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Transcript
Meiosis Reduction Division Genetics Vocabulary • Gene: – a discrete unit of hereditary information consisting of a specific nucleotide sequence in DNA (or RNA, in some viruses) at a specific locus (location) • Allele: – Any of the alternative versions of a gene that produce distinguishable phenotypic (visible) effects • Genome: – The genetic material of an organism or a virus; the complete complement of an organism’s or viruses genes along with its noncoding nucleic acid sequences Meiosis Vocabulary • Diploid cell: – a cell that contains all (2n) of the genetic info it should. • Haploid cell: – a cell that contains half (n) of the genetic info it should. • Homologous chromosomes: – “paired”(at the same locus) chromosomes that have the same traits arranged in the same order but the are not identical • Meiosis: – The process that creates cells with a haploid number of genetic info. Meiosis Vocabulary • Gametes: – The only cells in the body not produced by mitosis – Made in the gonads – Sex cells • Sperm: The male sex cell • Egg: The female sex cell • Each one represents 1 in 8.4 million possible genetic combinations • Zygote: – The result of sperm fertilizing egg. – Combo of sperm and egg makes a 1 in 70 trillion possible combinations • Somatic cell: – Any other cell other than those involved in gamete formation Miscellaneous Factoids • Typically, a thousand or more genes are arranged on each chromosome • Humans have 46 chromosomes • Why meiosis? • Offspring get information from mom and dad – Genetic diversity is key!! • If that info wasn’t split, you would get twice as much information as they would have (reduction division) Phases • • • • Interphase The same as interphase in mitosis Chromosomes replicate Each chromosome then has two identical sister chromatids held together by a centromere Prophase I • Chromosomes coil • Spindle forms • Tetrads are formed – Joining of two homologous chromosomes with two sister chromatids each (called synapsis) – Bind so tightly that information is exchanged • Now called Chiasmata (Chiasma) – Called Crossing over (remember the purpose of introns!!!) • Forms recombinant chromosomes Metaphase I • Tetrads line up at midline • Homologous chromosomes line up in pairs Anaphase I • Homologous chromosomes separate and migrate towards poles • Centromeres do not split – This ensures that each new cell gets only one chromosome Telophase I • • • • Spindle breaks down Chromosomes uncoil Cytoplasm divides (cytokinesis) Cell has half of original cells genetic info but still double the amount it should Interphase II** • Very short or non-existent • Chromosomes do not replicate Meiosis II • Prophase II – Spindle forms • Metaphase II – Sister chromatids line up at the equator • Anaphase II – Centromeres split – Sister chromatids split • Telophase II – Spindle breaks down – New nuclei form – Cytokinesis occurs Meiosis in Men and Women • Male version of meiosis • Spermatogenesis • 4 sperm cells for every 1 cell that divides • Female version of meiosis • Oogenesis • 4 egg (ova) cells for every 1 cell that divides • 3 die and 1 survives Meiosis is the same all around the world! Alternation of Generations The adult generation produces spores, while the spore generation produces sex cells. Only seen in plants. Errors • DNA mutations – Point • Base-pair substitution – Silent mutations » Harmless » Occur within non-coding areas or don’t affect the coded polypeptide – Missense mutations » Amino acid works but not the way it’s supposed to (i.e., “close but no cigar”) – Nonsense mutations » Functionless amino acid » Example: a premature stop code • Base-pair insertions/deletions – Almost always lead to frameshift mutations Errors • Chromosomal – Nondisjunction • Leads to aneuploidy (abnormal # of chromsomes) – Trisomic (2n+1) – Monosomic (2n-1) • Polyploidy – Triploidy (3n) – Tetraploidy (4n) (gray tree frog) – Chromsomal structure alterations • Deletion • Duplication • Inversion • translocation Examples of Aneuploidy • Trisomy 21: Down’s syndrome Examples of Aneuploidy Trisomy 13: Patau syndrome (heart and kidney defects among problems) Examples of Aneuploidy • Trisomy 18: Edwards syndrome (body wide effects) Examples of Aneuploidy • Klinefelter syndrome: XXY Examples of Aneuploidy • XYY syndrome: – Not defined as syndrome – taller than average – Violent tendencies? (Chino prison study) Examples of Aneuploidy • XXX syndrome: relatively normal Karyotyping Chorionic villus sampling &Amniocentesis