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IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
Uma iniciativa conjunta entre a Sociedade Latino
Americana de Interação Materno Fetal&Placenta
(SLIMP), Placenta Associações das Américas (PAA)e os
Cursos de Pós Graduação em Biologia Celular e Tecidual
(ICB-USP) e Obstetrícia e Ginecologia (FM-USP),
Tocoginecologia (UNICAMP), Obstetrícia (UNIFESP),
Ginecologia, Obstetrícia e Mastologia(UNESP)
Local: O workshop será realizado no Instituto de Ciências Biomédicas da Universidade de São Paulo de
6 a 11 de Abril de 2015.
Instituto de Ciências Biomédicas
AvProf Lineu Prestes, 1524, São Paulo - SP
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
IV Workshop on “Starting from the Beginning: Morphological Development of the Placenta”
Este é o 4º Workshopde uma série de eventos que ocorre desde 2006 e que tem como objetivo o
estudo prático da interface materno-fetal em suas várias possibilidades em um contexto
inter/multidisciplinar, onde os aspectos fundamentais, conceitos, noções e patologias associadas
possam ser discutidos para embasar novas idéias e resultados.
Público alvo
Potenciais candidatos são pesquisadores da área clínica ou básica com interesse nos problemas
gestacionais associados à interação materno-fetal: Estudantes de graduação e pós-graduação,
residentes, jovens investigadores e profissionais da saúde. O Workshop terá 44 horas de duração.
Pós-Graduandos. O workshop poderá valer créditos para cursos de pós-graduação. Para isso, o
estudante deve se matricular na seguinte disciplina de pós-graduação: BMH-5771 Seminários em
Biologia da Interação Materno Fetal – informações e inscrições diretamente com a Sra.
Regina Valbom (Secretaria do Programa dePós-Graduação em BiologiaCelular e Tecidual - ICB/USP,
tel. 3091-7306/7220).
Sobre o Workshop
O Workshop abordará aspectos teóricos relevantes das patologias gestacionais, abordagem clínica e
fisiopatogenética sob a luz das recentes análises científicas e suas publicações. Do ponto de vista
prático, esta iniciativa irá trabalhar junto aos participantes a análise morfológica, celular, imunológica
e funcional da placenta humana através de métodos relevantes e discussões sobre os principais
problemas gestacionais de modo a estabelecer um link entre a Clínica Obstétrica e a Pesquisa Básica.
Língua oficial do evento: O curso será ministrado em Português e em Inglês.
Informações e inscrições– [email protected] (11-3091-8050 - Estela Bevilacqua)
Comissão Organizadora
Estela Bevilacqua, Rossana Pulcinelli Vieira Francisco, Mara Sandra Hoshida, Silvia Daher
Débora Damasceno, Iracema Calderon, Marilza Rudge, Ricardo Barini
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
Datas importantes
09/02 – 09/03
Pré-inscrição (email)
20/03
Resultado da seleção de candidatos(se necessário)
20-30/03
Confirmação de inscrição dos candidatos
06 a 11/04
Workshop
Certificado
Certificado será emitido no final do Workshop para os participantes que tiverem 100% de freqüência.
Inscrições
A inscrição é obrigatória e deve ser realizada tanto para as atividades teóricas quanto para as práticas
do Workshop (teórica e prática). Não haverá cobrança de taxas aos participantes. As atividades desse
Workshop poderão valer créditos na pós-graduação, procurar informações junto a ficha de Inscrição.
Vagas
As apresentações teóricas do workshop são abertas a comunidade científica em geral (máximo de
120 vagas). Para as atividades práticas o número máximo de participantes é de 40 alunos. Se
necessário, será obedecida a ordem de inscrição para preenchimento das vagas e a possibilidade de
contemplar participantes de diferentes grupos de pesquisa na área.
Critérios para seleção dos candidatos para a parte prática do Workshop
Os candidatos serão selecionados pela comissão organizadoraa fim de contemplar pelo menos 1
candidato por grupo de pesquisa, considerando-se também o foco principal da pesquisa do
candidato. Candidatos em condiçõessemelhantes poderão ser selecionados de acordo com a ordem
de inscrição.
