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Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well? cytoskeleton/extracellular matrix extracellular/intracellular communications proteins/enzymes hemostasis/thrombosis nutrition bioenergetics/metabolism informational macromolecules http://www.ebi.ac.uk/microarray/biology_intro.html Eric Niederhoffer Southern Illinois University School of Medicine Organ-System-Based Integration of Biochemistry Clinical Sciences Basic Sciences Y1 (Carbondale) CRR SSB ERG Anatomy BSS Biochemistry Doctoring Genetics Histology Pharmacology Physiology PHP Y2 HII C NB ERG Doctoring Genetics Immunology Microbiology Neoplasia Pathology Pharmacology Radiology Y3 Y4 clerkships electives CRR Unit Organization SCD ASD PE COPD Overview of gene expression Hb gene/product/defect RBC structure Glycolysis/2,3-BPG, PPP/GSH HbO2/CO2 Chem panels PSGN Lifestyle MC Cholesterol/lipoproteins/plaques/lipid processing Cardiac markers Thrombolytic agents Muscle contraction/energy production Filtration barrier Amino acid processing/urea cycle Ion channels/membrane transport Clinical markers ATP production Clinical markers/BNP Collagen/anemia Surfactant Nutrition CVD MC Familial hyperlipidemia nutrition/metabolism F&E MC Clinical markers G proteins/ signal transduction Shock MC G proteins/ signal transduction ECM/proteases/antiproteases/1AT Electrolyte imbalance CHF SOB MC Coagulation/clinical markers Arrhythmia Ion channels/action potentials G proteins/signal transduction MI Genetics MC SAQs (mc, T/F, short answers) MU & EOU Exams (clinical scenarios) ePBLM Organization Sickle Cell Disease Introduction to genetics (basic principles) Introduction to molecular biology of gene expression: transcription, translation, protein processing Hemoglobin structure: HbA (22), HbF (22), HbA2 (22), HbS; overview of hemoglobin function Complete blood count: RBC parameter (Hct, Hb content, MCV, MCHC) and WBCs Red blood cells: structure and function, glycolysis (2,3-BPG), pentose phosphate pathway, glutathione Structure and function of the spleen Pathogenesis and natural history of sickle cell disease Introduction to child development: Denver development chart, normal milestones Introduction to immunology: cause of inflammation and pain (cytokines and phagocytes) The Best and Worst at Times Worst Features Best Features low priority Integration with other disciplines/clinical medicine Perceived orphan topics overlap/redundancy of topics Competition with other disciplines clinical relevance Non-biochemistry resources