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IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 Uma iniciativa conjunta entre a Sociedade Latino Americana de Interação Materno Fetal&Placenta (SLIMP), Placenta Associações das Américas (PAA)e os Cursos de Pós Graduação em Biologia Celular e Tecidual (ICB-USP) e Obstetrícia e Ginecologia (FM-USP), Tocoginecologia (UNICAMP), Obstetrícia (UNIFESP), Ginecologia, Obstetrícia e Mastologia(UNESP) Local: O workshop será realizado no Instituto de Ciências Biomédicas da Universidade de São Paulo de 6 a 11 de Abril de 2015. Instituto de Ciências Biomédicas AvProf Lineu Prestes, 1524, São Paulo - SP IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 IV Workshop on “Starting from the Beginning: Morphological Development of the Placenta” Este é o 4º Workshopde uma série de eventos que ocorre desde 2006 e que tem como objetivo o estudo prático da interface materno-fetal em suas várias possibilidades em um contexto inter/multidisciplinar, onde os aspectos fundamentais, conceitos, noções e patologias associadas possam ser discutidos para embasar novas idéias e resultados. Público alvo Potenciais candidatos são pesquisadores da área clínica ou básica com interesse nos problemas gestacionais associados à interação materno-fetal: Estudantes de graduação e pós-graduação, residentes, jovens investigadores e profissionais da saúde. O Workshop terá 44 horas de duração. Pós-Graduandos. O workshop poderá valer créditos para cursos de pós-graduação. Para isso, o estudante deve se matricular na seguinte disciplina de pós-graduação: BMH-5771 Seminários em Biologia da Interação Materno Fetal – informações e inscrições diretamente com a Sra. Regina Valbom (Secretaria do Programa dePós-Graduação em BiologiaCelular e Tecidual - ICB/USP, tel. 3091-7306/7220). Sobre o Workshop O Workshop abordará aspectos teóricos relevantes das patologias gestacionais, abordagem clínica e fisiopatogenética sob a luz das recentes análises científicas e suas publicações. Do ponto de vista prático, esta iniciativa irá trabalhar junto aos participantes a análise morfológica, celular, imunológica e funcional da placenta humana através de métodos relevantes e discussões sobre os principais problemas gestacionais de modo a estabelecer um link entre a Clínica Obstétrica e a Pesquisa Básica. Língua oficial do evento: O curso será ministrado em Português e em Inglês. Informações e inscrições– [email protected] (11-3091-8050 - Estela Bevilacqua) Comissão Organizadora Estela Bevilacqua, Rossana Pulcinelli Vieira Francisco, Mara Sandra Hoshida, Silvia Daher Débora Damasceno, Iracema Calderon, Marilza Rudge, Ricardo Barini IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 Datas importantes 09/02 – 09/03 Pré-inscrição (email) 20/03 Resultado da seleção de candidatos(se necessário) 20-30/03 Confirmação de inscrição dos candidatos 06 a 11/04 Workshop Certificado Certificado será emitido no final do Workshop para os participantes que tiverem 100% de freqüência. Inscrições A inscrição é obrigatória e deve ser realizada tanto para as atividades teóricas quanto para as práticas do Workshop (teórica e prática). Não haverá cobrança de taxas aos participantes. As atividades desse Workshop poderão valer créditos na pós-graduação, procurar informações junto a ficha de Inscrição. Vagas As apresentações teóricas do workshop são abertas a comunidade científica em geral (máximo de 120 vagas). Para as atividades práticas o número máximo de participantes é de 40 alunos. Se necessário, será obedecida a ordem de inscrição para preenchimento das vagas e a possibilidade de contemplar participantes de diferentes grupos de pesquisa na área. Critérios para seleção dos candidatos para a parte prática do Workshop Os candidatos serão selecionados pela comissão organizadoraa fim de contemplar pelo menos 1 candidato por grupo de pesquisa, considerando-se também o foco principal da pesquisa do candidato. Candidatos em condiçõessemelhantes poderão ser selecionados de acordo com a ordem de inscrição. Pré-requisito Ser apto a entender e ser entendido em inglês Disponibilidade para participar do evento inteiro Breve Justificativa mencionando a área de trabalho do candidato e o porquê de seu interesse específico nas atividades práticas do Workshop (EXCLUSIVAMENTE para as atividades práticas do workshop) + Ficha de inscrição IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 