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How scientists are developing ways to help children with muscular diseases By Antonio Scientists at the duke university medical centre discovered certain compounds or elements that could lead to promising new treatments for degenerative nerve diseases, such as Huntington’s disease, Alzheimer’s disease and Parkinson’s disease. Misfolded proteins in nerve cells (neurons) are a common factor in all of these diseases. These new compounds improve a cell’s ability to properly “fold” proteins. It activates a master regulator to increase the supply of molecules that help fold proteins properly. The scientists further explored one of the candidate molecules Heat Shock Factor 1 (HSF1), to learn whether it would work in model systems of Huntington’s disease, a devastating neurodegenerative disease of protein misfolding. They were able to show that the molecule stimulated protein chaperones in cells in an animal system. People with muscular dystrophy are treated with adult stem cells which are put into the diseased peoples bodies.