Pré-requisito
Ser apto a entender e ser entendido em inglês
Disponibilidade para participar do evento inteiro
Breve Justificativa mencionando a área de trabalho do candidato e o porquê de seu interesse
específico nas atividades práticas do Workshop (EXCLUSIVAMENTE para as atividades práticas do
workshop) + Ficha de inscrição
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
CONVIDADOS INTERNACIONAIS
B. Anne Croy, DVM, PhD
Professor – Department of Biomedical and Molecular Sciences
Queen`s University – Kingston, Ontario - Canada
Prof. Croy's research evaluates the functions, mechanisms of activation and lineage
relationships of immune competent cell populations that home to the maternal-fetal
interface during mammalian pregnancy. Her group is especially interested in uterine
Natural Killer lymphocyte, a mobile cell population that appears to promote changes to
maternal arteries supplying the developing placenta. Prof. Croy conducts investigations
using mice and women and creates custom models involving adoptive transfer of
lymphocytes, blastocysts and/or fetal trophoblast to immune deficient mice to advance
basic understanding of this complex interface. The role of immune cells in maternal hemodynamic changes over
pregnancy and in programming of the fetal cardiovascular system in normal and diabetic pregnancies is included in
her Research Group assessment. Mouse ultrasound and radio telemetric studies are conducted to complement
immune and genetic approaches. The goals of her studies are to promote improved fetal and maternal health.
John Aplin, PhD
Maternal and Fetal Health Research Group
The University of Manchester, Manchester, UK
Dr Aplin research group investigates the molecular and cellular mechanisms of embryo
implantation and placental development, and the implications for disease and treatment
of infertility and disorders of pregnancy. The work bridges the clinical disciplines of
reproductive medicine, obstetrics and maternal and fetal health. The group is embedded
in the collaborative environment of the Maternal and Fetal Health Research Centre. The Centre, with funding from
Tommy’s: The baby Charity is using molecular, cellular, systems biology and integrative approaches for
investigating aspects of pregnancy disease, including abnormalities in the way the placenta forms, grows, invades
the uterine wall and develops a vascular system in early pregnancy to provide for the demands of the growing
fetus. Our research is founded on appreciation of the importance of the very earliest events in pregnancy for later
health in the fetus, child and adult. He is a founder member of the Faculty of 1000, in the Reproductive
Endocrinology and Infertility Section of the Diabetes and Endocrinology Faculty: f1000.com
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
Shawn P. Murphy, Ph.D.
University of Rochester Medical Center, Rochester, USA
School of Medicine and Dentistry
One of the long term goals of his research is to determine why the maternal immune
system does not reject the genetically disparate fetus during pregnancy. His studies
are focused primarily on the immunoregulatory properties of trophoblast cells, which
are the first cells to differentiate from the embryo, and ultimately form the fetal
component of the placenta. Trophoblast cells are the only cells derived from the
blastocyst that are in direct contact with maternal blood, and therefore play an
essential role in protecting the fetus from attack from the maternal immune system.
Trophoblast cells are relatively unique in that they do not express major
histocompatibility complex (MHC) class II antigens, either constitutively, or after exposure to IFN-gamma. The
absence of MHC class II antigen expression on trophoblast cells is thought to be critical for prevention of
deleterious maternal immune responses against the fetus. Thus, successful reproduction of mammals may require
that MHC class II gene expression be stringently repressed in trophoblast cells. His previous studies have
demonstrated that the inability of human and rodent trophoblast cells to transcribe MHC class II genes following
IFN-gamma treatment results from silencing of expression of the class II transactivator (CIITA), a transacting
transcription factor essential for constitutive and IFN-gamma-inducible transcription in other cell types. He has
therefore been investigating the molecular mechanisms underlying transcriptional silencing of CIITA in trophoblast
cells.
James Cross, DVM, PhD
Faculty of Veterinary Medicine, University of Calgary, Alberta, Canada
Dr. Cross is an expert in animal reproduction and molecular genetics, particularly in
the areas of embryo implantation, placentation and pregnancy outcome. He was
founding Director of the Alberta Children’s Hospital Research Institute of Child &
Maternal Health, a multi-disciplinary institute focused on biomedical, clinical and
social aspects of child health, and initiated the Training Program in Genetics, Child
Development & Health and the Clara Christie Centre for Genomics & Modeling of
Human Disease. He is a Fellow of the Canadian Academy of Health Sciences. Major
awards include a Premier’s Research Excellence Award of Ontario in 1999, Investigator of the Canadian Institutes of
Health Research in 2001, Research Scientist of the Year Award from the Association of Professors of Obstetrics
&Gynecology in 2005, and Pioneer Award from the Frontiers in Reproduction Program at the Marine Biology
Laboratory, USA in 2009.
