COX-2 inhibitor
... The biosynthetic reactions are catalyzed by a enzyme complex commonly named Prostaglandin endoperoxide synthase which is located in the endoplasmic reticulum ...
... The biosynthetic reactions are catalyzed by a enzyme complex commonly named Prostaglandin endoperoxide synthase which is located in the endoplasmic reticulum ...
THEORETICAL STUDY ON PHYSICOCHEMICAL AND GEOMETRICAL PROPERTIES OF THE
... applied directly, it is without the tumor-targeting ability leading to poor bio-distribution and curative effects as well as critical unpleasant side effects. The scheme of Adriamycin is illustrated in Fig 1. ...
... applied directly, it is without the tumor-targeting ability leading to poor bio-distribution and curative effects as well as critical unpleasant side effects. The scheme of Adriamycin is illustrated in Fig 1. ...
a review on the pharmacology of embelia ribes burm.f.
... The plant world is a Pandora of active chemical compounds. Nearly half the medicines that we use today are of herbal origin, and a quarter contains plant extracts or active chemicals taken directly from plants. Though the new era has seen advances in chemistry, which have paved the way to reproduce ...
... The plant world is a Pandora of active chemical compounds. Nearly half the medicines that we use today are of herbal origin, and a quarter contains plant extracts or active chemicals taken directly from plants. Though the new era has seen advances in chemistry, which have paved the way to reproduce ...
Misc topic, Medicine and Drugs
... and precisely on the opiate receptor sites and interfere with the signal flowing through the nervous system. ...
... and precisely on the opiate receptor sites and interfere with the signal flowing through the nervous system. ...
MYRISTICA FRAGRANS NON-FILAMENTOUS Research Article
... Methanol with low viscosity has low density and high diffusibility and can easily diffuse into the pores of the plant material. Methanol was found to be the best extractant, showing high activity in both the fungal species 9. Furthermore, an interesting observation made during the course of the stud ...
... Methanol with low viscosity has low density and high diffusibility and can easily diffuse into the pores of the plant material. Methanol was found to be the best extractant, showing high activity in both the fungal species 9. Furthermore, an interesting observation made during the course of the stud ...
ACRIDINE: A VERSATILE HETEROCYCLIC NUCLEUS
... of 1-nitro-9-hydroxyethylaminoacridine (XXII) derivatives. The introduction of methyl group at C4 resulted in compounds which showed higher therapeutic efficacy and being developed as anticancer agent for solid tumors (44). ...
... of 1-nitro-9-hydroxyethylaminoacridine (XXII) derivatives. The introduction of methyl group at C4 resulted in compounds which showed higher therapeutic efficacy and being developed as anticancer agent for solid tumors (44). ...
ANTIBACTERIAL AND SYNERGISTIC ACTIVITY OF ETHANOLIC AJWAIN (TRACHYSPERMUM
... are rich in a wide variety of secondary metabolites like tannins, terpenoids and alkaloids that have been found to have antibacterial properties in vitro [11]. Herbal medicines have always been a rich source of drug discovery programs, and many plant derived compounds have shown promising activity a ...
... are rich in a wide variety of secondary metabolites like tannins, terpenoids and alkaloids that have been found to have antibacterial properties in vitro [11]. Herbal medicines have always been a rich source of drug discovery programs, and many plant derived compounds have shown promising activity a ...
Front Matter
... isolate pure vitamin B2. Wagner-Jauregg noticed that all extracts that proved active by this assay procedure exhibited an intense yellow–green fluorescence, the intensity of which was proportional to potency. When attempts were first made to isolate the fluorescent material, the growth-promoting act ...
... isolate pure vitamin B2. Wagner-Jauregg noticed that all extracts that proved active by this assay procedure exhibited an intense yellow–green fluorescence, the intensity of which was proportional to potency. When attempts were first made to isolate the fluorescent material, the growth-promoting act ...
On the specificity of antibiotics targeting the large ribosomal subunit
... CAM-1 binding site was observed in H50S structures solved with 20 mM CAM; however, a second binding site (CAM-2) was detected deeper within the tunnel, overlapping the binding position of the macrolide erythromycin (ERY) (Fig. 1E).9 Equilibrium dialysis studies reported two binding sites for CAM on ...
