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Anatomy & Physiology 2 Chapter 20 - The Heart Albert Grazia, M.S., N.D. (516) 486-8332 www.naturedoc.info Albert Grazia, M.S., N.D. www.naturedoc.info 1 The Cardiovascular System: The Heart • Heart pumps over 1 million gallons per year • Over 60,000 miles of blood vessels Albert Grazia, M.S., N.D. www.naturedoc.info 2 Heart Location Anterior surface of heart • Heart is located in the mediastinum – area from the sternum to the vertebral column and between the lungs Albert Grazia, M.S., N.D. www.naturedoc.info 3 Heart Orientation • Apex - directed anteriorly, inferiorly and to the left • Base - directed posteriorly, superiorly and to the right • Anterior surface - deep to the sternum and ribs • Inferior surface - rests on the diaphragm • Right border - faces right lung • Left border (pulmonary border) - faces left lung Albert Grazia, M.S., N.D. www.naturedoc.info 4 Heart Orientation • Heart has 2 surfaces: anterior and inferior, and 2 borders: right and left Albert Grazia, M.S., N.D. www.naturedoc.info 5 Surface Projection of the Heart • Superior right point at the superior border of the 3rd right costal cartilage • Superior left point at the inferior border of the 2nd left costal cartilage 3cm to the left of midline • Inferior left point at the 5th intercostal space, 9 cm from the midline • Inferior right point at superior border of the 6th right costal cartilage, 3 cm from the midline Albert Grazia, M.S., N.D. www.naturedoc.info 6 Pericardium • Fibrous pericardium – dense irregular CT – protects and anchors the heart, prevents overstretching • Serous pericardium – thin delicate membrane – contains • parietal layer-outer layer • pericardial cavity with pericardial fluid • visceral layer (epicardium) Albert Grazia, M.S., N.D. www.naturedoc.info 7 Albert Grazia, M.S., N.D. www.naturedoc.info 8 Layers of Heart Wall • Epicardium – visceral layer of serous pericardium • Myocardium – cardiac muscle layer is the bulk of the heart • Endocardium – chamber lining & valves Albert Grazia, M.S., N.D. www.naturedoc.info 9 Muscle Bundles of the Myocardium • Cardiac muscle fibers swirl diagonally around the heart in interlacingAlbert bundles Grazia, M.S., N.D. 10 www.naturedoc.info Chambers and Sulci of the Heart • Four chambers – 2 upper atria – 2 lower ventricles • Sulci - grooves on surface of heart containing coronary blood vessels and fat – coronary sulcus • encircles heart and marks the boundary between the atria and the ventricles – anterior interventricular sulcus • marks the boundary between the ventricles anteriorly – posterior interventricular sulcus • marks the boundary between the ventricles posteriorly Albert Grazia, M.S., N.D. www.naturedoc.info 11 Chambers and Sulci Anterior View Albert Grazia, M.S., N.D. www.naturedoc.info 12 Chambers and Sulci Posterior View Albert Grazia, M.S., N.D. www.naturedoc.info 13 Right Atrium • Receives blood from 3 sources – superior vena cava, inferior vena cava and coronary sinus • Interatrial septum partitions the atria • Fossa ovalis is a remnant of the fetal foramen ovale • Tricuspid valve – Blood flows through into right ventricle – has three cusps composed of dense CT covered by endocardium Albert Grazia, M.S., N.D. www.naturedoc.info 14 Right Ventricle • Forms most of anterior surface of heart • Papillary muscles are cone shaped trabeculae carneae (raised bundles of cardiac muscle) • Chordae tendineae: cords between valve cusps and papillary muscles • Interventricular septum: partitions ventricles • Pulmonary semilunar valve: blood flows into pulmonary trunk Albert Grazia, M.S., N.D. www.naturedoc.info 15 Left Atrium • Forms most of the base of the heart • Receives blood from lungs - 4 pulmonary veins (2 right + 2 left) • Bicuspid valve: blood passes through into left ventricle – has two cusps – to remember names of this valve, try the pneumonic LAMB • Left Atrioventricular, Mitral, or Bicuspid valve Albert Grazia, M.S., N.D. www.naturedoc.info 16 Left Ventricle • Forms the apex of heart • Chordae tendineae anchor bicuspid valve to papillary muscles (also has trabeculae carneae like right ventricle) • Aortic semilunar valve: – blood passes through valve into the ascending aorta – just above valve are the openings to the coronary arteries Albert Grazia, M.S., N.D. www.naturedoc.info 17 Myocardial Thickness and Function • Thickness of myocardium varies