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Transcript
COMPUTER SCIENCE - Interaction Site Evolution DNA is the blueprint for generating strings of amino acids which fold into proteins. The interactions these proteins form with each other are primary components of organismal physiology. Proteins assume very specific shapes, and the amino acids on their surface involved in protein interactions are specific as well. Much work has been done on determining both the 3D structure of proteins, and the “interaction sites” on protein surfaces. In order to better understand protein evolution, a protein “atlas” of proteins and their interaction sites will be developed. In particular, the atlas will show how interaction sites among related protein families have evolved. Despite the progress made on determining protein 3D structures and interaction sites, the structure of the vast majority of proteins remains unknown. Therefore prediction tools for both the structure and interaction sites of proteins must be used. Initial tasks include: 1. Identify protein families suitable for study 2. Identify protein structure prediction tools 3. Identify protein interaction site prediction tools 4. Develop a visual representation for the atlas which showcases interaction site evolution.