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Download Objective 11 Notes Tuesday Jan 17
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OBJECTIVE 11 NOTES Explain the evolutionary significance of a nearly universal genetic code The Central Dogma of Molecular Biology • What is it? – This is the term used when DNA is transcribed into RNA and RNA is translated into a protein. • Why does this work? – Because of the common genetic code What is the genetic code? Think Pair Share Talk to your classmates: What is the result of the common coding for amino acids? How is this important in genetic engineering /biotechnology? What do we mean by a nearly universal genetic code? DNA Evidence for Evolution Similarities • Living organisms share a common mechanism that copies and translates heritable genetic information. • All living organisms translate the genetic code using ribosomes. • They all translate it with the aid of small molecules called transfer RNA. • They all read it in the same direction, and they all read it in the same way, translating the code 3 letters at a time into sequences of amino acids, the building blocks of proteins. DNA Evidence for Evolution Differences • In some organisms, a handful of these 3-letter “words” have different meanings. Our own cells, for example, contain mitochondrial DNA in which 4 of the 64 words have different meanings from the “standard” code. In most organisms, these differences are so slight as to be trivial. • In common molds, for example, the sequence “UGA” is translated into the amino acid tryptophan. In the standard code, it's a “stop” signal. The other 63 words, however, are identical between humans, elephants, daisies, and molds. Mitochondrial DNA differences in Red from the Universal Code What else? • 48 of the 64 words are identical in all living organisms, and only 16 are known to vary across the enormous diversity of living things. • In fact, the entire biotechnology industry is built upon the universality of the genetic code. How Does DNA Relate to Evolution? • Mutations (changes) in DNA provide a source of genetic variation. • Commonalities in DNA between all organisms on Earth provide evidence for common descent. • Slight differences in the genetic code reflect branching evolutionary relationships.