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Immunology. Understanding The Immune System. 2nd Edition
Description:
Immunology: Understanding the Immune System, Second Edition has been thoughtfully and meticulously
updated to incorporate the many developments that have occurred in the field since publication of the
previous edition. In addition to the consolidation, reconstruction, and revision of key material, features
completely new to this edition include: three new chapters on innate immunity, immunodeficiencies, and
immunity to microbes; more than fifty new figures; coverage of the latest knowledge on signaling pathways,
lymphocyte trafficking, mucosal immunity, molecular mechanisms of receptor diversity, the T–lymphocyte
immunological synapse, B–lymphocyte subsets, dendritic cell–driving of CD–4
+ T–cell subset activities, biology of the CD–4
+ T–cell TH17 subset and regulatory T–cell, cross–presentation, mechanisms of tolerance induction,
immunoediting and tumor camouflage and the connection between inflammation and cancer development,
immunogenetics of primary immunodeficiencies and the immunology of HIV infections and AIDS, and
vaccines; and more all immersed in full–color artwork, design, and user–friendly text.
This Second Edition provides a completely up–to–date introduction to immunology through its careful
investigation of:
Cells and organs of the human system
Innate immunity
Antigens and antibodies
Antigen–antibody interactions and some experimental systems
Genetics of antibody formation and structure
The major histocompatibility complex and development of immunity
T–cell receptor complex
Cytokines
Cellular interactions
Hypersensitivities
Immunologic tolerance and autoimmunity
Transplantation immunology
Tumor immunology
Immunodeficiencies
Immunity to microbes
Successfully blending biology, clinical science, genetics, and molecular biology, this book represents a
complete account of our knowledge of immunology. It is complemented with a number of pedagogical aids
that assist readers in the learning process, including chapter outlines, objectives, mini–summaries that
provide "mental breathers" within the chapter to reassess the material just covered, full–chapter summaries,
figures, and a self–evaluation section. The book ends with anextensive glossary and an appendix. It serves as
an excellent textbook for courses in the life and medical sciences at the upper–undergraduate and graduate
levels and as a reference for practicing scientists and clinical researchers.
Contents:
Preface.
Note to Reader.
1. Introduction to the Immune System.
2. Cells and Organs of the Immune System.
3. Innate Immunity.
4. Antigens and Antibodies.
5. Antigen–Antibody Interactions and Some Experimental Systems.
6. The Genetics of Antibody Formation and Structure.
7. The Major Histocompatibility Complex and Development of Immunity.
8. The T–Cell Receptor Complex: Characterization, Diversification, Costimulatory Molecules, Thymic
Selection, and T–Cell Activation.
9. Cytokines.
10. Cellular Interactions: Development of Effector Functions and Their Regulation.
11. Complement.
12. Hypersensitivities.
13. Immunologic Tolerance and Autoimmunity.
14. Transplantation Immunology.
15. Tumor Immunology.
16. Immunodeficiencies.
17. Immunity to Microbes.
Glossary of Commonly Used Immunologic Terms.
Appendix: Human Cluster of Differentiation (CD) Molecules.
Index.
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