according to the function of the chamber • Atria are thin walled, deliver blood to adjacent ventricles • Ventricle walls are much thicker and stronger – right ventricle supplies blood to the lungs (little flow resistance) – left ventricle wall is the thickest to supply systemic circulation Albert Grazia, M.S., N.D. www.naturedoc.info 18 Thickness of Cardiac Walls Myocardium of left ventricle is much thicker than the right. Albert Grazia, M.S., N.D. www.naturedoc.info 19 Fibrous Skeleton of Heart • Dense CT rings surround the valves of the heart, fuse and merge with the interventricular septum • Support structure for heart valves • Insertion point for cardiac muscle bundles • Electrical insulator between atria and ventricles – prevents direct propagation of AP’s to ventricles Albert Grazia, M.S., N.D. www.naturedoc.info 20 Atrioventricular Valves Open • A-V valves open and allow blood to flow from atria into ventricles when ventricular pressure is lower than atrial pressure – occurs when ventricles are relaxed, chordae tendineae are slack and papillary muscles are relaxed Albert Grazia, M.S., N.D. www.naturedoc.info 21 Atrioventricular Valves Close • A-V valves close preventing backflow of blood into atria – occurs when ventricles contract, pushing valve cusps closed, chordae tendinae are pulled taut and papillary muscles contract to pull cords and prevent cusps from everting Albert Grazia, M.S., N.D. 22 www.naturedoc.info Semilunar Valves • SL valves open with ventricular contraction – allow blood to flow into pulmonary trunk and aorta • SL valves close with ventricular relaxation – prevents blood from returning to ventricles, blood fills valve cusps, tightly closing the SL valves Albert Grazia, M.S., N.D. www.naturedoc.info 23 Valve Function Review What are the ventricles doing? Albert Grazia, M.S., N.D. www.naturedoc.info 24 Valve Function Review Atria contract, blood fills ventricles through A-V valves Ventricles contract, blood pumped into aorta and pulmonary trunk through SL valves Albert Grazia, M.S., N.D. www.naturedoc.info 25 Albert Grazia, M.S., N.D. www.naturedoc.info 26 Albert Grazia, M.S., N.D. www.naturedoc.info 27 Blood Circulation • Two closed circuits, the systemic and pulmonic • Systemic circulation – – – – – left side of heart pumps blood through body left ventricle pumps oxygenated blood into aorta aorta branches into many arteries that travel to organs arteries branch into many arterioles in tissue arterioles branch into thin-walled capillaries for exchange of gases and nutrients – deoxygenated blood begins its return in venules – venules merge into veins and return to right atrium Albert Grazia, M.S., N.D. www.naturedoc.info 28 Blood Circulation (cont.) • Pulmonary circulation – – – – right side of heart pumps deoxygenated blood to lungs right ventricle pumps blood to pulmonary trunk pulmonary trunk branches into pulmonary arteries pulmonary arteries carry blood to lungs for exchange of gases – oxygenated blood returns to heart in pulmonary veins Albert Grazia, M.S., N.D. www.naturedoc.info 29 Blood Circulation • Blood flow – blue = deoxygenated – red = oxygenated Albert Grazia, M.S., N.D. www.naturedoc.info 30 Albert Grazia, M.S., N.D. www.naturedoc.info 31 Albert Grazia, M.S., N.D. www.naturedoc.info 32 Albert Grazia, M.S., N.D. www.naturedoc.info 33 Albert Grazia, M.S., N.D. www.naturedoc.info 34 Albert Grazia, M.S., N.D. www.naturedoc.info 35 Albert Grazia, M.S., N.D. www.naturedoc.info 36 • The Right Atrium, receives "used blood" from the body. Blood will be pushed through the tricuspid valve to the • Right Ventricle, the chamber which will pump to the lungs through the pulmonic valve to the • Pulmonary Arteries, providing blood to both lungs. Blood is circulated through the lungs where carbon dioxide is removed and oxygen added. It returns through the • Pulmonary Veins, which empty into the • Left Atrium, a chamber which will push the Mitral Valve open. Blood then passes into the • Left Ventricle is the largest and most important chamber in the heart. It pumps to the rest of the body. As it pumps, the pressure will close the mitral valve and open the aortic valve, with blood passing through to the • Aorta, where it will be delivered to the rest of the body. Albert Grazia, M.S., N.D. www.naturedoc.info 37 Albert Grazia, M.S., N.D. www.naturedoc.info 38 Albert Grazia, M.S., N.D. www.naturedoc.info 39 Coronary