CONVIDADOS INTERNACIONAIS B. Anne Croy, DVM, PhD Professor – Department of Biomedical and Molecular Sciences Queen`s University – Kingston, Ontario - Canada Prof. Croy's research evaluates the functions, mechanisms of activation and lineage relationships of immune competent cell populations that home to the maternal-fetal interface during mammalian pregnancy. Her group is especially interested in uterine Natural Killer lymphocyte, a mobile cell population that appears to promote changes to maternal arteries supplying the developing placenta. Prof. Croy conducts investigations using mice and women and creates custom models involving adoptive transfer of lymphocytes, blastocysts and/or fetal trophoblast to immune deficient mice to advance basic understanding of this complex interface. The role of immune cells in maternal hemodynamic changes over pregnancy and in programming of the fetal cardiovascular system in normal and diabetic pregnancies is included in her Research Group assessment. Mouse ultrasound and radio telemetric studies are conducted to complement immune and genetic approaches. The goals of her studies are to promote improved fetal and maternal health. John Aplin, PhD Maternal and Fetal Health Research Group The University of Manchester, Manchester, UK Dr Aplin research group investigates the molecular and cellular mechanisms of embryo implantation and placental development, and the implications for disease and treatment of infertility and disorders of pregnancy. The work bridges the clinical disciplines of reproductive medicine, obstetrics and maternal and fetal health. The group is embedded in the collaborative environment of the Maternal and Fetal Health Research Centre. The Centre, with funding from Tommy’s: The baby Charity is using molecular, cellular, systems biology and integrative approaches for investigating aspects of pregnancy disease, including abnormalities in the way the placenta forms, grows, invades the uterine wall and develops a vascular system in early pregnancy to provide for the demands of the growing fetus. Our research is founded on appreciation of the importance of the very earliest events in pregnancy for later health in the fetus, child and adult. He is a founder member of the Faculty of 1000, in the Reproductive Endocrinology and Infertility Section of the Diabetes and Endocrinology Faculty: f1000.com IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 Shawn P. Murphy, Ph.D. University of Rochester Medical Center, Rochester, USA School of Medicine and Dentistry One of the long term goals of his research is to determine why the maternal immune system does not reject the genetically disparate fetus during pregnancy. His studies are focused primarily on the immunoregulatory properties of trophoblast cells, which are the first cells to differentiate from the embryo, and ultimately form the fetal component of the placenta. Trophoblast cells are the only cells derived from the blastocyst that are in direct contact with maternal blood, and therefore play an essential role in protecting the fetus from attack from the maternal immune system. Trophoblast cells are relatively unique in that they do not express major histocompatibility complex (MHC) class II antigens, either constitutively, or after exposure to IFN-gamma. The absence of MHC class II antigen expression on trophoblast cells is thought to be critical for prevention of deleterious maternal immune responses against the fetus. Thus, successful reproduction of mammals may require that MHC class II gene expression be stringently repressed in trophoblast cells. His previous studies have demonstrated that the inability of human and rodent trophoblast cells to transcribe MHC class II genes following IFN-gamma treatment results from silencing of expression of the class II transactivator (CIITA), a transacting transcription factor essential for constitutive and IFN-gamma-inducible transcription in other cell types. He has therefore been investigating the molecular mechanisms underlying transcriptional silencing of CIITA in trophoblast cells. James Cross, DVM, PhD Faculty of Veterinary Medicine, University of Calgary, Alberta, Canada Dr. Cross is an expert in animal reproduction and molecular genetics, particularly in the areas of embryo implantation, placentation and pregnancy outcome. He was founding Director of the Alberta Children’s