... CAM-1 binding site was observed in H50S structures solved with 20 mM CAM; however, a second binding site (CAM-2) was detected deeper within the tunnel, overlapping the binding position of the macrolide erythromycin (ERY) (Fig. 1E).9 Equilibrium dialysis studies reported two binding sites for CAM on ...
Carbonic Anhydrase Inhibitors and Activators: Small
... Cytosol Cytosol Membrane-bound Cytosol Cytosol Membrane-bound Unknown Membrane-bound ...
... Cytosol Cytosol Membrane-bound Cytosol Cytosol Membrane-bound Unknown Membrane-bound ...
NIOSH List of Hazardous Drugs - University of Kansas Medical Center
... antivirals, antibiotics, and bioengineered drugs interfere with cell growth or proliferation, or with DNA synthesis. In some cases, the nonselective actions of these drugs disrupt the growth and function of both healthy and diseased cells, resulting in toxic side effects for treated patients. These ...
... antivirals, antibiotics, and bioengineered drugs interfere with cell growth or proliferation, or with DNA synthesis. In some cases, the nonselective actions of these drugs disrupt the growth and function of both healthy and diseased cells, resulting in toxic side effects for treated patients. These ...
Impact of membrane transporters polymorphisms on nucleoside-derived drug bioavailability and action
... Some of these analogues including 5-fluorouracil, 5-azacytidine and other deoxyguanosine derivatives have a 3’-hydroxyl group which enables chain elongation after incorporation into DNA or RNA leading to a mismatching which can cause mutagenesis, resulting in reduced infectivity. Ribavirin has also ...
... Some of these analogues including 5-fluorouracil, 5-azacytidine and other deoxyguanosine derivatives have a 3’-hydroxyl group which enables chain elongation after incorporation into DNA or RNA leading to a mismatching which can cause mutagenesis, resulting in reduced infectivity. Ribavirin has also ...
Pharmacologyonline 3: 201-216 (2006) Kumarappan et al. CT
... Anti-inflammatory Drugs) are not useful in all cases, because of these side effects. As a result, a search for other alternatives seems necessary and beneficial. The study of plants that have been traditionally used for inflammation is still fruitful and logical research strategy in the source of ne ...
... Anti-inflammatory Drugs) are not useful in all cases, because of these side effects. As a result, a search for other alternatives seems necessary and beneficial. The study of plants that have been traditionally used for inflammation is still fruitful and logical research strategy in the source of ne ...
Hit discovery and hit-to-lead approaches
... a primary biological assay. However, it is crucial to establish that the observed signal is caused by a desirable mechanism. In the past decade, the significant experience gathered from multiple HTS campaigns has facilitated improvement and refinement of the process. Particle count measurements for ...
... a primary biological assay. However, it is crucial to establish that the observed signal is caused by a desirable mechanism. In the past decade, the significant experience gathered from multiple HTS campaigns has facilitated improvement and refinement of the process. Particle count measurements for ...
Antibiotic distribution into the CNS
... lipophilic molecules are often highly protein bound or bind to lipid membranes. Diffusion can also be pH dependent ...
... lipophilic molecules are often highly protein bound or bind to lipid membranes. Diffusion can also be pH dependent ...
Comparative pharmacognosy of Pashanbhed
... activity by binding with adenosine A1 receptor associated with the diuretic action.[23] Many reports have extensively shown that terpenoids exert significant cardiovascular effects.[24-26] It has also been reported that some classes of diterpenes showed significant systemic hypotensive and coronary ...
... activity by binding with adenosine A1 receptor associated with the diuretic action.[23] Many reports have extensively shown that terpenoids exert significant cardiovascular effects.[24-26] It has also been reported that some classes of diterpenes showed significant systemic hypotensive and coronary ...
Preventing Occupational Exposure to Antineoplastic and Other
... bioengineered drugs, and other miscellaneous drugs. The definition of hazardous drugs used in this Alert is based on an ASHP definition that was originally developed in 1990 [ASHP 1990]. Thus the definition may not accurately reflect the toxicity criteria associated with the newer generation of phar ...