Circulation • Coronary circulation is blood supply to the heart • Heart as a very active muscle needs lots of O2 • When the heart relaxes high pressure of blood in aorta pushes blood into coronary vessels • Many anastomoses – connections between arteries supplying blood to the same region, provide alternate routes if one artery becomes occluded Albert Grazia, M.S., N.D. www.naturedoc.info 40 • The heart needs its own reliable blood supply in order to keep beating- the coronary circulation. • There are two main coronary arteries, the left and right coronary arteries, and these branch further to form several major branches. • The coronary arteries lie in grooves (sulci) running over the surface of the myocardium, covered over by the epicardium, and have many branches which terminate in arterioles supplying the vast capillary network of the myocardium. • Even though these vessels have multiple anastomoses, significant obstruction to one or other of the main branches will lead to ischaemia in the area supplied by that branch. Albert Grazia, M.S., N.D. www.naturedoc.info 41 Coronary Arteries • Branches off aorta above aortic semilunar valve • Left coronary artery – circumflex branch • in coronary sulcus, supplies left atrium and left ventricle – anterior interventricular art. • supplies both ventricles • Right coronary artery – marginal branch • in coronary sulcus, supplies right ventricle – posterior interventricular art. • supplies both ventricles Albert Grazia, M.S., N.D. www.naturedoc.info 42 Coronary Veins • Collects wastes from cardiac muscle • Drains into a large sinus on posterior surface of heart called the coronary sinus • Coronary sinus empties into right atrium Albert Grazia, M.S., N.D. www.naturedoc.info 43 Cardiac Muscle Histology • Branching, intercalated discs with gap junctions, involuntary, striated, single central nucleus per cell Albert Grazia, M.S., N.D. www.naturedoc.info 44 Cardiac Myofibril Albert Grazia, M.S., N.D. www.naturedoc.info 45 Conduction System of Heart Coordinates contraction of heart muscle. Albert Grazia, M.S., N.D. www.naturedoc.info 46 Conduction System of Heart • Autorhythmic Cells – Cells fire spontaneously, act as pacemaker and form conduction system for the heart • SA node – cluster of cells in wall of Rt. Atria – begins heart activity that spreads to both atria – excitation spreads to AV node • AV node – in atrial septum, transmits signal to bundle of His • AV bundle of His – the connection between atria and ventricles – divides into bundle branches & purkinje fibers, large diameter fibers that conduct signals quickly Albert Grazia, M.S., N.D. www.naturedoc.info 47 Rhythm of Conduction System • SA node fires spontaneously 90-100 times per minute • AV node fires at 40-50 times per minute • If both nodes are suppressed fibers in ventricles by themselves fire only 20-40 times per minute • Artificial pacemaker needed if pace is too slow • Extra beats forming at other sites are called ectopic pacemakers – caffeine & nicotine increase activity Albert Grazia, M.S., N.D. www.naturedoc.info 48 Timing of Atrial & Ventricular Excitation • SA node setting pace since is the fastest • In 50 msec excitation spreads through both atria and down to AV node • 100 msec delay at AV node due to smaller diameter fibers- allows atria to fully contract filling ventricles before ventricles contract • In 50 msec excitation spreads through both ventricles simultaneously Albert Grazia, M.S., N.D. www.naturedoc.info 49 Albert Grazia, M.S., N.D. www.naturedoc.info 50 Albert Grazia, M.S., N.D. www.naturedoc.info 51 Physiology of Contraction • Depolarization, plateau, repolarization Albert Grazia, M.S., N.D. www.naturedoc.info 52 Depolarization & Repolarization • Depolarization – Cardiac cell resting membrane potential is -90mv – excitation spreads through gap junctions – fast Na+ channels open for rapid depolarization • Plateau phase – 250 msec (only 1msec in neuron) – slow Ca+2 channels open, let Ca +2 enter from outside cell and from storage in sarcoplasmic reticulum, while K+ channels close – Ca +2 binds to troponin to allow for actin-myosin cross-bridge formation & tension development • Repolarization – Ca+2 channels close and K+ channels open & -90mv is restored as potassium leaves the cell • Refractory period – very long so heart can fill Albert Grazia, M.S., N.D. www.naturedoc.info 53 Action Potential in Cardiac Muscle Changes