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
Marijke M Faas, MD
Department of Pathology and Medical Biology
Universitair Medisch Centrum Groningen, Groningen, Netherlands
Her research line focusses on Pregnancy immunology; how does pregnancy influence
the immune response and how does the immune response influence pregnancy. The
acceptance of the semiallogeneic fetus depends on the adaptations in the maternal
immune response to pregnancy. Adaptations in the maternal immune response
involve a shift from the cellular immune response towards a humoral immune
response, an increase in regulatory T cells and a generalized activated innate immune response. Maladaptation of
the maternal immune response to pregnancy usually results in pregnancy-complications, such as preeclampsia or
fetal growth restriction. In the immune endocrinology section she study how the maternal immune response
adapts to pregnancy and which pregnancy factors induce these adaptations in both human and animal models.
Many factors may be involved, such as hormones and other factors produced by the placenta or the ovaries.
Moreover, she also studies how maladaptations of the immune response or activation of the immune response
influences pregnancies and induce pregnancy complications such as preeclampsia. Since reproductive hormones,
such as oestrogen and progesterone have been shown to be important in the regulation of the immune response
during pregnancy, it is also important to study the effect of these hormones on the immune response in various
reproductive conditions, apart from pregnancy. Therefore she also focuses on the effect of the reproductive
condition on immune response.
Matthew Ratsep
PhD Student, Department of Biomedical and Molecular Sciences
Queen`s University – Kingston, Ontario - Canada
My research is related to placental growth factor. Basically, there’s a protein that is
produced by the placenta which is thought to regulate growth and blood vessel formation. My research project’s
goal was to investigate as to what happens when you knock that factor out of a mouse and genetically delete it.
The aim was to discover what happens to women during pregnancy. Matthew has garnered four first-place
Meetings Awards, including IPFA meetings and SLIMP.
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
PROGRAMA PRELIMINAR
06/04/2015
9h00 Abertura
9h30-10h30
A interface maternal fetal: um olhar morfológico e funcional
Estela Bevilacqua
Instituto de Ciências Biomédicas da Universidade de São Paulo, USP, SP
A interface maternal fetal: um olhar clínico
Rossana PV Francisco
Faculdade de Medicina da Universidade de São Paulo, USP, SP
11h00-12h00
Hipertensão e patologias gestacionais associadas
Rossana Pulcineli V. Francisco
Faculdade de Medicina da Universidade de São Paulo, USP, SP
14h00-15h00
Hiperglicemia na gestação
Iracema Calderon
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio Mesquita
Filho, UNESP,Botucatu
15h00-16h0
Modelos experimentais para o estudo da hiperglicemia gestacional
Debora Damasceno
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio Mesquita
Filho, UNESP,Botucatu
16h30-17h30
Modelos experimentais para o estudo da diabete tipo I
Telma Zorn
Instituto de Ciências Biomédicas da Universidade de São Paulo, USP, SP
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
07/04/2015
9h00-9h45
Fatores de risco associados a abortos recorrentes
Ricardo Barini
Faculdade de Ciências Médicas, Universidade Estadual de Campinas, UNICAMP,
Campinas
9h45-10h30
Aspectos imunológicos da gestação normal e patológica
Silvia Daher
Escola Paulista de Medicina, Universidade Federal de São Paulo, UNIFESP, SP
11h00-12h00
Experimental models in preeclampsia
Marijke M Faas
UniversitairMedisch Centrum Groningen, Groningen, Netherlands
14h00-16h00*
Apresentação e Discussão de Projetos dos Participantes (exclusivo para participantes da
parte prática do Workshop)
16h30-17h30*
Morphology of the maternal-fetal interface
John Aplin
Manchester University, Manchester, UK
08/04/2015
8h30-9h30*
