Download Lecture 16. Physiology of leukocytes. Leukocyte formula. Immunity

PHYSIOLOGY OF
LEUKOCYTES.
LEUKOCYTE FORMULA.
IMMUNITY.
Function of leukocytes
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1. Protective
2. Transport
3. Metabolic
4. Regenerator
Quantity of leukocytes and their
changes
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White cells are nucleated and somewhat variable in
size and shape. Their numbering is 4-9•Giga per
liter. The number of lymphocytes are – 18-37 %,
monocytes – 3-11 %,
eosinophils –0,5-5 %,
basophils – 0-1 %,
juvenile neutrophile – 0-1 %,
relating to stab (rod-shaped) neutrophil – 1-6 %,
segmented neutrophil – 47-72 %.
The number of leukocytes may increase or
decrease.
Development of monocytes
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common progenitor cell –
uncommited stem cell –
commited stem cell –
monoblast –
promonocyte –
monocyte –
tissue macrophage.
Development of lymphocytes
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common progenitor cell –
bone marrow lymphocytes precursor –
lymphoblast –
prolymphocyte –
large lymphocyte –
small lymphocyte.
Lymphocytes in the fetus are thought to arise first in
the thymus. Later they are found in lymph nodes,
spleen, and other lymphoid tissues as well as in
bone marrow.
Development of gtanulocytes
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common progenitor cell –
uncommited stem cell –
commited stem cell –
myeloblast (basophil, neutrophil, eosinophil) –
promyelocyte –
myelocyte –
metamyelocyte –
juvenile –
rod-shaped neutrophil (basophil, eosinophil),
segmented neutrophil, basophil, eosinophil.
Physiological role of T-lymphocytes
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1. Immune memory.
2. Anti viruses immunity.
3. Anti tissue immunity.
4. Regulate phagocytosis.
 Function of В-lymphocytes
1. Immune memory.
2. Specific immunity. B-lymphocytes syntheses the
immunoglobulins such as IgM, IgN, IgA, IgG, IgB,
IgE.
System of mononucleares
phagocytes
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These is the system, which common the cells
with one nucleus,
common origin from red bone marrow,
common function of high specific
phagocytosis
EOSINOPHILS
The index of nuclear’s changing of
neutrophyls, it interpretation
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NCN=(M+J+S1)/S2, where
M – myelocytes,
J– juvenile,
S1 – stab neutrophils,
S2 – segmented neutrophils
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Norm is 0,06-0,09
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Thank you!