in cell membrane permeability. Albert Grazia, M.S., N.D. www.naturedoc.info 54 Albert Grazia, M.S., N.D. www.naturedoc.info 55 Electrocardiogram---ECG or EKG • EKG – Action potentials of all active cells can be detected and recorded • P wave – atrial depolarization • P to Q interval – conduction time from atrial to ventricular excitation • QRS complex – ventricular depolarization • T wave – ventricular repolarization Albert Grazia, M.S., N.D. www.naturedoc.info 56 • The P wave represents atrial depolarization- there is little muscle in the atrium so the deflection is small. • The Q wave represents depolarization at the bundle of His; again, this is small as there is little muscle there. • The R wave represents the main spread of depolarization, from the inside out, through the base of the ventricles. This involves large amounts of muscle so the deflection is large. • The S wave shows the subsequent depolarization of the rest of the ventricles upwards from the base of the ventricles. • The T wave represents Repolarization of the myocardium after systole is complete. This is a relatively slow process- hence the smooth curved deflection. Albert Grazia, M.S., N.D. 57 www.naturedoc.info One Cardiac Cycle • At 75 beats/min, one cycle requires 0.8 sec. – systole (contraction) and diastole (relaxation) of both atria, plus the systole and diastole of both ventricles • End diastolic volume (EDV) – volume in ventricle at end of diastole, about 130ml • End systolic volume (ESV) – volume in ventricle at end of systole, about 60ml • Stroke volume (SV) – the volume ejected per beat from each ventricle, about 70ml Grazia, M.S., N.D. 58 – SV = EDV - ESVAlbert www.naturedoc.info Phases of Cardiac Cycle • Isovolumetric relaxation – brief period when volume in ventricles does not change-as ventricles relax, pressure drops and AV valves open • Ventricular filling – rapid ventricular filling:as blood flows from full atria – diastasis: as blood flows from atria in smaller volume – atrial systole pushes final 20-25 ml blood into ventricle • Ventricular systole – ventricular systole – isovolumetric contraction • brief period, AV valves close before SL valves open – ventricular ejection: as SL valves open and blood is ejected Albert Grazia, M.S., N.D. www.naturedoc.info 59 Cardiac Cycle Albert Grazia, M.S., N.D. www.naturedoc.info 60 Ventricular Pressures • Blood pressure in aorta is 120mm Hg • Blood pressure in pulmonary trunk is 30mm Hg • Differences in ventricle wall thickness allows heart to push the same amount of blood with more force from the left ventricle • The volume of blood ejected from each ventricle is 70ml (stroke volume) Albert Grazia, M.S., N.D. www.naturedoc.info 61 Auscultation • Stethoscope • Sounds of heartbeat are from turbulence in blood flow caused by valve closure – first heart sound (lub) is created with the closing of the atrioventricular valves – second heart sound (dup) is created with the closing of semilunar valves Albert Grazia, M.S., N.D. www.naturedoc.info 62 Heart Sounds Where to listen on chest wall for heart sounds. Albert Grazia, M.S., N.D. www.naturedoc.info 63 Cardiac Output • Amount of blood pushed into aorta or pulmonary trunk by ventricle • Determined by stroke volume and heart rate • CO = SV x HR – at 70ml stroke volume & 75 beat/min----5 1/4 liters/min – entire blood supply passes through circulatory system every minute • Cardiac reserve is maximum output/output at rest - average is 4-5 while athlete is 7-8 Albert Grazia, M.S., N.D. www.naturedoc.info 64 Influences on Stroke Volume • Preload (affect of stretching) – Frank-Starling Law of Heart – more muscle is stretched, greater force of contraction – more blood more force of contraction results • Contractility – autonomic nerves, hormones, Ca+2 or K+ levels • Afterload – amount of pressure created by the blood in the way – high blood pressure creates high afterload Albert Grazia, M.S., N.D. www.naturedoc.info 65 Stroke Volume and Heart Rate Albert Grazia, M.S., N.D. www.naturedoc.info 66 Congestive Heart Failure • Causes of CHF – coronary artery disease, hypertension, MI, valve disorders, congenital defects • Left side heart failure – less effective pump so more blood remains in ventricle – heart is overstretched & even more blood remains – blood backs up into lungs as pulmonary edema – suffocation & lack of oxygen to the tissues • Right side failure – fluid builds