • It is primarily used to treat congestive hear failure and HTN • Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess flui ...
... •is a thiazide like drug • It is primarily used to treat congestive hear failure and HTN • Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess flui ...