Morphological analyses of the human placenta
9h30-10h30
Placental vascular changes in pathological conditions
John Aplin
Manchester University, Manchester, UK
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
11h00-12h00
Morphological and phenotypic analyses of the human placenta using whole mount
immunofluorescence
Shawn Murphy
Rochester University, Rochester, USA
14h00-16h00*
Morphology of the maternal-fetal interface
John Aplin
Manchester University, Manchester, UK
16h30-18h00*
Morphology of the maternal-fetal interface
John Aplin
Manchester University, Manchester, UK
09/04/2015
8h30-9h30*
Morphological analyses of the human placenta
9h30-10h30
Immunological factors associated with cardiovascular adaptation to pregnancy
Anne Croy
Queen's University, Kingston, Canada
11h00-12h00
The impact of placental growth factor deficiency on early mouse implant site
angiogenesis
Matthew T Rätsep
Queen's University, Kingston, Canada
14h00-16h00*
Morphology of the maternal-fetal interface
John Aplin
Manchester University, Manchester, UK
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
16h30 – 18h00*
Morphological analyses of the human placenta using whole mount immunofluorescence
Shawn Murphy
Rochester University, Rochester, USA
10/04/2015
8h30-9h30*
Morphological analyses of the human placenta
9h30-10h30
Three-dimensional cultures of trophoblast stem cells
James Cross
Calgary University, Alberta, Canada
11h00-12h00
In situ hybridization and placental differenciation
James Cross
Calgary University, Alberta, Canada
14h30 – 16h00*
Morphological analyses of the human placenta using whole mount immunofluorescence
Shawn Murphy
Rochester University, Rochester, USA
16h30 – 18h00*
Microscopic examination of the samples
Shawn Murphy
Rochester University, Rochester, USA
11/04/2015
9h30 – 10h30*
Microscopic examination of the samples
Shawn Murphy
Rochester University, Rochester, USA
11h00-12h00*
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
Discussion of the results and closing remarks
All participants and speakers
9h00
9h15
April 6th
April 7th
April 8th
April 9th
April 10th
April 11st
Monday
Twesday
Wednesday
Thursday
Friday
Saturday
Opening
Ricardo Barini
Gestational
Immunoregulation
10h15
The Maternal
Fetal Interface
Estela
Bevilacqua
Rossana
Francisco
10h30
Coffee
9h30
9h45
10h00
11h00
11h30
Rossana
Francisco
Hypertension
and Placental
Disorders
John Aplin
Placental
vascular
network
Anne Croy
Immunological
Gestational
Factors
James Cross
3DCultures and
Placental Studies
Coffee
Coffee
Coffee
Coffee
Coffee
Marijke Faas
Experimental
Model for
Preeclampsia
Studies
Shawn
Murphy
Whole
Mount
Immuno
fluorescence
Matthew
Rätsep
Implantation
Site
Angiogenesis
James Cross In situ
Hybridization
Concluding Remarks
(all speakers and
participants)
Silvia Daher
Gestational
Immunoregulation
12h00
14h00
14h30
Closing
Iracema
Calderon
Gestational
Hyperglycemia
Presentations of
the participants'
projects (all
speakers and
participants)
15h30
Debora
Damasceno
Experimental
Models
16h00
Coffee
Coffee
Telma Zorn
Experimental
Models
John Aplin
Placental
Morphology
15h00
16h30
17h00
17h30
Shawn Murphy
Microscopic
examination of the
samples
John Aplin
Placental
Morphology
John Aplin
Placental
Morphology
Shawn Murphy
Whole Mount
Immuno
fluorescence
Coffee
Coffee
Coffee
John Aplin
Placental
Morphology
Shawn Murphy
Whole Mount
Immuno
fluorescence
Shawn Murphy
Microscopic
examination of the
samples
18h00
Apoio Logístico Institucional
IV Workshop on Maternal Fetal
Interaction“Starting from the Beginning:
Morphological Development of the Placenta”
Instituto de Ciências Biomédicas - Universidade de São Paulo
6 a 11 de abril de 2015
Preparação e divulgação do evento, captação de Inscrições, preparação dos certificados,
cessão de material para a realização das aulas práticas, mídia e salas de aulas e de
microscopia.
ApoioFinanceiro solicitado a
Apoio das Sociedades Científicas: divulgação internacional
PAA – Placenta Associations of the Americas/ SLIMP – Latin American Society for
Maternal Fetal Interaction and Placenta