Hospital Research Institute of Child & Maternal Health, a multi-disciplinary institute focused on biomedical, clinical and social aspects of child health, and initiated the Training Program in Genetics, Child Development & Health and the Clara Christie Centre for Genomics & Modeling of Human Disease. He is a Fellow of the Canadian Academy of Health Sciences. Major awards include a Premier’s Research Excellence Award of Ontario in 1999, Investigator of the Canadian Institutes of Health Research in 2001, Research Scientist of the Year Award from the Association of Professors of Obstetrics &Gynecology in 2005, and Pioneer Award from the Frontiers in Reproduction Program at the Marine Biology Laboratory, USA in 2009. IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 Marijke M Faas, MD Department of Pathology and Medical Biology Universitair Medisch Centrum Groningen, Groningen, Netherlands Her research line focusses on Pregnancy immunology; how does pregnancy influence the immune response and how does the immune response influence pregnancy. The acceptance of the semiallogeneic fetus depends on the adaptations in the maternal immune response to pregnancy. Adaptations in the maternal immune response involve a shift from the cellular immune response towards a humoral immune response, an increase in regulatory T cells and a generalized activated innate immune response. Maladaptation of the maternal immune response to pregnancy usually results in pregnancy-complications, such as preeclampsia or fetal growth restriction. In the immune endocrinology section she study how the maternal immune response adapts to pregnancy and which pregnancy factors induce these adaptations in both human and animal models. Many factors may be involved, such as hormones and other factors produced by the placenta or the ovaries. Moreover, she also studies how maladaptations of the immune response or activation of the immune response influences pregnancies and induce pregnancy complications such as preeclampsia. Since reproductive hormones, such as oestrogen and progesterone have been shown to be important in the regulation of the immune response during pregnancy, it is also important to study the effect of these hormones on the immune response in various reproductive conditions, apart from pregnancy. Therefore she also focuses on the effect of the reproductive condition on immune response. Matthew Ratsep PhD Student, Department of Biomedical and Molecular Sciences Queen`s University – Kingston, Ontario - Canada My research is related to placental growth factor. Basically, there’s a protein that is produced by the placenta which is thought to regulate growth and blood vessel formation. My research project’s goal was to investigate as to what happens when you knock that factor out of a mouse and genetically delete it. The aim was to discover what happens to women during pregnancy. Matthew has garnered four first-place Meetings Awards, including IPFA meetings and SLIMP. IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 PROGRAMA PRELIMINAR 06/04/2015 9h00 Abertura 9h30-10h30 A interface maternal fetal: um olhar morfológico e funcional Estela Bevilacqua Instituto de Ciências Biomédicas da Universidade de São Paulo, USP, SP A interface maternal fetal: um olhar clínico Rossana PV Francisco Faculdade de Medicina da Universidade de São Paulo, USP, SP 11h00-12h00 Hipertensão e patologias gestacionais associadas Rossana Pulcineli V. Francisco Faculdade de Medicina da Universidade de São Paulo, USP, SP 14h00-15h00 Hiperglicemia na gestação Iracema Calderon Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio Mesquita Filho, UNESP,Botucatu 15h00-16h0 Modelos experimentais para o estudo da hiperglicemia gestacional Debora Damasceno Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio Mesquita Filho, UNESP,Botucatu 16h30-17h30 Modelos experimentais para o estudo da diabete tipo I Telma Zorn Instituto de Ciências Biomédicas da Universidade de São Paulo, USP, SP IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 07/04/2015 9h00-9h45 Fatores de risco associados a abortos recorrentes Ricardo Barini Faculdade de Ciências Médicas, Universidade Estadual de Campinas, UNICAMP, Campinas 9h45-10h30 Aspectos imunológicos da gestação normal e patológica Silvia Daher Escola Paulista de Medicina, Universidade Federal de São Paulo, UNIFESP, SP 11h00-12h00 Experimental