... bioengineered drugs, and other miscellaneous drugs. The definition of hazardous drugs used in this Alert is based on an ASHP definition that was originally developed in 1990 [ASHP 1990]. Thus the definition may not accurately reflect the toxicity criteria associated with the newer generation of phar ...
Alkaloids are
... •Are esters of hydroxytropanes and various acids (tropic, tiglic) -Tropane moiety is formed from ornithine -Acid moiety from Phenylalanine. •Plant family contains tropane alkaloids are Solanaceae •Alkaloids found in roots and leaves mainly. •Vary with age, length and light intensity. •Belladonna and ...
... •Are esters of hydroxytropanes and various acids (tropic, tiglic) -Tropane moiety is formed from ornithine -Acid moiety from Phenylalanine. •Plant family contains tropane alkaloids are Solanaceae •Alkaloids found in roots and leaves mainly. •Vary with age, length and light intensity. •Belladonna and ...
PerspectiVe
... drug discovery,9,51,53 but it is being adopted more generally by the medicinal chemistry community. The use of LE helps to reduce the seductive influence of increased potency after each iteration of compound design and serves to remind the chemist that consideration of the physicochemical properties ...
... drug discovery,9,51,53 but it is being adopted more generally by the medicinal chemistry community. The use of LE helps to reduce the seductive influence of increased potency after each iteration of compound design and serves to remind the chemist that consideration of the physicochemical properties ...
4-aminoquinolines as Antimalarial Drugs
... ,2001). As no effective malarial vaccines are yet available, health services rely on drugs for treatment and prophylaxis, however efficacy of antimalarial compounds has plummeted due to emerging Plasmodium resistance towards many different drug classes including first-line treatments such as chloroq ...
... ,2001). As no effective malarial vaccines are yet available, health services rely on drugs for treatment and prophylaxis, however efficacy of antimalarial compounds has plummeted due to emerging Plasmodium resistance towards many different drug classes including first-line treatments such as chloroq ...
Patrick chapter 19 part 2
... 1. Briefly describe the differences between the sympathetic and parasympathetic divisions of the autonomic nervous system, including the neurotransmitter used at the respective neuromuscular junctions. 2. Cholinergic receptors are divided into nicotinic and muscarinic classes. How are these receptor ...
... 1. Briefly describe the differences between the sympathetic and parasympathetic divisions of the autonomic nervous system, including the neurotransmitter used at the respective neuromuscular junctions. 2. Cholinergic receptors are divided into nicotinic and muscarinic classes. How are these receptor ...
FSC402H Forensic Toxicology of Common Pharmaceuticals
... Often information on dose, not plasma (blood) concentration is available No means through law to obtain a blood sample from an individual – seized hospital samples from motor vehicle collisions ...
... Often information on dose, not plasma (blood) concentration is available No means through law to obtain a blood sample from an individual – seized hospital samples from motor vehicle collisions ...
Ligand Residence Time at G-protein–Coupled Receptors—Why We
... acquired. In addition, nonhomogeneity of this assay system complicates the interpretation of the results obtained. Further problems might arise if the radiolabeled ligand cannot easily be removed during the assay. In these cases the phenomenon of rebinding can occur, and this can complicate the dete ...
... acquired. In addition, nonhomogeneity of this assay system complicates the interpretation of the results obtained. Further problems might arise if the radiolabeled ligand cannot easily be removed during the assay. In these cases the phenomenon of rebinding can occur, and this can complicate the dete ...
O R I G I N A L A R T I C L E
... found various. Conclusions: It was concluded that MAO activity is acutely affected by pharmacologically different antidepressants at relatively high drug concentrations; this effect is inhibitory. There are differences both in inhibitory potency and in mechanism of inhibition between both several dr ...
... found various. Conclusions: It was concluded that MAO activity is acutely affected by pharmacologically different antidepressants at relatively high drug concentrations; this effect is inhibitory. There are differences both in inhibitory potency and in mechanism of inhibition between both several dr ...