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Tissues and Organs Comprising the Immune Response System Where components of the immune response originate, differentiate, meet, interact, and function Folder Title: Tiss&Org Updated: October 30, 2014 APC and T-Cells Marcophage and T-Cell Kissing Macrophage to T-Cell Interaction Helper T-cell B-Cell Interaction CD4 co-receptor B-Cell Activation See figure 2-7, Kuby, 4th Ed., p. 36 B-Cell: Small, Blast, and Plasma See Figure 2-7, Kuby 4th Ed. p. 36 Where do these cells originate? Where do they go to interact with each other? Where do they carry out their functions? Related to Figure 2-13, Kuby, 4th Edition, p. 47 Primary and Secondary Lymphoid Animations Produced for Kuby Immunology Online Link http://bcs.whfreeman.com/immunology6e/ (In Class Do animations from the Book CD) Chapter 2 Animation. Cells and Organs Exactly* what kind of Cell is the one attached to the B-Cell? *(“exactly” means not just its general type of cell, but specifically what type of cell it is based on what this figure shows that the cell is doing) 5000% Rank 1 2 3 4 5 6 Responses 4500% 4000% 3500% 3000% Other 2500% East West 2000% North 1500% 1000% 500% 0% 1st Qtr 2nd Qtr 3rd Qtr 4th Qtr Thymus Photo Thymus Cartoon Diagrammatic Cross Section of Thymus. Figure 2-14, Kuby, 4th Edition, p. 48 ThymusCross CD4 and CD8 in Thymus MALT and M-Cells See Figure 2-22, Kuby 4th Ed. p. 56 MALT and IgA See Figure 2-22 Kuby, 4th Ed. p. 56 CD Antigen Table CDMarks CD Antigens Color Coded Animations Produced for Kuby Immunology http://bcs.whfreeman.com/immunology6e/ Chapter 11 Animation. Signal Transduction CD Antigen List: Pages A1 to A26: 339 Entries, 2007 Edition of Kuby How to Understand CD Antigens: 5 Persons in a Room Person 1: Person 2: Person 3: Person 4: Person 5: 5 ft 5”, 160 lbs bespectacled old geezer 5 ft 11”, 280 lbs, 22-year old guy, all muscle 5 ft 5”, 135 lbs, 20-year-old woman 7 ft 1” , 200 lbs, 22 year-old guy 5 ft 8”, 150 lbs, 22 year-old guy Person 1: Person 2: Person 3: Person 4: Person 5: 5 ft 5”, 160 lbs bespectacled old geezer 5 ft 11”, 280 lbs, 22-year old guy, all muscle 5 ft 5”, 135 lbs, 20-year-old woman 7 ft 1” , 200 lbs, 22 year-old guy 5 ft 8”, 150 lbs, 22 year-old guy This is a fill-in-the-blank question. Please enter your responses as a series of numbers from 1 to 5. Which Person: A. Is a varsity basketball player? B. Plays on the women’s field-hockey team? C. Is a boring old professor? D. Is a varsity football player for SU? E. Is a cross-country runner? __ __ __ __ __ Secrets of Signaling 1. How Do You Knock on a Door? 2. Why does the phone “ring” more than once? 3. Why can the police officer directing traffic blow his whistle only once? 4. Why does your computer say “Are You Sure You Want to Delete File XYZ?” 5. When the class was directed to do “Bunny Ears” behind the person next to them, only a few persons responded. Why was that? 6. A different set of persons responded when asked to raise their right hand. Why was that? Secrets of Signaling (2) 7. Only the guys in the front of the room responded when I invited the class to do what all classes would love to do to a pain-in-the next Prof. Why was that? 8. I asked the class to raise both hands but no one complied. Why is that? Signal, Receptors, and co-receptor Pairs Costimulatory signals: B7 – CD28 Costimulatory Signals: T-Cell to MPh Cancer Eluding Costimulatory Signal CD’s on B, T, and NK Cells (“ALL” = Acute Lymphocytic Leukemia) T-Cell ALL Markers Kuby, 5th Edition p. 157 Pre-B-Cell ALL Markers (“ALL” = Acute Lymphocytic Leukemia) Kuby, 5th Edition p. 157 (“CLL” = Chronic Lymphocytic Leukemia) B-Cell CLL Markers Kuby, 5th Edition p. 157 Leukocyte Recirculation Lymphocyte Recirculation Leucocytes in Capillaries Cartoon Leucocytes in Capillaries Photo Extravasation of Naïve T-Cell into Lymph Node Adhesion: Leucocytes to Endothelium (Non-inflamed Endothelium) CAM = Cell Adhesion Molecules Membrane of Circulating Leucocytes General Structures of Cell Adhesion Molecules (CAMs) Kuby, 3rd Edition Figure 15-2a CAMStruct Endothelial Cells Lining Capillaries (Inflamed Endothelium) CAMinCap Adhesion in Capilaries Animations Produced for Kuby Immunology OnLine Link http://bcs.whfreeman.com/immunology6e/ In Class Use Book CD: Chapter 2: Cells of the Immune-system (Static) Cell Death : (Animated) Chapter 11: Signal Transduction (Animated) Chapter 4 : Immunoglobulins (Static) Chapter 13 Animation. Leukocyte Extravasation (Animated) Please put away all notes and any devices except for your Turning Point NXT Transmitter. No papers or computers on your desk please. No communication between or among students. Animations Produced for Kuby Immunology http://bcs.whfreeman.com/immunology6e/ Or search “Kuby Immunology”, Click on “Kuby Immunology 6e” , go to Student Resources Chapter 2: Cells Cell Death (Also chapter 10) Chapter 11: Signal Transduction Chapter 13: Leucocyte Extravasation Actin Cytoskeleton Linkage to Collagen Extra-cellular Matrix Figure 19-14 ECB 1998, p. 603 Collagen Fibronectin Integrin Plasma Membrane Actin Microfilament MFtoECM Tissue-target Cells in Red Leucocyte CAM in Blue CAMFamly On Endothelial Cells On Neutrophils On Mucosal Epithelium On Leucocytes On Endothelial Cells On Leucocytes CamFamly On Endothelial Cells Families of Cell Adhesion Molecules Kuby, 3rd Ed. Figure 15-2b