up in tissues as peripheral edema Albert Grazia, M.S., N.D. www.naturedoc.info 67 Regulation of Heart Rate • Nervous control from the cardiovascular center in the medulla – Sympathetic impulses increase heart rate and force of contraction – parasympathetic impulses decrease heart rate. – Baroreceptors (pressure receptors) detect change in BP and send info to the cardiovascular center • located in the arch of the aorta and carotid arteries • Heart rate is also affected by hormones – epinephrine, norepinephrine, thyroid hormones – ions (Na+, K+, Ca2+) – age, gender, physical fitness, and temperature Albert Grazia, M.S., N.D. www.naturedoc.info 68 Regulation of Heart Rate Albert Grazia, M.S., N.D. www.naturedoc.info 69 Risk Factors for Heart Disease • Risk factors in heart disease: – – – – high blood cholesterol level high blood pressure cigarette smoking obesity & lack of regular exercise. • Other factors include: – – – – – diabetes mellitus genetic predisposition male gender high blood levels of fibrinogen left ventricular hypertrophy Albert Grazia, M.S., N.D. www.naturedoc.info 70 Plasma Lipids and Heart Disease • Risk factor for developing heart disease is high blood cholesterol level. – promotes growth of fatty plaques – Most lipids are transported as lipoproteins • low-density lipoproteins (LDLs) • high-density lipoproteins (HDLs) • very low-density lipoproteins (VLDLs) – HDLs remove excess cholesterol from circulation – LDLs are associated with the formation of fatty plaques – VLDLs contribute to increased fatty plaque formation • There are two sources of cholesterol in the body: in foods we ingest & formed by liver Albert Grazia, M.S., N.D. www.naturedoc.info 71 Desirable Levels of Blood Cholesterol for Adults • • • • TC (total cholesterol) under 200 mg/dl LDL under 130 mg/dl HDL over 40 mg/dl Normally, triglycerides are in the range of 10190 mg/dl. • Among the therapies used to reduce blood cholesterol level are exercise, diet, and drugs. Albert Grazia, M.S., N.D. www.naturedoc.info 72 Important Blood Tests: • Homocysteine • C-Reactive Protein (C-RP) • Lipoprotein (a) Albert Grazia, M.S., N.D. www.naturedoc.info 73 Coronary Artery Disease • Heart muscle receiving insufficient blood supply – narrowing of vessels--atherosclerosis, artery spasm or clot – atherosclerosis-smooth muscle & fatty deposits in walls of arteries • Treatment Albert Grazia, M.S., N.D. www.naturedoc.info – drugs, bypass graft, angioplasty, stent74 Clinical Problems • MI = myocardial infarction – death of area of heart muscle from lack of O2 – replaced with scar tissue – results depend on size & location of damage • Blood clot – use clot dissolving drugs streptokinase or t-PA & heparin – balloon angioplasty • Angina pectoris----heart pain from ischemia of cardiac muscle Albert Grazia, M.S., N.D. www.naturedoc.info 75 Unusual Sweating Predicts Oncoming Heart Attack • When individuals begin perspiring, after little or no exertion, while experiencing discomfort in their chest, arm, neck or jaw, it could indicate the onset of a heart attack. • Time is of the Essence • Time is of the essence during a heart attack. Doctors have urged people who experience common symptoms to get to a hospital as quickly as possible. These symptoms can include shortness of breath, cold sweats, nausea, lightheadedness, or discomfort in the chest, arm, neck or jaw. • Sweating is a Key Factor • Many seek treatment when they experience a high number of these symptoms; however, those who only experience a few may delay seeking treatment, which can be dangerous. Sweating may be a key factor in the symptoms that prompt individuals to seek treatment. Albert Grazia, M.S., N.D. www.naturedoc.info 76 Percutaneous Transluminal Coronary Angioplasty Albert Grazia, M.S., N.D. www.naturedoc.info 77 Stent in an Artery • Maintains patency of blood vessel Albert Grazia, M.S., N.D. www.naturedoc.info 78 By-pass Graft Albert Grazia, M.S., N.D. www.naturedoc.info 79 Albert Grazia, M.S., N.D. www.naturedoc.info 80 Exercise and the Heart • Sustained exercise increases oxygen demand in muscles. • Benefits of aerobic exercise (any activity that works large body muscles for at least 20 minutes, preferably 3-5 times per week) are; – – – – – increased cardiac output increased HDL and decreased triglycerides improved lung function decreased blood pressure weight control. Albert Grazia, M.S., N.D. www.naturedoc.info 81