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Transcript
DNA and the Cell Cycle
JEOPARDY!! 
Discovery of DNA
DNA structure
and replication
DNA
Replication and
the Cell Cycle
Mitosis
Potpourri
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50
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20
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40
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40
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10 Discovery of DNA
Which scientist discovered the
presence of a transforming factor
while working with mice and
pneumonia-causing bacteria?
10
Discovery of DNA
Griffith
20 Discovery of DNA
Using the conclusions of Griffith’s
experiment, which scientists
discovered DNA to be the hereditary
material?
20
Discovery of DNA
Hershey and Chase
30 Discovery of DNA
Using models and the research of
various other scientists, what were
Watson and Crick able to discover?
30 Discovery of DNA
The structure of DNA, and thus
were able to hypothesize DNA
replication
30 Community 1
40 Discovery of DNA
What two macromolecules were
suggested to be the transforming
factor, and how were they
distinguished from one another in
Hershey and Chases experiment?
40 Discovery of DNA
*DNA- phosphorus
*Protein-Sulfur
50 Discovery of DNA
What were the results of Griffith’s
experiment?
50
Discovery of DNA
Heat-killed pathogenic (harmful)
bacteria mixed with living nonpathogenic (harmless) bacteria
caused the formation of living
pathogenic (harmful) bacteria.
10 DNA structure and
replication
The monomers of the nucleic acids
are called…
10
DNA structure and
replication
Nucleotides
20
DNA structure and replication
Identify two differences between
DNA and RNA.
20
DNA structure and
replication
*DNA –thymine, deoxribose,
double stranded, longer
*RNA- uracil, ribose, single
stranded, shorter
30
DNA structure and
replication
Two polynucleotide strands are held
together by 1._______ bonds, and
the backbone of each strand is held
together by 2._______ bonds.
30
DNA structure and
replication
1. hydrogen
2. covalent
40
DNA structure and
replication
DNA Polymerase cannot start a new
polynucleotide chain, but can only
extend one. What is required to
mark the start? *be specific*
40
DNA structure and
replication
*an RNA primer laid down by
RNA primase.
50
DNA structure and
replication
Explain why DNA polymerase can
only make a new strand in one
direction and why?
50
DNA structure and
replication
5’3’; DNA polymerase can
only attach to the 3’ –OH of the
deoxyribose sugar at the end of
the template.
10
DNA Replication
and the Cell Cycle
Which enzyme unzips the
DNA molecule?
10
DNA Replication
and the Cell Cycle
Helicase
20
DNA Replication
and the Cell Cycle
Why is DNA replication considered
semi-conservative?
20
DNA Replication
and the Cell Cycle
One of the original strands of
DNA is retained (“conserved”) in
the newly constructed strands.
30
DNA Replication
and the Cell Cycle
What is the order of the Cell Cycle?
30
DNA Replication
and the Cell Cycle
G1SG2MCytokinesis
40
DNA Replication and the
Cell Cycle
Johnny smokes cigarettes. The
DNA of Johnny’s body has
become mutated due to exposure
to nicotine. He no longer contains
the correct gene instructions to
make certain surface proteins on
his cells. What could happen as a
result?
40
DNA Replication
and the Cell Cycle
The cells will not
recognize one
another, will continue
to divide although
bumping into each
other, and a tumor can
form.
50
DNA Replication
and the Cell Cycle
*What are the role of
checkpoints in the cell
cycle?
50
DNA Replication
and the Cell Cycle
*help to ensure phases of the cell
cycle are complete and accurate
before moving on to the next
phase.
10
What are the phases of
mitosis?
Mitosis
10
Prophase, Metaphase,
Anaphase, Telophase
Mitosis
20
Mitosis
What must happen to
complete cell division?
20
Cytokinesis
Mitosis
30
Mitosis
During which phase of mitosis is
the DNA split into chromatids?
30
Anaphase
Mitosis
40
Mitosis
What are the differences
between plant and animal
mitosis?
40
Mitosis
*no centrioles are used in
a plant cell during mitosis
(spindle fibers form
spontaneously)
*plant forms a cell plate,
instead of a cleavage
furrow, during telophase
leading into cytokinesis
50
Mitosis
A student observes a cell under the
microscope. She is able to see DNA. She
also notices the formation of tiny threadlike
structures.
(1)What phase of mitosis is she observing?
(2)Why can she see the DNA?
(3)What are the tiny threadlike structures?
50
Mitosis
(1) Prophase
(2) DNA has taken the form
of chromosomes
(3) Spindle fibers
10 Meiosis
My name is Bond, Ionic Bond;
Taken, not shared!
10 Population Growth
From: Mariano Cecowski
<MCecowski#NoSpam.sif.com.ar>
Q: if both a bear in Yosemite and one in
Alaska fall into the water
which one disolves faster?
A: The one in Alaska because it is
HIJKLMNO
10 Population Growth
Alimentary: What Sherlock Holmes said to Dr. Watson.
Urinate: What a nurse would say if a patient asked her what room
he's in.
Urine - The opposite of "You're out!"
Benign: What we want when we are eight.
Intestine - Currently taking an exam
CARDIOLOGY: advanced study of poker playing
TERMINAL ILLNESS: getting sick at the airport
10
Potpourri
What is the name of the strand of DNA
synthesized continuously during replication?
10
The Leading Strand
Potpourri
10
Population Growth
20
Potpourri
The lagging strand is made in short
fragments.
(1) What are these fragments called?
(2) Why?
20
Potpourri
(1) Okazaki fragments
(2) Multiple primers are used since the strand is made
away from the replication fork
30
Potpourri
What was Rosalind Franklin’s
contribution to the discovery of DNA?
30
Potpourri
*She used x-ray crystallography to take an
image that showed the double helix structure
of DNA.
30
Population Growth
40
What is the role of ligase
in DNA replication?
Potpourri
40
PotPouri
*It fills in the gaps on the lagging
strand
*helps to make sure there is no
damage to the DNA once
replication is complete
50
Potpourri
List the phases of the Cell Cycle in order.
50
Potpourri
1. G1SG2MCytokinesis