models in preeclampsia Marijke M Faas UniversitairMedisch Centrum Groningen, Groningen, Netherlands 14h00-16h00* Apresentação e Discussão de Projetos dos Participantes (exclusivo para participantes da parte prática do Workshop) 16h30-17h30* Morphology of the maternal-fetal interface John Aplin Manchester University, Manchester, UK 08/04/2015 8h30-9h30* Morphological analyses of the human placenta 9h30-10h30 Placental vascular changes in pathological conditions John Aplin Manchester University, Manchester, UK IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 11h00-12h00 Morphological and phenotypic analyses of the human placenta using whole mount immunofluorescence Shawn Murphy Rochester University, Rochester, USA 14h00-16h00* Morphology of the maternal-fetal interface John Aplin Manchester University, Manchester, UK 16h30-18h00* Morphology of the maternal-fetal interface John Aplin Manchester University, Manchester, UK 09/04/2015 8h30-9h30* Morphological analyses of the human placenta 9h30-10h30 Immunological factors associated with cardiovascular adaptation to pregnancy Anne Croy Queen's University, Kingston, Canada 11h00-12h00 The impact of placental growth factor deficiency on early mouse implant site angiogenesis Matthew T Rätsep Queen's University, Kingston, Canada 14h00-16h00* Morphology of the maternal-fetal interface John Aplin Manchester University, Manchester, UK IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 16h30 – 18h00* Morphological analyses of the human placenta using whole mount immunofluorescence Shawn Murphy Rochester University, Rochester, USA 10/04/2015 8h30-9h30* Morphological analyses of the human placenta 9h30-10h30 Three-dimensional cultures of trophoblast stem cells James Cross Calgary University, Alberta, Canada 11h00-12h00 In situ hybridization and placental differenciation James Cross Calgary University, Alberta, Canada 14h30 – 16h00* Morphological analyses of the human placenta using whole mount immunofluorescence Shawn Murphy Rochester University, Rochester, USA 16h30 – 18h00* Microscopic examination of the samples Shawn Murphy Rochester University, Rochester, USA 11/04/2015 9h30 – 10h30* Microscopic examination of the samples Shawn Murphy Rochester University, Rochester, USA 11h00-12h00* IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 Discussion of the results and closing remarks All participants and speakers 9h00 9h15 April 6th April 7th April 8th April 9th April 10th April 11st Monday Twesday Wednesday Thursday Friday Saturday Opening Ricardo Barini Gestational Immunoregulation 10h15 The Maternal Fetal Interface Estela Bevilacqua Rossana Francisco 10h30 Coffee 9h30 9h45 10h00 11h00 11h30 Rossana Francisco Hypertension and Placental Disorders John Aplin Placental vascular network Anne Croy Immunological Gestational Factors James Cross 3DCultures and Placental Studies Coffee Coffee Coffee Coffee Coffee Marijke Faas Experimental Model for Preeclampsia Studies Shawn Murphy Whole Mount Immuno fluorescence Matthew Rätsep Implantation Site Angiogenesis James Cross In situ Hybridization Concluding Remarks (all speakers and participants) Silvia Daher Gestational Immunoregulation 12h00 14h00 14h30 Closing Iracema Calderon Gestational Hyperglycemia Presentations of the participants' projects (all speakers and participants) 15h30 Debora Damasceno Experimental Models 16h00 Coffee Coffee Telma Zorn Experimental Models John Aplin Placental Morphology 15h00 16h30 17h00 17h30 Shawn Murphy Microscopic examination of the samples John Aplin Placental Morphology John Aplin Placental Morphology Shawn Murphy Whole Mount Immuno fluorescence Coffee Coffee Coffee John Aplin Placental Morphology Shawn Murphy Whole Mount Immuno fluorescence Shawn Murphy Microscopic examination of the samples 18h00 Apoio Logístico Institucional IV Workshop on Maternal Fetal Interaction“Starting from the Beginning: Morphological Development of the Placenta” Instituto de Ciências Biomédicas - Universidade de São Paulo 6 a 11 de abril de 2015 Preparação e divulgação do evento, captação de Inscrições, preparação dos certificados, cessão de material para a realização das aulas práticas, mídia e salas de aulas e de microscopia. ApoioFinanceiro solicitado a Apoio das Sociedades Científicas: divulgação internacional PAA – Placenta Associations of the Americas/ SLIMP – Latin American Society for Maternal Fetal Interaction and Placenta